CA2903583C - Microarray for delivery of therapeutic agent, methods of use, and methods of making - Google Patents

Microarray for delivery of therapeutic agent, methods of use, and methods of making Download PDF

Info

Publication number
CA2903583C
CA2903583C CA2903583A CA2903583A CA2903583C CA 2903583 C CA2903583 C CA 2903583C CA 2903583 A CA2903583 A CA 2903583A CA 2903583 A CA2903583 A CA 2903583A CA 2903583 C CA2903583 C CA 2903583C
Authority
CA
Canada
Prior art keywords
suspension
drying
mold
solution
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2903583A
Other languages
English (en)
French (fr)
Other versions
CA2903583A1 (en
Inventor
Guohua Chen
Zhongli Ding
Esi Ghartey-Tagoe
Ashutosh Shastry
Robert Wade Worsham
Parminder Singh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corium Innovations Inc
Original Assignee
Corium LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corium LLC filed Critical Corium LLC
Publication of CA2903583A1 publication Critical patent/CA2903583A1/en
Application granted granted Critical
Publication of CA2903583C publication Critical patent/CA2903583C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Bioinformatics & Cheminformatics (AREA)
CA2903583A 2013-03-15 2014-03-14 Microarray for delivery of therapeutic agent, methods of use, and methods of making Active CA2903583C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361792069P 2013-03-15 2013-03-15
US61/792,069 2013-03-15
PCT/US2014/029601 WO2014144973A1 (en) 2013-03-15 2014-03-14 Microarray for delivery of therapeutic agent, methods of use, and methods of making

Publications (2)

Publication Number Publication Date
CA2903583A1 CA2903583A1 (en) 2014-09-18
CA2903583C true CA2903583C (en) 2021-12-28

Family

ID=50629002

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2903583A Active CA2903583C (en) 2013-03-15 2014-03-14 Microarray for delivery of therapeutic agent, methods of use, and methods of making

Country Status (7)

Country Link
US (1) US9962534B2 (cg-RX-API-DMAC7.html)
EP (1) EP2968119B1 (cg-RX-API-DMAC7.html)
JP (3) JP2016512754A (cg-RX-API-DMAC7.html)
AU (1) AU2014233541B2 (cg-RX-API-DMAC7.html)
CA (1) CA2903583C (cg-RX-API-DMAC7.html)
ES (1) ES2761580T3 (cg-RX-API-DMAC7.html)
WO (1) WO2014144973A1 (cg-RX-API-DMAC7.html)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008241470B2 (en) 2007-04-16 2013-11-07 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
JP5584202B2 (ja) 2008-05-21 2014-09-03 セラジェクト， インコーポレイテッド 固溶体穿孔器パッチの製造方法及びその使用
ES2634667T3 (es) * 2009-04-24 2017-09-28 Corium International, Inc. Métodos para fabricar conjuntos de microproyección
WO2011140274A2 (en) 2010-05-04 2011-11-10 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
KR102265808B1 (ko) 2012-12-21 2021-06-16 코리움, 인크. 치료제의 전달을 위한 마이크로어레이 및 그것의 사용방법
EP2968887B1 (en) 2013-03-12 2022-05-04 Corium, Inc. Microprojection applicators
EP4194028A1 (en) 2013-03-15 2023-06-14 Corium Pharma Solutions, Inc. Multiple impact microprojection applicators
CN105246458B (zh) 2013-03-15 2020-09-15 考里安公司 用于治疗剂递送的微阵列及其使用方法
EP2968116A1 (en) 2013-03-15 2016-01-20 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
JP2016512754A (ja) * 2013-03-15 2016-05-09 コリウム インターナショナル， インコーポレイテッド 治療剤の送達のためのマイクロアレイ、使用方法および製造方法
JP6207459B2 (ja) * 2014-05-15 2017-10-04 富士フイルム株式会社 経皮吸収シートの製造方法
EP3193828B8 (en) * 2014-08-29 2023-04-05 Corium Pharma Solutions, Inc. Microstructure array for delivery of active agents
EP3188714A1 (en) 2014-09-04 2017-07-12 Corium International, Inc. Microstructure array, methods of making, and methods of use
JP6482323B2 (ja) 2015-03-03 2019-03-13 富士フイルム株式会社 経皮吸収シート
JP6317690B2 (ja) * 2015-03-03 2018-04-25 富士フイルム株式会社 経皮吸収シート、及びその製造方法
KR101676861B1 (ko) * 2015-04-10 2016-11-17 씨앤텍 주식회사 마이크로 니들 패치 제조장치와 방법, 및 이에 의해 제조되는 마이크로 니들 패치
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
CN105833424A (zh) * 2016-03-21 2016-08-10 南通纺织丝绸产业技术研究院 一种丝素蛋白微针贴及其制备方法
WO2017208962A1 (ja) * 2016-05-31 2017-12-07 Ｎｉｓｓｈａ株式会社 マイクロニードルアレイ及びその製造方法
JP6691025B2 (ja) * 2016-09-06 2020-04-28 富士フイルム株式会社 針状アレイシートの製造方法
EP3582752A1 (en) 2017-02-17 2019-12-25 Allergan, Inc. Microneedle array with active ingredient
JP7260250B2 (ja) * 2017-03-03 2023-04-18 Ｎｉｓｓｈａ株式会社 かゆみ止めパッチ
KR102703839B1 (ko) * 2018-04-24 2024-09-05 주식회사 엠씨넷 피부투과성이 우수한 다층 마이크로니들 패치의 제조 방법
KR102526228B1 (ko) 2018-05-23 2023-04-26 후지필름 가부시키가이샤 일본 뇌염 백신 함유 마이크로니들 어레이
WO2020005973A1 (en) 2018-06-25 2020-01-02 Corium, Inc. Hybrid method of forming microstructure array molds, methods of making microstructure arrays, and methods of use
EP3837002A1 (en) * 2018-08-15 2021-06-23 Allergan, Inc. Microneedle array with active ingredient
CN109674738A (zh) * 2019-01-21 2019-04-26 武汉长联来福制药股份有限公司 炎琥宁制剂、贴片及其制备方法

