GB1005726A - Processes for the preparation of 17ª‡-ethynyl-17ª‰-hydroxy derivatives of 13ª‰-?-propyl-18-nor-estradiol - Google Patents
Processes for the preparation of 17ª‡-ethynyl-17ª‰-hydroxy derivatives of 13ª‰-?-propyl-18-nor-estradiolInfo
- Publication number
- GB1005726A GB1005726A GB4469761A GB4469761A GB1005726A GB 1005726 A GB1005726 A GB 1005726A GB 4469761 A GB4469761 A GB 4469761A GB 4469761 A GB4469761 A GB 4469761A GB 1005726 A GB1005726 A GB 1005726A
- Authority
- GB
- United Kingdom
- Prior art keywords
- estradiol
- ethynyl
- processes
- preparation
- propyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises compounds having the formulae <FORM:1005726/C2/1> wherein R represents H or an acyl radical or alkyl radical and processes for the preparation of a 17a -ethynyl-13b -n-alkyl-18-nor-estradiol by selectively oxidizing 13b -n-alkyl 18-nor-estradiol at the 17-position so as to form the corresponding estrone which after preliminary etherification at the 3-position is then ethynylated by reaction with ethynyl magnesium halide. Selective oxidation may be effected with aluminium isopropylate in the presence of cyclohexanone and etherification may be effected with a -tetrahydropyranyl ether. Specifications 979,891 and 1,005,727 are referred to.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR846887A FR1366722A (en) | 1960-12-14 | 1960-12-14 | Novel ethynyl analogue of estradiol, its functional derivatives and method of preparation |
| FR862521A FR83552E (en) | 1961-05-23 | 1961-05-23 | Novel ethynyl analogue of estradiol, its functional derivatives and method of preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1005726A true GB1005726A (en) | 1965-09-29 |
Family
ID=26188552
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4469761A Expired GB1005726A (en) | 1960-12-14 | 1961-12-13 | Processes for the preparation of 17ª‡-ethynyl-17ª‰-hydroxy derivatives of 13ª‰-?-propyl-18-nor-estradiol |
| GB1265864A Expired GB1005727A (en) | 1960-12-14 | 1961-12-13 | Novel steroid compound and its preparation |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1265864A Expired GB1005727A (en) | 1960-12-14 | 1961-12-13 | Novel steroid compound and its preparation |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE611478A (en) |
| CH (1) | CH405293A (en) |
| ES (1) | ES272931A1 (en) |
| GB (2) | GB1005726A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115417908B (en) * | 2022-09-01 | 2024-06-18 | 英科新创（苏州）生物科技有限公司 | Estradiol derivative, preparation method thereof, detection kit and estradiol quantitative detection method |
| CN115353541B (en) * | 2022-09-01 | 2024-06-18 | 英科新创（苏州）生物科技有限公司 | Process for the preparation of estradiol derivatives, intermediates, process for the preparation thereof and use thereof |
-
1961
- 1961-12-12 CH CH1436261A patent/CH405293A/en unknown
- 1961-12-13 ES ES0272931A patent/ES272931A1/en not_active Expired
- 1961-12-13 BE BE611478A patent/BE611478A/en unknown
- 1961-12-13 GB GB4469761A patent/GB1005726A/en not_active Expired
- 1961-12-13 GB GB1265864A patent/GB1005727A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1005727A (en) | 1965-09-29 |
| ES272931A1 (en) | 1962-02-16 |
| BE611478A (en) | 1962-06-13 |
| CH405293A (en) | 1966-01-15 |
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