WO2019161050A1 - Cognitive platform including computerized elements coupled with a therapy for mood disorder - Google Patents

Abstract

Computer-implemented systems and methods for mood and cognitive assessment and treatment. A software platform is configured to facilitate assessment or measurement of a user's response to a mood disorder treatment and/or to provide data or other quantitative indicia of a user's mood or cognitive or affective bias. The mood disorder treatment may include administration of a psychedelic and/or dissociative drug.

Description

COGNITIVE PLATFORM INCLUDING COMPUTERIZED ELEMENTS COUPLED WITH A THERAPY FOR MOOD DISORDER

CROSS-REFERENCE TO RELATED APPLICATIONS

[1] This application claims priority to and benefit from U.S. Provisional Application No. 62/631,784 entitled“COGNITIVE PLATFORM INCLUDING COMPUTERIZED ELEMENTS COUPLED WITH A THERAPY FOR MOOD DISORDER” filed on February 18, 2018, and U.S. Provisional Application No. 62/648,917 entitled“COGNITIVE

PLATFORM INCLUDING COMPUTERIZED ELEMENTS COUPLED WITH A THERAPY FOR MOOD DISORDER” filed March 27, 2018. The entire disclosure of each of these two applications is incorporated herein in its entirety, including drawings.

FIELD OF THE DISCLOSURE

[2] The present disclosure relates generally to software for mood and cognitive assessment and treatment and particularly to a software platform configured to treat (as a standalone or adjunct to other therapies/treatments/medications), and to facilitate assessment or measurement of a user’s response to a mood disorder treatment and/or to provide data or other quantitative indicia of a user’s mood or cognitive or affective bias.

BACKGROUND

[3] Individuals with unipolar mood disorders, including major depressive disorder (MDD) and persistent depressive disorder (PDD), may be treated by the administration of pharmacotherapies including psychedelic drug or dissociative drugs to affect certain regions of the brain. In some instances, the mood disorder may be due to (or associated with) cognitive conditions, diseases, or executive function disorders that can result in compromised performance at tasks that require attention, memory, motor function, reaction, executive function, decision-making skills, problem-solving skills, language processing, or comprehension.

SUMMARY

[4] In an aspect, embodiments of the disclosure relate to system for generating a quantifier of cognitive skills in an individual undergoing therapy for a mood disorder. The system includes one or more processors; and a memory to store processor-executable instructions and communicatively coupled with the one or more processors. Upon execution of the processor-executable instructions by the one or more processors, the one or more processors are configured to generate a user interface. Via the user interface, a first instance of a task with an interference is presented at the user interface, requiring a first response from the individual to the first instance of the task in the presence of the interference. The individual (i) is preparing to undergo a therapy for a mood disorder comprising ingesting and/or injecting a psychedelic and/or a dissociative drug for treatment of the mood disorder and/or (ii) has undergone the therapy and/or (iii) has undergone cognitive behavioral therapy for the mood disorder. The first instance of the task is presented via the user interface, requiring a second response from the individual to the first instance of the task in the absence of the interference. The first instance of the task and/or the interference includes a computerized element. The first response from the individual to the first instance of the task and the response from the individual to the interference are measured substantially simultaneously. Data indicative of the first response and the second response is received. Data indicative of the first response and the second response is analyzed to compute at least one performance metric including at least one quantified indicator of cognitive abilities of the individual.

[5] One or more of the following features may be included. Based at least in part on the at least one performance metric, the one or more processors may be configured to generate an output for the user interface indicative of one or more of: (i) the cognitive abilities of the individual, (ii) a likelihood of effectiveness of the therapy for the mood disorder, (iii) a recommended amount, concentration, or dose titration of the psychedelic and/or dissociative drug to be administered to the individual in the therapy for the mood disorder, (iv) a likelihood of the individual experiencing an adverse event in response to administration of the psychedelic and/or dissociative drug, (v) a recommended treatment regimen using the cognitive platform following the therapy for the mood disorder, and/or (vi) a determination of a degree of effectiveness of the therapy for the mood disorder.

[6] The one or more processors may be configured to generate an output to the user interface indicative of a likelihood of the individual experiencing an adverse event in response to administration of the psychedelic and/or the dissociative drug, or a likelihood of the individual experiencing an adverse event in response to a change in one or more of the amount, concentration, or dose titration of the psychedelic and/or the dissociative drug.

[7] Prior to presenting the first instance of the task via the user interface, the one or more processors may be configured to receive data indicative of one or more of an amount, concentration, or dose titration of the psychedelic and/or dissociative drug previously administered to the individual in therapy for the mood disorder including the psychedelic and/or dissociative drug; and based at least in part on the performance metric, the one or more processors are configured to generate an output to the user interface indicative of one or more of: (i) a change in the cognitive abilities of the individual, (ii) a degree of effectiveness of the therapy for the mood disorder, (iii) a likelihood of the individual experiencing a relapse following administration of the therapy including the psychedelic and/or dissociative drug, (iv) a recommended change to a mood disorder treatment regimen using a cognitive platform comprising the processor-executable instructions following the therapy for the mood disorder, (v) a projected duration of remission of the mood disorder following the therapy, and/or (vi) a recommended training regimen using the cognitive platform to enhance the cognitive abilities of the individual.

[8] The at least one quantified indicator may provide an indication of a likelihood of at least one of an onset or a stage of progression of the mood disorder.

[9] The mood disorder may be due to a condition such as neuropsychological condition, a neurodegenerative condition, and/or an executive function disorder.

[10] The condition may be, e.g., social anxiety, depression, bipolar disorder, major depressive disorder, post-traumatic stress disorder, schizophrenia, autism spectrum disorder, attention deficit hyperactivity disorder, dementia, Parkinson's disease, Huntington's disease, Alzheimer’s disease, and/or multiple-sclerosis.

[11] The mood disorder may be, e.g., depression, anxiety, post-traumatic stress disorder (PTSD), and/or obsessive compulsive disorder (OCD).

[12] The system may include one or more sensor components, with the one or more processors being configured to control the one or more sensor components to measure the data indicative of one or both of the first response and the second response.

[13] The one or more sensor components may include a gyroscope, an accelerometer, a motion sensor, a position sensor, a pressure sensor, an optical sensor, a video camera, an auditory sensor, and/or a vibrational sensor.

[14] The one or more processors may be configured to transmit the performance metric to the individual and/or display the performance metric via the user interface.

[15] The one or more processors may be configured to present the task as a continuous visuo-motor tracking task, and the first instance of the task may be a first time interval of the continuous visuo-motor task. [16] The one or more processors may be configured to present via the user interface the interference as a target discrimination interference.

[17] The psychedelic and/or dissociative drug may be lysergic acid diethylamide, psilocybin, ketamine, methylenedioxy-n-methylamphetamine. mescaline, and/or N,N- Dimethyltryptamine.

[18] The psychedelic drug may be a tryptamine, a phenethylamine, and/or a lysergamide.

[19] A system may be a virtual reality system, an augmented reality system, and/or a mixed reality system.

[20] In another aspect, embodiments of the disclosure relate to a computer- implemented method for quantifying cognitive skills in an individual undergoing therapy for a mood disorder. The method includes using one or more processors to execute instructions stored in one or more memory storage devices including computer executable instructions to perform operations. The operation including presenting via a user interface a first instance of a task with an interference at the user interface, requiring a first response from the individual to the first instance of the task in the presence of the interference, with the individual (i) preparing to undergo a therapy for a mood disorder comprising ingesting and/or injecting a psychedelic and/or a dissociative drug for treatment of the mood disorder and/or (ii) has undergone the therapy and/or (iii) has undergone cognitive behavioral therapy for the mood disorder. The first instance of the task is presented via the user interface, requiring a second response from the individual to the first instance of the task in the absence of the interference. At least one of the first instance of the task and the interference includes a computerized element. The first response from the individual to the first instance of the task and the response from the individual to the interference are measured substantially simultaneously. Receive data indicative of the first response and the second response is received. The data indicative of the first response and the second response is analyzed to compute at least one performance metric including at least one quantified indicator of cognitive abilities of the individual.

[21] One or more of the following features may be included. The operations may further include, based at least in part on the at least one performance metric, generating an output for the user interface indicative of one or more of: (i) the cognitive abilities of the individual, (ii) the likelihood of effectiveness of the therapy for the mood disorder, (iii) a recommended amount, concentration, or dose titration of the psychedelic and/or dissociative drug to be administered to the individual in the therapy for the mood disorder, (iv) a likelihood of the individual experiencing an adverse event in response to administration of the psychedelic and/or dissociative drug, (v) a recommended treatment regimen using the cognitive platform following the therapy for the mood disorder, or (vi) a determination of a degree of effectiveness of the therapy for the mood disorder.

[22] The operations may further include generating an output to the user interface indicative of a likelihood of the individual experiencing an adverse event in response to administration of the psychedelic and/or the dissociative drug, or a likelihood of the individual experiencing an adverse event in response to a change in one or more of the amount, concentration, or dose titration of the psychedelic and/or the dissociative drug.

[23] The operations may further include, prior to presenting the first instance of the task via the user interface, receiving data indicative of one or more of an amount, concentration, or dose titration of the psychedelic and/or dissociative drug previously administered to the individual in therapy for the mood disorder including the psychedelic and/or dissociative drug; and based at least in part on the performance metric, generating an output to the user interface indicative of one or more of: (i) a change in the cognitive abilities of the individual, (ii) a degree of effectiveness of the therapy for the mood disorder, (iii) a likelihood of the individual experiencing a relapse following administration of the therapy including the psychedelic and/or dissociative drug, (iv) a recommended change to a mood disorder treatment regimen using a cognitive platform comprising the processor-executable instructions following the therapy for the mood disorder, (v) a projected duration of remission of the mood disorder following the therapy, or (vi) a recommended training regimen using the cognitive platform to enhance the cognitive abilities of the individual.

[24] The at least one quantified indicator may provide an indication of a likelihood of at least one of an onset or a stage of progression of the mood disorder.

[25] The mood disorder may be due to a condition a neuropsychological condition, a neurodegenerative condition, and/or an executive function disorder.

[26] The condition may be social anxiety, depression, bipolar disorder, major depressive disorder, post-traumatic stress disorder, schizophrenia, autism spectrum disorder, attention deficit hyperactivity disorder, dementia, Parkinson's disease, Huntington's disease, Alzheimer’s disease, and/or multiple-sclerosis. [27] The mood disorder may be depression, anxiety, post-traumatic stress disorder (PTSD), and/or obsessive compulsive disorder (OCD).

[28] In addition to or instead of the psychedelic and/or dissociative drugs, a drug for treating depression may be administered to the individual, such as but not limited to fluoxetine, doxepin, clomipramine, bupropion, amoxapine, nortiptyline, citalopram, and/or duloxetine.

[29] The operations may further include controlling one or more sensor components to measure the data indicative of one or both of the first response and the second response.

[30] The one or more sensor components may include a gyroscope, an accelerometer, a motion sensor, a position sensor, a pressure sensor, an optical sensor, a video camera, an auditory sensor, and/or a vibrational sensor.

[31] The operations may further include transmitting the performance metric to the individual and/or displaying the performance metric via the user interface.

[32] The task may be presented as a continuous visuo-motor tracking task, and the first instance of the task may be a first time interval of the continuous visuo-motor task.

[33] The interference may be presented as a target discrimination interference.

[34] The psychedelic and/or dissociative drug may be lysergic acid diethylamide, psilocybin, ketamine, methylenedioxy-n-methylamphetamine. mescaline, and/or N,N- Dimethyltryptamine. The psychedelic drug may be a tryptamine, a phenethylamine, and/or a lysergamide.

BRIEF DESCRIPTION OF DRAWINGS

[35] The skilled artisan will understand that the figures, described herein, are for illustration purposes only. It is to be understood that in some instances various aspects of the described implementations may be shown exaggerated or enlarged to facilitate an understanding of the described implementations. In the drawings, like reference characters generally refer to like features, functionally similar and/or structurally similar elements throughout the various drawings. The drawings are not necessarily to scale, emphasis instead being placed upon illustrating the principles of the teachings. The drawings are not intended to limit the scope of the present teachings in any way. The system and method may be better understood from the following illustrative description with reference to the following drawings in which: [36] FIG. 1 is a block diagram of an example system, according to the principles herein.

[37] FIG. 2 is a block diagram of an example computing device, according to the principles herein.

[38] FIGs. 3A - 3D show example user interfaces with instructions to a user that can be rendered to an example user interface, according to the principles herein.

[39] FIGs. 4 A - 4D show examples of the time-varying features of example objects (targets or non-targets) that can be rendered to an example user interface, according to the principles herein.

[40] FIGs. 5A - 5T show a non-limiting example of the tasks and interferences that can be rendered at user interfaces, according to the principles herein.

[41] FIG. 6 shows the architecture of an example computer system, according to the principles herein.

DETAILED DESCRIPTION

[42] It should be appreciated that all combinations of the concepts discussed in greater detail below (provided such concepts are not mutually inconsistent) are contemplated as being part of the inventive subject matter disclosed herein. It also should be appreciated that terminology explicitly employed herein that also may appear in any disclosure incorporated by reference should be accorded a meaning most consistent with the particular concepts disclosed herein.

[43] Following below are more detailed descriptions of various concepts related to, and embodiments of, inventive methods, apparatus and systems comprising a cognitive platform configured for using computerized elements (which in some examples may include one or more emotional or affective elements) in computerized tasks (including computerized tasks that appear to a user as platform interactions) that employ one or more interactive user elements to provide cognitive assessment or deliver a cognitive treatment. The example cognitive platform can be associated with a computer-implemented device platform that implements processor-executable instructions (including software programs) to provide an indication of the individual's performance, and/or for cognitive assessment, and/or to deliver a cognitive treatment. In the various examples, the computer-implemented device can be configured as a computer-implemented medical device or other type of computer- implemented device. [44] It should be appreciated that various concepts introduced above and discussed in greater detail below may be implemented in any of numerous ways, as the disclosed concepts are not limited to any particular manner of implementation. Examples of specific implementations and applications are provided primarily for illustrative purposes.

[45] As used herein, the term“includes” means includes but is not limited to, the term “including” means including but not limited to. The term“based on” means based at least in part on.

[46] As used herein, the term“target” refers to a type of stimulus that is specified to an individual (e.g., in instructions) to be the focus for an interaction. A target differs from a non-target in at least one characteristic or feature. Two targets may differ from each other by at least one characteristic or feature, but overall are still instructed to an individual as a target, in an example where the individual is instructed/required to make a choice (e.g., between two different degrees of a facial expression or other characteristic/feature difference, such as but not limited to between a happy face and a happier face or between an angry face and an angrier face).

[47] As used herein, the term“non-target” refers to a type of stimulus that is not to be the focus for an interaction, whether indicated explicitly or implicitly to the individual.

[48] As used herein, the term“task” refers to a goal and/or objective to be

accomplished by an individual. Using the example systems, methods, and apparatus described herein, the computerized task is rendered using programmed computerized components, and the individual is instructed (e.g., using a computing device) as to the intended goal or objective from the individual for performing the computerized task. The task may require the individual to provide or withhold a response to a particular stimulus, using at least one component of the computing device (e.g., one or more sensor components of the computing device). The“task” can be configured as a baseline cognitive function that is being measured.

[49] As used herein, the term“interference” refers to a type of stimulus presented to the individual such that it interferes with the individual’s performance of a primary task. In any example herein, an interference is a type of task that is presented/rendered in such a manner that it diverts or interferes with an individual’s attention in performing another task (including the primary task). In some examples herein, the interference is configured as a secondary task that is presented simultaneously with a primary task, either over a short, discrete time period or over an extended time period (less than the time frame over which the primary task is presented), or over the entire period of time of the primary task. In any example herein, the interference can be presented/rendered continuously, or continually (i.e., repeated in a certain frequency, irregularly, or somewhat randomly). For example, the interference can be presented at the end of the primary task or at discrete, interim periods during presentation of the primary task. The degree of interference can be modulated based on the type, amount, and/or temporal length of presentation of the interference relative to the primary task.

[50] As used herein, the term "stimulus," refers to a sensory event configured to evoke a specified functional response from an individual. The degree and type of response can be quantified based on the individual’s interactions with a measuring component (including using sensor devices or other measuring components). Non-limiting examples of a stimulus include a navigation path (with an individual being instructed to control an avatar or other processor-rendered guide to navigate the path), or a discrete object, whether a target or a non target, rendered to a user interface (with an individual being instructed to control a computing component to provide input or other indication relative to the discrete object). In any example herein, the task and/or interference includes a stimulus, which can be a

computerized element as described hereinbelow.

[51] As used herein, a“trial” includes at least one iteration of rendering of a task and/or interference (either or both with computerized element) and at least one receiving of the individual’s response(s) to the task and/or interference (either or both with computerized element). As non-limiting examples, a trial can include at least a portion of a single-tasking task and/or at least a portion of a multi-tasking task. For example, a trial can be a period of time during a navigation task (including a visuo-motor navigation task) in which the individual’s performance is assessed, such as but not limited to, assessing whether or the degree of success to which an individual’s actions in interacting with the platform result in a guide (including a computerized avatar) navigating along at least a portion of a certain path or in an environment for a time interval (such as but not limited to, fractions of a second, a second, several seconds, or more) and/or causes the guide (including computerized avatar) to cross (or avoid crossing) performance milestones along the path or in the environment. In another example, a trial can be a period of time during a targeting task in which the individual’s performance is assessed, such as but not limited to, assessing whether or the degree of success to which an individual’s actions in interacting with the platform result in identification/selection of a target versus a non-target (e.g., red object versus yellow object), or discriminates between two different types of targets (a happy face versus a happier face).

In these examples, the segment of the individual’s performance that is designated as a trial for the navigation task does not need to be co-extensive or aligned with the segment of the individual’s performance that is designated as a trial for the targeting task.

[52] In any example herein, an object may be rendered as a depiction of a physical object (including a polygonal or other object), a face (human or non-human), or a caricature, other type of object.

[53] In any of the examples herein, instructions can be provided to the individual to specify how the individual is expected to perform the task and/or interference (either or both with computerized element) in a trial and/or a session. In non-limiting examples, the instructions can inform the individual of the expected performance of a navigation task (e.g., stay on this path, go to these parts of the environment, cross or avoid certain milestone objects in the path or environment), a targeting task (e.g., describe or show the type of object that is the target object versus the non-target object, or describe or show the type of object that is the target object versus the non-target object, or two different types of target object that the individual is expected to choose between (e.g., happy face versus happier face)), and/or describe how the individual’s performance is to be scored. In examples, the instructions may be provided visually (e.g., based on a rendered user interface) or via sound. In various examples, the instructions may be provided once prior to the performance two or more trials or sessions, or repeated each time prior to the performance of a trial or a session, or some combination thereof.

[54] While some example systems, methods, and apparatus described herein are based on an individual being instructed/required to decide/select between a target versus a non target may, in other example implementations, the example systems, methods, and apparatus can be configured such that the individual is instructed/required to decide/choose between two different types of targets (such as but not limited to between two different degrees of a facial expression or other characteristic/feature difference).

[55] In addition, while example systems, methods, and apparatus may be described herein relative to an individual, in other example implementations, the example systems, methods, and apparatus can be configured such that two or more individuals, or members of a group (including a clinical population), perform the tasks and/or interference (either or both with computerized element), either individually or concurrently. [56] The example platform products and cognitive platforms according to the principles described herein can be applicable to many different types of conditions, such as but not limited to social anxiety, depression, bipolar disorder, major depressive disorder, post-traumatic stress disorder, schizophrenia, autism spectrum disorder, attention deficit hyperactivity disorder, dementia, Parkinson's disease, Huntington's disease, or other neurodegenerative condition, Alzheimer’s disease, or multiple-sclerosis.

[57] The instant disclosure is directed to computer-implemented devices formed as example platform products configured to implement software or other processor-executable instructions for the purpose of measuring data indicative of a user’s performance at one or more tasks, to provide a user performance metric. The performance metric can be used to derive an assessment of a user’s cognitive abilities and/or to measure a user’s response to a cognitive treatment, and/or to provide data or other quantitative indicia of a user’s mood or cognitive or affective bias. As used herein, indicia of cognitive or affective bias include data indicating a user’s preference for a negative emotion, perspective, or outcome as compared to a positive emotion, perspective, or outcome.

[58] Example therapies for certain mood disorders can be performed that involve administration of a psychedelic drug to affect certain regions of the brain. For example, the review article J. Rucker et al., (2016)“Psychedelics in the treatment of unipolar mood disorders: a systematic review,” Journal of Psychopharmacology, 30: 1220-1229, provided a systematic review of published clinical treatment studies that used psychedelic drugs in patients with mood disorders (including anxiety and depression). Improvement in symptoms was reported for up to about 80% of patients in some studies. Rucker et al. discussed the results of studies which demonstrated the use of psilocybin with psychological support in treatment-resistant depressive disorder. Rucker et al. also reported studies which showed that the therapy using the psychoactive drug can affect regions of the brain in patients, such as but not limited to the prefrontal cortex. See, e.g,, G.K. Aghajanian et al., (1999) Serotonin, via 5- HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release,” Brain Research 825: 161-171. It is also reported that processing biases towards negative stimuli are a feature of several mood disorders, such as depression and social anxiety disorder, and are associated with increased reactivity of the amygdala. See, e.g., N.A. Groenewold et al., (2013)“Emotional valence modulates brain functional abnormalities in depression: evidence from a meta-analysis of fMRI studies,” Neuroscience Biobehavior Review 37: 152-163; and A. Etkin et al., (2007)“Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia,” American Journal of Psychiatry 164: 1476-1488. Mueller et al. reported study data suggesting that acute administration of LSD modulated the engagement of brain regions that mediate emotional processing, including the amygdala. F Mueller et al., (2017)“Acute effects of LSD on amygdala activity during processing of fearful stimuli in healthy subjects,” Translational Psychiatry 7(4): el084. F.X. Vollenweider et al. reported studies that factors such as neuroplasticity can contribute to the positive long term effects even after the administration of the psychedelic drug in the therapy. See, e.g., F.X. Vollenweider et al., (2010)“The neurobiology of psychedelic drugs: implications for the treatment of mood disorders,” Nature Reviews Neuroscience 11: 642-51.

