CA2206754C - Benzimidazole derivatives with antihistaminic activity - Google Patents

Benzimidazole derivatives with antihistaminic activity Download PDF

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Publication number
CA2206754C
CA2206754C CA002206754A CA2206754A CA2206754C CA 2206754 C CA2206754 C CA 2206754C CA 002206754 A CA002206754 A CA 002206754A CA 2206754 A CA2206754 A CA 2206754A CA 2206754 C CA2206754 C CA 2206754C
Authority
CA
Canada
Prior art keywords
ethyl
benzimidazole
piperidine
phenyl
accordance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002206754A
Other languages
English (en)
French (fr)
Other versions
CA2206754A1 (en
Inventor
Aurelio Orjales
Victor Rubio
Maravillas Bordell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Faes Farma SA
Original Assignee
Faes Farma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Faes Farma SA filed Critical Faes Farma SA
Publication of CA2206754A1 publication Critical patent/CA2206754A1/en
Application granted granted Critical
Publication of CA2206754C publication Critical patent/CA2206754C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002206754A 1996-06-04 1997-06-03 Benzimidazole derivatives with antihistaminic activity Expired - Lifetime CA2206754C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (es) 1996-06-04 1996-06-04 Nuevos derivados del bencimidazol con actividad antihistaminica.
ESP9601236 1996-06-04

Publications (2)

Publication Number Publication Date
CA2206754A1 CA2206754A1 (en) 1997-12-04
CA2206754C true CA2206754C (en) 2007-01-23

Family

ID=8295035

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002206754A Expired - Lifetime CA2206754C (en) 1996-06-04 1997-06-03 Benzimidazole derivatives with antihistaminic activity

Country Status (27)

Country Link
US (1) US5877187A (OSRAM)
EP (1) EP0818454B1 (OSRAM)
JP (1) JP4218991B2 (OSRAM)
CN (1) CN1105716C (OSRAM)
AR (1) AR008386A1 (OSRAM)
AT (1) ATE264317T1 (OSRAM)
AU (1) AU725700B2 (OSRAM)
BR (1) BR9703276A (OSRAM)
CA (1) CA2206754C (OSRAM)
CZ (1) CZ289278B6 (OSRAM)
DE (2) DE122011000006I1 (OSRAM)
DK (1) DK0818454T3 (OSRAM)
ES (1) ES2124167B1 (OSRAM)
FR (1) FR11C0023I2 (OSRAM)
HR (1) HRP970307B1 (OSRAM)
HU (1) HU227598B1 (OSRAM)
IN (1) IN186319B (OSRAM)
LU (1) LU91798I2 (OSRAM)
MX (1) MXPA97004127A (OSRAM)
NO (2) NO313195B1 (OSRAM)
PL (1) PL188908B1 (OSRAM)
PT (1) PT818454E (OSRAM)
RU (1) RU2182150C2 (OSRAM)
SI (1) SI0818454T1 (OSRAM)
TR (1) TR199700464A2 (OSRAM)
TW (1) TW438794B (OSRAM)
ZA (1) ZA974893B (OSRAM)

