SE423903B - PROCEDURE FOR PREPARING 9 ALFA, 21-DIHALOGEN-11 BETA, 17 ALFA-DIHYDROXY-6 ALFA-FLOUR-16 ALFA-METHYL-PREGNA-1,4-DIENE-3,20-DIONE ESTARS - Google Patents

PROCEDURE FOR PREPARING 9 ALFA, 21-DIHALOGEN-11 BETA, 17 ALFA-DIHYDROXY-6 ALFA-FLOUR-16 ALFA-METHYL-PREGNA-1,4-DIENE-3,20-DIONE ESTARS

Info

Publication number
SE423903B
SE423903B SE7613920A SE7613920A SE423903B SE 423903 B SE423903 B SE 423903B SE 7613920 A SE7613920 A SE 7613920A SE 7613920 A SE7613920 A SE 7613920A SE 423903 B SE423903 B SE 423903B
Authority
SE
Sweden
Prior art keywords
alfa
dione
dihydroxy
diene
beta
Prior art date
Application number
SE7613920A
Other languages
Swedish (sv)
Other versions
SE7613920L (en
Inventor
J Kalvoda
G Anner
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of SE7613920L publication Critical patent/SE7613920L/en
Publication of SE423903B publication Critical patent/SE423903B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

9 alpha ,21-dihalo-11 beta ,17 alpha -dihydroxy-6-fluoro-16 alpha -methylpregna-1,4-diene- 3,20-dione 17-esters of the formula <IMAGE> in which X is chlorine or fluorine, X' is bromine or chlorine, and Ac is an acyl group derived from a carboxylic acid, are distinguished by high local antiinflammatory activity with a reduced systemic effect, for which reason they can be used in medicine to alleviate and control inflammatory states. They are obtained by conventional elimination of hydrogen chloride from a corresponding 1,2-dichloro compound.
SE7613920A 1975-12-12 1976-12-10 PROCEDURE FOR PREPARING 9 ALFA, 21-DIHALOGEN-11 BETA, 17 ALFA-DIHYDROXY-6 ALFA-FLOUR-16 ALFA-METHYL-PREGNA-1,4-DIENE-3,20-DIONE ESTARS SE423903B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1615175A CH621801A5 (en) 1975-12-12 1975-12-12 Process for the preparation of polyhalosteroids

Publications (2)

Publication Number Publication Date
SE7613920L SE7613920L (en) 1977-06-13
SE423903B true SE423903B (en) 1982-06-14

Family

ID=4414846

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7613920A SE423903B (en) 1975-12-12 1976-12-10 PROCEDURE FOR PREPARING 9 ALFA, 21-DIHALOGEN-11 BETA, 17 ALFA-DIHYDROXY-6 ALFA-FLOUR-16 ALFA-METHYL-PREGNA-1,4-DIENE-3,20-DIONE ESTARS

Country Status (4)

Country Link
BE (1) BE849268A (en)
CH (4) CH621801A5 (en)
SE (1) SE423903B (en)
ZA (1) ZA767382B (en)

Also Published As

Publication number Publication date
ZA767382B (en) 1977-11-30
SE7613920L (en) 1977-06-13
CH621801A5 (en) 1981-02-27
CH622270A5 (en) 1981-03-31
BE849268A (en) 1977-06-10
CH622271A5 (en) 1981-03-31
CH621802A5 (en) 1981-02-27

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