GB923125A - Steroid compounds - Google Patents

Steroid compounds

Info

Publication number
GB923125A
GB923125A GB2531759A GB2531759A GB923125A GB 923125 A GB923125 A GB 923125A GB 2531759 A GB2531759 A GB 2531759A GB 2531759 A GB2531759 A GB 2531759A GB 923125 A GB923125 A GB 923125A
Authority
GB
United Kingdom
Prior art keywords
compounds
general formula
represents hydrogen
keto
above general
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2531759A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB923125A publication Critical patent/GB923125A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J75/00Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises 4,6-pregnadienes of the general formula <FORM:0923125/IV(a)/1> wherein R represents hydrogen or an acyl group, R1 represents a hydroxyl or keto group, and X represents hydrogen or a halogen atom, and the 16-methyl group is in the a - and b -position, and the preparation thereof by reacting the corresponding 4-pregnene compounds with chloranil in an organic solvent such as t-butanol, at an elevated temperature. The 11-hydroxy compounds of the above general formula may be oxidised to the corresponding 11-keto compounds, and 21-ester compounds of the above general formula may be hydrolysed to 21-hydroxy compounds. Ester groups present may be a 21-acetate, 21-propionate or 21-butyrate. The preferred halogen at the 9-position is fluorine. Specifications 877,085 and 906,443 are referred to.
GB2531759A 1958-08-06 1959-07-23 Steroid compounds Expired GB923125A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75340758A 1958-08-06 1958-08-06

Publications (1)

Publication Number Publication Date
GB923125A true GB923125A (en) 1963-04-10

Family

ID=25030512

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2531759A Expired GB923125A (en) 1958-08-06 1959-07-23 Steroid compounds

Country Status (2)

Country Link
BE (1) BE581421A (en)
GB (1) GB923125A (en)

Also Published As

Publication number Publication date
BE581421A (en) 1960-02-08

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