[59] Example systems, methods, and apparatus according to the principles herein can be configured for use prior to and/or after an individual having a mood disorder is subjected to a therapy including administration of a psychedelic drug and/or a dissociative drug. The therapy using the psychedelic and/or dissociative drug may be performed to address a mood disorder such as but not limited to depression, anxiety, PTSD, or obsessive compulsive disorder (OCD).

[60] In an example where the systems, methods and apparatus are configured for the individual to interact with the example cognitive platform for at least one trial (or at least one session) prior to the therapy involving the psychedelic and/or dissociative drug, the cognitive platform can be configured to measure data indicative of the responses of the individual to the rendered tasks with and/or without interference. The data indicative of the responses can be analyzed to provide an indication of one or more of: (i) the cognitive abilities of the individual, (ii) the likelihood of effectiveness of the therapy for the mood disorder, (iil) a recommended amount, concentration, or dose titration of the psychedelic and/or dissociative drug to be administered to the individual in a therapy for the mood disorder, (iv) the likelihood of the individual experiencing an adverse event in response to administration of the psychedelic and/or dissociative drug, (v) a recommended treatment regimen using the cognitive platform following the therapy for the mood disorder, or (vi) a determination of a degree of effectiveness of therapy for the mood disorder. As described hereinbelow, the indicative of the responses of a plurality of individuals measured using the cognitive platform can be used to train one of more predictive models to provide the indication of one or more of: (i) the cognitive abilities of the individual, (ii) the likelihood of effectiveness of the therapy for the mood disorder, (iil) a recommended amount, concentration, or dose titration of the psychedelic and/or dissociative drug to be administered to the individual in a therapy for the mood disorder, (iv) the likelihood of the individual experiencing an adverse event in response to administration of the psychedelic and/or dissociative drug, (v) a recommended treatment regimen using the cognitive platform following the therapy for the mood disorder, or (vi) a determination of a degree of effectiveness of therapy for the mood disorder. The example treatment regimen using the cognitive platform is configured to selectively target the areas of the brain of the individual involved in affective or emotional processing, such as but not limited to the amygdala and the pre-frontal cortex, to increase the likelihood or duration of remission of the therapy.

[61] In an example where the systems, methods and apparatus are configured for the individual to interact with the example cognitive platform for at least one trial (or at least one session) following the therapy involving the psychedelic and/or dissociative drug, the cognitive platform can be configured to measure data indicative of the responses of the individual to the rendered tasks with and/or without interference. Prior to rendering the first instance of the task at the user interface, the cognitive platform can be configured to receive data indicative of one or more of an amount, concentration, or dose titration of a psychedelic and/or dissociative drug previously administered to to individual in the therapy for the mood disorder using a psychedelic and/or dissociative drug. The data indicative of the responses can be analyzed to provide an indication of one or more of: (i) the change in the cognitive abilities of the individual, (ii) the degree of effectiveness of the therapy for the mood disorder, (iil) the likelihood of the individual experiencing a relapse following administration of the therapy including the psychedelic and/or dissociative drug, (iv) a recommended change to the treatment regimen using the cognitive platform following the therapy for the mood disorder, (v) the projected duration of remission of the mood disorder following the therapy, or (vi) a recommended training regimen using the cognitive platform to enhance the cognitive abilities of the individual. As described hereinbelow, the indicative of the responses of a plurality of individuals measured using the cognitive platform can be used to train one of more predictive models to provide the indication of one or more of: (i) the change in the cognitive abilities of the individual, (ii) the degree of effectiveness of the therapy for the mood disorder, (iil) the likelihood of the individual experiencing a relapse following administration of the therapy including the psychedelic and/or dissociative drug, (iv) a recommended change to the treatment regimen using the cognitive platform following the therapy for the mood disorder, (v) the projected duration of remission of the mood disorder following the therapy, or (vi) a recommended training regimen using the cognitive platform to enhance the cognitive abilities of the individual.

[62] A benefit of using the cognitive platform described herein may be providing a greater and more durable or maintained improvement following treatment with a psychedelic and/or dissociative drug. Accordingly, the present disclosure describes examples using the cognitive platform described herein in conjunction with psychedelic and/or dissociative drugs, other drugs for the mood disorder, and/or cognitive behavioral therapy.

[63] Non-limiting examples of such drugs include lysergic acid diethylamide (LSD), psilocybin, ketamine, methylenedioxy-n-methylamphetamine (MDMA) mescaline, or N,N- Dimethyltryptamine (DMT or N,N-DMT). The psychedelic drug can be a tryptamine, a phenethylamine, or a lysergamide.

[64] As a non-limiting example, systems, methods and apparatus herein may be used in patients who have had or are having treatments for depression, such as but not limited to antidepressants, electroconvulsive therapy, trans-cranial magnetic stimulation, or a psychoactive (psychedelics) drug (such as but not limited to LSD, psilocybin and ketamine).

[65] As a non- limiting example of the therapy, an individual may be administered a pre-dose of the drug (a lower dose) to prepare them for the therapy. A higher dose of the drug is administered during the therapy session, which is supervised and clinically or medically monitored, and which may last for several hours (about 5 - 8 hours). Various techniques may be used during the therapy to address the mood disorder, including using music or other stimuli. The effects of the therapy may be derived shortly after the session is completed or may be derived after a certain period of time.

[66] As a non-limiting example, the HAM-D test or other similar test may be sued to measure/monitor the degree of improvement of an individual having major depressive disorder.

[67] The data indicative of the individual’s responses collected by the example cognitive platforms as the individual interacts with the computerized tasks with and/or without interference prior to the drug/therapy session can be analyzed to provide a baseline measure of the individual’s cognitive abilities prior to the therapy session and/or to provide an indication of the effect of the pre-dose (lower dose) of the psychedelic and/or dissociative drug. The data indicative of the individual’s responses collected by the example cognitive platforms as the individual interacts with the computerized tasks with and/or without interference after the drug/therapy session can be analyzed to provide an indication of the change the individual’s cognitive abilities as a result of the therapy session (including the longer term effects of the psychedelic and/or dissociative drug).

[68] In an example, the cognitive platform herein can be configured to administer a training session to the individual, to interact with the computerized tasks with and/or without interference, during a period of increased neuroplasticity shortly after completion of the therapy session using the drug. The period of neuroplasticity may last for several days or a few weeks (e.g., 1 - 3 weeks) following exposure to the therapy session using the drug. As described hereinbelow, the training session using the cognitive platforms implementing the computerized tasks with and/or without interference can be used to enhance the cognitive abilities of the individual. During this limited period of neuroplasticity, an individual may be more sensitive to other interventions, including interventions that selectively target the affective system or disease area implicated in mood disorders (e.g., amygdala and prefrontal cortex). By virtue of the increased neuroplasticity, there is a global period where the individual’s brain can be more amenable to executive function training and that training may be more powerful. In addition, the intervention may enhance remediation of the mood disorder, may help durability of remediated state, and may increase durability of the training from the cognitive product outside of the mood disorder (e.g., the results may last longer than they might normally have happened). The example cognitive platforms herein can be configured as the intervention, to implement the example training by rendering the tasks with and/or without interference at either the same or varying difficulty levels, to derive increased enhancement of the individual’s cognitive abilities during the period of increased neuroplasticity following administration of the therapy using the psychedelic and/or dissociative drug. The synergistic potential of the use of the example cognitive platform herein prior to and/or following the therapy session using the psychedelic and/or dissociative drug could result in greater and longer lasting benefits in treating the mood disorder.

[69] In an example, the cognitive platform herein can be configured to administer a training session to the individual as the individual interacts with the computerized tasks with and/or without interference rendered at a certain difficult level or at several differing difficulty levels.

[70] The example systems, methods and apparatus can be configured such that the individual interacts with cognitive platform and provide responses to the computerized tasks with and/or without interference in either a single session or in multiple sessions with the cognitive platform with some frequency (such as but not limited to daily, every other day, or other regular interval).

[71] The example systems, methods and apparatus can be configured as a monitoring tool or as an assessment tool. The assessment tool can be implemented to assess the individual’s cognitive abilities in a single monitoring session or through repeated assessment sessions prior to administration of the therapy using the psychedelic and/or dissociative drug as a treatment for mood disorders.

[72] For example, the metric computed based on the analysis of the collected data (such as but not limited to an interference cost, attention capacity, etc.) from the cognitive platform may be used to provide an indication of a likelihood of success of the therapy session using the drug, or the number of training sessions using the example cognitive platforms herein that the individual should complete in order to derive a certain amount of change in the indicator of cognitive abilities.

[73] The example cognitive platform can be configured to render the computerized tasks with and/or without interference such that the individual is subjected to a training regimen (as described hereinbelow). The cognitive platform may be configured to implement the training regimen by rendering the computerized tasks with and/or without interference over multiple sessions at the same difficulty level, or by adjusting the difficulty level from one trial to trial either by discrete values or through adapting the difficulty level based on the data indicative of the individual’s performance in previous trials.

[74] The example systems, methods, and apparatus herein can be configured to analyze the data indicative of the individual’s responses to the computerized tasks with and/or without interference to provide an indicator of the individual’s likely response to the therapy with the drug (a measure of the treatment durability).

[75] The example systems, methods, and apparatus herein can be configured to analyze the data indicative of the individual’s responses to the computerized tasks with and/or without interference to customize the treatment sessions from the example cognitive platforms herein.

[76] The example cognitive platform can be configured to perform measurements of the individual’s responses during monitoring and/or assessment sessions to determine a measure of the durability of the mood disorder, such as but not limited to a measure of the potential or likelihood for remission. [77] The example cognitive platform can be configured to perform measurements of the individual’s responses during monitoring and/or assessment sessions to determine a measure of the likelihood of the individual’s relapse and the need for additional therapeutic sessions. For example, changes in the indicator of the cognitive abilities of the individual showing a reduction in performance using a monitor may indicate the individual may benefit from returning for another session within a certain period of time (such as but not limited to within a few weeks or some other timeframe.

[78] In a non-limiting example, a machine learning tool can be applied to a training dataset collected from a plurality of individuals having a set of known outcomes (e.g., stage of mood disorder, reaction to treatment, amount of time pre- or post- drug/therapy session). The training dataset can include data collected from individuals interactive with the cognitive platform implementing the tasks with and/or without interference either prior to the drug/therapy session and/or after the drug/therapy session. For example, the training dataset can be collected has people responding to some sort of survey to indicate subjective and objective measures of how the individual’s experience with the mood disorder (e.g., how they feel), so the dataset can be used to calibrate the measurements from the cognitive platform used for monitoring and/or the cognitive platform used for assessment.

[79] The use of the cognitive monitor after treatment may identify changes in cognition that indicate relapse into the pre-treated state and could be used to facilitate the timing of subsequent re-administrations of the therapy using the psychedelic and or dissociative drug.

[80] The use of the example cognitive platform as a training tool can be configured for individuals to perform a directed cognitive treatment at home.

[81] No prior work is reported concerning the use of a targeted cognitive monitoring, assessment, and/or training (treatment) either prior to or following the therapy session using the psychedelic and/or dissociative drug for treatment of mood disorders. This combination has the potential to greatly increase patient outcomes over long term management of mood disorders.

[82] An example cognitive platform herein can be configured to implement a regimen for executive function and attention training to increase the effectiveness and durability of mood disorder remission.

[83] An example cognitive platform herein can be configured to provide attention bias training. Attention bias as a result of depression or anxiety is a tendency of an individual to orient towards negative stimuli. The attention bias training can increase the effectiveness and durability of mood disorder remission.

[84] An example cognitive platform herein can be configured to provide other training targeting affective processes specifically involving the prefrontal-cortex and/or the amygdala.

[85] Example systems, methods, and apparatus can be used as part of a treatment regimen following the therapy session using the psychedelic and/or dissociative drug for mood disorders. The example cognitive platforms can be implemented as a digital executive- function/affective treatment to be used periodically or at regular intervals by the individual in an at-home setting, following the therapy session using the psychedelic and/or dissociative drug.

[86] The example cognitive platform configured for executive-function or affective training may be used to enhance the individual’s response to a therapy using a psychedelic and/or dissociative drug in several ways such as but not limited to: reduced training time (to reach a specified outcome), greater reduction of mood disorder symptoms, prolonged duration of mood disorder remission, and increased improvements in attention/executive- function.

[87] In an example, the amount of reduction of mood disorder symptoms and the degree of prolonged duration of mood disorder remission can be measured/quantified using the Hamilton Depression Scale (HAM-D), Cognitive and Physical Functioning Questionnaire (CPFQ), and other applicable tests in the art.

[88] In an example, the increased improvements in attention/executive-function can be measured/quantified using the T.O.V.A.® test, the CANTAB® test, the Trail Making Test (TMT) Parts A & B, the Stroop test, and the Digit Symbol coding test (DST).

[89] In a non-limiting example implementation, the example platform product herein may be formed as, be based on, or be integrated with, an AKILI™ platform product (also referred to herein as an“APP”) by Akili Interactive Labs, Inc., Boston, MA.

[90] As described in greater detail below, the computing device can include an application (an“App program”) to perform such functionalities as analyzing the data. For example, the data from the at least one sensor component can be analyzed as described herein by a processor executing the App program on an example computing device to receive (including to measure) substantially simultaneously two or more of: (i) the response from the individual to a task, (i) a secondary response of the individual to an interference, and (iii) a response of the individual to at least one computerized element. As another example, the data from the at least one sensor component can be analyzed as described herein by a processor executing the App program on an example computing device to analyze the data indicative of the first response and the response of the individual to the at least one computerized element to compute at least one performance metric comprising at least one quantified indicator of cognitive abilities.

[91] An example system according to the principles herein provides for generating a quantifier of cognitive skills in an individual (including using a machine learning classifier) and/or enhancing cognitive skills in an individual. In an example implementation, the example system employs an App program running on a mobile communication device or other hand-held devices. Non-limiting examples of such mobile communication devices or hand-held device include a smartphone, such as but not limited to an iPhone®, a

BlackBerry®, or an Android-based smartphone, a tablet, a slate, an electronic-reader (e- reader), a digital assistant, or other electronic reader or hand-held, portable, or wearable computing device, or any other equivalent device, an Xbox®, a Wii®, or other computing system that can be used to render game-like elements. In some example implementations, the example system can include a head-mounted device, such as smart eyeglasses with built-in displays, a smart goggle with built-in displays, or a smart helmet with built-in displays, and the user can hold a controller or an input device having one or more sensors in which the controller or the input device communicates wirelessly with the head-mounted device. In some example implementations, the computing system may be stationary, such as a desktop computing system that includes a main computer and a desktop display (or a projector display), in which the user provides inputs to the App program using a keyboard, a computer mouse, a joystick, handheld consoles, wristbands, or other wearable devices having sensors that communicate with the main computer using wired or wireless communication. In other examples herein, the example system may be a virtual reality system, an augmented reality system, or a mixed reality system. In examples herein, the sensors can be configured to measure movements of the user’s hands, feet, and/or any other part of the body. In some example implementations, the example system can be formed as a virtual reality (VR) system (a simulated environment including as an immersive, interactive 3-D experience for a user), an augmented reality (AR) system (including a live direct or indirect view of a physical, real- world environment whose elements are augmented by computer-generated sensory input such as but not limited to sound, video, graphics and/or GPS data), or a mixed reality (MR) system (also referred to as a hybrid reality which merges the real and virtual worlds to produce new environments and visualizations where physical and digital objects co-exist and interact substantially in real time).

[92] As used herein, the term“cData” refers to data collected from measures of an interaction of a user with a computer-implemented device formed as a platform product.

[93] As used herein, the term“computerized stimuli or interaction” or“CSI” refers to a computerized element that is presented to a user to facilitate the user’s interaction with a stimulus or other interaction. As non-limiting examples, the computing device can be configured to present auditory stimulus (presented, e.g., as an auditory computerized element or an element of a computerized auditory task) or initiate other auditory-based interaction with the user, and/or to present vibrational stimuli (presented, e.g., as a vibrational computerized element or an element of a computerized vibrational task) or initiate other vibrational-based interaction with the user, and/or to present tactile stimuli (presented, e.g., as a tactile computerized element or an element of a computerized tactile task) or initiate other tactile-based interaction with the user, and/or to present visual stimuli or initiate other visual- based interaction with the user.

[94] In an example where the computing device is configured to present visual CSI, the CSI can be rendered at least one user interface to be presented to a user. In some examples, the at least one user interface is configured for measuring responses as the user interacts with CSI computerized element rendered at the at least one user interface. In a non-limiting example, the user interface can be configured such that the CSI computerized element(s) are active, and may require at least one response from a user, such that the user interface is configured to measure data indicative of the type or degree of interaction of the user with the platform product. In another example, the user interface can be configured such that the CSI computerized element(s) are a passive and are presented to the user using the at least one user interface but may not require a response from the user. In this example, the at least one user interface can be configured to exclude the recorded response of an interaction of the user, to apply a weighting factor to the data indicative of the response (e.g., to weight the response to lower or higher values), or to measure data indicative of the response of the user with the platform product as a measure of a misdirected response of the user (e.g., to issue a notification or other feedback to the user of the misdirected response).

[95] In an example, the platform product can be configured as a system including one or more processors, and a memory to store processor-executable instructions by the one or more processors. The one or more processors may be configured to generate a user interface.

[96] In an example, the platform product can be configured as a processor- implemented system, method or apparatus that includes a display component, an input device, and at least one processing unit. In an example, the at least one processing unit can be programmed to render at least one user interface, for display at the display component, to present the computerized stimuli or interaction (CSI) or other interactive elements to the user for interaction. In other examples, the at least one processing unit can be programmed to cause an actuating component of the platform product to effect auditory, tactile, or vibrational computerized elements (including CSIs) to effect the stimulus or other interaction with the user. The at least one processing unit can be programmed to cause a component of the program product to receive data indicative of at least one user response based on the user interaction with the CSI or other interactive element (such as but not limited to cData), including responses provided using the input device. In an example where at least one user interface is rendered to present the computerized stimuli or interaction (CSI) or other interactive elements to the user, the at least one processing unit can be programmed to cause user interface to receive the data indicative of at least one user response. The at least one processing unit also can be programmed to: analyze the differences in the individual's performance based on determining the differences between the user’s responses, and/or adjust the difficulty level of the computerized stimuli or interaction (CSI) or other interactive elements based on the individual's performance determined in the analysis, and/or provide an output or other feedback from the platform product indicative of the individual's

performance, and/or cognitive assessment, and/or response to cognitive treatment. In some examples, the results of the analysis may be used to modify the difficulty level or other property of the computerized stimuli or interaction (CSI) or other interactive elements.

[97] In a non-limiting example, the computerized element includes at least one task rendered at a user interface as a visual task or presented as an auditory, tactile, or vibrational task. Each task can be rendered as interactive mechanics that are designed to elicit a response from a user after the user is exposed to stimuli for the purpose of cData collection.

[98] In a non-limited example of a computerized auditory task, the individual may be required to follow a certain computer-rendered path or navigate other environment based on auditory cues emitted to the individual. The processing unit may be configured to cause an auditory component to emit the auditory cues (e.g., sounds or human voices) to provide the individual with performance progress milestones to maintain or modify the path of a computerized avatar in the computer environment, and/or to indicate to the individual their degree of success in performing the physical actions measured by the sensors of the computing device to cause the computerized avatar to maintain the expected course or path.

[99] In a non-limited example of a computerized vibrational task, the individual may be required to follow a certain computer-rendered path or navigate other environment based on vibrational cues emitted to the individual. The processing unit may be configured to control an actuating component to vibrate (including causing a component of the computing device to vibrate) to provide the individual with the performance progress milestones to maintain or modify the path of a computerized avatar in the computer environment, and/or to indicate to the individual their degree of success in performing the physical actions measured by the sensors of the computing device to cause the computerized avatar to maintain the expected course or path.

[100] In a non-limited example of a computerized tactile task, the individual may be required to interact with one or more sensations perceived through the sense of touch. In a non- limiting example, a computerized element may be controlled using a processing unit to actuate an actuating component to present differing types of tactile stimuli (e.g., sensation of touch, textured surfaces or temperatures) for interaction with an individual. For example, an individual with an autism spectrum disorder (ASD) may be sensitive to (including having an aversion to) certain tactile sensory sensations (including being touched as they dress or groom themselves); individuals with Alzheimer's disease and other dementias may benefit through the sense of touch or other tactile sensation. An example tactile task may engage a tactile-sensitive individual in physical actions that causes them to interact with textures and touch sensations.

[101] In a non-limiting example, the computerized element includes at least one platform interaction (gameplay) element of the platform rendered at a user interface, or as auditory, tactile, or vibrational element of a program product. Each platform interaction (gameplay) element of the platform product can include interactive mechanics (including in the form of videogame-like mechanics) or visual (or cosmetic) features that may or may not be targets for cData collection.

[102] As used herein, the term“gameplay” encompasses a user interaction (including other user experience) with aspects of the platform product.

[103] In a non-limiting example, the computerized element includes at least one element to indicate positive feedback to a user. Each element can include an auditory signal and/or a visual signal emitted to the user that indicates success at a task or other platform interaction element, i.e., that the user responses at the platform product has exceeded a threshold success measure on a task or platform interaction (gameplay) element.

[104] In a non-limiting example, the computerized element includes at least one element to indicate negative feedback to a user. Each element can include an auditory signal and/or a visual signal emitted to the user that indicates failure at a task or platform interaction

(gameplay) element, i.e., that the user responses at the platform product has not met a threshold success measure on a task or platform interaction element.

[105] In a non-limiting example, the computerized element includes at least one element for messaging, i.e., a communication to the user that is different from positive feedback or negative feedback.

[106] In a non-limiting example, the computerized element includes at least one element for indicating a reward. A reward computer element can be a computer generated feature that is delivered to a user to promote user satisfaction with the CSIs and as a result, increase positive user interaction (and hence enjoyment of the user experience).