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HUP0102470A3 (en) 1998-07-01 2002-05-28 Takeda Chemical Industries Ltd 1,3-azole derivatives as retinoid-associated receptor regulators and their use
JP3432800B2 (ja) 1998-11-27 2003-08-04 アボット ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 置換ベンゾイミダゾールおよびそのｐａｒｐ阻害剤としての使用
ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
MXPA04010313A (es) * 2002-04-19 2005-06-08 Faes Farma Sa Polimorfo del acido 4- [2-[4 -[1(2- etoxietil) -1h- bencimidazol -2-il]-1 -piperidinil] etil]- alfa, alfa- dimetil -bencenoacetico.
RU2288917C2 (ru) * 2002-04-19 2006-12-10 Фаэс Фарма, С.А. Полиморф 4-[2-[4-[1-(2-этоксиэтил)-1h-бензимидазол-2-ил]-1-пиперидинил]этил]-альфа, альфа-диметилбензолуксусной кислоты, способ его получения, фармацевтический препарат на его основе и его применение
RU2333208C2 (ru) * 2002-06-13 2008-09-10 Вертекс Фармасьютикалз Инкорпорейтед Производные 2-уреидо-6-гетероарил-3н-бензимидазол-6-карбоновой кислоты и родственные соединения в качестве ингибиторов гиразы и/или топоизомеразы iv для лечения бактериальных инфекций
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
EP2240464A4 (en) 2008-02-12 2011-09-14 Yuhan Corp PROCESS FOR THE PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
EP2969019A1 (en) * 2013-03-15 2016-01-20 Hercules Incorporated Composition and method of producing personal care compositions with improved deposition properties
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
CN103214455B (zh) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 一种比拉斯汀的制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103351380B (zh) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 一种制备比拉斯汀的方法
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106349214B (zh) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 一种比拉斯汀杂质的制备方法
CN107849007B (zh) * 2015-07-24 2024-08-09 乌奎玛公司 比拉斯汀的晶型及其制备方法
CN105272977A (zh) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 一种制备比拉斯汀中间体的方法
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
WO2017191651A1 (en) * 2016-05-05 2017-11-09 Msn Laboratories Private Limited, R & D Center Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof
CN107365298A (zh) * 2017-03-14 2017-11-21 罗欣生物科技（上海）有限公司 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法
CN109456316A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 一种比拉斯汀杂质的制备方法
ES2813561T3 (es) 2017-09-07 2021-03-24 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende bilastina
MX2020003834A (es) 2017-10-16 2020-08-06 Faes Farma Sa Composiciones acuosas que comprenden bilastina y mometasona.
PL3641735T3 (pl) 2017-12-18 2021-09-06 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Kompozycja farmaceutyczna tabletki zawierająca bilastynę w postaci 3 i rozpuszczalny w wodzie wypełniacz
ES2835287T3 (es) 2017-12-18 2021-06-22 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica de comprimido que comprende la forma polimórfica 3 de bilastina y aluminometasilicato de magnesio
DK3740191T3 (da) 2018-01-18 2021-06-07 Faes Farma Sa Oftalmiske sammensætninger omfattende bilastin, et beta-cyclodextrin og mindst et geleringsmiddel
CN109081827A (zh) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 一种比拉斯汀的制备方法及应用
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
WO2022023463A1 (en) 2020-07-30 2022-02-03 Faes Farma, S.A. Decongestant drug delivery system
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
US20230414597A1 (en) 2020-11-18 2023-12-28 BioPharma Synergies, S. L. Orodispersible powder composition comprising an antihistamine compound
EP4267109A1 (en) 2020-12-23 2023-11-01 Noucor Health S.A. A non-micronized bilastine composition
CN118891045A (zh) 2022-02-17 2024-11-01 费斯制药股份有限公司 用于每日一次肠胃外施用的比拉斯汀组合物
WO2024224308A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine free of cyclodextrins
WO2024224326A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
WO1991016313A1 (en) * 1990-04-13 1991-10-31 Smithkline Beecham Corporation Substituted benzimidazoles
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
DE69334145T2 (de) * 1992-08-03 2008-01-24 Sepracor Inc., Marlborough Terfenadincarboxylat und die Behandlung von Hautreizung
JP3712208B2 (ja) * 1993-06-25 2005-11-02 メレルファーマスーティカルズ インコーポレイテッド 抗ヒスタミン性の４−ジフェニルメチル／ジフェニルメトキシピペリジン誘導体類を製造する新規な中間体

Also Published As

Publication number Publication date
DE122011000006I1 (de) 2011-06-16
AU2467297A (en) 1997-12-11
DE69728608T2 (de) 2005-04-21
IN186319B (OSRAM) 2001-08-04
HU9700997D0 (en) 1997-07-28
HUP9700997A1 (hu) 1999-09-28
HRP970307A2 (en) 1998-04-30
CA2206754A1 (en) 1997-12-04
ES2124167B1 (es) 1999-09-16
EP0818454A1 (en) 1998-01-14
TR199700464A3 (tr) 1997-12-21
DE69728608D1 (de) 2004-05-19
DK0818454T3 (da) 2004-07-12
FR11C0023I2 (fr) 2012-03-16
NO972525D0 (no) 1997-06-03
ATE264317T1 (de) 2004-04-15
HRP970307B1 (en) 2002-02-28
NO2011008I1 (no) 2011-06-06
ZA974893B (en) 1997-12-30
PL188908B1 (pl) 2005-05-31
HU227598B1 (en) 2011-09-28
NO2011008I2 (no) 2012-05-14
ES2124167A1 (es) 1999-01-16
AR008386A1 (es) 2000-01-19
US5877187A (en) 1999-03-02
MXPA97004127A (es) 2005-07-25
NO972525L (no) 1997-12-05
CN1176964A (zh) 1998-03-25
CZ172397A3 (en) 1997-12-17
CZ289278B6 (cs) 2001-12-12
JP4218991B2 (ja) 2009-02-04
NO313195B1 (no) 2002-08-26
PT818454E (pt) 2004-08-31
FR11C0023I1 (OSRAM) 2011-08-19
LU91798I2 (fr) 2011-05-23
SI0818454T1 (en) 2004-08-31
CN1105716C (zh) 2003-04-16
RU2182150C2 (ru) 2002-05-10
AU725700B2 (en) 2000-10-19
TW438794B (en) 2001-06-07
BR9703276A (pt) 2004-08-17
EP0818454B1 (en) 2004-04-14
TR199700464A2 (xx) 1997-12-21
JPH1059961A (ja) 1998-03-03
PL320358A1 (en) 1997-12-08

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