GB951474A - Improvements in or relating to the bromination of steroid derivatives - Google Patents

Improvements in or relating to the bromination of steroid derivatives

Info

Publication number
GB951474A
GB951474A GB3106061A GB3106061A GB951474A GB 951474 A GB951474 A GB 951474A GB 3106061 A GB3106061 A GB 3106061A GB 3106061 A GB3106061 A GB 3106061A GB 951474 A GB951474 A GB 951474A
Authority
GB
United Kingdom
Prior art keywords
hydroxy
bromination
acyloxy
relating
steroid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3106061A
Inventor
Frances Ann Nice Nee Clark
Gordon Hanley Phillipps
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority to GB3106061A priority Critical patent/GB951474A/en
Priority to SE925062A priority patent/SE303490B/xx
Priority to CH1022962A priority patent/CH420136A/en
Publication of GB951474A publication Critical patent/GB951474A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

21 - Bromo -20- keto - pregnanes and -allopregnanes are prepared by bromination of the 21-unsubstituted compounds with bromine in the presence of a strong acid and in a solvent consisting essentially of a primary alkanol of 2 to 4 carbon atoms or a C-alkoxy derivative thereof. The steroids may contain one or more other substituents or unsaturation selected from 3-hydroxy, 3-acyloxy, 11-hydroxy, 11-acyloxy, a 9(11)-double bond, 16a - or 16b -methyl, 16-methylene and 17a -hydroxy. A small amount of a further inert organic solvent, such as a cyclic ether, may also be present in the reaction mixture to aid dissolution. Hydrogen chloride is a suitable acid. Examples are given, and the products are converted to 21-acetates.
GB3106061A 1961-08-29 1961-08-29 Improvements in or relating to the bromination of steroid derivatives Expired GB951474A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB3106061A GB951474A (en) 1961-08-29 1961-08-29 Improvements in or relating to the bromination of steroid derivatives
SE925062A SE303490B (en) 1961-08-29 1962-08-27
CH1022962A CH420136A (en) 1961-08-29 1962-08-28 Process for making 21-bromo steroids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3106061A GB951474A (en) 1961-08-29 1961-08-29 Improvements in or relating to the bromination of steroid derivatives

Publications (1)

Publication Number Publication Date
GB951474A true GB951474A (en) 1964-03-04

Family

ID=10317364

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3106061A Expired GB951474A (en) 1961-08-29 1961-08-29 Improvements in or relating to the bromination of steroid derivatives

Country Status (1)

Country Link
GB (1) GB951474A (en)

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