SE7706673L - PROCEDURE FOR PREPARING MULTIPLE HALOGENERATED STEROIDS - Google Patents

PROCEDURE FOR PREPARING MULTIPLE HALOGENERATED STEROIDS

Info

Publication number
SE7706673L
SE7706673L SE7706673A SE7706673A SE7706673L SE 7706673 L SE7706673 L SE 7706673L SE 7706673 A SE7706673 A SE 7706673A SE 7706673 A SE7706673 A SE 7706673A SE 7706673 L SE7706673 L SE 7706673L
Authority
SE
Sweden
Prior art keywords
alpha
halogenerated
steroids
procedure
chlorine
Prior art date
Application number
SE7706673A
Other languages
Unknown language ( )
Swedish (sv)
Other versions
SE436751B (en
Inventor
J Kalvoda
G Anner
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of SE7706673L publication Critical patent/SE7706673L/en
Publication of SE436751B publication Critical patent/SE436751B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Abstract

9 alpha ,21-Dihalo-11 beta ,17 alpha -dihydroxy-6 alpha -fluoro-16 alpha -methylpregna-1,4-diene -3,20-dione 17-esters of the formula <IMAGE> in which X1 is chlorine or fluorine, X2 is bromine or chlorine, and Ac is an acyl group derived from a carboxylic acid, are distinguished by high local antiinflammatory activity with a reduced systemic effect, for which reason they can be used in medicine to alleviate and control inflammatory states. They are obtained by conventional replacement of an organic 21-sulphonyloxy group by halogen X2.
SE7706673A 1976-09-29 1977-06-08 PROCEDURE IN accordance with Claim 1 of Patent 7613920-3 (PUBL. No. 423903) FOR PREPARATION OF 17ALFA-ACYLOXI-9ALFA, 21-DIHALOGEN-11BETA-HYDROXI-6ALFA-FLUOR-16BETA-METHYL-PREGNA 20-dione COMPOUNDS SE436751B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU75903A LU75903A1 (en) 1976-09-29 1976-09-29

Publications (2)

Publication Number Publication Date
SE7706673L true SE7706673L (en) 1978-03-30
SE436751B SE436751B (en) 1985-01-21

Family

ID=19728370

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7706673A SE436751B (en) 1976-09-29 1977-06-08 PROCEDURE IN accordance with Claim 1 of Patent 7613920-3 (PUBL. No. 423903) FOR PREPARATION OF 17ALFA-ACYLOXI-9ALFA, 21-DIHALOGEN-11BETA-HYDROXI-6ALFA-FLUOR-16BETA-METHYL-PREGNA 20-dione COMPOUNDS

Country Status (24)

Country Link
JP (1) JPS5356652A (en)
AT (3) AT363197B (en)
AU (1) AU514200B2 (en)
BE (1) BE859120A (en)
CA (1) CA1101410A (en)
CH (9) CH624967A5 (en)
CY (1) CY1178A (en)
DD (1) DD133150A5 (en)
DE (1) DE2743069A1 (en)
DK (1) DK146017C (en)
ES (1) ES462763A1 (en)
FR (1) FR2366311A1 (en)
GB (1) GB1563638A (en)
HK (1) HK16683A (en)
HU (1) HU175218B (en)
IE (1) IE46047B1 (en)
IL (1) IL53012A (en)
KE (1) KE3258A (en)
LU (1) LU75903A1 (en)
MY (1) MY8400092A (en)
NL (1) NL7710089A (en)
SE (1) SE436751B (en)
SG (1) SG3383G (en)
ZA (1) ZA775800B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL187577C (en) * 1978-04-05 1991-11-18 Sibla Srl 3-ACETOXY-9BETA, 11BETA-EPOXY-PREGNA-1,3,5-TRIEN, PROCESS FOR THE PREPARATION THEREOF, AND PROCESS FOR THE PREPARATION OF 6-alpha-halogen-1,4-diene-3-ones.
DE3227312A1 (en) * 1982-07-19 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen NEW 6.16 DIMETHYL CORTICOIDS, THEIR PRODUCTION AND USE
AU7556291A (en) * 1990-03-27 1991-10-21 Schering Corporation Process for 9alpha-hydroxy steroid dehydration
US5972922A (en) * 1990-06-11 1999-10-26 Alcon Laboratories, Inc. Steroids which inhibit angiogenesis
US7098328B2 (en) 2001-11-29 2006-08-29 Taro Pharmaceutical Industries Limited Method for the preparation of 6α-fluoro corticosteroids
US11957753B2 (en) 2010-11-22 2024-04-16 Bausch Health Ireland Limited Pharmaceutical formulations containing corticosteroids for topical administration
US8809307B2 (en) 2010-11-22 2014-08-19 Dow Pharmaceutical Sciences, Inc. Pharmaceutical formulations containing corticosteroids for topical administration
SI3310389T1 (en) 2015-06-18 2020-11-30 Bausch Health Ireland Limited Topical compositions comprising a corticosteroid and a retinoid for treating psoriasis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB898292A (en) * 1959-03-18 1962-06-06 Upjohn Co Improvements in or relating to steroids and the manufacture thereof
US3644340A (en) * 1970-03-19 1972-02-22 Syntex Corp Preparation of 21-chloro steroids
US3992422A (en) * 1975-08-14 1976-11-16 Schering Corporation Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes

Also Published As

Publication number Publication date
DD133150A5 (en) 1978-12-13
DK256977A (en) 1978-03-30
CH632521A5 (en) 1982-10-15
MY8400092A (en) 1984-12-31
DE2743069A1 (en) 1978-03-30
AT363203B (en) 1981-07-27
FR2366311B1 (en) 1982-12-03
ZA775800B (en) 1978-08-30
NL7710089A (en) 1978-03-31
ES462763A1 (en) 1978-05-16
JPS5356652A (en) 1978-05-23
HK16683A (en) 1983-05-27
JPS6214557B2 (en) 1987-04-02
AT363197B (en) 1981-07-10
CY1178A (en) 1983-06-10
CH631999A5 (en) 1982-09-15
DE2743069C2 (en) 1987-03-05
DK146017B (en) 1983-05-24
HU175218B (en) 1980-06-28
ATA151379A (en) 1980-12-15
CH625808A5 (en) 1981-10-15
ATA691077A (en) 1980-12-15
CH632000A5 (en) 1982-09-15
AU514200B2 (en) 1981-01-29
AU2914877A (en) 1979-04-05
DK146017C (en) 1983-10-24
IE46047B1 (en) 1983-02-09
CH625809A5 (en) 1981-10-15
BE859120A (en) 1978-03-28
IL53012A (en) 1982-05-31
CA1101410A (en) 1981-05-19
CH625810A5 (en) 1981-10-15
GB1563638A (en) 1980-03-26
CH632279A5 (en) 1982-09-30
CH631998A5 (en) 1982-09-15
IL53012A0 (en) 1977-11-30
IE46047L (en) 1978-03-29
SG3383G (en) 1983-09-09
AT363202B (en) 1981-07-27
KE3258A (en) 1983-03-04
SE436751B (en) 1985-01-21
LU75903A1 (en) 1978-05-16
FR2366311A1 (en) 1978-04-28
CH624967A5 (en) 1981-08-31
ATA151279A (en) 1980-12-15

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