ATA151379A - METHOD FOR PRODUCING NEW 9ALPHA, 21-DIHALOGEN-11BETA, 17ALPHA-DIHYDROXY-6ALPHA-FLUOR -16BETA-METHYL-PREGNA-1,4-DIEN COMPOUNDS - Google Patents

METHOD FOR PRODUCING NEW 9ALPHA, 21-DIHALOGEN-11BETA, 17ALPHA-DIHYDROXY-6ALPHA-FLUOR -16BETA-METHYL-PREGNA-1,4-DIEN COMPOUNDS

Info

Publication number
ATA151379A
ATA151379A AT151379A AT151379A ATA151379A AT A151379 A ATA151379 A AT A151379A AT 151379 A AT151379 A AT 151379A AT 151379 A AT151379 A AT 151379A AT A151379 A ATA151379 A AT A151379A
Authority
AT
Austria
Prior art keywords
16beta
9alpha
6alpha
11beta
17alpha
Prior art date
Application number
AT151379A
Other languages
German (de)
Other versions
AT363203B (en
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Priority to AT0151379A priority Critical patent/AT363203B/en
Publication of ATA151379A publication Critical patent/ATA151379A/en
Application granted granted Critical
Publication of AT363203B publication Critical patent/AT363203B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT0151379A 1976-09-29 1979-02-28 METHOD FOR PRODUCING NEW 9ALPHA, 21- AT363203B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT0151379A AT363203B (en) 1976-09-29 1979-02-28 METHOD FOR PRODUCING NEW 9ALPHA, 21-

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
LU75903A LU75903A1 (en) 1976-09-29 1976-09-29
AT0691077A AT363197B (en) 1976-09-29 1977-09-28 METHOD FOR PRODUCING NEW 9ALPHA, 21-DIHALOGEN-11BETA, 17ALPHA-DIHYDROXY-6ALPHA-FLUOR-16BETA-METHYL-PREGNA-1,4-DIEN-3,20-DION COMPOUNDS
AT0151379A AT363203B (en) 1976-09-29 1979-02-28 METHOD FOR PRODUCING NEW 9ALPHA, 21-

Publications (2)

Publication Number Publication Date
ATA151379A true ATA151379A (en) 1980-12-15
AT363203B AT363203B (en) 1981-07-27

Family

ID=19728370

Family Applications (3)

Application Number Title Priority Date Filing Date
AT0691077A AT363197B (en) 1976-09-29 1977-09-28 METHOD FOR PRODUCING NEW 9ALPHA, 21-DIHALOGEN-11BETA, 17ALPHA-DIHYDROXY-6ALPHA-FLUOR-16BETA-METHYL-PREGNA-1,4-DIEN-3,20-DION COMPOUNDS
AT0151279A AT363202B (en) 1976-09-29 1979-02-28 METHOD FOR PRODUCING NEW MULTIPLE HALOGENED STEROIDS
AT0151379A AT363203B (en) 1976-09-29 1979-02-28 METHOD FOR PRODUCING NEW 9ALPHA, 21-

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT0691077A AT363197B (en) 1976-09-29 1977-09-28 METHOD FOR PRODUCING NEW 9ALPHA, 21-DIHALOGEN-11BETA, 17ALPHA-DIHYDROXY-6ALPHA-FLUOR-16BETA-METHYL-PREGNA-1,4-DIEN-3,20-DION COMPOUNDS
AT0151279A AT363202B (en) 1976-09-29 1979-02-28 METHOD FOR PRODUCING NEW MULTIPLE HALOGENED STEROIDS

Country Status (24)