[107] In a non-limiting example, the cognitive platform can be configured to render at least one computerized element. As used herein, a“computerized element” is a computerized element that is configured to be change or otherwise modulate in content and/or appearance using the computing system based on the individual’s performance in providing response(s) to the task and/or the interference. The example system, apparatus, and method may be configured to adjust the computerized element on a real-time basis or near real-time basis as the individual(s) performs a task and/or interference (including a task with or without interference) to indicate to the individual(s) whether the individual’s performance has been achieving certain performance milestones within a given trial or session, how the individual’s performance in a given trial or session compares to other or previous performances, and/or whether the individual has achieved a particular achievement level in a given trial or session. For example, the computerized element based on the degree of success of the individual in performing a portion of a task, the computerized element may be modified in a manner that represents or otherwise embodies that success. In an example, the content and/or appearance of the computerized element may be configured to evoke an emotion, an affect, a mood, a parasympathetic arousal and/or other type of response from the individual.

[108] In the various examples herein, the computerized elements may include at least one emotional elements and/or at least one affective elements which can be rendered as CSIs including images (including images of faces), sounds (including voices), and/or objects that increase or decrease in number and/or complexity based on the performance of the individual. For example, the change or modulation in content and/or appearance of the computerized elements based on the individual’s performance in providing response(s) to the task and/or the interference may be one or more of an increase or decrease in the number of features included in the computerized element, the types of features included in the computerized element, and/or the speed or trajectory of movement of the features included in the computerized element.

[109] In a non-limiting example, the cognitive platform can be configured to render multi-task interactive elements. In some examples, the multi-task interactive elements are referred to as multi-task gameplay (MTG). The multi-task interactive elements include interactive mechanics configured to engage the user in multiple temporally-overlapping tasks, i.e., tasks that may require multiple, substantially simultaneous responses from a user.

[110] In any example herein, the multi-tasking tasks can include any combination of two or more tasks. The multi-task interactive elements of an implementation include interactive mechanics configured to engage the individual in multiple temporally-overlapping tasks, i.e., tasks that may require multiple, substantially simultaneous responses from an individual. In non- limiting examples herein, in an individual’s performance of at least a portion of a multi tasking task, the system, method, and apparatus are configured to measure data indicative of the individual’s multiple responses in real-time, and also to measure a first response from the individual to a task (as a primary task) substantially simultaneously with measuring a second response from the individual to an interference (as a secondary task).

[111] In an example implementation involving multi-tasking tasks, the computer device is configured (such as using at least one specially-programmed processing unit) to cause the cognitive platform to present to a user two or more different types of tasks, such as but not limited to, target discrimination and/or navigation and/or facial expression recognition or object recognition tasks, during a short time frame (including in real-time and/or substantially simultaneously). The computer device is also configured (such as using at least one specially- programmed processing unit) to collect data indicative of the type of user response received for the multi-tasking tasks, within the short time frame (including in real-time and/or substantially simultaneously). In these examples, the two or more different types of tasks can be presented to the individual within the short time frame (including in real-time and/or substantially simultaneously), and the computing device can be configured to receive data indicative of the user response(s) relative to the two or more different types of tasks within the short time frame (including in real-time and/or substantially simultaneously).

[112] Based on the type of computerized task presented to an individual using the cognitive platform, the types of response(s) expected as a result of the individual interacting with the cognitive platform to perform the task(s), and types of data expected to be received (including being measured) using the cognitive platform, depends on the type of the task(s). For a target discrimination task, the cognitive platform may require a temporally- specific and/or a position-specific response from an individual, including to select between a target and a non-target (e.g., in a GO/NO-GO task) or to select between two differing types of targets, e.g., in a two-altemative forced choice (2AFC) task (including choosing between two differing degrees of a facial expression or other characteristic/feature difference). For a navigation task, the cognitive platform may require a position-specific and/or a motion- specific response from the user. For a facial expression recognition or object recognition task, the cognitive platform may require temporally-specific and/or position- specific responses from the user. In non-limiting examples, the user response to tasks, such as but not limited to targeting and/or navigation and/or facial expression recognition or object recognition task(s), can be recorded using an input device of the cognitive platform. Non limiting examples of such input devices can include a device for capturing a touch, swipe or other gesture relative to a user interface, an audio capture device (e.g., a microphone input), or an image capture device (such as but not limited to a touch-screen or other pressure- sensitive or touch-sensitive surface, or a camera), including any form of user interface configured for recording a user interaction. In other non-limiting examples, the user response recorded using the cognitive platform for tasks, such as but not limited to targeting and/or navigation and/or facial expression recognition or object recognition task(s), can include user actions that cause changes in a position, orientation, or movement of a computing device including the cognitive platform. Such changes in a position, orientation, or movement of a computing device can be recorded using an input device disposed in or otherwise coupled to the computing device, such as but not limited to a sensor. Non-limiting examples of sensors include a motion sensor, position sensor, and/or an image capture device (such as but not limited to a camera).

[113] In the example herein,“substantially simultaneously” means tasks are rendered, or response measurements are performed, within less than about 5 milliseconds of each other, or within about 10 milliseconds, about 20 milliseconds, about 50 milliseconds, about 75 milliseconds, about 100 milliseconds, or about 150 milliseconds or less, about 200 milliseconds or less, about 250 milliseconds or less, of each other. In any example herein, “substantially simultaneously” is a period of time less than the average human reaction time. In another example, two tasks may be substantially simultaneous if the individual switches between the two tasks within a pre-set amount of time. The set amount of time for switching considered“substantially simultaneously” can be about 1 tenth of a second, 1 second, about 5 seconds, about 10 seconds, about 30 seconds, or greater.

[114] In some examples, the short time frame can be of any time interval at a resolution of up to about 1.0 millisecond or greater. The time intervals can be, but are not limited to, durations of time of any division of a periodicity of about 2.0 milliseconds or greater, up to any reasonable end time. The time intervals can be, but are not limited to, about 3.0 millisecond, about 5.0 millisecond, about 10 milliseconds, about 25 milliseconds, about 40 milliseconds, about 50 milliseconds, about 60 milliseconds, about 70 milliseconds, about 100 milliseconds, or greater. In other examples, the short time frame can be, but is not limited to, fractions of a second, about a second, between about 1.0 and about 2.0 seconds, or up to about 2.0 seconds, or more.

[115] In any example herein, the cognitive platform can be configured to collect data indicative of a reaction time of a user’ s response relative to the time of presentation of the tasks (including an interference with a task). For example, the computing device can be configured to cause the platform product or cognitive platform to provide smaller or larger reaction time window for a user to provide a response to the tasks as an example way of adjusting the difficulty level.

[116] In some examples, the tasks and/or interference are presented to the individual in two or more trials and/or sessions, with an interspersed interval between each trial and/or session. In some examples, the computing system is configured to implement the tasks and/or interference in the subsequent trial(s) and/or session(s) at a difficulty level that is changed or maintained the same from one trial to another and/or from one session to another. For example, the difficulty level in each subsequent trial and/or each subsequent session can be dependent on the performance of the individual in the previous trial and/or previous session. Based on an analysis by the computing system indicating that the number of correct inputs in the responses made by the individual in a previous trial and/or session increases or reaches a specific threshold (e.g. a pre-determined percentage of correct responses), the computing system is configured to implement the tasks and/or interference in the subsequent trial and/or session at a higher difficulty level than the previous trial and/or session. Based on an analysis by the computing system indicating that the number of correct inputs in the responses made by the individual is decreased, is at or below a specified threshold, achieves a specified level of failure, or fails to achieve a level of success, in the previous trial and/or session, the computing system is configured to implement the tasks and/or interference in the subsequent trial and/or session at a lower difficulty level than the previous trial and/or session. In some examples, the computing system is configured to implement the tasks and/or interference in the subsequent trial(s) and/or session(s) at a difficulty level in a step-wise and/or in a peaks and valley fashion.

[117] To modulate the difficulty level of a trial and/or a session, the computing system can be configured to modify the difficulty level of the primary task, or of the interference, or of some combination of the primary task and the interference. The modulation of the difficulty level may be based on either the data indicative of the actual performance of the individual in performing the task or interference (as determined by measurement as the input to a task or interference) or a more indirect parameter governed by the analysis, e.g., a performance metric such as but not limited to the interference cost. In some examples, the level of difficulty of the task and/or the interference can be adjusted based on an adaptive staircase algorithm at an accuracy of about 50%, about 55%, about 60%, about 65%, about 70%, about 75%, about 80%, about 85%, or about 90% or more.

[118] In another example, the computing system can be configured to modify the difficulty level such that the platform is specifically tailored to an individual, e.g., by maintaining the difficulty level at or around a threshold success rate for the individual. For example, the computing system can be configured to target the difficulty level to maintain a substantially constant error rate from an individual (e.g., to maintain substantially approximately 80% response accuracy). In other examples, the computing system can be configured to target the difficulty level to maintain an accuracy of performance from the individual of about 50%, about 55%, about 60%, about 65%, about 70%, about 75%, about 80%, about 85%, or about 90% or more. The difficulty level of a task for a given individual may be determined by implementing the task without interference (e.g., single-tasking) initially at a default difficulty level for a category of individuals (e.g. average for an age range), a lowest level of difficulty, or a level comparable based on the individual's prior assessment. In subsequent trials and/or sessions, the difficulty level can be change until analysis of the measured data indicates that the individual is performing at a specific threshold level (e.g., percent accuracy).

[119] In an example, the difficulty of the task (potentially including a computer- implemented time-varying element) adapts with every stimuli that is presented, which could occur more often than once at regular time intervals (e.g., every 5 seconds, every 10 seconds, every 20 seconds or other regular schedule).

[120] In another example, the difficulty of a continuous task (potentially including a computer-implemented time- varying element) can be adapted on a set schedule, such as but not limited to every 30 seconds, 10 seconds, 1 second, 2 times per second, or 30 times per second.

[121] In an example, the length of time of a trial depends on the number of iterations of rendering (of the tasks/interference) and receiving (of the individual’s responses) and can vary in time. In an example, a trial can be on the order of about 500 milliseconds, about 1 second (s), about 10 s, about 20 s, about 25 s, about 30 s, about 45 s, about 60 s, about 2 minutes, about 3 minutes, about 4 minutes, about 5 minutes, or greater. Each trial may have a pre-set length or may be dynamically set by the processing unit (e.g., dependent on an individual’s performance level or a requirement of the adapting from one level to another).

[122] In an example, the task and/or interference (either or both including a computer- implemented time-varying element) can be modified based on targeting changes in one or more specific metrics by selecting features, trajectory, and response window of the targeting task, and level/type of parallel task interference to progressively require improvements in those metrics in order for the apparatus to indicate to an individual that they have

successfully performed the task. This could include specific reinforcement, including explicit messaging, to guide the individual to modify performance according to the desired goals.

[123] In a non-limiting example, the cognitive platform can be configured to render single-task interactive elements. In some examples, the single-task interactive elements are referred to as single-task gameplay (STG). The single-task interactive elements include interactive mechanics configured to engage the user in a single task in a given time interval.

[124] According to the principles herein, the term“cognition” refers to the mental action or process of acquiring knowledge and understanding through thought, experience, and the senses. This includes, but is not limited to, psychological concepts/domains such as, executive function, memory, perception, attention, emotion, motor control, and interference processing. An example computer-implemented device according to the principles herein can be configured to collect data indicative of user interaction with a platform product, and to compute metrics that quantify user performance. The quantifiers of user performance can be used to provide measures of cognition (for cognitive assessment) or to provide measures of status or progress of a cognitive treatment.

[125] According to the principles herein, the term“treatment” refers to any

manipulation of CSI in a platform product (including in the form of an APP) that results in a measurable improvement of the abilities of a user, such as but not limited to improvements related to cognition, a user’s mood or level of cognitive or affective bias. The degree or level of improvement can be quantified based on user performance measures as describe herein.

[126] According to the principles herein, the term“session” refers to a discrete time period, with a clear start and finish, during which a user interacts with a platform product to receive assessment or treatment from the platform product (including in the form of an APP).□ In examples herein, a session can refer to at least one trial or can include at least one trial and at least one other type of measurement and/or other user interaction. As a non limiting example, a session can include at least one trial and one or more of a measurement using a physiological or monitoring component and/or a cognitive testing component. As another non-limiting example, a session can include at least one trial and receipt of data indicative of one or more measures of an individual’s condition, including physiological condition and/or cognitive condition.

[127] According to the principles herein, the term“assessment” refers to at least one session of user interaction with CSIs or other feature or element of a platform product. The data collected from one or more assessments performed by a user using a platform product (including in the form of an APP) can be used as to derive measures or other quantifiers of cognition, or other aspects of a user’s abilities.

[128] According to the principles herein, the term“cognitive load” refers to the amount of mental resources that a user may need to expend to complete a task. This term also can be used to refer to the challenge or difficulty level of a task or gameplay.

[129] According to the principles herein, the term“emotional load” refers to cognitive load that is specifically associated with processing emotional information or regulating emotions or with affective bias in an individual’s preference for a negative emotion, perspective, or outcome as compared to a positive emotion, perspective, or outcome. The emotional load may be modified (i.e., increased or decreased) by using an example apparatus, system or method to configure a computerized element to indicate to the individual(s) their degree of success in performing a portion of a task and/or an interference (including a task with or without an interference).

[130] According to the principles herein, the term“ego depletion” refers to a state reached by a user after a period of effortful exertion of self-control, characterized by diminished capacity to exert further self-control. The state of ego-depletion may be measured based on data collected for a user’s responses to the interactive elements rendered at user interfaces, or as auditory, tactile, or vibrational elements, of a platform product described hereinabove.

[131] According to the principles herein, the term“emotional processing” refers to a component of cognition specific to cognitive and/or neurologic processing of

emotion/affect/mood or parasympathetic arousal. The degree of emotional processing may be measured based on data collected for a user’ s responses to the interactive computerized elements rendered at user interfaces (including as an auditory, tactile, or vibrational element), of a platform product described hereinabove.

[132] An example system, method, and apparatus according to the principles herein includes a platform product (including using an APP) that uses a cognitive platform configured to render at least one computerized element, to provide additional control of cognitive load as an overt component for tasks in MTG or STG. In one example, the computerized element is used in the tasks configured to assess cognition or improve cognition related to emotions, and the data (including cData) collected as a measure of user interaction with the rendered computerized element in the platform product is used to determine the measures of the assessment of cognition or the improvement to measures of cognition after a treatment configured for interaction using the user interface, or as auditory, tactile, or vibrational elements, of the platform product. The computerized element can be configured to collect data to measure the impact of emotions on non-emotional cognition, such as by causing the user interface to render spatial tasks for the user to perform, and/or to collect data to measure the impact of non-emotional cognition on emotions, such as by causing the user interface to render features that employ measures of executive function to regulate emotions. In one example implementation, the user interface can be configured to render tasks for identifying the emotion indicated by the CSI (based on measurement data), maintaining that identification in working memory, and comparing it with the measures of emotion indicated by subsequent CSI, while under cognitive load due to MTG. [133] In one example, the user interface may be configured to present to a user a program platform based on a cognitive platform based on interference processing. In an example system, method and apparatus that implements interference processing, the at least one processing unit is programmed to render at least one first user interface, or auditory, tactile, or vibrational signal, to present a first task that requires a first type of response from a user, and to render at least one second user interface, or auditory, tactile, or vibrational signal, to present a first interference with the first task, requiring a second type of response from the user to the first task in the presence of the first interference. In a non- limiting example, the second type of response can include the first type of response to the first task and a secondary response to the first interference. In another non-limiting example, the second type of response may not include, and be quite different from, the first type of response. The at least one processing unit is also programmed to receive data indicative of the first type of response and the second type of response based on the user interaction with the platform product (such as but not limited to cData), such as but not limited to by rendering the at least one user interface to receive the data. The at least one processing unit also can be programmed to: analyze the differences in the individual's performance based on determining the differences between the measures of the user’s first type and second type of responses, and/or adjust the difficulty level of the first task and/or the first interference based on the individual's performance determined in the analysis, and/or provide an output or other feedback from the platform product that can be indicative of the individual's performance, and/or cognitive assessment, and/or response to cognitive treatment, and/or assessed measures of cognition.

As a non-limiting example, the cognitive platform based on interference processing can be the ProjeckEVO™ platform by Akili Interactive Labs, Inc., Boston, MA.

[134] In an example system, method and apparatus according to the principles herein that is based on interference processing, the user interface is configured such that, as a component of the interference processing, one of the discriminating features of the targeting task that the user responds to is a feature in the platform that displays an emotion, similar to the way that shape, color, and/or position may be used in an interference element in interference processing.

[135] In another example system, method and apparatus according to the principles herein that is based on interference processing, a platform product may include a

working-memory task such as cognitive tasks that employs computerized element, where the affective content is either a basis for matching or a distractive element as part of the user interaction, within a MTG or a STG.

[136] An example system, method, and apparatus according to the principles herein includes a platform product (including using an APP) that uses a cognitive platform configured to render at least one integrating computerized element in a MTG or a STG, where the user interface is configured to not explicitly call attention to the computerized element. The user interface of the platform product may be configured to render

computerized element for the purpose of assessing or adjusting emotional biases in attention, interpretation, or memory, and to collected data indicative of the user interaction with the platform product.

[137] An example system, method, and apparatus according to the principles herein includes a platform product (including using an APP) that uses a cognitive platform configured to render at least one computerized element that reinforces positive or negative feedback provided within the one or more tasks.

[138] An example system, method, and apparatus according to the principles herein includes a platform product (including using an APP) that uses a cognitive platform configured to render at least one computerized element that introduces fixed or adjustable levels of cognitive or emotional load to the user interaction (including to gameplay). This could be used for the purposes of modulating the difficulty of a MTG or a STG. This includes using computerized element(s) that conflicts with the positive feedback or negative feedback provided within the one or more tasks, or using computerized element(s) to induce ego depletion to impact the user’s cognitive control capabilities.

[139] An example system, method, and apparatus according to the principles herein includes a platform product (including using an APP) that uses a cognitive platform configured to render and integrate at least one simultaneous conflicting computerized element(s) into different tasks during a MTG.□ This could be used for the purpose of assessing or improving measures of cognition related to the user interaction with the platform product indicating the user’s handling of conflicting emotional information.

[140] An example system, method, and apparatus according to the principles herein includes a platform product (including using an APP) that uses video or audio sensors to detect the performance of physical or vocal actions by the user, as a means of response to CSI within a task. These actions may be representations of emotions, such as facial or vocal expressions, or words. [141] An example system, method, and apparatus according to the principles herein includes a platform product (including using an APP) that uses a cognitive platform configured to render at least one computerized element as part of an emotional regulation strategy to enable better user engagement with the platform product when the analysis of the collected date indicates that the user is in a non-optimal emotional state. For example, if the data analysis of the performance measures of the platform product determines that the user is frustrated and unable to properly engage in treatment or assessment, the platform product could be configured to introduce some sort of break in the normal interaction sequence that employs computerized elements until after a time interval that the user is deemed ready to engage sufficiently again. This can be a fixed interval of time or an interval of time computed based on the user’s previous performance data.

[142] An example system, method, and apparatus according to the principles herein includes a platform product (including using an APP) that uses a cognitive platform configured to render at least one computerized element in the interaction sequence, measure user responses, and adjust the CSI accordingly. These measurements may be compared with the user responses to interaction sequences in the platform that do not present computerized elements, in order to determine measures of the user’s emotional reactivity. This

measurement, with or without comparison to measurements made during interaction sequences that do not present computerized elements, may be for the purpose of assessing the user’s emotional state. The CSI adjustments might be initiating an emotional regulation strategy to enable better engagement with the platform product or initiating certain interactive elements, such as but not limited to tasks or rewards, only under certain emotional conditions. The user response measurement may employ use of inputs such as touchscreens, keyboards, or accelerometers, or passive external sensors such as video cameras, microphones, eye-tracking software/devices, bio-sensors, and/or neural recording (e.g.,

electroencephalogram), and may include responses that are not directly related to interactions with the platform product, as well as responses based on user interactions with the platform product. The platform product can present measures of a user’s emotional state that include a measure of specific moods and/or a measure of general state of ego depletion that impacts emotional reactivity.

[143] An example system, method, and apparatus according to the principles herein includes a platform product (including using an APP) that uses a cognitive platform configured to render at least one computerized element to suggest possible appropriate task responses. This may be used to evaluate the user’s ability to discern emotional cues, or to choose appropriate emotional responses.

[144] An example system, method, and apparatus according to the principles herein includes a platform product (including using an APP) that uses a cognitive platform configured to render at least one computerized element in time-limited tasks, where the time limits may be modulated. This may be for the purposes of measuring user responses via different cognitive processes, such as top-down conscious control vs. bottom-up reflexive response.

[145] An example system, method, and apparatus according to the principles herein includes a platform product (including using an APP) that uses a cognitive platform configured to render at least one computerized element with levels of valence determined based on previous user responses to computerized element at one or more level of valence. This may apply an adaptive algorithm to progressively adjust the level of valence to achieve specific goals, such as creating a psychometric curve of expected user performance on a task across stimulus or difficulty levels, or determining the specific level at which a user’ s task performance would meet a specific criterion like 50% accuracy in a Go/No-Go task.

[146] As described hereinabove, the example systems, methods, and apparatus according to the principles herein can be implemented, using at least one processing unit of a programmed computing device, to provide the cognitive platform. FIG. 1 shows an example apparatus 100 according to the principles herein that can be used to implement the cognitive platform described hereinabove herein. The example apparatus 100 includes at least one memory 102 and at least one processing unit 104. The at least one processing unit 104 is communicatively coupled to the at least one memory 102.

[147] Example memory 102 can include, but is not limited to, hardware memory, non- transitory tangible media, magnetic storage disks, optical disks, flash drives, computational device memory, random access memory, such as but not limited to DRAM, SRAM, EDO RAM, any other type of memory, or combinations thereof. Example processing unit 104 can include, but is not limited to, a microchip, a processor, a microprocessor, a special purpose processor, an application specific integrated circuit, a microcontroller, a field programmable gate array, any other suitable processor, or combinations thereof.

