GB806162A - Steroidal compounds - Google Patents

Steroidal compounds

Info

Publication number
GB806162A
GB806162A GB88455A GB88455A GB806162A GB 806162 A GB806162 A GB 806162A GB 88455 A GB88455 A GB 88455A GB 88455 A GB88455 A GB 88455A GB 806162 A GB806162 A GB 806162A
Authority
GB
United Kingdom
Prior art keywords
dibromo
acetate
prepared
pregnane
triol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB88455A
Inventor
Eugene P Oliveto
David H Gould
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to GB88455A priority Critical patent/GB806162A/en
Publication of GB806162A publication Critical patent/GB806162A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises 2,4-dibromoallopregnane - 11b ,17a ,21 - triol - 3,20 - dione 21-acetate and 2,4 - dibromo - normal - pregnanes of the general formula <FORM:0806162/IV (b)/1> wherein X represents = O, <FORM:0806162/IV (b)/2> and R represents hydrogen or an alkanoyl group having not more than 8 carbon atoms. The 21-esters may be prepared by treating the corresponding 21-esters with 2 mols. of bromine in one or two steps. The 2,4-dibromo-21-hydroxy compounds are prepared by hydrolysing the corresponding 21-esters. The 2,4-dibromo-11-keto-pregnones may also be prepared by oxidizing the corresponding 11-hydroxy compounds, e.g. by means of chromic acid. In the examples the following compounds are prepared: 2,4-dibromo-pregnane-17a ,21-diol-3,11,20-trione 21-acetate, 2,4 - dibromo - pregnane - 11b ,17a ,21-triol - 3,20 - dione 21 - acetate and the corresponding allopregnane, and 2,4-dibromo-pregnane - 11a ,17a ,21 - triol - 3,20 - dione 21 acetate. Specification 742,888 is referred to.
GB88455A 1955-01-11 1955-01-11 Steroidal compounds Expired GB806162A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB88455A GB806162A (en) 1955-01-11 1955-01-11 Steroidal compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB88455A GB806162A (en) 1955-01-11 1955-01-11 Steroidal compounds

Publications (1)

Publication Number Publication Date
GB806162A true GB806162A (en) 1958-12-17

Family

ID=9712182

Family Applications (1)

Application Number Title Priority Date Filing Date
GB88455A Expired GB806162A (en) 1955-01-11 1955-01-11 Steroidal compounds

Country Status (1)

Country Link
GB (1) GB806162A (en)

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