GB737291A - Improvements in or relating to steroid compounds - Google Patents

Improvements in or relating to steroid compounds

Info

Publication number
GB737291A
GB737291A GB12180/53A GB1218053A GB737291A GB 737291 A GB737291 A GB 737291A GB 12180/53 A GB12180/53 A GB 12180/53A GB 1218053 A GB1218053 A GB 1218053A GB 737291 A GB737291 A GB 737291A
Authority
GB
United Kingdom
Prior art keywords
diol
pregnene
trione
diacetate
dione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB12180/53A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB737291A publication Critical patent/GB737291A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises a cyclopentanophenanthrene compound having at C-17 a side chain of the formula <FORM:0737291/IV (b)/1> wherein Ac is an acyl group derived from a lower aliphatic acid containing not more than five carbon atoms and R is hydrogen, hydroxy, alkoxy or acyloxy and the preparation thereof by reacting the corresponding 17a -hydroxy-20-keto compound with the anhydride of a lower aliphatic acid. The reaction may be effected at a temperature in excess of about 100 DEG C. in the presence of an acid catalyst, e.g. hydrochloric, sulphuric or p-toluene sulfonic acid. Examples disclose the preparation of allopregnene - 17a ,21 - diol - 3,11,20 - trione 17,21-diacetate, pregnane - 3a ,17a ,21 - triol - 11,20-dione - 3,17,21 - triacetate, D 4 - pregnene-17a ,21 - diol - 3,11,20 - trione 17,21 - diacetate pregnane - 3a , 17a - diol - 11,20 - dione 3,17-diacetate. Specific starting materials mentioned are D 4 - pregnene - 3,11,20 - trione - 17a - ol-21 - methoxy, allopregnane - 17a ,21 - triol - 20-one 3,21 - diacetate, D 4 - pregnene - 17a ,21-diol - 3,20 - dione 21 - acetate, allopregnane-3,17a - diol - 20 - one - 3 - acetate, D 4 - pregnene - 17a - ol - 3,20 - dione, D 4 - allopregnene-17a - ol - 20 - one and pregnane - 17a ,21 - diol-3,11,20-trione 21-acetate.
GB12180/53A 1952-05-02 1953-05-01 Improvements in or relating to steroid compounds Expired GB737291A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US737291XA 1952-05-02 1952-05-02

Publications (1)

Publication Number Publication Date
GB737291A true GB737291A (en) 1955-09-21

Family

ID=22115448

Family Applications (1)

Application Number Title Priority Date Filing Date
GB12180/53A Expired GB737291A (en) 1952-05-02 1953-05-01 Improvements in or relating to steroid compounds

Country Status (1)

Country Link
GB (1) GB737291A (en)

Similar Documents

Publication Publication Date Title
US2865935A (en) 2-methyl steroids and process
US3065228A (en) Process for the production of delta5-androstene-19-ol and delta5-pregnene-19-ol compounds
GB737291A (en) Improvements in or relating to steroid compounds
US3184484A (en) 5, 10-methylene-19-nor- and 5, 10-seco-5, 19-cyclo-10-fluoro-androstenes and pregnenes and processes for their preparation
US2818408A (en) Steroid compounds and process
US3282929A (en) Method for preparation of aromatic a ring steroids
GB959378A (en) 21-substituted 17ª‡, 21-dioxy steroids and processes for their preparation
US2773072A (en) Steroid hydrolysis
US3538130A (en) Substituted methylene steroids and their preparation
US3014936A (en) 15-dehydro-cortical hormones
US3236866A (en) 21, 21-difluoro pregnenes
US2913456A (en) Intermediates for the production of 19-norhydrocortisone
US3082224A (en) Novel 16alpha-methyl-3, 5-pregnadienes and processes
GB842922A (en) Improvements in or relating to steroid compounds
GB892620A (en) Cyclopentanophenanthrene derivatives
US3350427A (en) Process for the dehydrohalogenation of steroids
GB1037772A (en) Improvements in or relating to í¸-steroid compounds
US3051703A (en) Process for preparing delta9(11)-pregnanes and intermediates
US3080395A (en) 2-halo methyl derivatives of the androstane series
US3580935A (en) Process for the preparation of 3-enol ethers of 3-keto-delta**4 - 6-(n-disubstituted) aminomethyl steroids
GB1073988A (en) Process for preparing steroid compounds, and the compounds thus prepared
US3274183A (en) 3-(17beta-hydroxy-1, 4-dimethylestra-1, 3, 5(10)-trien-17alpha-yl) propionic acid lactone and intermediates
GB889779A (en) Improvements in or relating to steroids and the manufacture thereof
GB802004A (en) Improvements in or relating to 6-methyl steroid compounds
GB852847A (en) Improvements in or relating to 6-methyl steroid compounds