[148] The at least one memory 102 is configured to store processor-executable instructions 106 and a computing component 108. In a non-limiting example, the computing component 108 can be used to receive (including to measure) substantially simultaneously two or more of: (i) the response from the individual to a task, (i) a secondary response of the individual to an interference, and (iii) a response of the individual to at least one

computerized element. In another non-limiting example, the computing component 108 can be used to analyze the data from the at least one sensor component as described herein and/or to analyze the data indicative of the first response and the response of the individual to the at least one computerized element to compute at least one performance metric comprising at least one quantified indicator of cognitive abilities. In another non-limiting example, the computing component 108 can be used to compute signal detection metrics in computer- implemented adaptive response-deadline procedures. As shown in Fig. 1, the memory 102 also can be used to store data 110, such as but not limited to the measurement data 112. In various examples, the measurement data 112 can include physiological measurement data (including data collected based on one or more measurements) of an individual received from a physiological component (not shown) and/or data indicative of the response of an individual to a task and/or an interference rendered at a user interface of the apparatus 100 (as described in greater detail below), or using an auditory, tactile, or vibrational signal from an actuating component of the apparatus 100, and/or data indicative of one or more of an amount, concentration, or dose titration, or other treatment regimen of a psychedelic and/or dissociative drug being or to be administered to an individual in a therapy for a mood disorder.

[149] In a non-limiting example, the at least one processing unit 104 executes the processor-executable instructions 106 stored in the memory 102 at least to measure substantially simultaneously two or more of: (i) the response from the individual to a task, (i) a secondary response of the individual to an interference, and (iii) a response of the individual to at least one computerized element. The at least one processing unit 104 also executes the processor-executable instructions 106 stored in the memory 102 at least to analyze the data collected using a measurement component (including the data indicative of the first response and the response of the individual to the at least one computerized element) to compute at least one performance metric comprising at least one quantified indicator of cognitive abilities using the computing component 108. The at least one processing unit 104 also may be programmed to execute processor-executable instructions 106 to control a transmission unit to transmit values indicative of the computed signal detection metrics and/or controls the memory 102 to store values indicative of the signal detection metrics. [150] In a non-limiting example, the at least one processing unit 104 also executes processor-executable instructions 106 to control a transmission unit to transmit values indicative of the computed performance metric and/or controls the memory 102 to store values indicative of the computed performance metric.

[151] In another non-limiting example, the at least one processing unit 104 executes the processor-executable instructions 106 stored in the memory 102 at least to apply signal detection metrics in computer-implemented adaptive response-deadline procedures.

[152] In any example herein, the user interface may be a graphical user interface.

[153] In another non-limiting example, the measurement data 112 can be collected from measurements using one or more physiological or monitoring components and/or cognitive testing components. In any example herein, the one or more physiological components are configured for performing physiological measurements. The physiological measurements provide quantitative measurement data of physiological parameters and/or data that can be used for visualization of physiological structure and/or functions.

[154] In any example herein, the measurement data 112 can include reaction time, response variance, correct hits, omission errors, number of false alarms (such as but not limited to a response to a non-target), learning rate, spatial deviance, subjective ratings, and/or performance threshold, or data from an analysis, including percent accuracy, hits, and/or misses in the latest completed trial or session. Other non-limiting examples of measurement data 112 include response time, task completion time, number of tasks completed in a set amount of time, preparation time for task, accuracy of responses, accuracy of responses under set conditions (e.g., stimulus difficulty or magnitude level and association of multiple stimuli), number of responses a participant can register in a set time limit number of responses a participant can make with no time limit, number of attempts at a task needed to complete a task, movement stability, accelerometer and gyroscope data, and/or self-rating.

[155] In any example herein, the one or more physiological components can include any means of measuring physical characteristics of the body and nervous system, including electrical activity, heart rate, blood flow, and oxygenation levels, to provide the measurement data 112. This can include camera-based heart rate detection, measurement of galvanic skin response, blood pressure measurement, electroencephalogram, electrocardiogram, magnetic resonance imaging, near- infrared spectroscopy, and/or pupil dilation measures, to provide the measurement data 112. The one or more physiological components can include one or more sensors for measuring parameter values of the physical characteristics of the body and nervous system, and one or more signal processors for processing signals detected by the one or more sensors.

[156] Other examples of physiological measurements to provide measurement data 112 include, but are not limited to, the measurement of body temperature, heart or other cardiac- related functioning using an electrocardiograph (ECG), electrical activity using an electroencephalogram (EEG), event-related potentials (ERPs), functional magnetic resonance imaging (fMRI), blood pressure, electrical potential at a portion of the skin, galvanic skin response (GSR), magneto-encephalogram (MEG), eye-tracking device or other optical detection device including processing units programmed to determine degree of pupillary dilation, functional near-infrared spectroscopy (fNIRS), and/or a positron emission tomography (PET) scanner. An EEG-fMRI or MEG-fMRI measurement allows for simultaneous acquisition of electrophysiology (EEG/MEG) data and hemodynamic (fMRI) data.

[157] The example apparatus of FIG. 1 can be configured as a computing device for performing any of the example methods described herein. The computing device can include an App program for performing some of the functionality of the example methods described herein.

[158] In any example herein, the example apparatus can be configured to communicate with one or more of a cognitive monitoring component, a disease monitoring component, and a physiological measurement component, to provide for biofeedback and/or neurofeedback of data to the computing device, for adjusting a type or a difficulty level of one or more of the task, the interference, and the computerized element, to achieve the desired performance level of the individual. As a non-limiting example, the biofeedback can be based on physiological measurements of the individual as they interact with the apparatus, to modify the type or a difficulty level of one or more of the task, the interference, and the computerized element based on the measurement data indicating, e.g., the individual’s attention, mood, or emotional state. As a non-limiting example, the neurofeedback can be based on measurement and monitoring of the individual using a cognitive and/or a disease monitoring component as the individual interacts with the apparatus, to modify the type or a difficulty level of one or more of the task, the interference, and the computerized element based on the measurement data indicating, e.g., the individual’s cognitive state, disease state (including based on data from monitoring systems or behaviors related to the disease state). [159] FIG. 2 shows another example apparatus according to the principles herein, configured as a computing device 200 that can be used to implement the cognitive platform according to the principles herein. The example computing device 200 can include a communication module 210 and an analysis engine 212. The communication module 210 can be implemented to receive data indicative of at least one response of an individual to the task in the absence of an interference, and/or at least one response of an individual to the task that is being rendered in the presence of the interference. In an example, the communication module 210 can be implemented to receive substantially simultaneously two or more of: (i) the response from the individual to a task, (ii) a secondary response of the individual to an interference, and (iii) a response of the individual to at least one computerized element. The analysis engine 212 can be implemented to analyze the data from the at least one sensor component as described herein and/or to analyze the data indicative of the first response and the response of the individual to the at least one computerized element to compute at least one performance metric comprising at least one quantified indicator of cognitive abilities. As shown in the example of Figure 2, the computing device 200 can include processor- executable instructions such that a processor unit can execute an application program (App 214) that a user can implement to initiate the analysis engine 212. In an example, the processor-executable instructions can include software, firmware, or other instructions.

[160] The example communication module 210 can be configured to implement any wired and/or wireless communication interface by which information may be exchanged between the computing device 200 and another computing device or computing system. Non limiting examples of wired communication interfaces include, but are not limited to, USB ports, RS232 connectors, RJ45 connectors, and Ethernet connectors, and any appropriate circuitry associated therewith. Non-limiting examples of wireless communication interfaces may include, but are not limited to, interfaces implementing Bluetooth® technology, Wi-Fi, Wi-Max, IEEE 802.11 technology, radio frequency (RF) communications, Infrared Data Association (IrDA) compatible protocols, Local Area Networks (LAN), Wide Area Networks (WAN), and Shared Wireless Access Protocol (SWAP).

[161] In an example implementation, the example computing device 200 includes at least one other component that is configured to transmit a signal from the apparatus to a second computing device. For example, the at least one component can include a transmitter or a transceiver configured to transmit a signal including data indicative of a measurement by at least one sensor component to the second computing device. [162] In any example herein, the App 214 on the computing device 200 can include processor-executable instructions such that a processor unit of the computing device implements an analysis engine to analyze data indicative of the individual’s response to the rendered tasks and/or interference (either or both with computerized element) and the response of the individual to the at least one computerized element to compute at least one performance metric comprising at least one quantified indicator of cognitive abilities. In another example, the App 214 on the computing device 200 can include processor-executable instructions such that a processor unit of the computing device implements an analysis engine to analyze the data indicative of the individual’s response to the rendered tasks and/or interference (either or both with computerized element) and the response of the individual to the at least one computerized element to provide a classifier based on the computed values of the performance metric, to generate a classifier output indicative of a measure of cognition, a mood, a level of cognitive bias, or an affective bias of the individual. In an example, the App 214 can include processor-executable instructions to generate one or more of: (i) a predictive model output indicative of the cognitive capabilities of the individual, (ii) the likelihood of effectiveness of the therapy for the mood disorder, (iil) a recommended amount,

concentration, or dose titration of the psychedelic and/or dissociative drug to be administered to the individual in a therapy for the mood disorder, (iv) the likelihood of the individual experiencing an adverse event in response to administration of the psychedelic and/or dissociative drug, (v) a recommended treatment regimen using the cognitive platform following the therapy for the mood disorder, or (vi) a determination of a degree of effectiveness of therapy for the mood disorder. In another example, the App 214 can include processor-executable instructions to receive data indicative of one or more of an amount, concentration, or dose titration of a psychedelic and/or dissociative drug previously administered to an individual in a therapy for a mood disorder including a psychedelic and/or dissociative drug, and to provide one or more of: (i) the change in the cognitive abilities of the individual, (ii) the degree of effectiveness of the therapy for the mood disorder, (iii) the likelihood of the individual experiencing a relapse following administration of the therapy including the psychedelic and/or dissociative drug, (iv) a recommended change to the treatment regimen using the cognitive platform following the therapy for the mood disorder, (v) the projected duration of remission of the mood disorder following the therapy, or (vi) a recommended treatment regimen using the cognitive platform to enhance the cognitive abilities of the individual. App 214 can be configured to implement a treatment regimen using the cognitive platform to selectively target the areas of the brain of the individual involved in affective or emotional processing, such as but not limited to the amygdala and the pre-frontal cortex, to increase the likelihood or duration of remission of the therapy.

[163] In any example herein, the App 214 can be configured to receive measurement data including physiological measurement data of an individual received from a physiological component, and/or data indicative of the response of an individual to a task and/or an interference rendered at a user interface of the apparatus 100 (as described in greater detail below), and/or data indicative of one or more of an amount, concentration, or dose titration, or other treatment regimen of a psychedelic and/or dissociative drug being or to be administered to an individual in a therapy for a mood disorder.

[164] Non- limiting examples of the computing device include a smartphone, a tablet, a slate, an e-reader, a digital assistant, or any other equivalent device, including any of the mobile communication devices described hereinabove. As an example, the computing device can include a processor unit that is configured to execute an application that includes an analysis module for analyzing the data indicative of the individual’s response to the rendered tasks and/or interference (either or both with computerized element).

[165] The example systems, methods, and apparatus can be implemented as a component in a product comprising a computing device that uses computer-implemented adaptive psychophysical procedures to assess human performance or delivers

psychological/perceptual therapy.

[166] The example systems, methods, and apparatus according to the principles herein can be configured to compute a response criterion based on the detection or classification task(s) described herein that are composed of signal and non-signal response targets (as stimuli), in which a user indicates a response that indicates a feature, or multiple features, are present in a series of sequential presentations of stimuli or simultaneous presentation of stimuli.

[167] The data indicative of the results of the classification of an individual according to the principles herein (including a classifier output) can be transmitted (with the pertinent consent) as a signal to one or more of a medical device, healthcare computing system, or other device, and/or to a medical practitioner, a health practitioner, a physical therapist, a behavioral therapist, a sports medicine practitioner, a pharmacist, or other practitioner, to allow formulation of a course of treatment for the individual or to modify an existing course of treatment, including to determine a change in one or more of an amount, concentration, or dose titration of a psychedelic and/or dissociative drug being or to be administered to an individual in a therapy for a mood disorder and/or to determine an optimal type or combination of psychedelic and/or dissociative drug to be administered to an individual in a therapy for a mood disorder.

[168] The example systems, methods, and apparatus herein provide computerized classifiers, treatment tools, and other tools that can be used by a medical, behavioral, healthcare, or other professional as an aid in an assessment and/or enhancement of an individual’s attention, working memory, and goal management. The example analysis performed using the example systems, methods, and apparatus according to the principles herein can be used to provide measures of attention deficits and impulsivity (including ADHD). The example systems, methods, and apparatus herein provide computerized classifiers, treatment tools, and other tools that can be used as aids in assessment and/or enhancement in other cognitive domains, such as but not limited to attention, memory, motor, reaction, executive function, decision-making, problem-solving, language processing, and comprehension. In some examples, the systems, methods, and apparatus can be used to compute measures for use for cognitive monitoring and/or disease monitoring. In some examples, the systems, methods, and apparatus can be used to compute measures for use for cognitive monitoring and/or disease monitoring during treatment of one or more cognitive conditions and/or diseases and/or executive function disorders.

[169] An example system, method, and apparatus according to the principles herein can be configured to execute an example classifier to generate a quantifier of the cognitive skills in an individual. The example classifier can be built using a machine learning tool, such as but not limited to linear/logistic regression, principal component analysis, generalized linear mixed models, random decision forests, support vector machines, and/or artificial neural networks. In a non-limiting example, classification techniques that may be used to train a classifier using the performance measures of a labeled population of individuals (e.g., individuals with known cognitive disorders, executive function disorder, disease or other cognitive condition). The trained classifier can be applied to the computed values of the performance metric, to generate a classifier output indicative of a measure of cognition, a mood, a level of cognitive bias, or an affective bias of the individual. The trained classifier can be applied to measures of the responses of the individual to the tasks and/or interference (either or both with computerized element) to classify the individual as to a population label (e.g., cognitive disorder, executive function disorder, disease or other cognitive condition).

In an example, machine learning may be implemented using cluster analysis. Each measurement of the cognitive response capabilities of participating individuals can be used as the parameter that groups the individuals to subsets or clusters. For example, the subset or cluster labels may be a diagnosis of a cognitive disorder, cognitive disorder, executive function disorder, disease or other cognitive condition. Using a cluster analysis, similarity metric of each subset and the separation between different subsets can be computed, and these similarity metrics may be applied to data indicative of an individual’s responses to a task and/or interference (either or both with computerized element) to classify that individual to a subset. In another example, the classifier may be a supervised machine learning tool based on artificial neural networks. In such a case, the performance measures of individuals with known cognitive abilities may be used to train the neural network algorithm to model the complex relationships among the different performance measures. A trained classifier can be applied to the performance/response measures of a given individual to generate a classifier output indicative of the cognitive response capabilities of the individual. Other applicable techniques for generating a classifier include a regression or Monte Carlo technique for projecting cognitive abilities based on his/her cognitive performance. The classifier may be built using other data, including a physiological measure (e.g., EEG) and demographic measures.

[170] In a non-limiting example, classification techniques that may be used to train a predictive model (including a classifier) using the performance measures of a labeled population of individuals that previously underwent the the therapy for the mood disorder including the psychedelic and/or dissociative drug. Based on each individual’s computed performance metrics, and other known outcome data on the individual, such as but not limited to outcome in the following categories: (i) any adverse event an individual experience in response to administration of the therapy including the psychedelic and/or dissociative drug; (ii) the amount, concentration, or dose titration of the psychedelic and/or dissociative drug administered to the individuals that resulted in a measurable or

characterizable outcome for the individual (whether positive or negative) as a result of the therapy for the mood disorder; (iii) any change in the individual’s cognitive capabilities prior to the therapy using the psychedelic and/or dissociative drug, based on one or more interactions of the individuals with the single-tasking and/or multi-tasking tasks rendered using the cognitive platform; (iv) a treatment regimen of one or more interactions of the individuals with the single-tasking and/or multi-tasking tasks using the cognitive platform following the therapy for the mood disorder; (v) a degree of effectiveness of the therapy for the mood disorder using the psychedelic and/or dissociative drug, based on a measurable or characterizable outcome of the individual (whether positive or negative); (v) the performance score of the individual at one or more of a cognitive test or a behavioral test, (vi) the status or degree of progression of any executive function disorder of the individual following the therapy using the psychedelic and/or dissociative drug; (vii) the amount, concentration, or dose titration of the psychedelic and/or dissociative drug administered to the individual in the therapy for the mood disorder; (viii) any experience of a relapse of any individual following administration of the therapy including the psychedelic and/or dissociative drug; (ix) the duration of remission of each individual the mood disorder following the therapy. The example predictive model (including a classifier) can be trained based on the computed values of performance metrics of the known individuals, to be able to classify other yet-to-be classified individuals as to potential outcome in any of the possible categories.

[171] In an example, the processing unit further uses the predictive model output for one or more of: (i) the likelihood of effectiveness of the therapy for the mood disorder, (ii) a recommended amount, concentration, or dose titration of the psychedelic and/or dissociative drug to be administered to the individual in a therapy for the mood disorder, (iii) the likelihood of the individual experiencing an adverse event in response to administration of the psychedelic and/or dissociative drug, (iv) a recommended treatment regimen using the cognitive platform following the therapy for the mood disorder, or (v) a determination of a degree of effectiveness of therapy for the mood disorder. The example treatment regimen using the cognitive platform is configured to selectively target the areas of the brain of the individual involved in affective or emotional processing, such as but not limited to the amygdala and the pre-frontal cortex, to increase the likelihood or duration of remission of the therapy.

[172] In another example, the processing unit further uses the predictive model output for one or more of: (i) the degree of effectiveness of the therapy for the mood disorder, (ii) the likelihood of the individual experiencing a relapse following administration of the therapy including the psychedelic and/or dissociative drug, (iii) a recommended change to the treatment regimen using the cognitive platform following the therapy for the mood disorder, (iv) the projected duration of remission of the mood disorder following the therapy, or (v) a recommended training regimen using the cognitive platform to enhance the cognitive abilities of the individual. The example treatment regimen using the cognitive platform is configured to selectively target the areas of the brain of the individual involved in affective or emotional processing, such as but not limited to the amygdala and the pre-frontal cortex, to increase the likelihood or duration of remission of the therapy.

[173] In any example herein, the example classifier can be used as an intelligent proxy for quantifiable assessments of an individual’s cognitive abilities. That is, once a classifier is trained, the classifier output can be used to provide the indication of the cognitive response capabilities of multiple individuals without use of other cognitive or behavioral assessment tests.

[174] Monitoring cognitive deficits allows individuals, and/or medical, healthcare, behavioral, or other professional (with consent) to monitor the status or progression of a mood disorder. If the status or progression of the cognitive symptoms can be regularly or periodically quantified, it can provide an indication of what form of psychedelic and/or dissociative drug may be administered in the therapy for the mood disorder or to indicate when quality of life might be compromised (such as in the evet of a relapse). Monitoring cognitive deficits also allows individuals, and/or medical, healthcare, behavioral, or other professional (with consent) to monitor the response of the individual to any treatment or intervention, particularly in cases where the intervention is known to be selectively effective for certain individuals. In another example, the classifiers and other tools herein can be used as a monitor of the presence and/or severity of any cognitive side effects from therapies with known cognitive impact, such as but not limited to chemotherapy, or that involve uncharacterized or poorly characterized pharmacodynamics. In any example herein, the cognitive performance measurements and/or classifier analysis of the data may be performed every 30 minutes, each few hours, daily, two or more times per week, weekly, bi-weekly, each month, or once per year.

[175] In an example, classifier can be used as an intelligent proxy for quantifiable measures of the performance of the individual.

[176] In a non-limiting example, the task and the interference can be rendered at the user interface such that the individual is required to provide the first response and the second response within a limited period of time. In an example, the individual is required to provide the first response and the second response substantially simultaneously.

[177] In an example, the processing unit executes further instructions including applying at least one adaptive procedure to modify the task and/or the interference, such that analysis of the data indicative of the first response and/or the second response indicates a modification of the first response profile. [178] In an example, the processing unit controls the user interface to modify a temporal length of the response window associated with the response-deadline procedure.

[179] In an example, the processing unit controls the user interface to modify a time- varying characteristics of an aspect of the task or the interference rendered to the user interface.

[180] In an example, modifying the time-varying characteristics of an aspect of the task or the interference includes adjusting a temporal length of the rendering of the task or interference at the user interface between two or more sessions of interactions of the individual.

[181] In an example, the time-varying characteristics can be one or more of a speed of an object, a rate of change of a facial expression, a direction of trajectory of an object, a change of orientation of an object, at least one color of an object, a type of an object, or a size of an object.

[182] In an example, the time- varying characteristics can be the rate of change or modulation in content and/or appearance of the computerized elements, including one or more of a rate of change of the increase or decrease in the number of features included in the computerized element, a rate of change of the types of features included in the computerized element, and/or a rate of change of the speed or trajectory of movement of the features included in the computerized element.

[183] In an example, the change in type of object is effected using morphing from a first type of object to a second type of object or rendering a blendshape as a proportionate combination of the first type of object and the second type of object.

[184] In a non-limiting example, the processing unit can be configured to render a user interface or cause another component to execute least one element for indicating a reward to the individual for a degree of success in interacting with a task and/or interference, or another feature or other element of a system or apparatus. A reward computer element can be a computer generated feature that is delivered to a user to promote user satisfaction with the example system, method or apparatus, and as a result, increase positive user interaction and hence enjoyment of the experience of the individual.

