SE7613920L - NEW POLYHALOGENSTEROIDS AND PROCEDURES FOR THE MANUFACTURE - Google Patents
NEW POLYHALOGENSTEROIDS AND PROCEDURES FOR THE MANUFACTUREInfo
- Publication number
- SE7613920L SE7613920L SE7613920A SE7613920A SE7613920L SE 7613920 L SE7613920 L SE 7613920L SE 7613920 A SE7613920 A SE 7613920A SE 7613920 A SE7613920 A SE 7613920A SE 7613920 L SE7613920 L SE 7613920L
- Authority
- SE
- Sweden
- Prior art keywords
- alpha
- polyhalogensteroids
- procedures
- chlorine
- manufacture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
9 alpha ,21-dihalo-11 beta ,17 alpha -dihydroxy-6-fluoro-16 alpha -methylpregna-1,4-diene- 3,20-dione 17-esters of the formula <IMAGE> in which X is chlorine or fluorine, X' is bromine or chlorine, and Ac is an acyl group derived from a carboxylic acid, are distinguished by high local antiinflammatory activity with a reduced systemic effect, for which reason they can be used in medicine to alleviate and control inflammatory states. They are obtained by conventional elimination of hydrogen chloride from a corresponding 1,2-dichloro compound.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1615175A CH621801A5 (en) | 1975-12-12 | 1975-12-12 | Process for the preparation of polyhalosteroids |
Publications (2)
Publication Number | Publication Date |
---|---|
SE7613920L true SE7613920L (en) | 1977-06-13 |
SE423903B SE423903B (en) | 1982-06-14 |
Family
ID=4414846
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7613920A SE423903B (en) | 1975-12-12 | 1976-12-10 | PROCEDURE FOR PREPARING 9 ALFA, 21-DIHALOGEN-11 BETA, 17 ALFA-DIHYDROXY-6 ALFA-FLOUR-16 ALFA-METHYL-PREGNA-1,4-DIENE-3,20-DIONE ESTARS |
Country Status (4)
Country | Link |
---|---|
BE (1) | BE849268A (en) |
CH (4) | CH621801A5 (en) |
SE (1) | SE423903B (en) |
ZA (1) | ZA767382B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN118271385A (en) * | 2024-04-01 | 2024-07-02 | 湖南玉新药业有限公司 | Refining method of crude halobetasol propionate |
-
1975
- 1975-12-12 CH CH1615175A patent/CH621801A5/en not_active IP Right Cessation
-
1976
- 1976-12-10 SE SE7613920A patent/SE423903B/en not_active IP Right Cessation
- 1976-12-10 ZA ZA767382A patent/ZA767382B/en unknown
- 1976-12-10 BE BE173138A patent/BE849268A/en not_active IP Right Cessation
-
1979
- 1979-09-18 CH CH841679A patent/CH622271A5/en not_active IP Right Cessation
- 1979-09-18 CH CH841479A patent/CH621802A5/en not_active IP Right Cessation
- 1979-09-18 CH CH841579A patent/CH622270A5/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CH622270A5 (en) | 1981-03-31 |
CH622271A5 (en) | 1981-03-31 |
CH621801A5 (en) | 1981-02-27 |
BE849268A (en) | 1977-06-10 |
SE423903B (en) | 1982-06-14 |
CH621802A5 (en) | 1981-02-27 |
ZA767382B (en) | 1977-11-30 |
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Legal Events
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