Family Cites Families (357)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1554510A (en) 1924-04-23 1925-09-22 Elsie W Kirby Massaging device
US1770632A (en) 1928-07-02 1930-07-15 Arthur E Smith Ampul syringe
US2046240A (en) 1932-07-01 1936-06-30 Thomas W Bayley Abrasive article
US2434407A (en) 1946-01-05 1948-01-13 Hofe George Douglas Depilatory device
NL200971A (cg-RX-API-DMAC7.html) 1954-10-04
JPS4637758Y1 (cg-RX-API-DMAC7.html) 1967-12-13 1971-12-27
US3675766A (en) 1970-02-04 1972-07-11 Sol Roy Rosenthal Multiple puncture injector device
US3704194A (en) 1970-07-02 1972-11-28 Gen Electric Perforated reinforced plastic member and method for making
US3873255A (en) 1971-01-27 1975-03-25 Johnson & Johnson Apparatus for producing nonwoven fabric
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) 1972-02-14 1973-08-13 Ici Ltd Pansements
DE2319591C2 (de) 1973-04-18 1982-02-25 Kirchner & Wilhelm, 7000 Stuttgart Medizinischer Apparat
FR2232331B1 (cg-RX-API-DMAC7.html) 1973-06-06 1978-03-24 Guerin A Ets
AT347283B (de) 1975-03-07 1978-12-27 Collo Gmbh Schaumstoffkoerper fuer reinigungs-, scheuer- und/oder polierzwecke u. dgl.
JPS5428369Y2 (cg-RX-API-DMAC7.html) 1976-08-10 1979-09-12
US4151240A (en) 1976-10-19 1979-04-24 The Procter & Gamble Company Method for debossing and perforating a running ribbon of thermoplastic film
US4180232A (en) 1977-01-13 1979-12-25 Hardigg James S Truss panel mold
US4117841A (en) 1977-02-07 1978-10-03 Anthony Perrotta Medicated bandage pocket
US4342314A (en) 1979-03-05 1982-08-03 The Procter & Gamble Company Resilient plastic web exhibiting fiber-like properties
US4402696A (en) 1979-10-15 1983-09-06 Gulko Bruce N Folded applicator
US4381963A (en) 1980-07-30 1983-05-03 The University Of Rochester Micro fabrication molding process
US4395215A (en) 1981-02-02 1983-07-26 The Procter & Gamble Company Film forming structure for uniformly debossing and selectively aperturing a resilient plastic web and method for its construction
US4509908A (en) 1981-02-02 1985-04-09 The Procter & Gamble Company Apparatus for uniformly debossing and aperturing a resilient plastic web
US4463045A (en) 1981-03-02 1984-07-31 The Procter & Gamble Company Macroscopically expanded three-dimensional plastic web exhibiting non-glossy visible surface and cloth-like tactile impression
US4460368A (en) 1981-10-29 1984-07-17 Almedco, Inc. Trans-dermal medication system
US4460370A (en) 1981-10-29 1984-07-17 Almedco, Inc. Trans-dermal medication application cell
US4585991A (en) 1982-06-03 1986-04-29 Texas Instruments Incorporated Solid state multiprobe testing apparatus
FR2535602B1 (fr) 1982-11-05 1986-06-13 Stallergenes Lab Dispositif scarificateur
US4556441A (en) 1983-01-24 1985-12-03 Faasse Jr Adrian L Pharmaceutical packaging method
US4515168A (en) 1983-07-22 1985-05-07 Chester Martin H Clamp-on nerve stimulator and locator
US5591123A (en) 1983-08-18 1997-01-07 Drug Delivery Systems Inc. Programmable control mounting system for transdermal drug applicator
US4708716A (en) 1983-08-18 1987-11-24 Drug Delivery Systems Inc. Transdermal drug applicator
US4695422A (en) 1984-02-16 1987-09-22 The Procter & Gamble Company Production of formed material by solid-state formation with a high-pressure liquid stream
US4583982A (en) 1984-08-24 1986-04-22 Vlock D G Fluid dispenser
US5135477A (en) 1984-10-29 1992-08-04 Medtronic, Inc. Iontophoretic drug delivery
US4597961A (en) 1985-01-23 1986-07-01 Etscorn Frank T Transcutaneous application of nicotine
AU590872B2 (en) 1985-02-26 1989-11-23 Johns Hopkins University, The Neovascularization inhibitors and methods for their production and use
US4904475A (en) 1985-05-03 1990-02-27 Alza Corporation Transdermal delivery of drugs from an aqueous reservoir
US4609518A (en) 1985-05-31 1986-09-02 The Procter & Gamble Company Multi-phase process for debossing and perforating a polymeric web to coincide with the image of one or more three-dimensional forming structures
US4630603A (en) 1986-02-13 1986-12-23 The Kendall Company Wound dressing
US4743249A (en) 1986-02-14 1988-05-10 Ciba-Geigy Corp. Dermal and transdermal patches having a discontinuous pattern adhesive layer
AU597890B2 (en) 1986-03-14 1990-06-14 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
US4784737A (en) 1986-04-18 1988-11-15 The United States Department Of Energy Electromicroinjection of particles into living cells
US4837049A (en) 1986-06-17 1989-06-06 Alfred E. Mann Foundation For Scientific Research Method of making an electrode array
US4842794A (en) 1987-07-30 1989-06-27 Applied Extrusion Technologies, Inc. Method of making apertured films and net like fabrics
US5061258A (en) 1987-08-07 1991-10-29 Martz Joel D Vapor permeable dressing with releasable medication
DE3880763T2 (de) 1987-08-24 1993-12-02 Procter & Gamble Im wesentlichen flüssigkeitsundurchlässige polymere Warenbahn mit Mikrobläschen und Verfahren und Vorrichtung für deren Herstellung.
US4846821A (en) 1987-08-24 1989-07-11 The Procter & Gamble Company Substantially fluid-impervious microbubbled polymeric web exhibiting low levels of noise when subjected to movement
US4812305A (en) 1987-11-09 1989-03-14 Vocal Rodolfo S Well medicine strip
SU1641346A1 (ru) 1987-12-08 1991-04-15 Мгту Им.Н.Э.Баумана Устройство дл электростимул ции
DK157899C (da) 1987-12-15 1990-09-03 Coloplast As Hudpladeprodukt
FR2625937B1 (fr) 1988-01-19 1993-04-30 Vuillaume Andre Procede et dispositif pour perforer un produit en feuille, et produit perfore ainsi obtenu
US5362307A (en) 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
US5198192A (en) 1988-05-18 1993-03-30 Inax Corporation Apparatus for detecting ingredient in urine, a toilet stool equipped with a urine detecting device and a room for urine detecting facility
