AU514200B2 - 9a, 21-dijalogeno-11b, 17a-dihydroxy-6a-fluro-16b-methyl pregna-1, 4-diene-3, 20-diones - Google Patents

9a, 21-dijalogeno-11b, 17a-dihydroxy-6a-fluro-16b-methyl pregna-1, 4-diene-3, 20-diones

Info

Publication number
AU514200B2
AU514200B2 AU29148/77A AU2914877A AU514200B2 AU 514200 B2 AU514200 B2 AU 514200B2 AU 29148/77 A AU29148/77 A AU 29148/77A AU 2914877 A AU2914877 A AU 2914877A AU 514200 B2 AU514200 B2 AU 514200B2
Authority
AU
Australia
Prior art keywords
dijalogeno
fluro
diones
dihydroxy
diene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU29148/77A
Other languages
English (en)
Other versions
AU2914877A (en
Inventor
J. and Avner G Kalvoda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of AU2914877A publication Critical patent/AU2914877A/en
Application granted granted Critical
Publication of AU514200B2 publication Critical patent/AU514200B2/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J21/00Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J31/00Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring
    • C07J71/001Oxiranes
    • C07J71/0015Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU29148/77A 1916-09-11 1977-09-27 9a, 21-dijalogeno-11b, 17a-dihydroxy-6a-fluro-16b-methyl pregna-1, 4-diene-3, 20-diones Expired AU514200B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LULU75903 1916-09-11
LU75903A LU75903A1 (no) 1976-09-29 1976-09-29

Publications (2)

Publication Number Publication Date
AU2914877A AU2914877A (en) 1979-04-05
AU514200B2 true AU514200B2 (en) 1981-01-29

Family

ID=19728370

Family Applications (1)

Application Number Title Priority Date Filing Date
AU29148/77A Expired AU514200B2 (en) 1916-09-11 1977-09-27 9a, 21-dijalogeno-11b, 17a-dihydroxy-6a-fluro-16b-methyl pregna-1, 4-diene-3, 20-diones

Country Status (24)

Country Link
JP (1) JPS5356652A (no)
AT (3) AT363197B (no)
AU (1) AU514200B2 (no)
BE (1) BE859120A (no)
CA (1) CA1101410A (no)
CH (9) CH624967A5 (no)
CY (1) CY1178A (no)
DD (1) DD133150A5 (no)
DE (1) DE2743069A1 (no)
DK (1) DK146017C (no)
ES (1) ES462763A1 (no)
FR (1) FR2366311A1 (no)
GB (1) GB1563638A (no)
HK (1) HK16683A (no)
HU (1) HU175218B (no)
IE (1) IE46047B1 (no)
IL (1) IL53012A (no)
KE (1) KE3258A (no)
LU (1) LU75903A1 (no)
MY (1) MY8400092A (no)
NL (1) NL7710089A (no)
SE (1) SE436751B (no)
SG (1) SG3383G (no)
ZA (1) ZA775800B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL187577C (nl) * 1978-04-05 1991-11-18 Sibla Srl 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
DE3227312A1 (de) * 1982-07-19 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung
EP0523132A1 (en) * 1990-03-27 1993-01-20 Schering Corporation PROCESS FOR 9$g(a)-HYDROXY STEROID DEHYDRATION
US5972922A (en) * 1990-06-11 1999-10-26 Alcon Laboratories, Inc. Steroids which inhibit angiogenesis
MXPA04005188A (es) 2001-11-29 2004-08-11 Taro Pharma Ind Metodo para la produccion de 6-alfa-fluorocorticosteroides.
US8809307B2 (en) 2010-11-22 2014-08-19 Dow Pharmaceutical Sciences, Inc. Pharmaceutical formulations containing corticosteroids for topical administration
US11957753B2 (en) 2010-11-22 2024-04-16 Bausch Health Ireland Limited Pharmaceutical formulations containing corticosteroids for topical administration
ES2812451T3 (es) 2015-06-18 2021-03-17 Bausch Health Ireland Ltd Composiciones tópicas que comprenden un corticosteroide y un retinoide para tratar la psoriasis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB898292A (en) * 1959-03-18 1962-06-06 Upjohn Co Improvements in or relating to steroids and the manufacture thereof
US3644340A (en) * 1970-03-19 1972-02-22 Syntex Corp Preparation of 21-chloro steroids
US3992422A (en) * 1975-08-14 1976-11-16 Schering Corporation Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes

Also Published As

Publication number Publication date
CH631999A5 (en) 1982-09-15
CH624967A5 (en) 1981-08-31
CH632000A5 (en) 1982-09-15
FR2366311B1 (no) 1982-12-03
AU2914877A (en) 1979-04-05
HU175218B (hu) 1980-06-28
AT363202B (de) 1981-07-27
CA1101410A (en) 1981-05-19
IE46047L (en) 1978-03-29
DE2743069A1 (de) 1978-03-30
CH632279A5 (en) 1982-09-30
ZA775800B (en) 1978-08-30
JPS5356652A (en) 1978-05-23
IL53012A0 (en) 1977-11-30
ATA151379A (de) 1980-12-15
AT363203B (de) 1981-07-27
HK16683A (en) 1983-05-27
CH631998A5 (en) 1982-09-15
JPS6214557B2 (no) 1987-04-02
DE2743069C2 (no) 1987-03-05
SE436751B (sv) 1985-01-21
DK146017B (da) 1983-05-24
MY8400092A (en) 1984-12-31
SG3383G (en) 1983-09-09
ES462763A1 (es) 1978-05-16
NL7710089A (nl) 1978-03-31
IL53012A (en) 1982-05-31
FR2366311A1 (fr) 1978-04-28
CH625810A5 (en) 1981-10-15
KE3258A (en) 1983-03-04
ATA151279A (de) 1980-12-15
CH625808A5 (en) 1981-10-15
ATA691077A (de) 1980-12-15
IE46047B1 (en) 1983-02-09
CY1178A (en) 1983-06-10
CH625809A5 (en) 1981-10-15
SE7706673L (sv) 1978-03-30
BE859120A (fr) 1978-03-28
GB1563638A (en) 1980-03-26
DK146017C (da) 1983-10-24
AT363197B (de) 1981-07-10
CH632521A5 (en) 1982-10-15
DD133150A5 (de) 1978-12-13
DK256977A (da) 1978-03-30
LU75903A1 (no) 1978-05-16

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