GB951474A - Improvements in or relating to the bromination of steroid derivatives - Google Patents
Improvements in or relating to the bromination of steroid derivativesInfo
- Publication number
- GB951474A GB951474A GB3106061A GB3106061A GB951474A GB 951474 A GB951474 A GB 951474A GB 3106061 A GB3106061 A GB 3106061A GB 3106061 A GB3106061 A GB 3106061A GB 951474 A GB951474 A GB 951474A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydroxy
- bromination
- acyloxy
- relating
- steroid derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
21 - Bromo -20- keto - pregnanes and -allopregnanes are prepared by bromination of the 21-unsubstituted compounds with bromine in the presence of a strong acid and in a solvent consisting essentially of a primary alkanol of 2 to 4 carbon atoms or a C-alkoxy derivative thereof. The steroids may contain one or more other substituents or unsaturation selected from 3-hydroxy, 3-acyloxy, 11-hydroxy, 11-acyloxy, a 9(11)-double bond, 16a - or 16b -methyl, 16-methylene and 17a -hydroxy. A small amount of a further inert organic solvent, such as a cyclic ether, may also be present in the reaction mixture to aid dissolution. Hydrogen chloride is a suitable acid. Examples are given, and the products are converted to 21-acetates.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3106061A GB951474A (en) | 1961-08-29 | 1961-08-29 | Improvements in or relating to the bromination of steroid derivatives |
SE925062A SE303490B (en) | 1961-08-29 | 1962-08-27 | |
CH1022962A CH420136A (en) | 1961-08-29 | 1962-08-28 | Process for making 21-bromo steroids |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3106061A GB951474A (en) | 1961-08-29 | 1961-08-29 | Improvements in or relating to the bromination of steroid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB951474A true GB951474A (en) | 1964-03-04 |
Family
ID=10317364
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3106061A Expired GB951474A (en) | 1961-08-29 | 1961-08-29 | Improvements in or relating to the bromination of steroid derivatives |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB951474A (en) |
-
1961
- 1961-08-29 GB GB3106061A patent/GB951474A/en not_active Expired
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US2694080A (en) | 11-hydroxy-13-methyl-17-(beta-hydroxyethylidene)-1, 2, 3, 6, 7, 8, 9, 10, 11, 12, 13, 14, 16, 17-tetradecahydro-15h-cyclopenta[a]-phenanthren-3-one | |
GB951474A (en) | Improvements in or relating to the bromination of steroid derivatives | |
GB948268A (en) | Improvements in or relating to 11, 18-epoxy steroid compounds | |
GB989881A (en) | Improvements in or relating to 10 -methyl steroids and the production thereof | |
GB936391A (en) | Process for the fluorination of steroids | |
GB1084467A (en) | Improvements in or relating to steroids and the manufacture thereof | |
GB983125A (en) | Preparation of 9(11)-dehydro spirostanes and 3-esters thereof | |
US3113143A (en) | Steroid-3-enol-acylates | |
GB916951A (en) | New process for the preparation of 6ª--fluoro-steroids | |
GB935116A (en) | New cyclopentanophenanthrene derivatives and processes for the production thereof | |
GB996079A (en) | 17ª‡,21-substituted methylenedioxy steroids and methods therefor | |
GB970482A (en) | New 17-desoxy corticosteroids and processes for their preparation | |
GB944716A (en) | 10ª -fluoro steroids and their preparation | |
GB899375A (en) | Improvements in or relating to the manufacture of steroids | |
GB959869A (en) | Oxasteroids of the pregnane series | |
GB1101118A (en) | 2ª-cyano steroids | |
GB1082954A (en) | Steroid derivatives | |
ES234653A1 (en) | 21-fluoro-9alpha-halo-steroids of the pregnane series | |
GB854672A (en) | Preparation of 12ª‡-halo-16ª‡,17ª‡,21-trihydroxy-4-pregnene-3,11,20-triones and 16ª‡,21-acyl esters thereof | |
GB896817A (en) | Improvements in or relating to steroids and the manufacture thereof | |
GB965292A (en) | Halogenated steroid derivatives | |
GB885850A (en) | Pregnatetraenes and method of preparation | |
GB965572A (en) | New steroid compounds and their formation | |
GB886964A (en) | Improvements in or relating to steroids and the manufacture thereof | |
GB963964A (en) | Improvements in or relating to the bromination of hecogenin and esters thereof |