JP2608921B2 (ja) 1988-06-27 1997-05-14 ティーディーケイ株式会社 高誘電率セラミックス組成物
GB2221394B (en) 1988-08-05 1992-03-04 Eilert Eilertsen An injection device
DE3844247A1 (de) 1988-12-29 1990-07-12 Minnesota Mining & Mfg Vorrichtung, insbesondere pflaster zum transdermalen verabreichen eines medikaments
SU1667864A1 (ru) 1989-03-23 1991-08-07 Опытный завод энергетического машиностроения Электростимул тор
US5134079A (en) 1989-03-27 1992-07-28 International Technidyne Corp. Fluid sample collection and delivery system and methods particularly adapted for body fluid sampling
US5788983A (en) 1989-04-03 1998-08-04 Rutgers, The State University Of New Jersey Transdermal controlled delivery of pharmaceuticals at variable dosage rates and processes
US5531675A (en) 1989-05-10 1996-07-02 Yoo; Tae W. Micro-acupuncture needle for a finger of a hand
CA2016900A1 (en) 1989-07-06 1991-01-06 Ronald J. Filipski Tines structure in clinical applicator
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5215088A (en) 1989-11-07 1993-06-01 The University Of Utah Three-dimensional electrode device
JP2646766B2 (ja) 1989-11-08 1997-08-27 日本電気株式会社 皮膚角層の除去器具
US5190558A (en) 1989-11-08 1993-03-02 Nec Corporation Method of eliminating stratum corneum from the skin and an instrument to be used therefor
US5697901A (en) 1989-12-14 1997-12-16 Elof Eriksson Gene delivery by microneedle injection
US5244711A (en) 1990-03-12 1993-09-14 Mcneil-Ppc, Inc. Apertured non-woven fabric
US5162043A (en) 1990-03-30 1992-11-10 Alza Corporation Iontophoretic delivery device
US5139029A (en) 1990-04-06 1992-08-18 Henry Fishman Allergy testing apparatus and method
IT1246382B (it) 1990-04-17 1994-11-18 Eurand Int Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
US5156591A (en) 1990-12-13 1992-10-20 S. I. Scientific Innovations Ltd. Skin electrode construction and transdermal drug delivery device utilizing same
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
TW279133B (cg-RX-API-DMAC7.html) 1990-12-13 1996-06-21 Elan Med Tech
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5158073A (en) 1990-12-18 1992-10-27 Bukowski Voytek Z Acupressure foot massage mat
US5252279A (en) 1991-01-17 1993-10-12 Reinhold Industries Method for making perforated articles
US5312456A (en) 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
US5160315A (en) 1991-04-05 1992-11-03 Minnesota Mining And Manufacturing Company Combined adhesive strip and transparent dressing delivery system
TW273531B (en) 1991-08-14 1996-04-01 Chicopee Textile-like apertured plastic films
JP3189337B2 (ja) 1991-11-08 2001-07-16 日本電気株式会社 皮膚角層の除去器具および除去方法
JPH05162076A (ja) 1991-12-13 1993-06-29 Sony Corp 遊離微粒子噴射加工装置
DE69230408T2 (de) 1992-02-18 2000-06-08 Mcneil-Ppc, Inc. Textilähnliche, gelochte plastikfolie
US6319471B1 (en) 1992-07-10 2001-11-20 Gambro, Inc. Apparatus for producing blood component products
US5256360A (en) 1992-03-25 1993-10-26 Panasonic Technologies, Inc. Method of manufacturing a precision micro-filter
US5756117A (en) 1992-04-08 1998-05-26 International Medical Asscociates, Inc. Multidose transdermal drug delivery system
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
IE930532A1 (en) 1993-07-19 1995-01-25 Elan Med Tech Liquid material dispenser and valve
US5308625A (en) 1992-09-02 1994-05-03 Cygnus Therapeutic Systems Enhancement of transdermal drug delivery using monoalkyl phosphates and other absorption promoters
US5462743A (en) 1992-10-30 1995-10-31 Medipro Sciences Limited Substance transfer system for topical application
US5250067A (en) 1992-11-30 1993-10-05 Ala Gelfer Body treatment pad having a multiple number of sharpened skin-penetration protuberances
US5383512A (en) 1993-01-27 1995-01-24 Midwest Research Institute Method for fabricating a substrate having spaced apart microcapillaries thereon
JPH06238644A (ja) 1993-02-15 1994-08-30 Taiyo Yuden Co Ltd セラミックグリーンシートの加工方法
GB9305930D0 (en) 1993-03-22 1993-05-12 Moran Peter L Electrical circuit board
US6685682B1 (en) 1993-03-22 2004-02-03 3M Innovative Properties Company Carrier delivered dressing and method of manufacture
CN1222258C (zh) 1993-03-22 2005-10-12 美国3M公司 无窗的框架供给的敷料及其制备方法
IE68890B1 (en) 1993-04-08 1996-07-24 Elan Med Tech Intradermal delivery device
AU667766B2 (en) 1993-05-27 1996-04-04 Paul Hartmann Ag Hydrogel wound dressing product
US5330452A (en) 1993-06-01 1994-07-19 Zook Gerald P Topical medicating device
US5728089A (en) 1993-06-04 1998-03-17 The Regents Of The University Of California Microfabricated structure to be used in surgery
US5320600A (en) 1993-06-14 1994-06-14 Lambert Wm S Plural content container for simultaneous ejection
CA2132277C (en) 1993-10-22 2005-05-10 Giorgio Cirelli Injection device
JP3590805B2 (ja) 1993-11-10 2004-11-17 株式会社ニコン 採血装置
US5962011A (en) 1993-12-06 1999-10-05 Schering-Plough Healthcare Products, Inc. Device for delivery of dermatological ingredients
AU1848395A (en) 1994-02-22 1995-09-04 Board Of Trustees Of The University Of Illinois, The Genes and genetic elements associated with sensitivity to platinum-based drugs
US5457041A (en) 1994-03-25 1995-10-10 Science Applications International Corporation Needle array and method of introducing biological substances into living cells using the needle array
US5536263A (en) 1994-03-30 1996-07-16 Lectec Corporation Non-occulusive adhesive patch for applying medication to the skin
US5503843A (en) 1994-04-22 1996-04-02 Flora Inc. Transdermal delivery of alpha adrenoceptor blocking agents
KR0134152B1 (ko) 1994-05-23 1998-04-14 이형도 의약품 투여용 피부흠집 형성장치
KR0134151B1 (ko) 1994-05-23 1998-04-14 이형도 인슐린 패치
CA2149943C (en) 1994-05-23 1999-07-13 Kwang Kyun Jang Skin perforating device for transdermal medication
CA2149836C (en) 1994-05-23 1999-07-06 Sang Bae Choi Perforating device for dermal administration
