CA2641933C - Thiophene and thiazole substituted trifluoroethanone derivatives as histone deacetylase (hdac) inhibitors - Google Patents

Thiophene and thiazole substituted trifluoroethanone derivatives as histone deacetylase (hdac) inhibitors Download PDF

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CA2641933C
CA2641933C CA2641933A CA2641933A CA2641933C CA 2641933 C CA2641933 C CA 2641933C CA 2641933 A CA2641933 A CA 2641933A CA 2641933 A CA2641933 A CA 2641933A CA 2641933 C CA2641933 C CA 2641933C
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6alkyl
thienyl
ring containing
independently selected
trifluoro
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French (fr)
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CA2641933A1 (en
Inventor
Federica Ferrigno
Philip Jones
Ester Muraglia
Jesus Maria Ontoria Ontoria
Rita Scarpelli
Carsten Schultz-Fademrecht
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MSD Italia SRL
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Istituto di Ricerche di Biologia Molecolare P Angeletti SpA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • General Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
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CA2641933A 2006-02-15 2007-02-14 Thiophene and thiazole substituted trifluoroethanone derivatives as histone deacetylase (hdac) inhibitors Active CA2641933C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0603041.5A GB0603041D0 (en) 2006-02-15 2006-02-15 Therapeutic compounds
GB0603041.5 2006-02-15
PCT/GB2007/050061 WO2007093827A1 (en) 2006-02-15 2007-02-14 Thiophene and thiazole substituted trifluoroethanone derivatives as histone deacetylase (hdac) inhibitors

Publications (2)

Publication Number Publication Date
CA2641933A1 CA2641933A1 (en) 2007-08-23
CA2641933C true CA2641933C (en) 2014-04-08

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ID=36141881

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CA2641933A Active CA2641933C (en) 2006-02-15 2007-02-14 Thiophene and thiazole substituted trifluoroethanone derivatives as histone deacetylase (hdac) inhibitors

Country Status (7)

Country Link
US (1) US7799825B2 (enExample)
EP (1) EP1987024B1 (enExample)
JP (2) JP5798285B2 (enExample)
AU (1) AU2007216323B2 (enExample)
CA (1) CA2641933C (enExample)
GB (1) GB0603041D0 (enExample)
WO (1) WO2007093827A1 (enExample)

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GB0603041D0 (en) * 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
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HK1220916A1 (zh) 2013-03-14 2017-05-19 基因泰克公司 治疗癌症和预防癌症药物抗性的方法
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MY197262A (en) * 2015-07-27 2023-06-08 Chong Kun Dang Pharmaceutical Corp 1,3,4-oxadiazole sulfonamide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
WO2018165520A1 (en) 2017-03-10 2018-09-13 Vps-3, Inc. Metalloenzyme inhibitor compounds
KR102316234B1 (ko) 2018-07-26 2021-10-22 주식회사 종근당 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물
US20220154282A1 (en) 2019-03-12 2022-05-19 The Broad Institute, Inc. Detection means, compositions and methods for modulating synovial sarcoma cells
CA3136223C (en) 2019-05-31 2023-09-12 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole homophthalimide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
WO2023219456A1 (ko) * 2022-05-12 2023-11-16 숙명여자대학교 산학협력단 퀴놀린 계열 히스톤디아세틸화 효소 저해활성물질, 이의 제조방법 및 이를 유효성분으로 포함하는 약학적 조성물

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