GB1042292A - 5ª‡-hydroxy-6ª‰-amino steroids and the preparation thereof - Google Patents
5ª‡-hydroxy-6ª‰-amino steroids and the preparation thereofInfo
- Publication number
- GB1042292A GB1042292A GB3998861A GB3998861A GB1042292A GB 1042292 A GB1042292 A GB 1042292A GB 3998861 A GB3998861 A GB 3998861A GB 3998861 A GB3998861 A GB 3998861A GB 1042292 A GB1042292 A GB 1042292A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acyl
- preparation
- steroids
- group
- oxido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises compounds of the formula <FORM:1042292/C2/1> (wherein X is H(OH) or H(O acyl); Y is H (b OH), H(b O acyl), = O, H(COCH3), H(CHOH-CH3) or H(CHO acyl CH3) and R1 and R2 are hydrogen, or alkyl of at most 6 carbon atoms, or -NR1R2 is a saturated heterocyclic amino radical) and acid-addition salts and quaternary ammonium derivatives thereof; and their preparation by reacting the appropriate amine NHR1R2 with the corresponding 5a ,6a -oxido-steroid, and then, when required, esterifying free hydroxy groups in the 3-, 17- and/or 20-positions; or reducing a 17- or 20-keto group to a hydroxyl group; or oxidizing a 3-, 17- or 20-hydroxy group to a keto group. Esterified hydroxy groups may be hydrolysed. Examples are given. 5a ,6a -oxido-steroids used as starting materials are prepared by reacting the corresponding D 5-steroids with, for example, an organic peracid.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3998861A GB1042292A (en) | 1961-11-08 | 1961-11-08 | 5ª‡-hydroxy-6ª‰-amino steroids and the preparation thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3998861A GB1042292A (en) | 1961-11-08 | 1961-11-08 | 5ª‡-hydroxy-6ª‰-amino steroids and the preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1042292A true GB1042292A (en) | 1966-09-14 |
Family
ID=10412589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3998861A Expired GB1042292A (en) | 1961-11-08 | 1961-11-08 | 5ª‡-hydroxy-6ª‰-amino steroids and the preparation thereof |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1042292A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0208497A2 (en) | 1985-07-01 | 1987-01-14 | Richter Gedeon Vegyeszeti Gyar R.T. | Diamino-androstane derivatives |
WO2007118832A2 (en) * | 2006-04-13 | 2007-10-25 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders |
-
1961
- 1961-11-08 GB GB3998861A patent/GB1042292A/en not_active Expired
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0208497A2 (en) | 1985-07-01 | 1987-01-14 | Richter Gedeon Vegyeszeti Gyar R.T. | Diamino-androstane derivatives |
EP0208497A3 (en) * | 1985-07-01 | 1987-09-30 | Richter Gedeon Vegyeszeti Gyar R.T. | Diamino-androstane derivatives |
US5410040A (en) * | 1985-07-01 | 1995-04-25 | Richter Gedeon Vegyeszeti Gyar Rt. | Diamino-androstane derivatives |
WO2007118832A2 (en) * | 2006-04-13 | 2007-10-25 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders |
WO2007118832A3 (en) * | 2006-04-13 | 2008-04-17 | Sigma Tau Ind Farmaceuti | Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders |
EA015257B1 (en) * | 2006-04-13 | 2011-06-30 | Сигма-Тау Индустрие Фармасьютике Риуните С.П.А. | Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders |
TWI392682B (en) * | 2006-04-13 | 2013-04-11 | Sigma Tau Ind Farmaceuti | Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders |
US8609644B2 (en) | 2006-04-13 | 2013-12-17 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders |
CN101466725B (en) * | 2006-04-13 | 2014-06-25 | 西格马-陶工业制药重组有限公司 | Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders |
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