GB965572A - New steroid compounds and their formation - Google Patents

New steroid compounds and their formation

Info

Publication number
GB965572A
GB965572A GB4687563A GB4687563A GB965572A GB 965572 A GB965572 A GB 965572A GB 4687563 A GB4687563 A GB 4687563A GB 4687563 A GB4687563 A GB 4687563A GB 965572 A GB965572 A GB 965572A
Authority
GB
United Kingdom
Prior art keywords
bromo
formation
pregna
pregnane
trione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4687563A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB965572A publication Critical patent/GB965572A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B15/00—Layered products comprising a layer of metal
    • B32B15/01—Layered products comprising a layer of metal all layers being exclusively metallic
    • B32B15/016—Layered products comprising a layer of metal all layers being exclusively metallic all layers being formed of aluminium or aluminium alloys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0052—Nitrogen only at position 16(17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises 21-bromo-pregna-3, 11, 20-triones having the formula: <FORM:0965572/C1/1> in which R1 and R2, and R3 and R4 each form a double bond between the 4(5) and the 16(17) positions respectively or R1 is a bromine atom, R3 is an a -bromine atom, and R2 and R4 are hydrogen atoms and processes for the preparation thereof by oxidising and brominating 3a -hydroxy-17a , 21-dibromo-pregnane-11, 20-dione to form 4, 17a , 21-tribromo-pregnane-3, 11, 20-trione and eliminating hydrogen bromide therefrom to obtain 21-bromo-pregna-4, 16-dien-3, 11, 20-trione. Oxidation and bromination may be effected with N-bromo-succinimide and elimination of hydrogen bromide with lithium halide-lithium carbonate couple in dimethyl formamide.
GB4687563A 1960-02-05 1961-02-01 New steroid compounds and their formation Expired GB965572A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR817687A FR1331320A (en) 1960-02-05 1960-02-05 New nitrogenous steroid compounds

Publications (1)

Publication Number Publication Date
GB965572A true GB965572A (en) 1964-07-29

Family

ID=8724803

Family Applications (2)

Application Number Title Priority Date Filing Date
GB384461A Expired GB965571A (en) 1960-02-05 1961-02-01 New steroid compounds and their formation
GB4687563A Expired GB965572A (en) 1960-02-05 1961-02-01 New steroid compounds and their formation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB384461A Expired GB965571A (en) 1960-02-05 1961-02-01 New steroid compounds and their formation

Country Status (7)

Country Link
BE (1) BE599847A (en)
BR (1) BR6126296D0 (en)
CH (1) CH394178A (en)
ES (1) ES264322A1 (en)
FR (1) FR1331320A (en)
GB (2) GB965571A (en)
NL (1) NL106374C (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232013A (en) * 1977-12-03 1980-11-04 Lark S.P.A. 16,17-Pyrazolino- and 16,17-isopyrazolino-1,4-pregnadiene derivatives

Also Published As

Publication number Publication date
CH394178A (en) 1965-06-30
BE599847A (en) 1961-08-03
NL106374C (en)
GB965571A (en) 1964-07-29
ES264322A1 (en) 1961-04-01
FR1331320A (en) 1963-07-05
BR6126296D0 (en) 1973-07-10

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