Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB33628/53A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Philips Gloeilampenfabrieken NV
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Filing date
Publication date
Application filed by Philips Gloeilampenfabrieken NVfiledCriticalPhilips Gloeilampenfabrieken NV
Publication of GB744804ApublicationCriticalpatent/GB744804A/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
Acid halides of the general formula <FORM:0744804/IV(a)/1> where n = 1 or 2 and Hlg is a halogen atom are made by treating the corresponding alpha hydro-beta hydroxy acid with a halogenating agent capable of converting a carboxylic acid into its acid halide to cause halogenation with removal of water to give the alpha unsaturated acid halide. The halogenation is preferably effected by phosphorus trichloride, phosphorus pentachloride, phosphorus tribromide or thionyl chloride in benzene, toluene or xylene at 50 DEG to 70 DEG C. or in chloroform at -50 DEG to 0 DEG C. In examples (1) beta-ionol acetic acid ethyl ester is saponified and the resulting beta-ionol acetic acid is treated with phosphorus trichloride to give beta ionylidene acetic acid chloride; and (2) the hydroxy C20 acid ethyl ester, prepared from the C18 ketone by Reformatsky, is saponified and treatd with phosphorus pentachloride to give Vitamin A acid chloride.
GB33628/53A1953-01-221953-12-03Improvements in or relating to the manufacture of acid halides of the vitamin a-series
ExpiredGB744804A
(en)
Procedure for the obtaining of esters of 1,2-alpha-methylen-delta-17-alpha hydroxyprogesterone halogenated in position 6 (Machine-translation by Google Translate, not legally binding)