SE8400145L - PROCEDURE FOR THE PREPARATION OF 17-ESTERS OF CLOBETASOL - Google Patents

PROCEDURE FOR THE PREPARATION OF 17-ESTERS OF CLOBETASOL

Info

Publication number
SE8400145L
SE8400145L SE8400145A SE8400145A SE8400145L SE 8400145 L SE8400145 L SE 8400145L SE 8400145 A SE8400145 A SE 8400145A SE 8400145 A SE8400145 A SE 8400145A SE 8400145 L SE8400145 L SE 8400145L
Authority
SE
Sweden
Prior art keywords
beta
esters
clobetasol
preparation
procedure
Prior art date
Application number
SE8400145A
Other languages
Unknown language ( )
Swedish (sv)
Other versions
SE8400145D0 (en
Inventor
P Macdonald
Original Assignee
Sicor Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicor Spa filed Critical Sicor Spa
Publication of SE8400145D0 publication Critical patent/SE8400145D0/en
Publication of SE8400145L publication Critical patent/SE8400145L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCESS FOR THE PRODUCTION OF 17-ESTERS OF CLOBETASOL This invention relates to an improved process for the preparation of 17-esters of Clobetasol having the formula <IMG> II which consists in treatment of 9.beta.,11.beta.-epoxy-16.beta.-methyl-pregna-1,4-diene-17,21-diol-3,20-dione 17-esters with mesyl chloride to give the corresponding 21-chloro-deriv-ative, followed by opening of the epoxide grouping with hydrogen fluoride. The invention also relates to new 17-esters of 21-chloro-9.beta.,11.beta.-epoxy-17-hydroxy-16.beta.-methyl-pregna-1,4-diene-3,20-dione, useful as intermediates for the preparation of therapeutically active 9.alpha.-halo-11.beta.-hydroxy derivatives.
SE8400145A 1983-03-29 1984-01-12 PROCEDURE FOR THE PREPARATION OF 17-ESTERS OF CLOBETASOL SE8400145L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20334/83A IT1194178B (en) 1983-03-29 1983-03-29 PROCESS FOR THE PREPARATION OF 17-ESTERS OF CLOBETASOLO AND COMPOUNDS OBTAINED

Publications (2)

Publication Number Publication Date
SE8400145D0 SE8400145D0 (en) 1984-01-12
SE8400145L true SE8400145L (en) 1984-09-30

Family

ID=11165811

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8400145A SE8400145L (en) 1983-03-29 1984-01-12 PROCEDURE FOR THE PREPARATION OF 17-ESTERS OF CLOBETASOL

Country Status (10)

Country Link
JP (2) JPS59205397A (en)
CA (1) CA1220468A (en)
CH (1) CH661930A5 (en)
DK (1) DK42884A (en)
FI (1) FI840344A (en)
IT (1) IT1194178B (en)
NL (1) NL8400910A (en)
NO (1) NO840065L (en)
SE (1) SE8400145L (en)
YU (1) YU54684A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108727458A (en) * 2018-05-10 2018-11-02 浙江仙居仙乐药业有限公司 A kind of synthetic method of 17- propionic esters
CN111944002A (en) * 2020-07-29 2020-11-17 河南利华制药有限公司 Beclomethasone dipropionate intermediate and preparation method thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1253831A (en) * 1968-01-19 1971-11-17 Glaxo Lab Ltd 9alpha,21-DIHALOPREGNANE COMPOUNDS
JPS51125372A (en) * 1975-03-31 1976-11-01 Taisho Pharmaceut Co Ltd Aprocess for preparing pregnane steroid-17-ester-21-halides

Also Published As

Publication number Publication date
DK42884A (en) 1984-09-30
CA1220468A (en) 1987-04-14
JPS6228160B2 (en) 1987-06-18
FI840344A0 (en) 1984-01-27
IT8320334A0 (en) 1983-03-29
FI840344A (en) 1984-09-30
YU54684A (en) 1986-10-31
NO840065L (en) 1984-10-01
JPS59205397A (en) 1984-11-20
JPS59205399A (en) 1984-11-20
CH661930A5 (en) 1987-08-31
SE8400145D0 (en) 1984-01-12
NL8400910A (en) 1984-10-16
DK42884D0 (en) 1984-01-31
IT1194178B (en) 1988-09-14

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Legal Events

Date Code Title Description
NAV Patent application has lapsed

Ref document number: 8400145-2

Effective date: 19881025