Country Link
JP (1) JPS5356652A (en)
AT (3) AT363197B (en)
AU (1) AU514200B2 (en)
BE (1) BE859120A (en)
CA (1) CA1101410A (en)
CH (9) CH624967A5 (en)
CY (1) CY1178A (en)
DD (1) DD133150A5 (en)
DE (1) DE2743069C2 (en)
DK (1) DK146017C (en)
ES (1) ES462763A1 (en)
FR (1) FR2366311A1 (en)
GB (1) GB1563638A (en)
HK (1) HK16683A (en)
HU (1) HU175218B (en)
IE (1) IE46047B1 (en)
IL (1) IL53012A (en)
KE (1) KE3258A (en)
LU (1) LU75903A1 (en)
MY (1) MY8400092A (en)
NL (1) NL7710089A (en)
SE (1) SE436751B (en)
SG (1) SG3383G (en)
ZA (1) ZA775800B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL187577C (en) * 1978-04-05 1991-11-18 Sibla Srl 3-ACETOXY-9BETA, 11BETA-EPOXY-PREGNA-1,3,5-TRIEN, PROCESS FOR THE PREPARATION THEREOF, AND PROCESS FOR THE PREPARATION OF 6-alpha-halogen-1,4-diene-3-ones.
DE3227312A1 (en) * 1982-07-19 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen NEW 6.16 DIMETHYL CORTICOIDS, THEIR PRODUCTION AND USE
EP0523132A1 (en) * 1990-03-27 1993-01-20 Schering Corporation PROCESS FOR 9$g(a)-HYDROXY STEROID DEHYDRATION
US5972922A (en) * 1990-06-11 1999-10-26 Alcon Laboratories, Inc. Steroids which inhibit angiogenesis
BR0214520A (en) 2001-11-29 2006-05-30 Taro Pharmaceuticals Usa Inc Method for the preparation of 6alphafluoro corticosteroids
US11957753B2 (en) 2010-11-22 2024-04-16 Bausch Health Ireland Limited Pharmaceutical formulations containing corticosteroids for topical administration
US8809307B2 (en) 2010-11-22 2014-08-19 Dow Pharmaceutical Sciences, Inc. Pharmaceutical formulations containing corticosteroids for topical administration
KR102643849B1 (en) 2015-06-18 2024-03-07 밸리언트 파마슈티컬즈 노오쓰 아메리카 엘엘씨 Topical composition containing corticosteroids and retinoids for treating psoriasis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB898292A (en) * 1959-03-18 1962-06-06 Upjohn Co Improvements in or relating to steroids and the manufacture thereof
US3644340A (en) * 1970-03-19 1972-02-22 Syntex Corp Preparation of 21-chloro steroids
US3992422A (en) * 1975-08-14 1976-11-16 Schering Corporation Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes

Also Published As

Publication number Publication date
HU175218B (en) 1980-06-28
CH631998A5 (en) 1982-09-15
ES462763A1 (en) 1978-05-16
CH632000A5 (en) 1982-09-15
JPS5356652A (en) 1978-05-23
ATA151279A (en) 1980-12-15
SE7706673L (en) 1978-03-30
CA1101410A (en) 1981-05-19
CH632521A5 (en) 1982-10-15
CH625808A5 (en) 1981-10-15
DK146017B (en) 1983-05-24
JPS6214557B2 (en) 1987-04-02
FR2366311B1 (en) 1982-12-03
ZA775800B (en) 1978-08-30
AU514200B2 (en) 1981-01-29
CH625809A5 (en) 1981-10-15
AT363202B (en) 1981-07-27
CH625810A5 (en) 1981-10-15
KE3258A (en) 1983-03-04
CH631999A5 (en) 1982-09-15
NL7710089A (en) 1978-03-31
AU2914877A (en) 1979-04-05
BE859120A (en) 1978-03-28
DK146017C (en) 1983-10-24
DD133150A5 (en) 1978-12-13
DK256977A (en) 1978-03-30
CY1178A (en) 1983-06-10
SG3383G (en) 1983-09-09
LU75903A1 (en) 1978-05-16
SE436751B (en) 1985-01-21
IE46047B1 (en) 1983-02-09
HK16683A (en) 1983-05-27
DE2743069A1 (en) 1978-03-30
CH632279A5 (en) 1982-09-30
CH624967A5 (en) 1981-08-31
FR2366311A1 (en) 1978-04-28
GB1563638A (en) 1980-03-26
ATA691077A (en) 1980-12-15
IL53012A (en) 1982-05-31
IE46047L (en) 1978-03-29
DE2743069C2 (en) 1987-03-05
AT363203B (en) 1981-07-27
IL53012A0 (en) 1977-11-30
MY8400092A (en) 1984-12-31
AT363197B (en) 1981-07-10

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Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee
ELA Expired due to lapse of time