YU40821B - Process for obtaining spirohy dantoin compounds - Google Patents

Process for obtaining spirohy dantoin compounds

Info

Publication number
YU40821B
YU40821B YU2442/77A YU244277A YU40821B YU 40821 B YU40821 B YU 40821B YU 2442/77 A YU2442/77 A YU 2442/77A YU 244277 A YU244277 A YU 244277A YU 40821 B YU40821 B YU 40821B
Authority
YU
Yugoslavia
Prior art keywords
spirohy
dantoin
compounds
obtaining
spirohy dantoin
Prior art date
Application number
YU2442/77A
Other versions
YU244277A (en
Inventor
R Serges
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/767,803 external-priority patent/US4117230A/en
Application filed by Pfizer filed Critical Pfizer
Publication of YU244277A publication Critical patent/YU244277A/en
Publication of YU40821B publication Critical patent/YU40821B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/12Ophthalmic agents for cataracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
YU2442/77A 1976-10-18 1977-10-10 Process for obtaining spirohy dantoin compounds YU40821B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73306276A 1976-10-18 1976-10-18
US05/767,803 US4117230A (en) 1976-10-18 1977-02-11 Hydantoin derivatives as therapeutic agents

Publications (2)

Publication Number Publication Date
YU244277A YU244277A (en) 1982-08-31
YU40821B true YU40821B (en) 1986-06-30

Family

ID=27112515

Family Applications (1)

Application Number Title Priority Date Filing Date
YU2442/77A YU40821B (en) 1976-10-18 1977-10-10 Process for obtaining spirohy dantoin compounds

Country Status (29)

Country Link
JP (3) JPS5353653A (en)
AR (1) AR220901A1 (en)
AT (1) AT356136B (en)
AU (1) AU504978B2 (en)
BG (1) BG28847A3 (en)
CA (1) CA1088945A (en)
CH (1) CH625511A5 (en)
DD (1) DD131931A5 (en)
DE (4) DE2759927C2 (en)
DK (1) DK150302C (en)
ES (1) ES463267A1 (en)
FI (1) FI62307C (en)
FR (1) FR2367754A1 (en)
GB (1) GB1566171A (en)
GR (1) GR70201B (en)
HK (1) HK53881A (en)
IE (1) IE45805B1 (en)
IL (1) IL53094A0 (en)
KE (1) KE3167A (en)
LU (1) LU78330A1 (en)
MX (1) MX4899E (en)
MY (1) MY8200157A (en)
NL (1) NL167434C (en)
NO (1) NO148453C (en)
NZ (1) NZ185358A (en)
PH (1) PH15639A (en)
PT (1) PT67164B (en)
SE (1) SE437024B (en)
YU (1) YU40821B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents
US4127665A (en) * 1978-01-18 1978-11-28 Pfizer Inc. Thienohydantoin derivatives
US4147797A (en) * 1978-08-11 1979-04-03 Pfizer Inc. Spiro-furanohydantoin derivatives
US4200642A (en) * 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones
US4181728A (en) * 1978-11-16 1980-01-01 Pfizer Inc. Spiro-polycyclicimidazolidinedione derivatives
US4181729A (en) * 1979-03-21 1980-01-01 Pfizer Inc. Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives
US4235911A (en) * 1979-06-13 1980-11-25 Pfizer Inc. Hydantoin derivatives
US4283409A (en) * 1979-10-29 1981-08-11 Pfizer Inc. Imidazolone derivatives
US4286098A (en) * 1980-03-28 1981-08-25 Pfizer Inc. Process for the preparation of chiral hydantoins
JPS5745185A (en) * 1980-07-21 1982-03-13 Eisai Co Ltd Hydantoin derivative and its preparation
EP0065392B1 (en) * 1981-05-13 1985-02-13 Imperial Chemical Industries Plc Pharmaceutical compositions containing spiro succinimide derivatives
JPS58213717A (en) * 1982-01-20 1983-12-12 Eisai Co Ltd Remedy containing hydantoin derivative
JPS59500617A (en) * 1982-04-15 1984-04-12 アルコン・ラボラトリ−ズ・インコ−ポレ−テッド Hydantoin therapeutic agent
ZA839023B (en) * 1982-12-06 1985-07-31 Pfizer Spiro-3-hetero-azolones for treatment of diabetic complications
US4474967A (en) * 1983-04-27 1984-10-02 Pfizer Inc. 8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione
WO1986002647A1 (en) * 1984-10-30 1986-05-09 Pfizer Inc. Spiro-heteroazolones for treatment of diabetes complications
JPS61200991A (en) * 1985-03-04 1986-09-05 Sanwa Kagaku Kenkyusho:Kk Novel spiro-3-heteroazolidine compound, production thereof, preventive and remedy for diabetic complication comprising same as active ingredient
US4575507A (en) * 1985-05-29 1986-03-11 Pfizer Inc. Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
JPS6357588A (en) * 1986-08-28 1988-03-12 Sanwa Kagaku Kenkyusho Co Ltd Hydantoin derivative, salt and, production thereof and preventing and treating, agent for diabetic complication
WO1989001775A1 (en) * 1987-09-04 1989-03-09 Pfizer Inc. Azolidinedione derivatives
GB2355264A (en) 1999-09-30 2001-04-18 Merck & Co Inc Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
CN1659136A (en) 2002-04-18 2005-08-24 弗吉尼亚大学专利基金会 Novel sodium channel blockers
FR2955107B1 (en) 2010-01-08 2012-03-02 Servier Lab NOVEL THIOCHROMAN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB818724A (en) * 1956-10-18 1959-08-19 Ici Ltd Hydantoin derivatives
DE1135915B (en) * 1961-06-29 1962-09-06 Asta Werke Ag Chem Fab Process for the production of new, anticonvulsant spirohydantoins
US3532744A (en) * 1967-07-28 1970-10-06 American Home Prod 1- and 2-amino substituted indane and tetralene carboxylic acids
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
DE2449030A1 (en) * 1974-10-11 1976-05-20 Schering Ag NEW PYRIDINE DERIVATIVES
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents

Also Published As

Publication number Publication date
FI62307C (en) 1982-12-10
NL167434B (en) 1981-07-16
DE2746244A1 (en) 1978-04-20
AR220901A1 (en) 1980-12-15
AU504978B2 (en) 1979-11-01
ES463267A1 (en) 1978-07-16
PT67164A (en) 1977-11-01
KE3167A (en) 1981-11-06
GB1566171A (en) 1980-04-30
GR70201B (en) 1982-08-31
NZ185358A (en) 1979-06-08
DK150302B (en) 1987-02-02
JPS607997B2 (en) 1985-02-28
PT67164B (en) 1979-03-20
JPS5534132B2 (en) 1980-09-04
IE45805L (en) 1978-04-18
YU244277A (en) 1982-08-31
HK53881A (en) 1981-11-13
FI773060A (en) 1978-04-19
BG28847A3 (en) 1980-07-15
NL7711358A (en) 1978-04-20
DK150302C (en) 1987-09-28
AT356136B (en) 1980-04-10
DD131931A5 (en) 1978-08-09
PH15639A (en) 1983-03-11
DK461377A (en) 1978-04-19
DE2759543C2 (en) 1987-04-09
LU78330A1 (en) 1979-06-01
NL167434C (en) 1981-12-16
FR2367754B1 (en) 1982-07-09
MX4899E (en) 1982-12-14
NO773548L (en) 1978-04-19
NO148453B (en) 1983-07-04
CA1088945A (en) 1980-11-04
SE437024B (en) 1985-02-04
ATA745977A (en) 1979-09-15
JPS5353653A (en) 1978-05-16
DE2759542C2 (en) 1988-07-07
AU2943177A (en) 1979-04-12
IL53094A0 (en) 1977-12-30
IE45805B1 (en) 1982-12-01
FR2367754A1 (en) 1978-05-12
JPS5940388B2 (en) 1984-09-29
CH625511A5 (en) 1981-09-30
DE2746244C2 (en) 1983-05-19
DE2759927C2 (en) 1986-12-04
MY8200157A (en) 1982-12-31
JPS5495570A (en) 1979-07-28
SE7711053L (en) 1978-04-19
NO148453C (en) 1983-10-12
FI62307B (en) 1982-08-31
JPS5495575A (en) 1979-07-28

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