GB911946A - Psilocybin and psilocin and processes for their preparation - Google Patents
Psilocybin and psilocin and processes for their preparationInfo
- Publication number
- GB911946A GB911946A GB484159A GB484159A GB911946A GB 911946 A GB911946 A GB 911946A GB 484159 A GB484159 A GB 484159A GB 484159 A GB484159 A GB 484159A GB 911946 A GB911946 A GB 911946A
- Authority
- GB
- United Kingdom
- Prior art keywords
- heim
- active compounds
- extraction
- stropharia
- degreasing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The invention comprises the psychotropically active compounds Psilocybin of the formula: <FORM:0911946/IV (b)/1> and Psilocin of the formula: <FORM:0911946/IV (b)/2> and a process for their extraction from fungal material of the genera Psilocybe, Stropharia and Panaeolus or biological variants or mutants thereof, by treatment with water or a water-miscible organic solvent, degreasing the product, isolating the active material by chromatography and removing any halogen material present. Examples detail the extraction of the active compounds from Psilocybe mexicana Heim, P. caerulescens Murill var. Mazatecorum Heim, P. Zapotecorum Heim, P. semperviva Heim and Cailleux, P. Aztecorum Heim, Stropharia cubensis Earle preferably by cultivation on a synthetic medium, extraction of the dried fruit bodies with methanol or aqueous methanol, degreasing the extract with petroleum ether and chloroform, chromatographing the product on cellulose, eluting with aqueous butanol (detection of active compounds is effected with the Keller reagent), removing halogen by treatment with silver carbonate and purifying the active compounds by crystallisation. The compounds may be formulated into psychotherapeutic compositions with inert carriers suitable for sub-cutaneous injection or oral administration.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH5614358A CH393637A (en) | 1958-02-21 | 1958-02-21 | Process for preparing psilocybin and psilocin |
CH6239358A CH377482A (en) | 1958-07-30 | 1958-07-30 | Process for obtaining psilocybin and psilocin |
Publications (1)
Publication Number | Publication Date |
---|---|
GB911946A true GB911946A (en) | 1962-12-05 |
Family
ID=25737584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB484159A Expired GB911946A (en) | 1958-02-21 | 1959-02-11 | Psilocybin and psilocin and processes for their preparation |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB911946A (en) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1474126A2 (en) * | 2002-01-18 | 2004-11-10 | Massachusetts Institute Of Technology | Treatments for neurotoxicity in alzheimer's disease |
US10519175B2 (en) | 2017-10-09 | 2019-12-31 | Compass Pathways Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
US11331357B2 (en) | 2020-06-17 | 2022-05-17 | Psilo Scientific Ltd. | Methods and compositions comprising psychoactive compounds from psychoactive organisms |
WO2022140851A1 (en) * | 2020-12-28 | 2022-07-07 | Psilo Scientific Ltd | Injectable psychoactive alkaloid composition and preparation thereof |
US11382942B2 (en) | 2020-06-17 | 2022-07-12 | Psilo Scientific Ltd. | Extraction of psychoactive compounds from psilocybin fungus |
US11510952B2 (en) | 2020-06-17 | 2022-11-29 | Psilo Scientific Ltd. | Ethanol extraction of psychoactive compounds from psilocybin fungus |
US11564935B2 (en) | 2019-04-17 | 2023-01-31 | Compass Pathfinder Limited | Method for treating anxiety disorders, headache disorders, and eating disorders with psilocybin |
US11724985B2 (en) | 2020-05-19 | 2023-08-15 | Cybin Irl Limited | Deuterated tryptamine derivatives and methods of use |
EP4161547A4 (en) * | 2020-06-17 | 2023-11-01 | Psilo Scientific Ltd | Methanol-based extraction of psychoactive compounds from fungus |
EP4339200A3 (en) * | 2020-06-17 | 2024-03-27 | Psilo Scientific Ltd | Ethanol extraction of psychoactive compounds from psilocybin fungus |
US12060328B2 (en) | 2022-03-04 | 2024-08-13 | Reset Pharmaceuticals, Inc. | Co-crystals or salts of psilocybin and methods of treatment therewith |
-
1959
- 1959-02-11 GB GB484159A patent/GB911946A/en not_active Expired
Cited By (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1474126A2 (en) * | 2002-01-18 | 2004-11-10 | Massachusetts Institute Of Technology | Treatments for neurotoxicity in alzheimer's disease |
