CA3138094A1 - Methods for treating anxiety disorders, headache disorders, and eating disorders with psilocybin - Google Patents

Methods for treating anxiety disorders, headache disorders, and eating disorders with psilocybin Download PDF

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Publication number
CA3138094A1
CA3138094A1 CA3138094A CA3138094A CA3138094A1 CA 3138094 A1 CA3138094 A1 CA 3138094A1 CA 3138094 A CA3138094 A CA 3138094A CA 3138094 A CA3138094 A CA 3138094A CA 3138094 A1 CA3138094 A1 CA 3138094A1
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Canada
Prior art keywords
psilocybin
disorder
subject
hours
polymorph
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3138094A
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English (en)
French (fr)
Inventor
Derek John Londesbrough
Christopher Brown
Julian Scott Northen
Gillian Moore
Hemant Kashinath Patil
David E. Nichols
Megan CROAL
Hans Ake Eriksson
George GOLDSMITH
Molly Tabitha HICKEY
Shaun HURLEY
Ekaterina MALIEVSKAIA
Lindsey MARWOOD
Drummond E-Wen Joe MCCULLOCH
Laurie Emma MEDHURST
Nathan POULSEN
Aslihan SELIMBEYOGLU
Anais Soula
Amanda Tan SHUXIANG
Manon Cecile Elisabeth VERAART
Tobias Patrick WHELAN
Lars Christian WILDE
Stephen Wright
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Compass Pathfinder Ltd
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Compass Pathfinder Ltd
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Filing date
Publication date
Application filed by Compass Pathfinder Ltd filed Critical Compass Pathfinder Ltd
Publication of CA3138094A1 publication Critical patent/CA3138094A1/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
CA3138094A 2019-04-17 2020-04-17 Methods for treating anxiety disorders, headache disorders, and eating disorders with psilocybin Pending CA3138094A1 (en)

Applications Claiming Priority (41)

Application Number Priority Date Filing Date Title
US201962835474P 2019-04-17 2019-04-17
US201962835460P 2019-04-17 2019-04-17
US201962835450P 2019-04-17 2019-04-17
US201962835478P 2019-04-17 2019-04-17
US201962835449P 2019-04-17 2019-04-17
US201962835481P 2019-04-17 2019-04-17
US201962835472P 2019-04-17 2019-04-17
US201962835480P 2019-04-17 2019-04-17
US201962835479P 2019-04-17 2019-04-17
US201962835465P 2019-04-17 2019-04-17
US201962835458P 2019-04-17 2019-04-17
US201962835485P 2019-04-17 2019-04-17
US201962835476P 2019-04-17 2019-04-17
US201962835464P 2019-04-17 2019-04-17
US201962835482P 2019-04-17 2019-04-17
US201962835477P 2019-04-17 2019-04-17
US201962835484P 2019-04-17 2019-04-17
US62/835,449 2019-04-17
US62/835,482 2019-04-17
US62/835,458 2019-04-17
US62/835,476 2019-04-17
US62/835,464 2019-04-17
US62/835,485 2019-04-17
US62/835,484 2019-04-17
US62/835,481 2019-04-17
US62/835,472 2019-04-17
US62/835,474 2019-04-17
US62/835,480 2019-04-17
US62/835,478 2019-04-17
US62/835,450 2019-04-17
US62/835,479 2019-04-17
US62/835,460 2019-04-17
US62/835,477 2019-04-17
US62/835,465 2019-04-17
US201962893110P 2019-08-28 2019-08-28
US62/893,110 2019-08-28
US201962893611P 2019-08-29 2019-08-29
US62/893,611 2019-08-29
US201962946159P 2019-12-10 2019-12-10
US62/946,159 2019-12-10
PCT/IB2020/053687 WO2020212951A1 (en) 2019-04-17 2020-04-17 Methods for treating anxiety disorders, headache disorders, and eating disorders with psilocybin

Publications (1)

Publication Number Publication Date
CA3138094A1 true CA3138094A1 (en) 2020-10-22

Family

ID=70465167

Family Applications (3)

Application Number Title Priority Date Filing Date
CA3138094A Pending CA3138094A1 (en) 2019-04-17 2020-04-17 Methods for treating anxiety disorders, headache disorders, and eating disorders with psilocybin
CA3138008A Pending CA3138008A1 (en) 2019-04-17 2020-04-17 Methods of treating neurocognitive disorders, chronic pain and reducing inflammation
CA3138100A Pending CA3138100A1 (en) 2019-04-17 2020-04-17 Treatment of depression and other various disorders with psilocybin

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA3138008A Pending CA3138008A1 (en) 2019-04-17 2020-04-17 Methods of treating neurocognitive disorders, chronic pain and reducing inflammation
CA3138100A Pending CA3138100A1 (en) 2019-04-17 2020-04-17 Treatment of depression and other various disorders with psilocybin

Country Status (9)

Country Link
US (10) US12433904B2 (enExample)
EP (3) EP3955919A1 (enExample)
JP (6) JP2022529781A (enExample)
KR (3) KR20220008824A (enExample)
CN (3) CN113993522A (enExample)
AU (6) AU2020259406B2 (enExample)
CA (3) CA3138094A1 (enExample)
TW (1) TW202103699A (enExample)
WO (3) WO2020212948A1 (enExample)

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