[185] In an example, the processing unit further computes as the classifier output parameters indicative of one or more of a bias sensitivity derived from the data indicative of the first response and the second response, a non-decision time sensitivity to parallel tasks, a belief accumulation sensitivity to parallel task demands, a reward rate sensitivity, or a response window estimation efficiency. Bias sensitivity can be a measure of how sensitive an individual is to certain of the tasks based on their bias (tendency to one type of response versus another (e.g., Response A vs. Response B)). Non-decision time sensitivity to parallel tasks can be a measure of how much the interference interferes with the individual's performance of the primary task. Belief accumulation sensitivity to parallel task demands can be a measure of the rate of the individual to develop/accumulate belief for responding to the interference during the individual's performance of the primary task. Reward rate sensitivity can be used to measure how an individual's response changes based on the temporal length of the response deadline window. When near the end of a response deadline window (e.g., as individual sees interference about to move off the field of view), the individual realizes that he is running out of time to make a decision. This measures how the individual’s responses change accordingly. Response window estimation efficiency is explained as follows. When the individual is making a decision to act/respond or not act/no response, the decision needs to be based on when the individual thinks his time to respond is running out. For a varying window, the individual will not be able to measure that window perfectly, but with enough trials/session, based the response data, it may be possible to infer how good the individual is at making that estimation based on the time-varying aspect (e.g., trajectory) of the objects in the task or interference.

[186] An example system, method, and apparatus according to the principles herein can be configured to train a predictive model of a measure of the cognitive capabilities of individuals based on feedback data from the output of the computational model of human decision-making for individuals that are previously classified as to the measure of cognitive abilities of interest. As used herein, the term“predictive model” encompasses models trained and developed based on models providing continuous output values and/or models based on discrete labels. In any example herein, the predictive model encompasses a classifier model. For example, the classifier can be trained using a plurality of training datasets, where each training dataset is associated with a previously classified individual from a group of individuals. Each of the training dataset includes data indicative of the first response of the classified individual to the task and data indicative of the second response of the classified individual to the interference, based on the classified individual’s interaction with an example apparatus, system, or computing device described herein. The example classifier also can take as input data indicative of the performance of the classified individual at a cognitive test, and/or a behavioral test, and/or data indicative of a diagnosis of a status or progression of a cognitive condition, a disease, or a disorder (including an executive function disorder) of the classified individual.

[187] In any example herein, the at least one processing unit can be programmed to cause an actuating component of the apparatus (including the cognitive platform) to effect auditory, tactile, or vibrational computerized elements to effect the stimulus or other interaction with the individual. In a non- limiting example, the at least one processing unit can be programmed to cause a component of the cognitive platform to receive data indicative of at least one response from the individual based on the user interaction with the task and/or interference, including responses provided using an input device. In an example where at least one graphical user interface is rendered to present the computerized stimulus to the individual, the at least one processing unit can be programmed to cause the graphical user interface to receive the data indicative of at least one response from the individual.

[188] In any example herein, the data indicative of the response of the individual to a task and/or an interference can be measured using at least one sensor device contained in and/or coupled to an example system or apparatus herein, such as but not limited to a gyroscope, an accelerometer, a motion sensor, a position sensor, a pressure sensor, an optical sensor, an auditory sensor, a vibrational sensor, a video camera, a pressure-sensitive surface, a touch-sensitive surface, or other type of sensor. In other examples, the data indicative of the response of the individual to the task and/or an interference can be measured using other types of sensor devices, including a video camera, a microphone, joystick, keyboard, a mouse, a treadmill, elliptical, bicycle, steppers, or a gaming system (including a Wii®, a Playstation®, or an Xbox® or other gaming system). The data can be generated based on physical actions of the individual that are detected and/or measured using the at least one sensor device, as the individual executed a response to the stimuli presented with the task and/or interference.

[189] The user may respond to tasks by interacting with the computer device. In an example, the user may execute a response using a keyboard for alpha-numeric or directional inputs; a mouse for GO/NO-GO clicking, screen location inputs, and movement inputs; a joystick for movement inputs, screen location inputs, and clicking inputs; a microphone for audio inputs; a camera for still or motion optical inputs; sensors such as accelerometer and gyroscopes for device movement inputs; among others. Non-limiting example inputs for a game system include but are not limited to a game controller for navigation and clicking inputs, a game controller with accelerometer and gryroscope inputs, and a camera for motion optical inputs. Example inputs for a mobile device or tablet include a touch screen for screen location information inputs, virtual keyboard alpha-numeric inputs, go/no go tapping inputs, and touch screen movement inputs; accelerometer and gyroscope motion inputs; a microphone for audio inputs; and a camera for still or motion optical inputs, among others. In other examples, data indicative of the individual’s response can include physiological sensors/measures to incorporate inputs from the user's physical state, such as but not limited to electroencephalogram (EEG), magnetoencephalography (MEG), heart rate, heart rate variability, blood pressure, weight, eye movements, pupil dilation, electrodermal responses such as the galvanic skin response, blood glucose level, respiratory rate, and blood oxygenation.

[190] In any example herein, the individual may be instructed to provide a response via a physical action of clicking a button and/or moving a cursor to a correct location on a screen, head movement, finger or hand movement, vocal response, eye movement, or other action of the individual.

[191] As a non-limiting example, an individual’s response to a task or interference rendered at the user interface that requires a user to navigate a course or environment or perform other visuo-motor activity may require the individual to make movements (such as but not limited to steering) that are detected and/or measured using at least one type of the sensor device. The data from the detection or measurement provides the response to the data indicative of the response.

[192] As a non- limiting example, an individual’s response to a task or interference rendered at the user interface that requires a user to discriminate between a target and a non target may require the individual to make movements (such as but not limited to tapping or other spatially or temporally discriminating indication) that are detected and/or measured using at least one type of the sensor device. The data that is collected by a component of the system or apparatus based on the detection or other measurement of the individual’s movements (such as but not limited to at least one sensor or other device or component described herein) provides the data indicative of the individual’s responses.

[193] The example system, method, and apparatus can be configured to apply the predictive model, using computational techniques and machine learning tools, such as but not limited to linear/logistic regression, principal component analysis, generalized linear mixed models, random decision forests, support vector machines, or artificial neural networks, to the data indicative of the individual’s response to the tasks and/or interference, and/or data from one or more physiological measures, to create composite variables or profiles that are more sensitive than each measurement alone for generating a classifier output indicative of the cognitive response capabilities of the individual. In an example, the classifier output can be configured for other indications such as but not limited to detecting an indication of a disease, disorder or cognitive condition, or assessing cognitive health.

[194] The example classifiers herein can be trained to be applied to data collected from interaction sessions of individuals with the cognitive platform to provide the output. In a non- limiting example, the predictive model can be used to generate a standards table, which can be applied to the data collected from the individual’s response to task and/or interference to classify the individual’s cognitive response capabilities.

[195] Non- limiting examples of assessment of cognitive abilities include assessment scales or surveys such as the Mini Mental State Exam, CANTAB cognitive battery, Test of Variables of Attention (TOVA), Repeatable Battery for the Assessment of

Neuropsychological Status, Clinical Global Impression scales relevant to specific conditions, Clinician’s Interview-Based Impression of Change, Severe Impairment Battery, Alzheimer’s Disease Assessment Scale, Positive and Negative Syndrome Scale, Schizophrenia Cognition Rating Scale, Conners Adult ADHD Rating Scales, Hamilton Rating Scale for Depression, Hamilton Anxiety Scale, Montgomery- Asberg Depressing Rating scale, Young Mania Rating Scale, Children’s Depression Rating Scale, Penn State Worry Questionnaire, Hospital Anxiety and Depression Scale, Aberrant Behavior Checklist, Activities for Daily Living scales, ADHD self-report scale, Positive and Negative Affect Schedule, Depression Anxiety Stress Scales, Quick Inventory of Depressive Symptomatology, and PTSD Checklist.

[196] In other examples, the assessment may test specific functions of a range of cognitions in cognitive or behavioral studies, including tests for perceptive abilities, reaction and other motor functions, visual acuity, long-term memory, working memory, short-term memory, logic, and decision-making, and other specific example measurements, including but are not limited to TOVA, MOT (motion-object tracking), SART, CDT (Change detection task), UFOV (useful Field of view), Filter task, WAIS digit symbol, Troop, Simon task, Attentional Blink, N-back task, PRP task, task- switching test, and Flanker task.

[197] In non-limiting examples, the example systems, methods, and apparatus according to the principles described herein can be applicable to many different types of mood disorders, such as but not limited to depression (major depressive disorder), anxiety, PTSD, or obsessive compulsive disorder (OCD). In some examples, the individual may also have other neuropsychological condition, such as but not limited to dementia, Parkinson’s disease, cerebral amyloid angiopathy, familial amyloid neuropathy, Huntington’s disease, or other neurodegenerative condition, autism spectrum disorder (ASD), presence of the l6pll.2 duplication, and/or an executive function disorder, such as but not limited to attention deficit hyperactivity disorder (ADHD), sensory-processing disorder (SPD), mild cognitive impairment (MCI), Alzheimer’s disease, multiple-sclerosis, schizophrenia, major depressive disorder (MDD), or anxiety (including social anxiety), bipolar disorder, post-traumatic stress disorder, schizophrenia, dementia, Alzheimer’s disease, or multiple-sclerosis.

[198] The instant disclosure is directed to computer-implemented devices formed as example cognitive platforms configured to implement software and/or other processor- executable instructions for the purpose of measuring data indicative of a user’s performance at one or more tasks, to provide a user performance metric. The example performance metric can be used to derive an assessment of a user’s cognitive abilities and/or to measure a user’s response to a cognitive treatment, and/or to provide data or other quantitative indicia of a user’s condition (including physiological condition and/or cognitive condition). Non- limiting example cognitive platforms according to the principles herein can be configured to classify an individual as to a mood disorder, such as but not limited to depression, anxiety, PTSD, or obsessive compulsive disorder (OCD), and/or an executive function disorder, and/or potential efficacy of use of the cognitive platform when the individual is being administered (or about to be administered) a psychedelic and/or dissociative drug in a therapy for the mood disorder based on the data collected from the individual’s interaction with the cognitive platform and/or metrics computed based on the analysis (and associated computations) of that data.

Yet other non-limiting example cognitive platforms according to the principles herein can be configured to classify an individual as to likelihood of onset and/or stage of progression of a neuropsychological condition, including as to a neurodegenerative condition, based on the data collected from the individual’s interaction with the cognitive platform and/or metrics computed based on the analysis (and associated computations) of that data. The

neurodegenerative condition can be, but is not limited to, Alzheimer’ s disease, dementia, Parkinson’s disease, cerebral amyloid angiopathy, familial amyloid neuropathy, or

Huntington’s disease.

[199] Any classification of an individual as to likelihood of onset and/or stage of progression of a neurodegenerative condition according to the principles herein can be transmitted as a signal to a medical device, healthcare computing system, or other device, and/or to a medical practitioner, a health practitioner, a physical therapist, a behavioral therapist, a sports medicine practitioner, a pharmacist, or other practitioner, to allow formulation of a course of treatment for the individual or to modify an existing course of treatment, including to determine a change in dosage of a psychedelic and/or dissociative drug being or to be administered to an individual in a therapy for a mood disorder or to determine an optimal type or combination of the psychedelic and/or dissociative drug to be administered to an individual in a therapy for a mood disorder.

[200] In any example herein, the cognitive platform can be configured as any combination of a medical device platform, a monitoring device platform, a screening device platform, or other device platform.

[201] The instant disclosure is also directed to example systems that include cognitive platforms that are configured for coupling with one or more physiological or monitoring component and/or cognitive testing component. In some examples, the systems include cognitive platforms that are integrated with the one or more other physiological or monitoring component and/or cognitive testing component. In other examples, the systems include cognitive platforms that are separately housed from and configured for communicating with the one or more physiological or monitoring component and/or cognitive testing component, to receive data indicative of measurements made using such one or more components.

[202] In an example system, method, and apparatus herein, the processing unit can be programmed to control the user interface to modify a temporal length of the response window associated with a response-deadline procedure.

[203] In an example system, method, and apparatus herein, the processing unit can be configured to control the user interface to modify a time-varying characteristics of an aspect of the task or the interference rendered to the user interface. For example, modifying the time-varying characteristics of an aspect of the task or the interference can include adjusting a temporal length of the rendering of the task or interference at the user interface between two or more sessions of interactions of the individual. As another example, the time- varying characteristics is one or more of a speed of an object, a rate of change of a facial expression, a direction of trajectory of an object, a change of orientation of an object, at least one color of an object, a type of an object, or a size of an object. In any example herein, the foregoing time-varying characteristic can be applied to an object that includes the computerized element to modify an cognitive or emotional load of the individual’s interaction with the apparatus (e.g., computing device or cognitive platform).

[204] In an example system, method, and apparatus herein, the change in type of object is effected using morphing from a first type of object to a second type of object or rendering a blendshape as a proportionate combination of the first type of object and the second type of object.

[205] In an example system, method, and apparatus herein, the processing unit can be further programmed to compute as the classifier output parameters indicative of one or more of a bias sensitivity derived from the data indicative of the first response and the second response, a non-decision time sensitivity to parallel tasks, a belief accumulation sensitivity to parallel task demands, a reward rate sensitivity, or a response window estimation efficiency.

[206] In an example system, method, and apparatus herein, the processing unit can be further programmed to control the user interface to render the task as a continuous visuo- motor tracking task.

[207] In an example system, method, and apparatus herein, the processing unit controls the user interface to render the interference as a target discrimination task.

[208] As used herein, a target discrimination task may also be referred to as a perceptual reaction task, in which the individual is instructed to perform a two-feature reaction task including target stimuli and non-target stimuli through a specified form of response. As a non- limiting example, that specified type of response can be for the individual to make a specified physical action in response to a target stimulus (e.g. , move or change the orientation of a device, tap on a sensor-coupled surface such as a screen, move relative to an optical sensor, make a sound, or other physical action that activates a sensor device) and refrain from making such specified physical action in response to a non-target stimulus.

[209] In a non-limiting example, the individual is required to perform a visuomotor task (as a primary task) with a target discrimination task as an interference (secondary task) (either or both including a computerized element). To effect the visuomotor task, a programmed processing unit renders visual stimuli that require fine motor movement as reaction of the individual to the stimuli. In some examples, the visumotor task is a continuous visuomotor task. The processing unit is programmed to alter the visual stimuli and recording data indicative of the motor movements of the individual over time (e.g., at regular intervals including 1, 5, 10, or 30 times per second). Example stimuli rendered using the programmed processing unit for a visuomotor task requiring fine motor movement may be a visual presentation of a path that an avatar is required to remain within. The programmed processing unit may render the path with certain types of obstacles that the individual is either required to avoid or to navigate towards. In an example, the fine motor movements effect by the individual, such as but not limited to tilting or rotating a device, are measured using an accelerometer and/or a gyroscope (e.g., to steer or otherwise guide the avatar on the path while avoiding or crossing the obstacles as specified). The target discrimination task (serving as the interference), can be based on targets and non-targets that differ in shape and/or color.

[210] In any example, the apparatus may be configured to instruct the individual to provide the response to the computerized element as an action that is read by one or more sensors (such as a movement that is sensed using a gyroscope or accelerometer or a motion or position sensor, or a touch that is sensed using a touch-sensitive, pressure sensitive or capacitance-sensitive sensor.

[211] In some examples, the task and/or interference can be a visuomotor task, a target discrimination task, and/or a memory task.

[212] Within the context of a computer- implemented adaptive response-deadline procedure, the response-deadline can be adjusted between trials or blocks of trials to manipulate the individual’s performance characteristics towards certain goals. A common goal is driving the individual’s average response accuracy towards a certain value by controlling the response deadline.

[213] In a non-limiting example, the hit rate may be defined as the number of correct responses to a target stimuli divided by the total number of target stimuli presented, or the false alarm rate (e.g., the number of responses to a distractor stimuli divided by the number of distractor stimuli presented), the miss rate (e.g., the number of nonresponses to a target stimuli divided by the number of incorrect responses, including the nonresponses to a target stimuli added to the number of responses to a distractor stimuli), the correct response rate (the proportion of correct responses not containing signal). In an example, the correct response rate may be calculated as the number of non-responses to the distractor stimuli divided by the number of non-responses to the distractor stimuli plus the number of responses to the target stimuli.

[214] An example system, method, and apparatus according to the principles herein can be configured to apply adaptive performance procedures to modify measures of performance to a specific stimulus intensity. The procedure can be adapted based on a percent correct (PC) signal detection metric of sensitivity to a target. In an example system, the value of percent correct (i.e., percent of correct responses of the individual to a task or computerized element) may be used in the adaptive algorithms as the basis for adapting the stimulus level of tasks and/or interferences rendered at the user interface for user interaction from one trial to another. An adaptive procedure based on a computational model of human decision making (such as but not limited to the modified drift diffusion model), classifiers built from outputs of such models, and the analysis described herein based on the output of the computational model, can be more quantitatively informative on individual differences or on changes in sensitivity to a specific stimulus level. The performance metric provides a flexible tool for determining a performance of the individual. Accordingly, an adaptation procedure based on performance metric measurements at the individual or group level become a desirable source of information about the changes in performance at the individual or group level over time with repeated interactions with the tasks and computerized elements described herein, and measurements of the individual’s responses with the interactions.

[215] Executive function training, such as that delivered by the example systems, methods, and apparatus described herein can be configured to apply an adaptive algorithm to modify the stimulus levels (including cognitive or emotional load based on the computerized element(s) implemented) between trials, to move a user’s performance metric to the desired level (value), depending on the needs or preference of the individual or based on the clinical population receiving the treatment.

[216] The example systems, methods, and apparatus described herein can be configured to apply an adaptive algorithm that is adapted based on the computed performance metric as described herein to modify the difficulty levels of the tasks and/or interference (either or both including a computerized element) rendered at the user interface for user interaction from one trial to another.

[217] In an example, the task and/or interference (either or both including a

computerized element) can be modified/adjusted/adapted based on an iterative estimation of metrics by tracking current estimates and selecting the features, trajectory, and response window of the targeting task, and level/type of parallel task interference for the next trial in order to maximize information the trial can provide.

[218] In some examples, the task and/or interference (either or both including a computerized element) are adaptive tasks. The task and/or interference can be adapted or modified in difficulty level based on the performance metric, as described hereinabove. Such difficulty adaptation may be used to determine the ability of the participant. [219] In an example, the difficulty of the task (potentially including a computerized element) adapts with every stimuli that is presented, which could occur more often than once at regular time intervals (e.g., every 5 seconds, every 10 seconds, every 20 seconds or other regular schedule).

[220] In another example, the difficulty of a continuous task (potentially including a computerized element) can be adapted on a set schedule, such as but not limited to every 30 seconds, 10 seconds, 1 second, 2 times per second, or 30 times per second.

[221] In an example, the length of time of a trial depends on the number of iterations of rendering (of the tasks/interference) and receiving (of the individual’s responses) and can vary in time. In an example, a trial can be on the order of about 500 milliseconds, about 1 second (s), about 10 s, about 20 s, about 25 s, about 30 s, about 45 s, about 60 s, about 2 minutes, about 3 minutes, about 4 minutes, about 5 minutes, or greater. Each trial may have a pre-set length or may be dynamically set by the processing unit (e.g., dependent on an individual’s performance level or a requirement of the adapting from one level to another).

[222] In an example, the task and/or interference (either or both including a

computerized element) can be modified based on targeting changes in one or more specific metrics by selecting features, trajectory, and response window of the targeting task, and level/type of parallel task interference to progressively require improvements in those metrics in order for the apparatus to indicate to an individual that they have successfully performed the task. This could include specific reinforcement, including explicit messaging, to guide the individual to modify performance according to the desired goals.

[223] In an example, the task and/or interference (either or both including a

computerized element) can be modified based on a comparison of an individual’s performance with normative data or a computer model or taking user input (the individual performing the task/interference or another individual such as a clinician) to select a set of metrics to target for changing in a specific order, and iteratively modifying this procedure based on the subject’s response to treatment. This could include feedback to the individual performing the task/interference or another individual to serve as notification of changes to the procedure, potentially enabling them to approve or modify these changes before they take effect.

[224] In various examples, the difficulty level may be kept constant or may be varied over at least a portion of a session in an adaptive implementation, where the adaptive task (primary task or secondary task) increases or decreases in difficulty based on the performance metric.

[225] An example system, method, and apparatus according to the principles herein can be configured to enhance the cognitive skills in an individual. In an example implementation, a programmed processing unit is configured to execute processor-executable instructions to render a task with an interference at a user interface. As described in greater detail herein, one or more of the task and the interference (either or both including a computerized element) can be time-varying and have a response deadline, such that the user interface imposes a limited time period for receiving at least one type of response from the individual interacting with the apparatus or system.

[226] An example processing unit is configured to control the user interface to render a first instance of a task with an interference at the user interface, requiring a first response from the individual to the first instance of the task in the presence of the interference and a response from the individual to at least one computerized element. Either or both of the first instance of the task and the interference includes at least one a computerized element. The user interface can be configured to measure data indicative of the response of the individual to the at least one computerized element, the data including at least one measure of cognitive capabilities of the individual. The example processing unit is configured to measure substantially simultaneously the first response from the individual to the first instance of the task and the response from the individual to the at least one computerized element, and to receive data indicative of the first response and the response of the individual to the at least one computerized element. The example processing unit is also configured to analyze the data indicative of the first response and the response of the individual to the at least one computerized element to compute at least one performance metric comprising at least one quantified indicator of cognitive abilities of the individual.

[227] In an example, the indication of the modification of the cognitive response capabilities can be based on observation of a change in a measure of a degree of

impulsiveness or conservativeness of the individual’s cognitive response capabilities.

[228] In an example, the indication of the modification of the cognitive abilities can include a change in a measure of one or more of affective bias, mood, level of cognitive bias, sustained attention, selective attention, attention deficit, impulsivity, inhibition, perceptive abilities, reaction and other motor functions, visual acuity, long-term memory, working memory, short-term memory, logic, and decision-making. [229] In an example, adapting the task and/or interference based on the first performance metric includes one or more of modifying the temporal length of the response window, modifying a type of reward or rate of presentation of rewards to the individual, and modifying a time- varying characteristic of the task and/or interference (including the computerized element).

[230] In an example, modifying the time-varying characteristics of an aspect of the task or the interference (including the computerized element) can include adjusting a temporal length of the rendering of the task or interference at the user interface between two or more sessions of interactions of the individual.

[231] In an example, the time- varying characteristics can include one or more of a speed of an object, a rate of change of a facial expression, a direction of trajectory of an object, a change of orientation of an object, at least one color of an object, a type of an object, or a size of an object, or modifying a sequence or balance of rendering of targets versus non-targets at the user interface.

[232] In an example, the change in type of object is effected using morphing from a first type of object to a second type of object or rendering a blendshape as a proportionate combination of the first type of object and the second type of object.

[233] Designing the computer-implemented adaptive procedure using a goal of explicitly measuring the shape and/or area of the decision boundary, the response deadlines can be adjusted to points where measurements produce maximal information of use for defining this boundary. These optimal deadlines may be determined using an information theoretic approach to minimize the expected information entropy.

[234] Example systems, methods and apparatus according to the principles herein can be implemented using a programmed computing device including at least one processing unit, to determine a potential biomarker for clinical populations.

[235] Example systems, methods and apparatus according to the principles herein can be implemented using a programmed computing device including at least one processing unit to measure change in response profile in individuals or groups after use of an intervention.

[236] Example systems, methods and apparatus according to the principles herein can be implemented using a programmed computing device including at least one processing unit to apply the example metrics herein, to add another measurable characteristic of individual or group data that can be implemented for greater measurement of psychophysical-threshold accuracy and assessment of response profile to computer-implemented adaptive

psychophysical procedures.

[237] Example systems, methods and apparatus according to the principles herein can be implemented using a programmed computing device including at least one processing unit to apply the example metrics herein to add a new dimension to available data that can be used to increase the amount of information harvested from psychophysical testing.

[238] An example system, method, and apparatus according to the principles herein can be configured to enhance the cognitive skills in an individual. In an example implementation, a programmed processing unit is configured to execute processor-executable instructions to render a task with an interference at a user interface. As described in greater detail herein, one or more of the task and the interference can be time-varying and have a response deadline, such that the user interface imposes a limited time period for receiving at least one type of response from the individual interacting with the apparatus or system. An example processing unit is configured to control the user interface to render a first instance of a task with an interference at the user interface, requiring a first response from the individual to the first instance of the task in the presence of the interference and a response from the individual to at least one computerized element. Either or both of the first instance of the task and the interference includes at least one a computerized element. The user interface can be configured to measure data indicative of the response of the individual to the at least one computerized element, the data including at least one measure of cognitive capabilities of the individual. The example processing unit is configured to measure substantially

simultaneously the first response from the individual to the first instance of the task and the response from the individual to the at least one computerized element, and to receive data indicative of the first response and the response of the individual to the at least one computerized element. The example processing unit is also configured to analyze the data indicative of the first response and the response of the individual to the at least one computerized element to compute a first performance metric comprising at least one quantified indicator of cognitive abilities of the individual. The programmed processing unit is further configured to adjust a difficulty of one or more of the task and the interference based on the computed at least one first performance metric such that the apparatus renders the task with the interference at a second difficulty level, and compute a second performance metric representative of cognitive abilities of the individual based at least in part on the data indicative of the first response and the response of the individual to the at least one computerized element.

[239] Another example system, method, and apparatus according to the principles herein can be configured to enhance the cognitive skills in an individual. In an example

implementation, a programmed processing unit is configured to execute processor-executable instructions to render a task with an interference at a user interface. As described in greater detail herein, one or more of the task and the interference can be time- varying and have a response deadline, such that the user interface imposes a limited time period for receiving at least one type of response from the individual interacting with the apparatus or system. An example processing unit is configured to control the user interface to render a first instance of a task with an interference at the user interface, requiring a first response from the individual to the first instance of the task in the presence of the interference and a response from the individual to at least one computerized element. Either or both of the first instance of the task and the interference includes at least one a computerized element. The user interface can be configured to measure data indicative of the response of the individual to the at least one computerized element, the data including at least one measure of cognitive capabilities of the individual. The example processing unit is configured to measure substantially

simultaneously the first response from the individual to the first instance of the task and the response from the individual to the at least one computerized element, and to receive data indicative of the first response and the response of the individual to the at least one computerized element. The example processing unit is also configured to analyze the data indicative of the first response and the response of the individual to the at least one computerized element to compute at least one performance metric comprising at least one quantified indicator of cognitive abilities of the individual. Based at least in part on the at least one performance metric, the example processing unit is also configured to generate an output to the user interface indicative of at least one of: (i) the cognitive abilities of the individual, (ii) the likelihood of effectiveness of the therapy for the mood disorder, (iil) a recommended amount, concentration, or dose titration of the psychedelic and/or dissociative drug administered during the therapy for the mood disorder, (iv) the likelihood of the individual experiencing an adverse event in response to administration of the psychedelic and/or dissociative drug, (v) a recommended treatment regimen using the cognitive platform following the therapy for the mood disorder, or (vi) a determination of a degree of effectiveness of therapy for the mood disorder. The example treatment regimen using the cognitive platform is configured to selectively target the areas of the brain of the individual involved in affective or emotional processing, such as but not limited to the amygdala and the pre-frontal cortex, to increase the likelihood or duration of remission of the therapy.

[240] In a non-limiting example, the processing unit can be further configured to measure substantially simultaneously the first response from the individual to the first instance of the task, a secondary response of the individual to the interference, and the response to the at least one computerized element.

[241] In a non- limiting example, the processing unit can be further configured to output to the individual or transmits to a computing device the computed at least one performance metric.

[242] In a non-limiting example, the processing unit can be further configured to render a second instance of the task at the user interface, requiring a second response from the individual to the second instance of the task, and analyze a difference between the data indicative of the first response and the second response to compute an interference cost as a measure of at least one additional indication of cognitive abilities of the individual.

[243] In a non-limiting example, based on the results of the analysis of the performance metrics, a medical, healthcare, or other professional (with consent of the individual) can gain a better understanding of potential adverse events which may occur (or potentially are occurring) if the individual is administered a particular type of, amount, concentration, or dose titration of a psychedelic and/or dissociative drug in a therapy for a mood disorder, including potentially affecting cognition.

[244] In a non-limiting example, a searchable database is provided herein that includes data indicative of the results of the analysis of the performance metrics for particular individuals, along with known levels of efficacy of at least one types of psychedelic and/or dissociative drug used in a therapy for a mood disorder experienced by the individuals, and/or quantifiable information on one or more adverse events experienced by the individual with administration of the at least one types of psychedelic and/or dissociative drug in the therapy for the mood disorder. The searchable database can be configured to provide metrics for use to determine whether a given individual is a candidate for benefiting from a particular type of psychedelic and/or dissociative drug administered in a therapy for a mood disorder based on the performance metrics, response measures, response profiles, and/or decision boundary metric (such as but not limited to response criteria) obtained for the individual in interacting with the task and/or interference rendered at the computing device. [245] As a non-limiting example, performance metrics can assist with identifying whether the individual is a candidate for a particular type of drug (such as but not limited to a stimulant, e.g., methylphenidate or amphetamine) or whether it might be beneficial for the individual to have the drug administered in conjunction with a regimen of specified repeated interactions with the tasks and/or interference rendered to the computing device. In other non-limiting examples, a biologic, drug or other pharmaceutical agent that may be applicable to any example described herein may include methylphenidate (MPH), scopolamine, donepezil hydrochloride, rivastigmine tartrate, memantine HC1, solanezumab, aducanumab, and crenezumab.

[246] In a non-limiting example, based on the results of the analysis of the performance metric, a medical, healthcare, or other professional (with consent of the individual) can gain a better understanding of potential adverse events which may occur (or potentially are occurring) if the individual is administered a different amount, concentration, or dose titration of a psychedelic and/or dissociative drug in a therapy for a mood disorder, including potentially affecting cognition.

[247] In a non-limiting example, a searchable database is provided herein that includes data indicative of the results of the analysis of the performance metrics for particular individuals, along with known levels of efficacy of at least one types of psychedelic and/or dissociative drug in a therapy for a mood disorder experiences by the individuals, and/or quantifiable information on one or more adverse events experienced by the individual with administration of the at least one types of psychedelic and/or dissociative drug in a therapy for a mood disorder. The searchable database can be configured to provide metrics for use to determine whether a given individual is a candidate for benefiting from a particular type of psychedelic and/or dissociative drug in a therapy for a mood disorder based on the response measures, response profiles, and/or decision boundary metric (such as but not limited to response criteria) obtained for the individual in interacting with the task and/or interference rendered at the computing device. As a non-limiting example, based on data indicative of a user interaction with the tasks and/or interference (including the computerized element) rendered at a user interface of a computing device, the performance metrics could provide information on the individual, based on the cognitive capabilities of the individual. This data can assist with identifying whether the individual is a candidate for a particular type of drug (such as but not limited to a stimulant, e.g., methylphenidate or amphetamine) or whether it might be beneficial for the individual to have the drug administered in conjunction with a regimen of specified repeated interactions with the tasks and/or interference rendered to the computing device. In other non-limiting examples, a biologic, drug or other pharmaceutical agent that may be applicable to any example described herein may include methylphenidate (MPH), scopolamine, donepezil hydrochloride, rivastigmine tartrate, memantine HC1, solanezumab, aducanumab, and crenezumab.

[248] In an example, the change in the individual’s cognitive response capabilities comprises an indication of a change in degree of impulsiveness or conservativeness of the individual’s cognitive response strategy.

[249] As a non-limiting example, given that impulsive behavior is attendant with ADHD, an example cognitive platform that is configured for delivering treatment (including of executive function) may promote less impulsive behavior in a regimen. This may target dopamine systems in the brain, increasing normal regulation, which may result in a transfer of benefits of the reduction of impulsive behavior to the everyday life of an individual.

[250] Stimulants such as methylphenidate and amphetamine are also administered to individuals with ADHD, to increase levels of norepinephrine and dopamine in the brain. Their cognitive effects may be attributed to their actions at the prefrontal cortex, however, there may not be remediation of cognitive control deficits or other cognitive abilities. An example cognitive platform herein can be configured for delivering treatment (including of executive function) to remediate an individual’s cognitive control deficit.

[251] The use of the example systems, methods, and apparatus according to the principles described herein can be applicable to many different types of mood disorders, such as but not limited to depression (major depressive disorder), anxiety, PTSD, or obsessive compulsive disorder (OCD). In some examples, the individual may also have other neuropsychological condition, such as but not limited to dementia, Parkinson’s disease, cerebral amyloid angiopathy, familial amyloid neuropathy, Huntington’s disease, or other neurodegenerative condition, autism spectrum disorder (ASD), presence of the l6pll.2 duplication, and/or an executive function disorder, such as but not limited to attention deficit hyperactivity disorder (ADHD), sensory-processing disorder (SPD), mild cognitive impairment (MCI), Alzheimer’s disease, multiple-sclerosis, or schizophrenia,.

[252] In any example implementation, data and other information from an individual is collected, transmitted, and analyzed with their consent. [253] As a non-limiting example, the cognitive platform described in connection with any example system, method and apparatus herein, including a cognitive platform based on interference processing, can be based on or include the Project: EVO™ platform by Akili Interactive Labs, Inc., Boston, MA.

Non-limiting Example Tasks and Interference

[254] Following is a summary of reported results showing the extensive physiological, behavioral, and cognitive measurements data and analysis of the regions of the brain, neural activity, and/or neural pathways mechanisms involved (e.g., activated or suppressed) as an individual interact with stimuli under differing cognitive or emotional load. The articles also described the differences that can be sensed and quantifiably measured based on the individual’s performance at cognitive tasks versus stimuli with computerized elements.

[255] Based on physiological and other measurements, regions of the brain implicated in emotional processing, cognitive tasks, and tasks, are reported. For example, in the review article by Pourtois et ak, 2013,“Brain mechanisms for emotional influences on perception and attention: What is magic and what is not,” Biological Psychology, 92, 492-512, it is reported that the amygdala monitors the emotional value of stimuli, projects to several other areas of the brain, and sends feedback to sensory pathways (including striate and extrastriate visual cortex). It is also reported that, due to an individual’s limited processing capacity, the individual cannot fully analyze simultaneous stimuli in parallel, and these stimuli compete for processing resources in order to gain access to higher cognitive stages and awareness of the individual. With an individual having to direct attention to the location or features of a given stimulus, neural activity in brain regions representing this stimulus increases, at the expense of other concurrent stimuli. Pourtois et al. indicates that this phenomenon has been extensively demonstrated by neuronal recordings as well as imaging methods (EEG, PET, fMRI), and attributed to a gain control. Pourtois et al. concludes that emotion signals may enhance processing efficiency and competitive strength of emotionally significant events through gain control mechanisms similar to those of other attentional systems, but mediated by distinct neural mechanisms in the amygdala and interconnected prefrontal areas, and indicate that alterations in these brain mechanisms might be associated with

psychopathological conditions, such as anxiety or phobia. It is also reported that anxious or depressed patients can show maladaptive attentional biases towards negative information. Pourtois et al. also reports that imaging results from EEG and fMRI support a conclusion that the processing of emotional (such as fearful or threat-related) stimuli yields a gain control effect in the visual cortex and the emotional gain control effect can account for the more efficient processing of threat-related stimuli, in addition to or in parallel with any concurrent modulation by other task-dependent or exogenous stimulus-driven mechanisms of attention (see also Brosch et al., 2011,“Additive effects of emotional, endogenous, and exogenous attention: behavioral and electrophysiological evidence,” Neuropsychologia 49, 1779-1787).

[256] As described hereinabove, emotional processing and cognitive processing each require interactions within and among specific brain networks. Major depressive disorder and other similar or related disorders can be associated with changes to cognitive capabilities in multiple cognitive domains including attention (concentration), memory (learning), decision making (judgment), comprehension, judgment, reasoning, understanding, learning, and remembering. The cognitive changes associated with depression can contribute to some of the disabilities experienced by individuals with this disorder.

[257] Individuals with major depressive disorder may respond to some treatment, such as antidepressants, to diminish the non-cognitive symptoms of depression. However, such treatments do not provide objective assessments of the individual’s cognitive deficits or decline, and existing clinical examinations provide few useful tools to assess changes in cognition. Individuals who have resolution of mood symptoms but not cognitive symptoms could be at risk for relapse, particularly when they are trying to function in complex work and social environments where cognitive defects could impact performance.

[258] Shilyansky et ak, 2016,“Effect of antidepressant treatment on cognitive impairments associated with depression: a randomized longitudinal study,” The Lancet Psychiatry, 3, 425 435, reports on the influence of antidepressant treatment on the cognitive deficits associated with major depression. Shilyansky et al. described a study of over 1,000 adults between the ages 18 and 65 suffering from major depressive disorder, none of whom was taking antidepressant medication at the start of the study. Various aspects of cognition were measured in the individuals before and after treatment with one of three antidepressants, using a variety of neuropsychological tests. The test results were compared to the results derived from administering these neuropsychological tests to a group of age- and education- matched individuals not diagnosed as suffering from major depressive disorder.

[259] Shilyansky et al. discloses that, prior to treatment, the study individuals demonstrated diminished abilities in seven cognitive domains: attention, response inhibition, verbal memory, executive function, cognitive flexibility, decision speed, and information processing. Following treatment and remission of clinical symptoms, the neuropsychological test results showed that five of the seven cognitive domains remained compromised after the non-cognitive symptoms of depression improved in the study individuals. Executive function and cognitive flexibility showed some change with antidepressant treatment. The results indicated that individuals with a history of depression may still be handicapped by the cognitive deficits of this illness even after other depressive symptoms improve (independent of the type of antidepressants used).

[260] Shilyansky et al. demonstrates major depressive disorder is associated with cognitive impairment, which may persist even after other symptoms of the disorder are managed. Unless this cognitive impairment is addressed, individuals with depression may not be able to function in complex environments, even if mood symptoms are under control. The systems, methods, and apparatus described herein are configured to provide an indication of the individual's performance, and/or for cognitive assessment, (e.g., to determine the degree of cognitive impairment), and/or to deliver a cognitive treatment (i.e., through enhancing cognitive capabilities using adaptive application of tasks and/or interference through interference processing).

[261] As described hereinabove, the individual’ response to a stimulus can vary depending on the state of the individual, including based on the individual’s cognitive condition, disease, or executive function disorder. Measurements of the individual’s performance can provide insight into the individual’s status relative to a cognitive condition, disease, or executive function disorder, including the likelihood of onset and/or stage of progression of the cognitive condition, disease, or executive function disorder.

[262] The foregoing non-limiting examples of physiological measurement data, behavioral data, and other cognitive data, show that the responses of an individual to tasks can differ based on the type of stimuli. Furthermore, the foregoing examples indicate that the degree to which an individual is affected by a computerized element, and the degree to which the performance of the individual at a task is affected in the presence of the computerized element, is dependent on the degree to which the individual exhibits a form of emotional or affective bias. As described herein, the differences in the individual’s performance may be quantifiably sensed and measured based on the performance of the individual at cognitive tasks versus stimuli with computerized elements (which in some examples may include one or more emotional or affective elements). The reported physiological measurement data, behavioral data, and other cognitive data, also show that the cognitive or emotional load evoked by a stimulus can vary depending on the state of an individual, including based on the individual’s cognitive condition, disease state, or presence or absence of executive function disorder. As described herein, measurements of the differences in the individual’s performance at cognitive tasks versus stimuli with computerized elements can provide quantifiable insight into the likelihood of onset and/or stage of progression of a cognitive condition, disease, and/or executive function disorder, in the individual, such as but not limited to, social anxiety, depression, bipolar disorder, major depressive disorder, post- traumatic stress disorder, schizophrenia, autism spectrum disorder, attention deficit hyperactivity disorder, dementia, Parkinson's disease, Huntington's disease, or other neurodegenerative condition, Alzheimer’s disease, or multiple-sclerosis.

[263] The effects of interference processing on the cognitive control abilities of individuals has been reported. See, e.g., A. Anguera, Nature 501, p. 97 (September 5, 2013) (the "Nature article”). See, also, U.S. Publication No. 20140370479A1 (U.S. Application 13/879,589), filed on Nov. 10, 2011, which is incorporated herein by reference. Some of those cognitive abilities include cognitive control abilities in the areas of attention

(selectivity, sustainability, etc.), working memory (capacity and the quality of information maintenance in working memory) and goal management (ability to effectively parallel process two attention-demanding tasks or to switch tasks). As an example, children diagnosed with ADHD (attention deficit hyperactivity disorder) exhibit difficulties in sustaining attention. Attention selectivity was found to depend on neural processes involved in ignoring goal-irrelevant information and on processes that facilitate the focus on goal relevant information. The publications report neural data showing that when two objects are simultaneously placed in view, focusing attention on one can pull visual processing resources away from the other. Studies were also reported showing that memory depended more on effectively ignoring distractions, and the ability to maintain information in mind is vulnerable to interference by both distraction and interruption. Interference by distraction can be, e.g., an interference that is a non-target, that distracts the individual's attention from the primary task, but that the instructions indicate the individual is not to respond to. Interference by interruption/interruptor can be, e.g., an interference that is a target or two or more targets, that also distracts the individual's attention from the primary task, but that the instructions indicate the individual is to respond to (e.g., for a single target) or choose between/among (e.g., a forced-choose situation where the individual decides between differing degrees of a feature).

[264] There were also fMRI results reported showing that diminished memory recall in the presence of a distraction can be associated with a disruption of a neural network involving the prefrontal cortex, the visual cortex, and the hippocampus (involved in memory consolidation). Prefrontal cortex networks (which play a role in selective attention) can be vulnerable to disruption by distraction. The publications also report that goal management, which requires cognitive control in the areas of working memory or selective attention, can be impacted by a secondary goal that also demands cognitive control. The publications also reported data indicating beneficial effects of interference processing as an intervention with effects on an individual’s cognitive abilities, including to diminish the detrimental effects of distractions and interruptions. The publications described cost measures that can be computed (including an interference cost) to quantify the individual’s performance, including to assess single-tasking or multitasking performance.

[265] An example cost measure disclosed in the publications is the percentage change in an individual’s performance at a single-tasking task as compared to a multi-tasking task, such that greater cost (that is, a more negative percentage cost) indicates increased interference when an individual is engaged in single-tasking vs multi-tasking. The publications describe an interference cost determined as the difference between an individual's performance on a task in isolation versus a task with one or more interference applied, where the interference cost provide an assessment of the individual’s susceptibility to interference.

[266] The tangible benefits of computer-implemented interference processing are also reported. For example, the Nature paper states that multi-tasking performance assessed using computer-implemented interference processing was able to quantify a linear age-related decline in performance in adults from 20 to 79 years of age. The Nature paper also reports that older adults (60 to 85 years old) who interacted with an adaptive form of the computer- implemented interference processing exhibited reduced multitasking costs, with the gains persisting for six (6) months. The Nature paper also reported that age-related deficits in neural signatures of cognitive control, as measured with electroencephalography, were remediated by the multitasking training (using the computer-implemented interference processing), with enhanced midline frontal theta power and frontal-posterior theta coherence. Interacting with the computer-implemented interference processing resulted in performance benefits that extended to untrained cognitive control abilities (enhanced sustained attention and working memory), with an increase in midline frontal theta power predicting a boost in sustained attention and preservation of multitasking improvement six (6) months later.

[267] The example systems, methods, and apparatus according to the principles herein are configured to classify an individual as to cognitive abilities and/or to enhance those cognitive abilities based on implementation of interference processing using a computerized cognitive platform. The example systems, methods, and apparatus are configured to implement a form of multi-tasking using the capabilities of a programmed computing device, where an individual is required to perform a task and an interference substantially simultaneously, where the task and/or the interference includes a computerized element, and the individual is required to respond to the computerized element. The sensing and measurement capabilities of the computing device are configured to collect data indicative of the physical actions taken by the individual during the response execution time to respond to the task at substantially the same time as the computing device collects the data indicative of the physical actions taken by the individual to respond to the computerized element. The capabilities of the computing devices and programmed processing units to render the task and/or the interference in real time to a user interface, and to measure the data indicative of the individual’s responses to the task and/or the interference and the computerized element in real time and substantially simultaneously can provide quantifiable measures of an individual’s cognitive capabilities, to rapidly switch to and from different tasks and interferences, or to perform multiple, different, tasks or interferences in a row (including for single-tasking, where the individual is required to perform a single type of task for a set period of time).