EP1474126A4 (en) * | 2002-01-18 | 2007-08-08 | Massachusetts Inst Technology | Treatments for neurotoxicity in alzheimer's disease |
US11851451B2 (en) | 2017-10-09 | 2023-12-26 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
US10519175B2 (en) | 2017-10-09 | 2019-12-31 | Compass Pathways Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
US10954259B1 (en) | 2017-10-09 | 2021-03-23 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
US11149044B2 (en) | 2017-10-09 | 2021-10-19 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
US11180517B2 (en) | 2017-10-09 | 2021-11-23 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
US11629159B2 (en) | 2017-10-09 | 2023-04-18 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
US11939346B2 (en) | 2017-10-09 | 2024-03-26 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
US10947257B2 (en) | 2017-10-09 | 2021-03-16 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
US11447510B2 (en) | 2017-10-09 | 2022-09-20 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
US11505564B2 (en) | 2017-10-09 | 2022-11-22 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
US11738035B2 (en) | 2019-04-17 | 2023-08-29 | Compass Pathfinder Limited | Method for treating anxiety disorders, headache disorders, and eating disorders with psilocybin |
US11564935B2 (en) | 2019-04-17 | 2023-01-31 | Compass Pathfinder Limited | Method for treating anxiety disorders, headache disorders, and eating disorders with psilocybin |
US11958807B2 (en) | 2020-05-19 | 2024-04-16 | Cybin Irl Limited | Deuterated tryptamine derivatives and methods of use |
US11724985B2 (en) | 2020-05-19 | 2023-08-15 | Cybin Irl Limited | Deuterated tryptamine derivatives and methods of use |
US11746088B2 (en) | 2020-05-19 | 2023-09-05 | Cybin Irl Limited | Deuterated tryptamine derivatives and methods of use |
US11834410B2 (en) | 2020-05-19 | 2023-12-05 | Cybin Irl Limited | Deuterated tryptamine derivatives and methods of use |
EP4372094A3 (en) * | 2020-06-17 | 2024-08-07 | Psilo Scientific Ltd | Aqueous extraction of psychoactive compounds from psilocybin fungus |
US11571450B2 (en) | 2020-06-17 | 2023-02-07 | Psilo Scientific Ltd | Aqueous extraction of psychoactive compounds from psilocybin fungus |
EP4161547A4 (en) * | 2020-06-17 | 2023-11-01 | Psilo Scientific Ltd | Methanol-based extraction of psychoactive compounds from fungus |
US11510952B2 (en) | 2020-06-17 | 2022-11-29 | Psilo Scientific Ltd. | Ethanol extraction of psychoactive compounds from psilocybin fungus |
US11331357B2 (en) | 2020-06-17 | 2022-05-17 | Psilo Scientific Ltd. | Methods and compositions comprising psychoactive compounds from psychoactive organisms |
US11642385B2 (en) | 2020-06-17 | 2023-05-09 | Psilo Scientific Ltd. | Basic extraction of psychoactive compounds from psychoactive organisms |
US11382942B2 (en) | 2020-06-17 | 2022-07-12 | Psilo Scientific Ltd. | Extraction of psychoactive compounds from psilocybin fungus |
EP4161548A4 (en) * | 2020-06-17 | 2024-04-24 | Psilo Scientific Ltd | Extraction of psychoactive compounds from psychedelic fungus |
EP4339200A3 (en) * | 2020-06-17 | 2024-03-27 | Psilo Scientific Ltd | Ethanol extraction of psychoactive compounds from psilocybin fungus |
US11786506B2 (en) | 2020-12-28 | 2023-10-17 | Psilo Scientific Ltd | Transmucosal psychoactive alkaloid composition and preparation thereof |
US11957659B2 (en) | 2020-12-28 | 2024-04-16 | Psilo Scientific Ltd. | Transmucosal dephosphorylated psychoactive alkaloid composition and preparation thereof |
WO2022140851A1 (en) * | 2020-12-28 | 2022-07-07 | Psilo Scientific Ltd | Injectable psychoactive alkaloid composition and preparation thereof |
US11992476B2 (en) | 2020-12-28 | 2024-05-28 | Psilo Scientific Ltd | Transdermal psychoactive alkaloid composition and preparation thereof |
US12070446B2 (en) | 2020-12-28 | 2024-08-27 | Psilo Scientific, Ltd. | Standardized psychoactive alkaloid extract composition |
US11491138B2 (en) | 2020-12-28 | 2022-11-08 | Psilo Scientific Ltd. | Injectable psychoactive alkaloid composition and preparation thereof |
US12060328B2 (en) | 2022-03-04 | 2024-08-13 | Reset Pharmaceuticals, Inc. | Co-crystals or salts of psilocybin and methods of treatment therewith |
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