EP1865980A4 - Abuse-resistant amphetamine prodrugs - Google Patents

Abuse-resistant amphetamine prodrugs

Info

Publication number
EP1865980A4
EP1865980A4 EP06769808A EP06769808A EP1865980A4 EP 1865980 A4 EP1865980 A4 EP 1865980A4 EP 06769808 A EP06769808 A EP 06769808A EP 06769808 A EP06769808 A EP 06769808A EP 1865980 A4 EP1865980 A4 EP 1865980A4
Authority
EP
European Patent Office
Prior art keywords
abuse
resistant amphetamine
amphetamine prodrugs
prodrugs
resistant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06769808A
Other languages
German (de)
French (fr)
Other versions
EP1865980A2 (en
Inventor
Barney Bishop
Suma Krishnan
Travis Mickle
Rob Oberlender
Christopher Lauderback
James Scott Moncrief
Thomas Piccariello
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire LLC
Original Assignee
Shire LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire LLC filed Critical Shire LLC
Publication of EP1865980A2 publication Critical patent/EP1865980A2/en
Publication of EP1865980A4 publication Critical patent/EP1865980A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP06769808A 2005-04-08 2006-04-10 Abuse-resistant amphetamine prodrugs Withdrawn EP1865980A4 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US66938505P 2005-04-08 2005-04-08
US66938605P 2005-04-08 2005-04-08
US68117005P 2005-05-16 2005-05-16
US75654806P 2006-01-06 2006-01-06
US75995806P 2006-01-19 2006-01-19
PCT/US2006/013221 WO2006121552A2 (en) 2005-04-08 2006-04-10 Abuse-resistant amphetamine prodrugs

Publications (2)

Publication Number Publication Date
EP1865980A2 EP1865980A2 (en) 2007-12-19
EP1865980A4 true EP1865980A4 (en) 2009-11-11

Family

ID=37397039

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06769808A Withdrawn EP1865980A4 (en) 2005-04-08 2006-04-10 Abuse-resistant amphetamine prodrugs

Country Status (6)

Country Link
EP (1) EP1865980A4 (en)
JP (1) JP2008535860A (en)
BR (1) BRPI0612440A2 (en)
CA (1) CA2603873A1 (en)
MX (1) MX2007012507A (en)
WO (1) WO2006121552A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8318813B2 (en) 2007-09-13 2012-11-27 Lcs Group, Llc Method of treating binge eating disorder
WO2010042120A1 (en) 2008-10-09 2010-04-15 Archimica, Inc. Process for the synthesis of amphetamine derivatives
GB201002612D0 (en) * 2010-02-16 2010-03-31 Jagotec Ag Improvements in or relating to organic compounds
WO2014002039A1 (en) * 2012-06-27 2014-01-03 Shire Ag Amphetamine prodrugs
WO2018118902A1 (en) 2016-12-19 2018-06-28 The Regents Of The University Of California Dual-enzyme responsive peptides
WO2018118903A1 (en) 2016-12-19 2018-06-28 The Regents Of The University Of California Noncrushable pill formulatiions
DK3459538T3 (en) 2017-09-20 2020-08-03 Sandoz Ag Crystalline salts of a dextroamphetamine prodrug
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
WO2020212948A1 (en) 2019-04-17 2020-10-22 Compass Pathfinder Limited Methods of treating neurocognitive disorders, chronic pain and reducing inflammation
PT3845215T (en) 2019-12-30 2022-10-17 Labomed Pharmaceutical Company S A Oral solutions comprising lisdexamfetamine salts
EP4237007A1 (en) 2020-11-18 2023-09-06 Mind Medicine, Inc. Mdma prodrugs to assist psychotherapy
WO2023111325A1 (en) 2021-12-16 2023-06-22 Labomed Pharmaceutical Company S.A. Container comprising a lisdexamfetamine containing oral solution
WO2024023367A1 (en) 2022-07-29 2024-02-01 Labomed Pharmaceutical Company S.A. Lisdexamfetamine containing oral solution

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001005407A1 (en) * 1999-07-14 2001-01-25 Shire Laboratories, Inc. Rapid immediate release oral dosage form
WO2005032474A2 (en) * 2003-09-30 2005-04-14 New River Pharmaceuticals Inc. Pharmaceutical compositions for prevention of overdose or abuse

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3878187A (en) * 1972-09-11 1975-04-15 Syva Co Polypeptide derivatives of amphetamine and analogs for immunoassays
DE60219005T2 (en) * 2001-05-25 2007-12-13 Cephalon, Inc. Modafinil comprehensive solid pharmaceutical formulations
US7105486B2 (en) * 2002-02-22 2006-09-12 New River Pharmaceuticals Inc. Abuse-resistant amphetamine compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001005407A1 (en) * 1999-07-14 2001-01-25 Shire Laboratories, Inc. Rapid immediate release oral dosage form
WO2005032474A2 (en) * 2003-09-30 2005-04-14 New River Pharmaceuticals Inc. Pharmaceutical compositions for prevention of overdose or abuse

Also Published As

Publication number Publication date
EP1865980A2 (en) 2007-12-19
WO2006121552A3 (en) 2007-07-05
BRPI0612440A2 (en) 2010-11-23
JP2008535860A (en) 2008-09-04
MX2007012507A (en) 2008-03-11
WO2006121552A2 (en) 2006-11-16
CA2603873A1 (en) 2006-11-16
WO2006121552A9 (en) 2007-03-08

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Owner name: SHIRE LLC

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Inventor name: PICCARIELLO, THOMAS

Inventor name: MONCRIEF, JAMES SCOTT

Inventor name: LAUDERBACK, CHRISTOPHER

Inventor name: OBERLENDER, ROB

Inventor name: MICKLE, TRAVIS

Inventor name: KRISHNAN, SUMA

Inventor name: BISHOP, BARNEY

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Inventor name: PICCARIELLO, THOMAS

Inventor name: MONCRIEF, JAMES SCOTT

Inventor name: OBERLENDER, ROB

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Inventor name: KRISHNAN, SUMA

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Inventor name: VERBICKY, CHRISTOPHER A

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Inventor name: LAUDERBACK, CHRISTOPHER

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