[268] In any example herein, the task and/or interference includes a response deadline, such that the user interface imposes a limited time period for receiving at least one type of response from the individual interacting with the apparatus or computing device. For example, the period of time that an individual is required to interact with a computing device or other apparatus to perform a task and/or an interference can be a predetermined amount of time, such as but not limited to about 30 seconds, about 1 minute, about 4 minutes, about 7 minutes, about 10 minutes, or greater than 10 minutes.

[269] The example systems, methods, and apparatus can be configured to implement a form of multi-tasking to provide measures of the individual’s capabilities in deciding whether to perform one action instead of another and to activate the rules of the current task in the presence of an interference such that the interference diverts the individual’s attention from the task, as a measure of an individual’s cognitive abilities in executive function control.

[270] The example systems, methods, and apparatus can be configured to implement a form of single-tasking, where measures of the individual’s performance at interacting with a single type of task (i.e., with no interference) for a set period of time (such as but not limited to navigation task only or a target discriminating task only) can also be used to provide measure of an individual’s cognitive abilities.

[271] The example systems, methods, and apparatus can be configured to implement sessions that involve differing sequences and combinations of single-tasking and multi tasking trials. In a first example implementation, a session can include a first single-tasking trial (with a first type of task), a second single-tasking trial (with a second type of task), and a multi-tasking trial (a primary task rendered with an interference). In a second example implementation, a session can include two or more multi-tasking trials (a primary task rendered with an interference). In a third example implementation, a session can include two or more single-tasking trials (all based on the same type of tasks or at least one being based on a different type of task).

[272] The performance can be further analyzed to compare the effects of two different types of interference (e.g. distraction or interruptor) on the performances of the various tasks. Some comparisons can include performance without interference, performance with distraction, and performance with interruption. The cost of each type of interference (e.g. distraction cost and interruptor/multi-tasking cost) on the performance level of a task is analyzed and reported to the individual.

[273] In any example herein, the interference can a secondary task that includes a stimulus that is either a non- target (as a distraction) or a target (as an interruptor), or a stimulus that is differing types of targets (e.g., differing degrees of a facial expression or other characteristic/feature difference).

[274] Based on the capability of a programmed processing unit to control the effecting of multiple separate sources (including sensors and other measurement components) and the receiving of data selectively from these multiple different sources at substantially

simultaneously (i.e., at roughly the same time or within a short time interval) and in real-time, the example systems, methods, and apparatus herein can be used to collect quantitative measures of the responses form an individual to the task and/or interference, which could not be achieved using normal human capabilities. As a result, the example systems, methods, and apparatus herein can be configured to implement a programmed processing unit to render the interference substantially simultaneously with the task over certain time periods.

[275] In some example implementations, the example systems, methods, and apparatus herein also can be configured to receive the data indicative of the measure of the degree and type of the individual’s response to the task substantially simultaneously as the data indicative of the measure of the degree and type of the individual’s response to the interference is collected (whether the interference includes a target or a non-target). In some examples, the example systems, methods, and apparatus are configured to perform the analysis by applying scoring or weighting factors to the measured data indicative of the individual’s response to a non-target that differ from the scoring or weighting factors applied to the measured data indicative of the individual’s response to a target, in order to compute a cost measure (including an interference cost).

[276] In an example systems, methods, and apparatus herein, the cost measure can be computed based on the difference in measures of the performance of the individual at one or more tasks in the absence of interference as compared to the measures of the performance of the individual at the one or more tasks in the presence of interference, where the one or more tasks and/or the interference includes one or more computerized elements. As described herein, the requirement of the individual to interact with (and provide a response to) the computerized element(s) can introduce cognitive or emotional load that quantifiably affects the individuals capability at performing the task(s) and/or interference due to the requirement for emotional processing to respond to the computerized element. In an example, the interference cost computed based on the data collected herein can provide a quantifiable assessment of the individual’s susceptibility to interference. The determination the difference between an individual's performance on a task in isolation versus a task in the presence of one or more interference (the task and/or interference including the computerized element) provides an interference cost metric that can be used to assess and classify cognitive capabilities of the individual. The interference cost computed based on the individuals performance of tasks and/or interference performed can also provide a quantifiable measure of the individual’s cognitive condition, disease state, or presence or stage of an executive function disorder, such as but not limited to, social anxiety, depression, bipolar disorder, major depressive disorder, post-traumatic stress disorder, schizophrenia, autism spectrum disorder, attention deficit hyperactivity disorder, dementia, Parkinson's disease, Huntington's disease, or other neurodegenerative condition, Alzheimer’s disease, or multiple-sclerosis.

[277] The example systems, methods, and apparatus herein can be configured to perform the analysis of the individual’s susceptibility to interference (including as a cost measure such as the interference cost), as a reiterating, cyclical process. For example, where an individual is determined to have minimized interference cost for a given task and/or interference, the example systems, methods, and apparatus can be configured to require the individual to perform a more challenging task and/or interference (i.e., having a higher difficulty level) until the individual’s performance metric indicates a minimized interference cost in that given condition, at which point example systems, methods, and apparatus can be configured to present the individual with an even more challenging task and/or interference until the individual’s performance metric once again indicates a minimized interference cost for that condition. This can be repeated any number of times until a desired end-point of the individual’s performance is obtained.

[278] As a non- limiting example, the interference cost can be computed based on measurements of the individual’s performance at a single-tasking task (without an interference) as compared to a multi-tasking task (with interference), to provide an assessment. For example, an individual’s performance at a multi-tasking task (e.g., targeting task with interference) can be compared to their performance at a single-tasking targeting task without interference to provide the interference cost.

[279] Example systems, apparatus and methods herein are configured to analyze data indicative of the degree to which an individual is affected by a computerized element, and/or the degree to which the performance of the individual at a task is affected in the presence of the computerized element, to provide performance metric including a quantified indicator of cognitive abilities of the individual. The performance metric can be used as an indicator of the degree to which the individual exhibits a form of emotional or affective bias.

[280] In some example implementations, the example systems, methods, and apparatus herein also can be configured to selectively receive data indicative of the measure of the degree and type of the individual’s response to an interference that includes a target stimulus (i.e., an interruptor) substantially simultaneously (i.e., at substantially the same time) as the data indicative of the measure of the degree and type of the individual’s response to the task is collected and to selectively not collect the measure of the degree and type of the individual’s response to an interference that includes a non- target stimulus (i.e., a distraction) substantially simultaneously (i.e., at substantially the same time) as the data indicative of the measure of the degree and type of the individual’s response to the task is collected. That is, the example systems, methods, and apparatus are configured to discriminate between the windows of response of the individual to the target versus non-target by selectively controlling the state of the sensing/measurement components for measuring the response either temporally and/or spatially. This can be achieved by selectively activating or de activating sensing/measurement components based on the presentation of a target or non- target, or by receiving the data measured for the individual’s response to a target and selectively not receiving (e.g., disregarding, denying, or rejecting) the data measured for the individual’s response to a non-target.

[281] As described herein, using the example systems, methods, and apparatus herein can be implemented to provide a measure of the cognitive abilities of an individual in the area of attention, including based on capabilities for sustainability of attention over time, selectivity of attention, and reduction of attention deficit. Other areas of an individual’s cognitive abilities that can be measured using the example systems, methods, and apparatus herein include affective bias, mood, level of cognitive bias, impulsivity, inhibition, perceptive abilities, reaction and other motor functions, visual acuity, long-term memory, working memory, short-term memory, logic, and decision-making.

[282] As described herein, using the example systems, methods, and apparatus herein can be implemented to adapt the tasks and/or interference (at least one including a computerized element) from one user session to another (or even from one user trial to another) to enhance the cognitive skills of an individual based on the science of brain plasticity. Adaptivity is a beneficial design element for any effective plasticity-harnessing tool. In example systems, methods, and apparatus, the processing unit is configured to control parameters of the tasks and/or interference, such as but not limited to the timing, positioning, and nature of the stimuli, so that the physical actions of the individual can be recorded during the interaction(s). As described hereinabove, the individual’s physical actions are affected by their neural activity during the interactions with the computing device to perform single-tasking and multi-tasking tasks. The science of interference processing shows (based on the results from physiological and behavioral measurements) that the aspect of adaptivity can result in changes in the brain of an individual in response to the training from multiple sessions (or trials) based on neuroplasticity, thereby enhancing the cognitive skills of the individual. The example systems, methods, and apparatus are configured to implement tasks and/or interference with at least one computerized element, where the individual performs the interference processing. As supported in the published research results described hereinabove, the effect on an individual of performing tasks can tap into novel aspects of cognitive training to enhance the cognitive abilities of the individual.

[283] FIGs. 3A - 5T show non-limiting example user interfaces that can be rendered using example systems, methods, and apparatus herein to render the tasks and/or

interferences (either or both with computerized element) for user interactions. The non- limiting example user interfaces of FIGs. 3A - 5T also can be used for one or more of: to display instructions to the individual for performing the tasks and/or interferences, interact with the computerized element, to collect the data indicative of the individual’s responses to the tasks and/or the interferences and the computerized element, to show progress metrics, and to provide the analysis metrics.

[284] FIGs. 3A - 3D show non-limiting example user interfaces rendered using example systems, methods, and apparatus herein. As shown in FIGs. 3A - 3B, an example programmed processing unit can be used to render to the user interfaces (including graphical user interfaces) display features 300 for displaying instructions to the individual for performing the tasks and/or interferences and to interact with the computerized element, and metric features 302 to show status indicators from progress metrics and/or results from application of analytics to the data collected from the individual’ s interactions (including the responses to tasks/interferences) to provide the analysis metrics. In any example systems, methods, and apparatus herein, the classifier can be used to provide the analysis metrics provided as a response output. In any example systems, methods, and apparatus herein, the data collected from the user interactions can be used as input to train the classifier. As shown in FIGs. 3A - 3B, an example programmed processing unit also may be used to render to the user interfaces (including graphical user interfaces) an avatar or other processor-rendered guide 304 that an individual is required to control (such as but not limited to navigate a path or other environment in a visuo-motor task, and/or to select an object in a target

discrimination task). In an example, the computerized element may be includes as a component of the visuo-motor task (e.g., as a milestone object along the math) or as a component of the target discrimination task, e.g., where a specific type of computerized element (such as but not limited to an angry or happy face, loud or angry voice or a threat or fear-inducing word) is the target, and other types of the computerized element are not (such as but not limited to a neutral face, a happy voice, or a neutral word). As shown in FIG. 3B, the display features 300 can be used to instruct the individual what is expected to perform a navigation task while the user interface depicts (using the dashed line) the type of movement of the avatar or other processor-rendered guide 304 required for performing the navigation task. In an example, the navigation task may include milestone objects (possibly including computerized elements) that the individual is required to steer an avatar to cross or avoid, in order to determine the scoring. As shown in FIG. 3C, the display features 300 can be used to instruct the individual what is expected to perform a target discrimination task while the user interface depicts the type of object(s) 306 and 308 that may be rendered to the user interface, with one type of object 306 (possibly including a target computerized element) designated as a target while the other type of object 308 that may be rendered to the user interface is designated as a non-target (possibly including a non-target computerized element), e.g., by being crossed out in this example. As shown in FIG. 3D, the display features 300 can be used to instruct the individual what is expected to perform both a navigation task as a primary task and a target discrimination as a secondary task (i.e., an interference) while the user interface depicts (using the dashed line) the type of movement of the avatar or other processor-rendered guide 304 required for performing the navigation task, and the user interface renders the object type designated as a target object 306 and the object type designated as a non-target object 308.

[285] FIGs. 4A - 4D show examples of the features of object(s) (targets or non-targets) that can be rendered as time- varying characteristics to an example user interface, according to the principles herein. FIG. 4A shows an example where the modification to the time-varying characteristics of an aspect of the object 400 rendered to the user interface is a dynamic change in position and/or speed of the object 400 relative to environment rendered in the graphical user interface. FIG. 4B shows an example where the modification to the time- varying characteristics of an aspect of the object 402 rendered to the user interface is a dynamic change in size and/or direction of trajectory/motion, and/or orientation of the object 402 relative to the environment rendered in the graphical user interface. FIG. 4C shows an example where the modification to the time-varying characteristics of an aspect of the object 404 rendered to the user interface is a dynamic change in shape or other type of the object 404 relative to the environment rendered in the graphical user interface. In this non- limiting example, the time-varying characteristic of object 404 is effected using morphing from a first type of object (a star object) to a second type of object (a round object). In another non limiting example, the time- varying characteristic of object 404 is effected by rendering a blendshape as a proportionate combination of a first type of object and a second type of object. FIG. 4C shows an example where the modification to the time- varying characteristics of an aspect of the object 404 rendered to the user interface is a dynamic change in shape or other type of the object 404 rendered in the graphical user interface (in this non-limiting example, from a star object to a round object). FIG. 4D shows an example where the modification to the time-varying characteristics of an aspect of the object 406 rendered to the user interface is a dynamic change in pattern, or color, or visual feature of the object 406 relative to environment rendered in the graphical user interface (in this non-limiting example, from a star object having a first pattern to a round object having a second pattern). In another non-limiting example, the time-varying characteristic of object can be a rate of change of a facial expression depicted on or relative to the object. In any example herein, the foregoing time-varying characteristic can be applied to an object including the computerized element to modify an cognitive or emotional load of the individual’s interaction with the apparatus (e.g., computing device or cognitive platform).

[286] FIGs. 5A - 5T show a non-limiting example of the dynamics of tasks and interferences that can be rendered at user interfaces, according to the principles herein. In this example, the primary task is a visuo-motor navigation task, and the interference is target discrimination (as a secondary task). As shown in FIGs. 5D, 51 - 5K, and 50 - 5Q, the individual is required to perform the navigation task by controlling the motion of the avatar 502 along a path that coincides with the milestone objects 504. FIGs. 5A - 5T show a non limiting example implementation where the individual is expected to actuate an apparatus or computing device (or other sensing device) to cause the avatar 502 to coincide with the milestone object 504 as the response in the navigation task, with scoring based on the success of the individual at crossing paths with (e.g., hitting) the milestone objects 504. In another example, the individual is expected to actuate an apparatus or computing device (or other sensing device) to cause the avatar 502 to miss the milestone object 504, with scoring based on the success of the individual at avoiding the milestone objects 504. FIGs. 5A - 5C show the dynamics of a target object 506 (a star having a first type of pattern). FIGs. 5E - 5H show the dynamics of a non-target object 508 (a star having a second type of pattern). FIGs. 51 - 5T show the dynamics of other portions of the navigation task, where the individual is expected to guide the avatar 502 to cross paths with the milestone object 504 in the absence of an interference (an instance of a secondary task).

[287] In the example of FIGs. 5A - 5T, the processing unit of the example system, method, and apparatus is configured to receive data indicative of the individual’s physical actions to cause the avatar 502 to navigate the path. For example, the individual may be required to perform physical actions to“steer” the avatar, e.g., by changing the rotational orientation or otherwise moving a computing device. Such action can cause a gyroscope or accelerometer or other motion or position sensor device to detect the movement, thereby providing measurement data indicative of the individual’s degree of success in performing the navigation task. [288] In the example of FIGs. 5A - 5C and 5E - 5H, the processing unit of the example system, method, and apparatus is configured to receive data indicative of the individual’s physical actions to perform the target discrimination task. For example, the individual may be instructed prior to a trial or other session to tap, or make other physical indication, in response to display of a target object 506, and not to tap to make the physical indication in response to display of a non-target object 508. In FIGs. 5A - 5C and 5E - 5H, the target discrimination task acts as an interference (i.e., an instance of a secondary task) to the primary navigation task, in an interference processing multi-tasking implementation. As described hereinabove, the example systems, methods, and apparatus can cause the processing unit to render a display feature to display the instructions to the individual as to the expected performance. As also described hereinabove, the processing unit of the example system, method, and apparatus can be configured to (i) receive the data indicative of the measure of the degree and type of the individual’s response to the primary task substantially simultaneously as the data indicative of the measure of the degree and type of the individual’s response to the interference is collected (whether the interference includes a target or a non target), or (ii) to selectively receive data indicative of the measure of the degree and type of the individual’s response to an interference that includes a target stimulus (i.e., an interruptor) substantially simultaneously (i.e., at substantially the same time) as the data indicative of the measure of the degree and type of the individual’s response to the task is collected and to selectively not collect the measure of the degree and type of the individual’s response to an interference that includes a non- target stimulus (i.e., a distraction) substantially

simultaneously (i.e., at substantially the same time) as the data indicative of the measure of the degree and type of the individual’s response to the task is collected.

[289] In various examples, the degree of non-linearity of the accumulation of belief for an individual’s decision making (i.e., as to whether to execute a response) can be modulated based on adjusting the time- varying characteristics of the task and/or interference. As a non limiting example, where the time-varying characteristic is a trajectory, speed, orientation, type and/or size of the object (target or non-target), the amount of information available to an individual to develop a belief (in order to make decision as to whether to execute a response) can be made smaller initially, e.g., where the object caused to be more difficult to

discriminate by being rendered as farther away or smaller, and can be made to increase at differing rates (nonlinearly) depending on how quickly more information is made available to the individual to develop belief (e.g., as the object is rendered to appear to get larger, change orientation, move slower, or move closer in the environment). Other non-limiting example time-varying characteristics of the task and/or interference that can be adjusted to modulate the degree of non-linearity of the accumulation of belief include one or more of a rate of change of a facial expression, at least one color of an object, the type of the object (including whether there is one or two or more differing types of target objects), a rate of morphing of a first type of object to change to a second type of object, and a blendshape of computerized elements.

[290] The data indicative of the individual’s response to the task and the response of the individual to the at least one computerized element is used to compute at least one performance metric comprising at least one quantified indicator of cognitive abilities of the individual. In a non-limiting example, the performance metric can include the computed interference cost.

[291] The difficulty levels (including the difficulty of the task and/or interference, and of the computerized element) of a subsequent session can be set based on the performance metric computed for the individual’s performance from a previous session, and can be optimized to modify an individual’s performance metric (e.g., to lower or optimize the interference cost).

[292] In a non-limiting example, the adaptation of the difficulty of a task and/or interference may be adapted with each different stimulus that is presented as a computerized element.

[293] In another non-limiting example, the example system, method, and apparatus herein can be configured to adapt a difficulty level of a task and/or interference (including the computerized element) one or more times in fixed time intervals or in other set schedule, such as but not limited to each second, in 10 second intervals, every 30 seconds, or on frequencies of once per second, 2 times per second, or more (such as but not limited to 30 times per second).

[294] In an example, the difficulty level of a task or interference can be adapted by changing the time- varying characteristics, such as but not limited to a speed of an object, a rate of change of a facial expression, a direction of trajectory of an object, a change of orientation of an object, at least one color of an object, a type of an object, or a size of an object, or changing a sequence or balance of presentation of a target stimulus versus a non target stimulus. [295] In a non-limiting example of a visuo-motor task (a type of navigation task), one or more of navigation speed, shape of the course (changing frequency of turns, changing turning radius), and number or size of obstacles can be changed to modify the difficulty of a navigation game level, with the difficulty level increasing with increasing speed and/or increasing numbers and/or sizes of obstacles (including types of milestone objects (e.g., some milestone objects to avoid or some milestone objects to cross/coincide with)).

[296] In a non-limiting example, the difficulty level of a task and/or interference of a subsequent level can also be changed in real-time as feedback, e.g., the difficulty of a subsequent level can be increased or decreased in relation to the data indicative of the performance of the task.

[297] FIG. 6 is a block diagram of an example computing device 6110 that can be used as a computing component according to the principles herein. In any example herein, computing device 6110 can be configured as a console that receives user input to implement the computing component, including to apply the signal detection metrics in computer- implemented adaptive response-deadline procedures. For clarity, FIG. 6 also refers back to and provides greater detail regarding various elements of the example system of FIG. 1 and the example computing device of FIG. 2. The computing device 6110 can include one or more non-transitory computer-readable media for storing one or more computer-executable instructions or software for implementing examples. The non-transitory computer-readable media can include, but are not limited to, one or more types of hardware memory, non- transitory tangible media (for example, one or more magnetic storage disks, one or more optical disks, one or more flash drives), and the like. For example, memory 102 included in the computing device 6110 can store computer-readable and computer-executable instructions or software for performing the operations disclosed herein. For example, the memory 102 can store a software application 6140 which is configured to perform various of the disclosed operations (e.g., analyze cognitive platform measurement data and response data (including response to the computerized element), compute a performance metric (including an interference cost), or perform other computation as described herein). The computing device 6110 also includes configurable and/or programmable processor 104 and an associated core 6114, and optionally, one or more additional configurable and/or programmable processing devices, e.g., processor(s) 6112' and associated core(s) 6114' (for example, in the case of computational devices having multiple processors/cores), for executing computer-readable and computer-executable instructions or software stored in the memory 102 and other programs for controlling system hardware. Processor 104 and processor(s) 6112' can each be a single core processor or multiple core (6114 and 6114') processor.

[298] Virtualization can be employed in the computing device 6110 so that infrastructure and resources in the console can be shared dynamically. A virtual machine 6124 can be provided to handle a process running on multiple processors so that the process appears to be using only one computing resource rather than multiple computing resources. Multiple virtual machines can also be used with one processor.

[299] Memory 102 can include a computational device memory or random access memory, such as DRAM, SRAM, EDO RAM, and the like. Memory 102 can include other types of memory as well, or combinations thereof.

[300] A user can interact with the computing device 6110 through a visual display unit 6128, such as a computer monitor, which can display one or more user interfaces (UI) 6130 that can be provided in accordance with example systems and methods. The computing device 6110 can include other I/O devices for receiving input from a user, for example, a keyboard or any suitable multi -point touch interface 6118, a pointing device 6120 (e.g., a mouse). The keyboard 6118 and the pointing device 6120 can be coupled to the visual display unit 6128. The computing device 6110 can include other suitable conventional I/O peripherals.

[301] The computing device 6110 can also include one or more storage devices 6134, such as a hard-drive, CD-ROM, or other computer readable media, for storing data and computer-readable instructions and/or software that perform operations disclosed herein. Example storage device 6134 can also store one or more databases for storing any suitable information required to implement example systems and methods. The databases can be updated manually or automatically at any suitable time to add, delete, and/or update one or more items in the databases.

[302] The computing device 6110 can include a network interface 6122 configured to interface via one or more network devices 6132 with one or more networks, for example, Local Area Network (LAN), Wide Area Network (WAN) or the Internet through a variety of connections including, but not limited to, standard telephone lines, LAN or WAN links (for example, 802.11, Tl, T3, 56kb, X.25), broadband connections (for example, ISDN, Lrame Relay, ATM), wireless connections, controller area network (CAN), or some combination of any or all of the above. The network interface 6122 can include a built-in network adapter, network interface card, PCMCIA network card, card bus network adapter, wireless network adapter, USB network adapter, modem or any other device suitable for interfacing the computing device 6110 to any type of network capable of communication and performing the operations described herein. Moreover, the computing device 6110 can be any computational device, such as a workstation, desktop computer, server, laptop, handheld computer, tablet computer, or other form of computing or telecommunications device that is capable of communication and that has sufficient processor power and memory capacity to perform the operations described herein.

[303] The computing device 6110 can ran any operating system 6126, such as any of the versions of the Microsoft® Windows® operating systems, the different releases of the Unix and Linux operating systems, any version of the MacOS® for Macintosh computers, any embedded operating system, any real-time operating system, any open source operating system, any proprietary operating system, or any other operating system capable of running on the console and performing the operations described herein. In some examples, the operating system 6126 can be run in native mode or emulated mode. In an example, the operating system 6126 can be run on one or more cloud machine instances.

[304] Examples of the systems, methods and operations described herein can be implemented in digital electronic circuitry, or in computer software, firmware, or hardware, including the structures disclosed in this specification and their structural equivalents, or in combinations of one or more thereof. Examples of the systems, methods and operations described herein can be implemented as one or more computer programs, i.e., one or more modules of computer program instructions, encoded on computer storage medium for execution by, or to control the operation of, data processing apparatus. The program instructions can be encoded on an artificially generated propagated signal, e.g., a machine generated electrical, optical, or electromagnetic signal, that is generated to encode information for transmission to suitable receiver apparatus for execution by a data processing apparatus. A computer storage medium can be, or be included in, a computer-readable storage device, a computer-readable storage substrate, a random or serial access memory array or device, or a combination of one or more of them. Moreover, while a computer storage medium is not a propagated signal, a computer storage medium can be a source or destination of computer program instructions encoded in an artificially generated propagated signal. The computer storage medium can also be, or be included in, one or more separate physical components or media (e.g., multiple CDs, disks, or other storage devices). [305] The operations described in this specification can be implemented as operations performed by a data processing apparatus on data stored on one or more computer-readable storage devices or received from other sources.

[306] The term“data processing apparatus” or“computing device” encompasses all kinds of apparatus, devices, and machines for processing data, including by way of example a programmable processor, a computer, a system on a chip, or multiple ones, or combinations, of the foregoing. The apparatus can include special purpose logic circuitry, e.g., an FPGA (field programmable gate array) or an ASIC (application specific integrated circuit). The apparatus can also include, in addition to hardware, code that creates an execution environment for the computer program in question, e.g., code that constitutes processor firmware, a protocol stack, a database management system, an operating system, a cross platform runtime environment, a virtual machine, or a combination of one or more of them.

[307] A computer program (also known as a program, software, software application, script, application or code) can be written in any form of programming language, including compiled or interpreted languages, declarative or procedural languages, and it can be deployed in any form, including as a stand alone program or as a module, component, subroutine, object, or other unit suitable for use in a computing environment. A computer program may, but need not, correspond to a file in a file system. A program can be stored in a portion of a file that holds other programs or data (e.g., one or more scripts stored in a markup language document), in a single file dedicated to the program in question, or in multiple coordinated files (e.g., files that store one or more modules, sub programs, or portions of code). A computer program can be deployed to be executed on one computer or on multiple computers that are located at one site or distributed across multiple sites and interconnected by a communication network.

[308] The processes and logic flows described in this specification can be performed by one or more programmable processors executing on one or more computer programs to perform actions by operating on input data and generating output. The processes and logic flows can also be performed by, and apparatuses can also be implemented as, special purpose logic circuitry, e.g., an FPGA (field programmable gate array) or an ASIC (application specific integrated circuit).

[309] Processors suitable for the execution of a computer program include, by way of example, both general and special purpose microprocessors, and any one or more processors of any kind of digital computer. Generally, a processor will receive instructions and data from a read only memory or a random access memory or both. The essential elements of a computer are a processor for performing actions in accordance with instructions and one or more memory devices for storing instructions and data. Generally, a computer will also include, or be operatively coupled to receive data from or transfer data to, or both, one or more mass storage devices for storing data, e.g., magnetic, magneto-optical disks, or optical disks. However, a computer need not have such devices. Moreover, a computer can be embedded in another device, e.g., a mobile telephone, a personal digital assistant (PDA), a mobile audio or video player, a game console, a Global Positioning System (GPS) receiver, or a portable storage device (e.g., a universal serial bus (USB) flash drive), for example. Devices suitable for storing computer program instructions and data include all forms of non volatile memory, media and memory devices, including by way of example semiconductor memory devices, e.g., EPROM, EEPROM, and flash memory devices; magnetic disks, e.g., internal hard disks or removable disks; magneto-optical disks; and CD ROM and DVD-ROM disks. The processor and the memory can be supplemented by, or incorporated in, special purpose logic circuitry.

[310] To provide for interaction with a user, embodiments of the subject matter described in this specification can be implemented on a computer having a display device, for displaying information to the user and a keyboard and a pointing device, e.g., a mouse, a stylus, touch screen or a trackball, by which the user can provide input to the computer. Other kinds of devices can be used to provide for interaction with a user as well. For example, feedback (i.e., output) provided to the user can be any form of sensory feedback, e.g., visual feedback, auditory feedback, or tactile feedback; and input from the user can be received in any form, including acoustic, speech, or tactile input. In addition, a computer can interact with a user by sending documents to and receiving documents from a device that is used by the user; for example, by sending web pages to a web browser on a user’ s client device in response to requests received from the web browser.

[311] In some examples, a system, method or operation herein can be implemented in a computing system that includes a back end component, e.g., as a data server, or that includes a middleware component, e.g., an application server, or that includes a front end component, e.g., a client computer having a graphical user interface or a Web browser through which a user can interact with an implementation of the subject matter described in this specification, or any combination of one or more such back end, middleware, or front end components. The components of the system can be interconnected by any form or medium of digital data communication, e.g., a communication network. Examples of communication networks include a local area network (“LAN”) and a wide area network (“WAN”), an inter-network (e.g., the Internet), and peer-to-peer networks (e.g., ad hoc peer-to-peer networks).

[312] Example computing system 400 can include clients and servers. A client and server are generally remote from each other and typically interact through a communication network. The relationship of client and server arises by virtue of computer programs running on the respective computers and having a client-server relationship to each other. In some embodiments, a server transmits data to a client device (e.g., for purposes of displaying data to and receiving user input from a user interacting with the client device). Data generated at the client device (e.g., a result of the user interaction) can be received from the client device at the server.

Conclusion

[313] The above-described embodiments can be implemented in any of numerous ways. For example, some embodiments may be implemented using hardware, software or a combination thereof. When any aspect of an embodiment is implemented at least in part in software, the software code can be executed on any suitable processor or collection of processors, whether provided in a single computer or distributed among multiple computers.

[314] In this respect, various aspects of the invention may be embodied at least in part as a computer readable storage medium (or multiple computer readable storage media) (e.g., a computer memory, compact disks, optical disks, magnetic tapes, flash memories, circuit configurations in Field Programmable Gate Arrays or other semiconductor devices, or other tangible computer storage medium or non-transitory medium) encoded with one or more programs that, when executed on one or more computers or other processors, perform methods that implement the various embodiments of the technology discussed above. The computer readable medium or media can be transportable, such that the program or programs stored thereon can be loaded onto one or more different computers or other processors to implement various aspects of the present technology as discussed above.

[315] The terms“program” or“software” are used herein in a generic sense to refer to any type of computer code or set of computer-executable instructions that can be employed to program a computer or other processor to implement various aspects of the present technology as discussed above. Additionally, it should be appreciated that according to one aspect of this embodiment, one or more computer programs that when executed perform methods of the present technology need not reside on a single computer or processor, but may be distributed in a modular fashion amongst a number of different computers or processors to implement various aspects of the present technology.

[316] Computer-executable instructions may be in many forms, such as program modules, executed by one or more computers or other devices. Generally, program modules include routines, programs, objects, components, data structures, etc. that perform particular tasks or implement particular abstract data types. Typically the functionality of the program modules may be combined or distributed as desired in various embodiments.

[317] Also, the technology described herein may be embodied as a method, of which at least one example has been provided. The acts performed as part of the method may be ordered in any suitable way. Accordingly, embodiments may be constructed in which acts are performed in an order different than illustrated, which may include performing some acts simultaneously, even though shown as sequential acts in illustrative embodiments.

[318] All definitions, as defined and used herein, should be understood to control over dictionary definitions, definitions in documents incorporated by reference, and/or ordinary meanings of the defined terms.

[319] The indefinite articles“a” and“an,” as used herein in the specification and in the claims, unless clearly indicated to the contrary, should be understood to mean“at least one.”

[320] The phrase“and/or,” as used herein in the specification and in the claims, should be understood to mean“either or both” of the elements so conjoined, i.e., elements that are conjunctively present in some cases and disjunctively present in other cases. Multiple elements listed with“and/or” should be construed in the same fashion, i.e.,“one or more” of the elements so conjoined. Other elements may optionally be present other than the elements specifically identified by the“and/or” clause, whether related or unrelated to those elements specifically identified. Thus, as a non-limiting example, a reference to“A and/or B”, when used in conjunction with open-ended language such as“comprising” can refer, in one embodiment, to A only (optionally including elements other than B); in another embodiment, to B only (optionally including elements other than A); in yet another embodiment, to both A and B (optionally including other elements); etc.

[321] As used herein in the specification and in the claims,“or” should be understood to have the same meaning as“and/or” as defined above. For example, when separating items in a list,“or” or“and/or” shall be interpreted as being inclusive, i.e., the inclusion of at least one, but also including more than one, of a number or list of elements, and, optionally, additional unlisted items. Only terms clearly indicated to the contrary, such as“only one of’ or“exactly one of,” or, when used in the claims,“consisting of,” will refer to the inclusion of exactly one element of a number or list of elements. In general, the term“or” as used herein shall only be interpreted as indicating exclusive alternatives (i.e.“one or the other but not both”) when preceded by terms of exclusivity, such as“either,”“one of,”“only one of,” or “exactly one of.”“Consisting essentially of,” when used in the claims, shall have its ordinary meaning as used in the field of patent law.

[322] As used herein in the specification and in the claims, the phrase“at least one,” in reference to a list of one or more elements, should be understood to mean at least one element selected from any one or more of the elements in the list of elements, but not necessarily including at least one of each and every element specifically listed within the list of elements and not excluding any combinations of elements in the list of elements. This definition also allows that elements may optionally be present other than the elements specifically identified within the list of elements to which the phrase“at least one” refers, whether related or unrelated to those elements specifically identified. Thus, as a non-limiting example,“at least one of A and B” (or, equivalently,“at least one of A or B,” or, equivalently“at least one of A and/or B”) can refer, in one embodiment, to at least one, optionally including more than one, A, with no B present (and optionally including elements other than B); in another embodiment, to at least one, optionally including more than one, B, with no A present (and optionally including elements other than A); in yet another embodiment, to at least one, optionally including more than one, A, and at least one, optionally including more than one,

B (and optionally including other elements); etc.

[323] In the claims, as well as in the specification above, all transitional phrases such as “comprising,”“including,”“carrying,”“having,”“containing,”“involving,”“holding,” “composed of,” and the like are to be understood to be open-ended, i.e., to mean including but not limited to. Only the transitional phrases“consisting of’ and“consisting essentially of’ shall be closed or semi-closed transitional phrases, respectively, as set forth in the United States Patent Office Manual of Patent Examining Procedures, Section 2111.03.

Claims

WHAT IS CLAIMED IS:

1. A system for generating a quantifier of cognitive skills in an individual undergoing therapy for a mood disorder, the system comprising:

one or more processors; and

a memory to store processor-executable instructions and communicatively coupled with the one or more processors,

wherein upon execution of the processor-executable instructions by the one or more processors, the one or more processors are configured to:

generate a user interface;

present via the user interface a first instance of a task with an interference at the user interface, requiring a first response from the individual to the first instance of the task in the presence of the interference, wherein the individual is at least one of (i) preparing to undergo a therapy for a mood disorder comprising at least one of ingesting or injecting at least one of a psychedelic or a dissociative drug for treatment of the mood disorder or (ii) has undergone the therapy;

present via the user interface the first instance of the task, requiring a second response from the individual to the first instance of the task in the absence of the interference;

wherein:

at least one of the first instance of the task and the interference comprises a computerized element;

measure substantially simultaneously the first response from the individual to the first instance of the task and the response from the individual to the interference; receive data indicative of the first response and the second response; and analyze the data indicative of the first response and the second response to compute at least one performance metric comprising at least one quantified indicator of cognitive abilities of the individual.

2. The apparatus of claim 1, wherein:

based at least in part on the at least one performance metric, the one or more processors are configured to generate an output for the user interface indicative of one or more of: (i) the cognitive abilities of the individual, (ii) a likelihood of effectiveness of the therapy for the mood disorder, (iii) a recommended amount, concentration, or dose titration of the psychedelic and/or dissociative drug to be administered to the individual in the therapy for the mood disorder, (iv) a likelihood of the individual experiencing an adverse event in response to administration of the at least one of the psychedelic or dissociative drug, (v) a recommended treatment regimen using the cognitive platform following the therapy for the mood disorder, or (vi) a determination of a degree of effectiveness of the therapy for the mood disorder.

3. The system of claim 1, wherein the one or more processors are configured to generate an output to the user interface indicative of a likelihood of the individual experiencing an adverse event in response to administration of the at least one of the psychedelic or the dissociative drug, or a likelihood of the individual experiencing an adverse event in response to a change in one or more of the amount, concentration, or dose titration of the at least one of the psychedelic or the dissociative drug.

4. The system of claim 1, wherein:

prior to presenting the first instance of the task via the user interface, the one or more processors are configured to receive data indicative of one or more of an amount, concentration, or dose titration of the at least one psychedelic or dissociative drug previously administered to the individual in therapy for the mood disorder including the at least one psychedelic and/or dissociative drug; and

based at least in part on the performance metric, the one or more processors are configured to generate an output to the user interface indicative of one or more of: (i) a change in the cognitive abilities of the individual, (ii) a degree of effectiveness of the therapy for the mood disorder, (iii) a likelihood of the individual experiencing a relapse following administration of the therapy including the at least one psychedelic or dissociative drug, (iv) a recommended change to a mood disorder treatment regimen using a cognitive platform comprising the processor-executable instructions following the therapy for the mood disorder, (v) a projected duration of remission of the mood disorder following the therapy, or (vi) a recommended training regimen using the cognitive platform to enhance the cognitive abilities of the individual.

5. The system of claim 1, wherein the at least one quantified indicator provides an indication of a likelihood of at least one of an onset or a stage of progression of the mood disorder.

6. The system of claim 1, wherein the mood disorder is due to a condition selected from the group consisting of a neuropsychological condition, a neurodegenerative condition, and an executive function disorder.

7. The system of claim 5, wherein the condition is selected from the group consisting of social anxiety, depression, bipolar disorder, major depressive disorder, post-traumatic stress disorder, schizophrenia, autism spectrum disorder, attention deficit hyperactivity disorder, dementia, Parkinson's disease, Huntington's disease, Alzheimer’s disease, and multiple- sclerosis.

8. The system of claim 1, wherein the mood disorder is selected from the group consisting of depression, anxiety, post- traumatic stress disorder (PTSD), and obsessive compulsive disorder (OCD).

9. The system of claim 1, further comprising one or more sensor components, wherein the one or more processors are configured to control the one or more sensor components to measure the data indicative of one or both of the first response and the second response.

10. The system of claim 9, wherein the one or more sensor components comprise at least one of a gyroscope, an accelerometer, a motion sensor, a position sensor, a pressure sensor, an optical sensor, a video camera, an auditory sensor, or a vibrational sensor.

11. The system of claim 1, wherein the one or more processors are configured to at least one of transmit the performance metric to the individual or display the performance metric via the user interface.

12. The system of claim 1, wherein the one or more processors are configured to present the task as a continuous visuo-motor tracking task, and wherein the first instance of the task is a first time interval of the continuous visuo-motor task.

13. The system of claim 1, wherein the one or more processors are configured to present via the user interface the interference as a target discrimination interference.

14. The system of claim 1, wherein the at least one psychedelic or dissociative drug is one or more of lysergic acid diethylamide, psilocybin, ketamine, methylenedioxy-n- methylamphetamine. mescaline, or N,N-Dimethyltryptamine.

15. The system of claim 1, wherein the psychedelic drug is a tryptamine, a

phenethylamine, or a lysergamide.

16. A system of any of the foregoing claims, wherein the system is at least one of a virtual reality system, an augmented reality system, or a mixed reality system.

17. A computer-implemented method for quantifying cognitive skills in an individual undergoing therapy for a mood disorder, the method comprising:

using one or more processors to execute instructions stored in one or more memory storage devices comprising computer executable instructions to perform operations including:

present via a user interface a first instance of a task with an interference at the user interface, requiring a first response from the individual to the first instance of the task in the presence of the interference, wherein the individual at least one of (i) preparing to undergo a therapy for a mood disorder comprising at least one of ingesting or injecting at least one of a psychedelic or a dissociative drug for treatment of the mood disorder or (ii) has undergone the therapy;

present via the user interface the first instance of the task, requiring a second response from the individual to the first instance of the task in the absence of the interference;

wherein:

at least one of the first instance of the task and the interference comprises a computerized element;

measure substantially simultaneously the first response from the individual to the first instance of the task and the response from the individual to the interference;

receive data indicative of the first response and the second response; and analyze the data indicative of the first response and the second response to compute at least one performance metric comprising at least one quantified indicator of cognitive abilities of the individual.

18. The method of claim 17, wherein the operations further comprise:

based at least in part on the at least one performance metric, generate an output for the user interface indicative of one or more of: (i) the cognitive abilities of the individual, (ii) a likelihood of effectiveness of the therapy for the mood disorder, (iii) a recommended amount, concentration, or dose titration of the psychedelic and/or dissociative drug to be administered to the individual in the therapy for the mood disorder, (iv) a likelihood of the individual experiencing an adverse event in response to administration of the at least one of the psychedelic or dissociative drug, (v) a recommended treatment regimen using the cognitive platform following the therapy for the mood disorder, or (vi) a determination of a degree of effectiveness of the therapy for the mood disorder.

19. The method of claim 17, wherein the operations further comprise:

generate an output to the user interface indicative of a likelihood of the individual experiencing an adverse event in response to administration of the at least one of the psychedelic or the dissociative drug, or a likelihood of the individual experiencing an adverse event in response to a change in one or more of the amount, concentration, or dose titration of the at least one of the psychedelic or the dissociative drug.

20. The method of claim 17, wherein the operations further comprise:

prior to presenting the first instance of the task via the user interface, receive data indicative of one or more of an amount, concentration, or dose titration of the at least one psychedelic or dissociative drug previously administered to the individual in therapy for the mood disorder including the at least one psychedelic and/or dissociative drug; and

based at least in part on the performance metric, generate an output to the user interface indicative of one or more of: (i) a change in the cognitive abilities of the individual, (ii) a degree of effectiveness of the therapy for the mood disorder, (iii) a likelihood of the individual experiencing a relapse following administration of the therapy including the at least one psychedelic or dissociative drug, (iv) a recommended change to a mood disorder treatment regimen using a cognitive platform comprising the processor-executable instructions following the therapy for the mood disorder, (v) a projected duration of remission of the mood disorder following the therapy, or (vi) a recommended training regimen using the cognitive platform to enhance the cognitive abilities of the individual.

21. The method of claim 17, wherein the at least one quantified indicator provides an indication of a likelihood of at least one of an onset or a stage of progression of the mood disorder.

22. The method of claim 17 wherein the mood disorder is due to a condition selected from the group consisting of a neuropsychological condition, a neurodegenerative condition, and an executive function disorder.

23. The method of claim 22, wherein the condition is selected from the group consisting of social anxiety, depression, bipolar disorder, major depressive disorder, post-traumatic stress disorder, schizophrenia, autism spectrum disorder, attention deficit hyperactivity disorder, dementia, Parkinson's disease, Huntington's disease, Alzheimer’s disease, and multiple-sclerosis.

24. The method of claim 17, wherein the mood disorder is selected from the group consisting of depression, anxiety, post- traumatic stress disorder (PTSD), and obsessive compulsive disorder (OCD).

25. The method of claim 17, wherein the operations further comprise controlling one or more sensor components to measure the data indicative of one or both of the first response and the second response.

26. The method of claim 25, wherein the one or more sensor components comprise at least one of a gyroscope, an accelerometer, a motion sensor, a position sensor, a pressure sensor, an optical sensor, a video camera, an auditory sensor, or a vibrational sensor.

27. The method of claim 17, wherein the operations further comprise:

at least one of transmit the performance metric to the individual or display the performance metric via the user interface.

28. The method of claim 17, wherein the task is presented as a continuous visuo-motor tracking task, and wherein the first instance of the task is a first time interval of the continuous visuo-motor task.

29. The method of claim 17, wherein the interference is presented as a target discrimination interference.

30. The method of claim 17, wherein the at least one psychedelic or dissociative drug is one or more of lysergic acid diethylamide, psilocybin, ketamine, methylenedioxy-n- methylamphetamine. mescaline, or N,N-Dimethyltryptamine.

31. The method of claim 17, wherein the psychedelic drug is a tryptamine, a phenethylamine, or a lysergamide.