US5851549A (en) 1994-05-25 1998-12-22 Becton Dickinson And Company Patch, with system and apparatus for manufacture
US5512219A (en) 1994-06-03 1996-04-30 Reflexite Corporation Method of casting a microstructure sheet having an array of prism elements using a reusable polycarbonate mold
US5591139A (en) 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US5487726A (en) 1994-06-16 1996-01-30 Ryder International Corporation Vaccine applicator system
US5771890A (en) 1994-06-24 1998-06-30 Cygnus, Inc. Device and method for sampling of substances using alternating polarity
US5496304A (en) 1994-07-20 1996-03-05 University Of Utah Research Foundation Surgical marking pen
US5498235A (en) 1994-09-30 1996-03-12 Becton Dickinson And Company Iontophoresis assembly including patch/controller attachment
US5551953A (en) 1994-10-31 1996-09-03 Alza Corporation Electrotransport system with remote telemetry link
IE72524B1 (en) 1994-11-04 1997-04-23 Elan Med Tech Analyte-controlled liquid delivery device and analyte monitor
US6120488A (en) 1994-11-28 2000-09-19 The Procter & Gamble Company Absorbent articles having cuffs and topsheet with skin care composition(s) disposed thereon
ATE177325T1 (de) 1994-12-09 1999-03-15 Novartis Erfind Verwalt Gmbh Transdermales system
WO1996037155A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
WO1996037256A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
JP2713255B2 (ja) 1995-08-11 1998-02-16 日本電気株式会社 浸出液吸引装置
IE77523B1 (en) 1995-09-11 1997-12-17 Elan Med Tech Medicament delivery device
US5735273A (en) 1995-09-12 1998-04-07 Cygnus, Inc. Chemical signal-impermeable mask
JP2718408B2 (ja) 1995-09-20 1998-02-25 日本電気株式会社 浸出液吸引装置
US5645977A (en) 1995-09-22 1997-07-08 Industrial Technology Research Institute Method of making molds for manufacturing multiple-lead microstructures
US5658515A (en) 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
US5776103A (en) 1995-10-11 1998-07-07 Science Incorporated Fluid delivery device with bolus injection site
US5662127A (en) 1996-01-17 1997-09-02 Bio-Plas, Inc. Self-contained blood withdrawal apparatus and method
US5730721A (en) 1996-01-25 1998-03-24 Vesture Corporation Medical applicator and method
JP3430771B2 (ja) 1996-02-05 2003-07-28 株式会社デンソー 半導体力学量センサの製造方法
JPH09215755A (ja) 1996-02-09 1997-08-19 Poritoronikusu:Kk 皮接治療具
US5948488A (en) 1996-04-30 1999-09-07 3M Innovative Properties Company Glittering cube-corner article
US6219574B1 (en) 1996-06-18 2001-04-17 Alza Corporation Device and method for enchancing transdermal sampling
DE19624578A1 (de) 1996-06-20 1998-01-08 Nancy L Divers Vorrichtung zur Hautpflege
ATE241405T1 (de) 1996-07-03 2003-06-15 Altea Therapeutics Corp Mehrfache mechanische mikroperforierung von haut oder schleimhäuten
US6512010B1 (en) 1996-07-15 2003-01-28 Alza Corporation Formulations for the administration of fluoxetine
WO1998011937A1 (en) 1996-09-17 1998-03-26 Deka Products Limited Partnership System for delivery of drugs by transport
DE19649100A1 (de) 1996-11-27 1998-06-04 Lohmann Therapie Syst Lts Verfahren zur verlustarmen Herstellung wirkstoffhaltiger scheibenförmiger Formkörper und diese enthaltende transdermale therapeutische Systeme
WO1998028307A1 (en) 1996-12-23 1998-07-02 Sartomer Company, Inc. Free radically polymerizable silane monomers and oligomers and the method for making them
US5873849A (en) 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
JP3097600B2 (ja) 1997-05-30 2000-10-10 日本電気株式会社 角質層穿刺装置
US5904712A (en) 1997-06-12 1999-05-18 Axelgaard Manufacturing Co., Ltd. Current-controlling electrode
US5928207A (en) 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6216034B1 (en) 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
US6241701B1 (en) 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US6047208A (en) 1997-08-27 2000-04-04 Becton, Dickinson And Company Iontophoretic controller
US20010023324A1 (en) 1997-11-03 2001-09-20 Allan Pronovost Glucose detector and method for diagnosing diabetes
US5938684A (en) 1997-12-09 1999-08-17 Sierra Self Healing Products, Inc. Accupressure device for therapeutic relief
US6918901B1 (en) 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
EP1037686B1 (en) 1997-12-11 2005-08-17 Alza Corporation Device for enhancing transdermal agent flux
KR100557261B1 (ko) 1997-12-11 2006-03-07 알자 코포레이션 경피성 작용제 유동률을 증진시키기 위한 장치
CA2313458C (en) 1997-12-11 2007-04-17 Alza Corporation Device for enhancing transdermal agent flux
US6135990A (en) 1997-12-17 2000-10-24 University Of South Florida Electroporation device and method
US6778853B1 (en) 1997-12-17 2004-08-17 University Of South Florida Electroporation device
ES2182379T3 (es) 1997-12-22 2003-03-01 Alza Corp Membrana de regulacion del regimen de liberacion para dispositivos de administracion controlada de farmacos.
US6024553A (en) 1997-12-22 2000-02-15 Mcneil-Ppc, Inc. Apparatus for supporting a starting web during formation of the apertured web
CA2575064C (en) 1997-12-31 2010-02-02 Medtronic Minimed, Inc. Insertion device for an insertion set and method of using the same
JPH11230707A (ja) 1998-02-10 1999-08-27 Mitsutoyo Corp マイクロセンサデバイスの製造方法
US6106751A (en) 1998-03-18 2000-08-22 The Regents Of The University Of California Method for fabricating needles via conformal deposition in two-piece molds
US6136008A (en) 1998-03-19 2000-10-24 3M Innovative Properties Company Skin abrader for biomedical electrode
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
US6120792A (en) 1998-04-29 2000-09-19 Juni; Jack E. Medicated skin patch and method for its use
AU763433B2 (en) 1998-05-22 2003-07-24 California Institute Of Technology Microfabricated cell sorter
AU767122B2 (en) 1998-06-10 2003-10-30 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
GB9815820D0 (en) 1998-07-22 1998-09-16 Secr Defence Improvements relating to micro-machining
GB9815819D0 (en) 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
US6532386B2 (en) 1998-08-31 2003-03-11 Johnson & Johnson Consumer Companies, Inc. Electrotransort device comprising blades
JP2000146777A (ja) 1998-09-08 2000-05-26 Matsushita Electric Ind Co Ltd 検体採取方法、検体採取装置、検体採取用容器、検体測定方法、検体測定装置および検体測定用容器
US6036659A (en) 1998-10-09 2000-03-14 Flexsite Diagnostics, Inc. Collection device for biological samples and methods of use
US6038465A (en) 1998-10-13 2000-03-14 Agilent Technologies, Inc. Telemedicine patient platform
US6611706B2 (en) 1998-11-09 2003-08-26 Transpharma Ltd. Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
EP1003078A3 (en) 1998-11-17 2001-11-07 Corning Incorporated Replicating a nanoscale pattern
JP4214584B2 (ja) 1998-11-27 2009-01-28 株式会社デンソー 半導体力学量センサおよびその製造方法
CA2352974A1 (en) 1998-12-18 2000-06-22 John H. Livingston Insertion sets with micro-piercing members for use with medical devices and methods of using the same
JP2000194142A (ja) 1998-12-25 2000-07-14 Fujitsu Ltd パタ―ン形成方法及び半導体装置の製造方法
JP2000232095A (ja) 1999-02-12 2000-08-22 Nippon Telegr & Teleph Corp <Ntt> 半導体表面の微細パターン形成方法
JP2000232971A (ja) 1999-02-15 2000-08-29 Arkray Inc 吸引浸出液採取方法および装置
US5997549A (en) 1999-02-16 1999-12-07 Sauceda; Charles J. Wart removing tool
US6132449A (en) 1999-03-08 2000-10-17 Agilent Technologies, Inc. Extraction and transportation of blood for analysis
US6183770B1 (en) 1999-04-15 2001-02-06 Acutek International Carrier patch for the delivery of agents to the skin
US6689103B1 (en) 1999-05-07 2004-02-10 Scimed Life System, Inc. Injection array apparatus and method
JP2000323461A (ja) 1999-05-11 2000-11-24 Nec Corp 微細パターン形成装置、その製造方法、および形成方法
NO311797B1 (no) 1999-05-12 2002-01-28 Thin Film Electronics Asa Fremgangsmåter til mönstring av polymerfilmer og anvendelse av fremgangsmåtene
JP4114761B2 (ja) 1999-05-14 2008-07-09 国立大学法人群馬大学 情報記録ディスク用スタンパー、その製造方法、情報記録ディスク、および情報記録ディスク製造方法
CA2376128C (en) 1999-06-04 2009-01-06 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6312612B1 (en) * 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
DE19927359A1 (de) 1999-06-16 2000-12-21 Creavis Tech & Innovation Gmbh Elektrophoretische Displays aus lichtstreuenden Trägermaterialien
JP3654059B2 (ja) 1999-06-25 2005-06-02 松下電工株式会社 赤外線センサーの製造方法
IT1313184B1 (it) 1999-07-19 2002-06-17 Enel Spa Apparecchiatura e metodo per misurare gli incombusti nelle ceneri dicarbone.
JP3387897B2 (ja) 1999-08-30 2003-03-17 キヤノン株式会社 構造体の製造方法、並びに該製造方法により製造される構造体及び該構造体を用いた構造体デバイス
JP2001148485A (ja) 1999-09-06 2001-05-29 Seiko Epson Corp 半導体装置
US6623457B1 (en) 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US20030093089A1 (en) 1999-10-20 2003-05-15 Greenberg Ronald Allan Apparatus for variable micro abrasion of human tissue and/or hides using different size and types of abrasive particles
US6355054B1 (en) 1999-11-05 2002-03-12 Ceramoptec Industries, Inc. Laser system for improved transbarrier therapeutic radiation delivery
CN101238998A (zh) 1999-11-15 2008-08-13 维尔克工业有限公司 皮肤附着件
EP1233927A4 (en) 1999-11-17 2003-01-08 Univ California APPARATUS AND METHOD FOR FORMING A NANOMETRIC SCALE MEMBRANE
US6511463B1 (en) 1999-11-18 2003-01-28 Jds Uniphase Corporation Methods of fabricating microneedle arrays using sacrificial molds
US20010023351A1 (en) 1999-12-01 2001-09-20 Eilers George J. Skin abrasion system and method
DK1239916T3 (da) 1999-12-10 2006-04-03 Alza Corp Indretning og fremgangsmåde til at forbedre perforering af hud med mikrofremspring
HK1048773B (en) 1999-12-10 2005-10-14 Alza Corporation Skin treatment apparatus for sustained transdermal drug delivery
EP1239775B1 (en) 1999-12-16 2005-03-16 ALZA Corporation Device for enhancing transdermal flux of sampled agents
US6406638B1 (en) 2000-01-06 2002-06-18 The Regents Of The University Of California Method of forming vertical, hollow needles within a semiconductor substrate, and needles formed thereby
US6248120B1 (en) 2000-01-10 2001-06-19 P. Z. “HTL” Spolka Akcyjna Puncturing device
US6375627B1 (en) 2000-03-02 2002-04-23 Agilent Technologies, Inc. Physiological fluid extraction with rapid analysis
US6558361B1 (en) 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US6629949B1 (en) 2000-05-08 2003-10-07 Sterling Medivations, Inc. Micro infusion drug delivery device
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
JP4001311B2 (ja) 2000-06-01 2007-10-31 株式会社リコー 液滴吐出ヘッド、インクジェット記録装置、マイクロアクチュエータ
US6537242B1 (en) 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US6607513B1 (en) 2000-06-08 2003-08-19 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US6494830B1 (en) 2000-06-22 2002-12-17 Guidance Interactive Technologies, Inc. Handheld controller for monitoring/using medical parameters
US6589202B1 (en) 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
US6603987B2 (en) 2000-07-11 2003-08-05 Bayer Corporation Hollow microneedle patch
US6440096B1 (en) 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
US6656147B1 (en) 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
US20080164638A1 (en) 2006-11-28 2008-07-10 Wei Zhang Method and apparatus for rapid imprint lithography
GB0017999D0 (en) 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
AU2000261716A1 (en) 2000-07-25 2002-02-05 Dickinson Legg Limited Lamina separator
US6533949B1 (en) 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
JP2002079499A (ja) 2000-09-08 2002-03-19 Terumo Corp 針形状物の作製方法および作製された針
CA2357386C (en) 2000-09-15 2009-03-24 Timberjack Inc. High rotation felling head mechanism
AU2001293460A1 (en) 2000-10-05 2002-04-15 Thomas Marsoner Medical injection device
KR20030068137A (ko) 2000-10-13 2003-08-19 알자 코포레이션 충격 어플리케이터용 미세 돌기 부재 리테이너
HUP0303583A2 (en) 2000-10-13 2004-01-28 Alza Corp Microblade array impact applicator
RU2275871C2 (ru) 2000-10-13 2006-05-10 Алза Корпорейшн Устройство и способ для прокалывания кожи микровыступами
US7419481B2 (en) 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US6821281B2 (en) 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US6533884B1 (en) 2000-11-03 2003-03-18 Printpack Illinois, Inc. Method and system for extrusion embossing
JP3525177B2 (ja) 2000-11-14 2004-05-10 関西ティー・エル・オー株式会社 Ｘ線を用いた材料の加工方法
US6591133B1 (en) 2000-11-27 2003-07-08 Microlin Llc Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices
US9302903B2 (en) 2000-12-14 2016-04-05 Georgia Tech Research Corporation Microneedle devices and production thereof
US6508947B2 (en) 2001-01-24 2003-01-21 Xerox Corporation Method for fabricating a micro-electro-mechanical fluid ejector
WO2002062202A2 (en) 2001-02-05 2002-08-15 Becton, Dickinson And Company Microprotrusion array and methods of making a microprotrusion
JP3696513B2 (ja) 2001-02-19 2005-09-21 住友精密工業株式会社 針状体の製造方法
WO2002072169A2 (en) 2001-03-09 2002-09-19 Antares Pharma, Inc. Ocular drug delivery nebulizer
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
CN100349632C (zh) 2001-04-20 2007-11-21 阿尔扎公司 具有包含有益药剂的涂层的微小突出物阵列
US6585742B2 (en) 2001-05-08 2003-07-01 Dowling B. Stough Wart removal method and device
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
US6921410B2 (en) 2001-05-29 2005-07-26 Scimed Life Systems, Inc. Injection molded vaso-occlusive elements
US20020188310A1 (en) 2001-06-08 2002-12-12 Seward Kirk Partick Microfabricated surgical device
WO2002100476A2 (en) 2001-06-08 2002-12-19 Becton, Dickinson And Company Device for manipulating a needle or abrader array
US6767341B2 (en) 2001-06-13 2004-07-27 Abbott Laboratories Microneedles for minimally invasive drug delivery
US20040204669A1 (en) 2001-07-05 2004-10-14 Hofmann Gunter A. Apparatus for electroporation mediated delivery for drugs and genes
US6749792B2 (en) 2001-07-09 2004-06-15 Lifescan, Inc. Micro-needles and methods of manufacture and use thereof
JP5055672B2 (ja) 2001-07-31 2012-10-24 大日本印刷株式会社 薄膜パターン形成用スタンプ
JP4919446B2 (ja) 2001-08-09 2012-04-18 学校法人東京電機大学 微細溝加工方法及びその装置
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
US20040087992A1 (en) 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
JP2005503210A (ja) 2001-09-14 2005-02-03 ザ プロクター アンド ギャンブル カンパニー 回転可能構造を用いて皮膚を介して組成物を皮膚に送達するための微細構造
EP1424928B1 (en) 2001-09-14 2019-09-11 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
WO2003024507A2 (en) 2001-09-19 2003-03-27 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
US20030135201A1 (en) 2001-09-28 2003-07-17 Gonnelli Robert R. Microneedle with membrane
US20030093028A1 (en) 2001-11-09 2003-05-15 Michael Spiegel Appararus and method for magnetic induction of therapeutic electric fields
EP1485317A2 (en) 2001-11-30 2004-12-15 Alza Corporation Methods and apparatuses for forming microprojection arrays
JP4469610B2 (ja) 2002-02-04 2010-05-26 ベクトン・ディキンソン・アンド・カンパニー 皮膚アクセス部材
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US7115108B2 (en) 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
DK1534376T3 (en) 2002-06-25 2016-12-05 Theraject Inc QUICK-SOLVING MICROPERFORATORS FOR PHARMACEUTICAL DELIVERY AND OTHER APPLICATIONS
US6945952B2 (en) 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
ATE336277T1 (de) 2002-06-28 2006-09-15 Alza Corp Verfahren zur oberflächenbeschichtung von vorrichtungen zur transdermalen verabreichung von arzneien mit beschichteten mikrovorsprüngen
CA2492867C (en) 2002-07-19 2011-07-05 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus
AR040819A1 (es) 2002-08-08 2005-04-20 Alza Corp Dispositivo de administracion transdermica de vacuna que tiene microproyecciones revestidas
JP2004065775A (ja) 2002-08-08 2004-03-04 Sanwa Kagaku Kenkyusho Co Ltd 針状構造体を備えたデバイス
US7166086B2 (en) 2002-08-29 2007-01-23 Becton, Dickinson And Company Substance delivery via a rotating microabrading surface
AU2003275311A1 (en) 2002-09-16 2004-04-30 Sung-Yun Kwon Solid micro-perforators and methods of use
EP1590034B1 (en) 2002-10-07 2014-05-14 Biovalve Technologies, Inc. Microneedle array patch
GB0226401D0 (en) * 2002-11-12 2002-12-18 Koninkl Philips Electronics Nv Electroluminescent devices and their manufacture
US7578954B2 (en) 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US7572405B2 (en) 2003-06-02 2009-08-11 Corium International Inc. Method for manufacturing microstructures having hollow microelements using fluidic jets during a molding operation
CA2530520A1 (en) 2003-06-30 2005-01-20 Alza Corporation Method for coating skin piercing microprojections
WO2005016441A1 (en) 2003-08-04 2005-02-24 Alza Corporation Method and device for enhancing transdermal agent flux
US8353861B2 (en) 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
EP1680057A4 (en) 2003-10-24 2007-10-31 Alza Corp DEVICE AND METHOD FOR IMPROVING TRANSDERMAL DRUG DELIVERY
BRPI0415629A (pt) 2003-10-31 2006-12-12 Alza Corp aplicador auto-atuador para conjunto de microprojeções
WO2005046769A2 (en) 2003-11-12 2005-05-26 Vidacare Corporation Reusable intraosseous device and method for accessing bone marrow in the sternum
AT500095B8 (de) 2004-01-23 2007-02-15 Braun Werner Mag Transdermales abgabesystem
US8551391B2 (en) 2004-02-17 2013-10-08 Avery Dennison Corporation Method of making microneedles
US20070191761A1 (en) 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
US20050203575A1 (en) 2004-03-15 2005-09-15 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Skin microactivation system and method
JP5085317B2 (ja) 2004-03-24 2012-11-28 コリウム インターナショナル， インコーポレイテッド 経皮送達デバイス
WO2005123173A1 (en) 2004-06-10 2005-12-29 3M Innovative Properties Company Patch application device and kit
WO2006015299A2 (en) 2004-07-30 2006-02-09 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
