AT356136B - METHOD FOR PRODUCING NEW SPIRO-HYDANTOINES - Google Patents

METHOD FOR PRODUCING NEW SPIRO-HYDANTOINES

Info

Publication number
AT356136B
AT356136B AT745977A AT745977A AT356136B AT 356136 B AT356136 B AT 356136B AT 745977 A AT745977 A AT 745977A AT 745977 A AT745977 A AT 745977A AT 356136 B AT356136 B AT 356136B
Authority
AT
Austria
Prior art keywords
hydantoines
producing new
new spiro
spiro
producing
Prior art date
Application number
AT745977A
Other languages
German (de)
Other versions
ATA745977A (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/767,803 external-priority patent/US4117230A/en
Application filed by Pfizer filed Critical Pfizer
Publication of ATA745977A publication Critical patent/ATA745977A/en
Application granted granted Critical
Publication of AT356136B publication Critical patent/AT356136B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
AT745977A 1976-10-18 1977-10-18 METHOD FOR PRODUCING NEW SPIRO-HYDANTOINES AT356136B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73306276A 1976-10-18 1976-10-18
US05/767,803 US4117230A (en) 1976-10-18 1977-02-11 Hydantoin derivatives as therapeutic agents

Publications (2)

Publication Number Publication Date
ATA745977A ATA745977A (en) 1979-09-15
AT356136B true AT356136B (en) 1980-04-10

Family

ID=27112515

Family Applications (1)

Application Number Title Priority Date Filing Date
AT745977A AT356136B (en) 1976-10-18 1977-10-18 METHOD FOR PRODUCING NEW SPIRO-HYDANTOINES

Country Status (29)

Country Link
JP (3) JPS5353653A (en)
AR (1) AR220901A1 (en)
AT (1) AT356136B (en)
AU (1) AU504978B2 (en)
BG (1) BG28847A3 (en)
CA (1) CA1088945A (en)
CH (1) CH625511A5 (en)
DD (1) DD131931A5 (en)
DE (4) DE2759542C2 (en)
DK (1) DK150302C (en)
ES (1) ES463267A1 (en)
FI (1) FI62307C (en)
FR (1) FR2367754A1 (en)
GB (1) GB1566171A (en)
GR (1) GR70201B (en)
HK (1) HK53881A (en)
IE (1) IE45805B1 (en)
IL (1) IL53094A0 (en)
KE (1) KE3167A (en)
LU (1) LU78330A1 (en)
MX (1) MX4899E (en)
MY (1) MY8200157A (en)
NL (1) NL167434C (en)
NO (1) NO148453C (en)
NZ (1) NZ185358A (en)
PH (1) PH15639A (en)
PT (1) PT67164B (en)
SE (1) SE437024B (en)
YU (1) YU40821B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents
US4127665A (en) * 1978-01-18 1978-11-28 Pfizer Inc. Thienohydantoin derivatives
US4147797A (en) * 1978-08-11 1979-04-03 Pfizer Inc. Spiro-furanohydantoin derivatives
US4200642A (en) * 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones
US4181728A (en) * 1978-11-16 1980-01-01 Pfizer Inc. Spiro-polycyclicimidazolidinedione derivatives
US4181729A (en) * 1979-03-21 1980-01-01 Pfizer Inc. Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives
US4235911A (en) * 1979-06-13 1980-11-25 Pfizer Inc. Hydantoin derivatives
US4283409A (en) * 1979-10-29 1981-08-11 Pfizer Inc. Imidazolone derivatives
US4286098A (en) * 1980-03-28 1981-08-25 Pfizer Inc. Process for the preparation of chiral hydantoins
JPS5745185A (en) * 1980-07-21 1982-03-13 Eisai Co Ltd Hydantoin derivative and its preparation
DE3262294D1 (en) * 1981-05-13 1985-03-28 Ici Plc Pharmaceutical compositions containing spiro succinimide derivatives
JPS58213717A (en) * 1982-01-20 1983-12-12 Eisai Co Ltd Remedy containing hydantoin derivative
JPS59500617A (en) * 1982-04-15 1984-04-12 アルコン・ラボラトリ−ズ・インコ−ポレ−テッド Hydantoin therapeutic agent
SU1380610A3 (en) * 1982-12-06 1988-03-07 Пфайзер Инк. (Фирма) Method of producing spiroheteroazolydindiones or pharmaceutically acceptable salts thereof
US4474967A (en) * 1983-04-27 1984-10-02 Pfizer Inc. 8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione
HU198051B (en) * 1984-10-30 1989-07-28 Pfizer Process for producing spiro square brackets open imidazolidine-4,5'(6h)-quinoline square brackets closed-2,5-dione derivatives
JPS61200991A (en) * 1985-03-04 1986-09-05 Sanwa Kagaku Kenkyusho:Kk Novel spiro-3-heteroazolidine compound, production thereof, preventive and remedy for diabetic complication comprising same as active ingredient
US4575507A (en) * 1985-05-29 1986-03-11 Pfizer Inc. Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
JPS6357588A (en) * 1986-08-28 1988-03-12 Sanwa Kagaku Kenkyusho Co Ltd Hydantoin derivative, salt and, production thereof and preventing and treating, agent for diabetic complication
MX12896A (en) * 1987-09-04 1993-06-01 Pfizer PROCEDURE FOR PREPARING A SPYRO-HETEROAZOLON COMPOUND
GB2355264A (en) 1999-09-30 2001-04-18 Merck & Co Inc Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
AU2003225077A1 (en) 2002-04-18 2003-11-03 University Of Virginia Patent Foundation Novel sodium channel blockers
FR2955107B1 (en) 2010-01-08 2012-03-02 Servier Lab NOVEL THIOCHROMAN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB818724A (en) * 1956-10-18 1959-08-19 Ici Ltd Hydantoin derivatives
DE1135915B (en) * 1961-06-29 1962-09-06 Asta Werke Ag Chem Fab Process for the production of new, anticonvulsant spirohydantoins
US3532744A (en) * 1967-07-28 1970-10-06 American Home Prod 1- and 2-amino substituted indane and tetralene carboxylic acids
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
DE2449030A1 (en) * 1974-10-11 1976-05-20 Schering Ag NEW PYRIDINE DERIVATIVES
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents

Also Published As

Publication number Publication date
KE3167A (en) 1981-11-06
MX4899E (en) 1982-12-14
DE2746244C2 (en) 1983-05-19
NO148453C (en) 1983-10-12
FI773060A (en) 1978-04-19
IL53094A0 (en) 1977-12-30
PT67164A (en) 1977-11-01
NL7711358A (en) 1978-04-20
FI62307B (en) 1982-08-31
SE437024B (en) 1985-02-04
NZ185358A (en) 1979-06-08
AU504978B2 (en) 1979-11-01
YU244277A (en) 1982-08-31
JPS5495570A (en) 1979-07-28
NO148453B (en) 1983-07-04
DE2759542C2 (en) 1988-07-07
NL167434B (en) 1981-07-16
FI62307C (en) 1982-12-10
YU40821B (en) 1986-06-30
DK461377A (en) 1978-04-19
FR2367754A1 (en) 1978-05-12
IE45805L (en) 1978-04-18
MY8200157A (en) 1982-12-31
ATA745977A (en) 1979-09-15
JPS5495575A (en) 1979-07-28
JPS5534132B2 (en) 1980-09-04
JPS607997B2 (en) 1985-02-28
CA1088945A (en) 1980-11-04
PT67164B (en) 1979-03-20
NO773548L (en) 1978-04-19
PH15639A (en) 1983-03-11
AU2943177A (en) 1979-04-12
DK150302B (en) 1987-02-02
ES463267A1 (en) 1978-07-16
CH625511A5 (en) 1981-09-30
DE2746244A1 (en) 1978-04-20
FR2367754B1 (en) 1982-07-09
JPS5353653A (en) 1978-05-16
GR70201B (en) 1982-08-31
IE45805B1 (en) 1982-12-01
JPS5940388B2 (en) 1984-09-29
GB1566171A (en) 1980-04-30
HK53881A (en) 1981-11-13
SE7711053L (en) 1978-04-19
NL167434C (en) 1981-12-16
AR220901A1 (en) 1980-12-15
DE2759543C2 (en) 1987-04-09
DD131931A5 (en) 1978-08-09
DE2759927C2 (en) 1986-12-04
LU78330A1 (en) 1979-06-01
DK150302C (en) 1987-09-28
BG28847A3 (en) 1980-07-15

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee