CA2648719C - Modulators of atp-binding cassette transporters - Google Patents

Modulators of atp-binding cassette transporters Download PDF

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Publication number
CA2648719C
CA2648719C CA2648719A CA2648719A CA2648719C CA 2648719 C CA2648719 C CA 2648719C CA 2648719 A CA2648719 A CA 2648719A CA 2648719 A CA2648719 A CA 2648719A CA 2648719 C CA2648719 C CA 2648719C
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Prior art keywords
optionally substituted
compound
halo
independently
hydroxy
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CA2648719A
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English (en)
French (fr)
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CA2648719A1 (en
Inventor
Sara S. Hadida Ruah
Peter D. J. Grootenhuis
Fredrick Van Goor
Jinglan Zhou
Brian Bear
Mark T. Miller
Jason Mccartney
Mehdi Michel Jamel Numa
Xiaoqing Yang
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Priority to CA2869945A priority Critical patent/CA2869945C/en
Publication of CA2648719A1 publication Critical patent/CA2648719A1/en
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Publication of CA2648719C publication Critical patent/CA2648719C/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C—CHEMISTRY; METALLURGY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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CA2648719A 2006-04-07 2007-04-09 Modulators of atp-binding cassette transporters Active CA2648719C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2869945A CA2869945C (en) 2006-04-07 2007-04-09 Modulators of atp-binding cassette transporters

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79045906P 2006-04-07 2006-04-07
US60/790,459 2006-04-07
PCT/US2007/008975 WO2007117715A2 (en) 2006-04-07 2007-04-09 Modulators of atp-binding cassette transporters

Related Child Applications (1)

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CA2869945A Division CA2869945C (en) 2006-04-07 2007-04-09 Modulators of atp-binding cassette transporters

Publications (2)

Publication Number Publication Date
CA2648719A1 CA2648719A1 (en) 2007-10-18
CA2648719C true CA2648719C (en) 2015-02-24

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CA2648719A Active CA2648719C (en) 2006-04-07 2007-04-09 Modulators of atp-binding cassette transporters
CA2869945A Active CA2869945C (en) 2006-04-07 2007-04-09 Modulators of atp-binding cassette transporters

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CA2869945A Active CA2869945C (en) 2006-04-07 2007-04-09 Modulators of atp-binding cassette transporters

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US (9) US7776905B2 (index.php)
EP (5) EP2007756B1 (index.php)
JP (3) JP5420395B2 (index.php)
CN (2) CN103254177A (index.php)
AU (1) AU2007235260B2 (index.php)
BR (1) BRPI0710965B8 (index.php)
CA (2) CA2648719C (index.php)
CY (3) CY1116979T1 (index.php)
DK (3) DK2674428T3 (index.php)
ES (4) ES2554353T3 (index.php)
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