TW200618830A (en) 2004-08-10 2006-06-16 Alza Corp Micorprojection apparatus and system with low infection potential
US20080009811A1 (en) 2004-11-18 2008-01-10 3M Innovative Properties Company Non-Skin-Contacting Microneedle Array Applicator
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
JP4927752B2 (ja) 2004-11-18 2012-05-09 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルアレイアプリケーターおよび保持装置
US8267889B2 (en) 2004-11-18 2012-09-18 3M Innovative Properties Company Low-profile microneedle array applicator
US20070043320A1 (en) 2005-02-09 2007-02-22 Kenany Saad A Microstream injector
WO2006101459A1 (en) 2005-03-23 2006-09-28 Agency For Science, Technology And Research Microneedles
EP1871459B1 (en) 2005-04-07 2019-06-19 3M Innovative Properties Company System for tool feedback sensing
US20060253078A1 (en) 2005-04-25 2006-11-09 Wu Jeffrey M Method of treating skin disorders with stratum corneum piercing device
JP2006341089A (ja) 2005-05-13 2006-12-21 Fujikura Ltd 医薬物運搬用器具およびその製造方法
WO2007002523A2 (en) 2005-06-24 2007-01-04 3M Innovative Properties Company Collapsible patch with microneedle array
WO2007002521A2 (en) 2005-06-27 2007-01-04 3M Innovative Properties Company Microneedle array applicator device
CA2629393C (en) 2005-09-06 2014-06-10 Theraject, Inc. Solid solution perforator containing drug particle and/or drug-adsorbed particles
JP2007130030A (ja) 2005-11-08 2007-05-31 Toray Ind Inc マイクロニードル、マイクロニードル集合体及びその製造方法
US20080278727A1 (en) 2005-11-18 2008-11-13 Koninklijke Philips Electronics, N.V. Device For Imaging an Interior of a Turbid Medium
US7658728B2 (en) 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
JP2007190112A (ja) 2006-01-18 2007-08-02 Toray Ind Inc マイクロニードル
JP2009529400A (ja) 2006-03-10 2009-08-20 アルザ コーポレイション 高バリア保持具を備えた微小突起アレイの適用
US9119945B2 (en) 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
WO2008024141A2 (en) 2006-05-09 2008-02-28 Apogee Technology, Inc. Nanofiber structures on asperities for sequestering, carrying and transferring substances
JP2008006178A (ja) 2006-06-30 2008-01-17 Fujifilm Corp マイクロニードルシートの製造方法及び製造装置
WO2008011625A2 (en) 2006-07-21 2008-01-24 Georgia Tech Researh Corporation Microneedle devices and methods of drug delivery or fluid withdrawal
CN101505816B (zh) 2006-08-24 2012-05-30 霍夫曼-拉罗奇有限公司 适于插入头部尤其是适于插入输注装置的插入工具
US7785301B2 (en) 2006-11-28 2010-08-31 Vadim V Yuzhakov Tissue conforming microneedle array and patch for transdermal drug delivery or biological fluid collection
US20080214987A1 (en) 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
WO2008091602A2 (en) 2007-01-22 2008-07-31 Corium International, Inc. Applicators for microneedle arrays
JP4959363B2 (ja) 2007-02-14 2012-06-20 凸版印刷株式会社 針状体の製造方法
AU2008241470B2 (en) * 2007-04-16 2013-11-07 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
US7578985B2 (en) 2007-04-18 2009-08-25 Gas Technology Institute Method for direct oxidation of hydrogen sulfide to elemental sulfur at low temperatures
JP2008284318A (ja) 2007-05-15 2008-11-27 Kosumedei Seiyaku Kk 生体由来物質からなる投薬用微細針
EP2153863B1 (en) 2007-05-15 2022-03-16 Hisamitsu Pharmaceutical Co., Inc. Method of coating microneedle
US20090017210A1 (en) 2007-07-09 2009-01-15 Andrianov Alexander K Methods and systems for coating a microneedle with a dosage of a biologically active compound
US8366677B2 (en) 2007-08-06 2013-02-05 Transderm, Inc. Microneedle arrays formed from polymer films
US20120150023A1 (en) 2007-08-06 2012-06-14 Kaspar Roger L Microneedle arrays for active agent delivery
US8409145B2 (en) 2007-09-17 2013-04-02 Tecpharma Licensing Ag Insertion devices for infusion devices
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US20090117158A1 (en) 2007-10-23 2009-05-07 Mahmoud Ameri Transdermal sustained release drug delivery
JP5584202B2 (ja) * 2008-05-21 2014-09-03 セラジェクト， インコーポレイテッド 固溶体穿孔器パッチの製造方法及びその使用
KR20100037389A (ko) 2008-10-01 2010-04-09 연세대학교 산학협력단 다중 약물방출조절이 가능한 솔리드 마이크로구조체 및 이의 제조방법
WO2010040271A1 (en) 2008-10-07 2010-04-15 Tuo Jin Phase-transition polymeric microneedles
KR20100064669A (ko) 2008-12-05 2010-06-15 폴 곽 마이크로 니들 피부 미용기
JP2010233674A (ja) 2009-03-30 2010-10-21 Fujifilm Corp マイクロニードルシート及びその使用方法並びに製造方法
ES2634667T3 (es) 2009-04-24 2017-09-28 Corium International, Inc. Métodos para fabricar conjuntos de microproyección
JP2011012050A (ja) * 2009-06-03 2011-01-20 Bioserentack Co Ltd 多孔性基盤を用いたマイクロニードル・アレイとその製造方法
JP5587647B2 (ja) * 2010-03-29 2014-09-10 東レエンジニアリング株式会社 マイクロニードルシートの製造方法
WO2011121023A1 (en) 2010-03-30 2011-10-06 Unomedical A/S Medical device
AU2011248166B2 (en) 2010-05-04 2015-12-17 Corium Pharma Solutions, Inc. Applicators for microneedles
WO2011140274A2 (en) 2010-05-04 2011-11-10 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
EP2399624B1 (en) 2010-06-21 2015-10-07 F.Hoffmann-La Roche Ag Device for inserting a soft member into the tissue of the body of a patient
JP5937092B2 (ja) 2010-10-19 2016-06-22 トラスティーズ オブ タフツ カレッジ シルクフィブロインベースのマイクロニードルおよびその製造方法
CA2822428A1 (en) 2010-12-22 2012-06-28 Valeritas, Inc. Microneedle patch applicator
DK2683359T3 (en) 2011-03-07 2015-07-20 3M Innovative Properties Co MICROWAVE DEVICES AND METHODS
KR102265808B1 (ko) 2012-12-21 2021-06-16 코리움, 인크. 치료제의 전달을 위한 마이크로어레이 및 그것의 사용방법
EP2968887B1 (en) 2013-03-12 2022-05-04 Corium, Inc. Microprojection applicators
JP2016512754A (ja) * 2013-03-15 2016-05-09 コリウム インターナショナル， インコーポレイテッド 治療剤の送達のためのマイクロアレイ、使用方法および製造方法
EP4194028A1 (en) 2013-03-15 2023-06-14 Corium Pharma Solutions, Inc. Multiple impact microprojection applicators
EP2968116A1 (en) 2013-03-15 2016-01-20 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
MX2015012433A (es) 2013-03-15 2016-02-03 Corium Int Inc Matriz de microestructura para suministro de agentes activos.
CN105246458B (zh) 2013-03-15 2020-09-15 考里安公司 用于治疗剂递送的微阵列及其使用方法

Also Published As

Publication number Publication date
JP2019076752A (ja) 2019-05-23
EP2968119A1 (en) 2016-01-20
AU2014233541A1 (en) 2015-09-17
US20140272101A1 (en) 2014-09-18
US9962534B2 (en) 2018-05-08
EP2968119B1 (en) 2019-09-18
ES2761580T3 (es) 2020-05-20
JP2020203127A (ja) 2020-12-24
JP6894455B2 (ja) 2021-06-30
WO2014144973A1 (en) 2014-09-18
AU2014233541B2 (en) 2018-11-22
JP2016512754A (ja) 2016-05-09
CA2903583A1 (en) 2014-09-18

Similar Documents

Publication Publication Date Title
CA2903583C (en) Microarray for delivery of therapeutic agent, methods of use, and methods of making
JP2016512754A5 (cg-RX-API-DMAC7.html)
US10857093B2 (en) Microarray for delivery of therapeutic agent, methods of use, and methods of making
CA2896188C (en) Microarray for delivery of therapeutic agent and methods of use
EP2968118B1 (en) Microarray for delivery of therapeutic agent and methods of use
CA2686093C (en) Solvent-cast microneedle arrays containing active
JP2016511014A5 (cg-RX-API-DMAC7.html)
US20250114981A1 (en) Hybrid method of forming microstructure array molds, methods of making microstructure arrays, and methods of use
EP3188714A1 (en) Microstructure array, methods of making, and methods of use
AU2014200648B2 (en) Solvent-cast microneedle arrays containing active

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20190214