LU91798I2 - Bilastine - Google Patents

Bilastine

Info

Publication number
LU91798I2
LU91798I2 LU91798C LU91798C LU91798I2 LU 91798 I2 LU91798 I2 LU 91798I2 LU 91798 C LU91798 C LU 91798C LU 91798 C LU91798 C LU 91798C LU 91798 I2 LU91798 I2 LU 91798I2
Authority
LU
Luxembourg
Prior art keywords
bilastine
Prior art date
Application number
LU91798C
Other languages
English (en)
French (fr)
Original Assignee
Faes Farma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Faes Farma Sa filed Critical Faes Farma Sa
Publication of LU91798I2 publication Critical patent/LU91798I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
LU91798C 1996-06-04 2011-03-22 Bilastine LU91798I2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (es) 1996-06-04 1996-06-04 Nuevos derivados del bencimidazol con actividad antihistaminica.

Publications (1)

Publication Number Publication Date
LU91798I2 true LU91798I2 (fr) 2011-05-23

Family

ID=8295035

Family Applications (1)

Application Number Title Priority Date Filing Date
LU91798C LU91798I2 (fr) 1996-06-04 2011-03-22 Bilastine

Country Status (27)

Country Link
US (1) US5877187A (OSRAM)
EP (1) EP0818454B1 (OSRAM)
JP (1) JP4218991B2 (OSRAM)
CN (1) CN1105716C (OSRAM)
AR (1) AR008386A1 (OSRAM)
AT (1) ATE264317T1 (OSRAM)
AU (1) AU725700B2 (OSRAM)
BR (1) BR9703276A (OSRAM)
CA (1) CA2206754C (OSRAM)
CZ (1) CZ289278B6 (OSRAM)
DE (2) DE122011000006I1 (OSRAM)
DK (1) DK0818454T3 (OSRAM)
ES (1) ES2124167B1 (OSRAM)
FR (1) FR11C0023I2 (OSRAM)
HR (1) HRP970307B1 (OSRAM)
HU (1) HU227598B1 (OSRAM)
IN (1) IN186319B (OSRAM)
LU (1) LU91798I2 (OSRAM)
MX (1) MXPA97004127A (OSRAM)
NO (2) NO313195B1 (OSRAM)
PL (1) PL188908B1 (OSRAM)
PT (1) PT818454E (OSRAM)
RU (1) RU2182150C2 (OSRAM)
SI (1) SI0818454T1 (OSRAM)
TR (1) TR199700464A2 (OSRAM)
TW (1) TW438794B (OSRAM)
ZA (1) ZA974893B (OSRAM)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9911752A (pt) 1998-07-01 2001-04-03 Takeda Chemical Industries Ltd Agente de regulagem da função do receptor relacionado com a retinóide, derivados de oxazol, de imidazol e de tiazol, composto, processo para regular uma função de receptor relacionado com a retinóide, e, uso de um derivado
IL143303A0 (en) 1998-11-27 2002-04-21 Basf Ag Substituted benzimidazoles and their use as parp inhibitors
ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
RU2288917C2 (ru) * 2002-04-19 2006-12-10 Фаэс Фарма, С.А. Полиморф 4-[2-[4-[1-(2-этоксиэтил)-1h-бензимидазол-2-ил]-1-пиперидинил]этил]-альфа, альфа-диметилбензолуксусной кислоты, способ его получения, фармацевтический препарат на его основе и его применение
NZ536551A (en) 2002-04-19 2006-08-31 Faes Farma S Preparation of polymorphous cyrstalline form, known as bilastine, and its antihistaminic and antiallergenic use
JP4489586B2 (ja) * 2002-06-13 2010-06-23 バーテックス ファーマシューティカルズ インコーポレイテッド 細菌感染を治療するジャイレースおよび／またはトポイソメラーゼｉｖ阻害剤としての２−ウレイド−６−ヘテロアリール−３ｈ−ベンゾイミダゾール−４−カルボン酸誘導体および関連化合物
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
US8367704B2 (en) * 2008-02-12 2013-02-05 Yuhan Corporation Process for preparation of 2-methyl-2′ phenylpropionic acid derivatives and novel intermediate compounds
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
MX366869B (es) * 2013-03-15 2019-07-29 Hercules Inc Composición y método para producir composiciones para el cuidado personal con propiedades de deposición mejoradas.
CN103214455B (zh) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 一种比拉斯汀的制备方法
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103351380B (zh) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 一种制备比拉斯汀的方法
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106349214B (zh) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 一种比拉斯汀杂质的制备方法
CN107849007B (zh) * 2015-07-24 2024-08-09 乌奎玛公司 比拉斯汀的晶型及其制备方法
CN105272977A (zh) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 一种制备比拉斯汀中间体的方法
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
EP3452462A4 (en) * 2016-05-05 2019-10-23 MSN Laboratories Private Limited, R&D Center Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof
CN107365298A (zh) * 2017-03-14 2017-11-21 罗欣生物科技（上海）有限公司 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法
CN109456316A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 一种比拉斯汀杂质的制备方法
EP3453384B1 (en) 2017-09-07 2020-05-27 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine
CA3079303A1 (en) 2017-10-16 2019-04-25 Faes Farma, S.A. Aqueous compositions comprising bilastine and mometasone
ES2864176T3 (es) 2017-12-18 2021-10-13 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende la forma 3 de bilastina y una carga soluble en agua
ES2835287T3 (es) 2017-12-18 2021-06-22 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica de comprimido que comprende la forma polimórfica 3 de bilastina y aluminometasilicato de magnesio
PL3740191T3 (pl) 2018-01-18 2021-11-29 Faes Farma, S.A. Kompozycje oftalmiczne zawierające bilastynę, beta-cyklodektrynę i co najmniej jeden środek żelatujący
CN109081827A (zh) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 一种比拉斯汀的制备方法及应用
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
WO2022023463A1 (en) 2020-07-30 2022-02-03 Faes Farma, S.A. Decongestant drug delivery system
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
EP4247331B1 (en) 2020-11-18 2025-10-08 BioPharma Synergies, S. L. Orodispersible powder composition comprising an antihistamine compound
CA3200779A1 (en) 2020-12-23 2022-06-30 Strusi ORAZIO LUCA A non-micronized bilastine composition
MX2024009978A (es) 2022-02-17 2024-08-26 Faes Farma Sa Composicion de bilastina para administracion parenteral una vez al dia.
WO2024224308A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine free of cyclodextrins
WO2024224326A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
AU7759591A (en) * 1990-04-13 1991-11-11 Smithkline Beecham Corporation Substituted benzimidazoles
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
ES2086270T5 (es) * 1992-08-03 2001-02-01 Sepracor Inc Metabolitos de terfenadina y sus isomeros opticamente puros para tratar trastornos alergicos.
HU226037B1 (en) * 1993-06-25 2008-03-28 Aventis Inc Process for producing antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives and novel intermediates

Also Published As

Publication number Publication date
AU725700B2 (en) 2000-10-19
HU9700997D0 (en) 1997-07-28
HUP9700997A1 (hu) 1999-09-28
NO972525L (no) 1997-12-05
AU2467297A (en) 1997-12-11
HU227598B1 (en) 2011-09-28
JPH1059961A (ja) 1998-03-03
ES2124167A1 (es) 1999-01-16
CZ172397A3 (en) 1997-12-17
NO313195B1 (no) 2002-08-26
DE69728608T2 (de) 2005-04-21
EP0818454B1 (en) 2004-04-14
DE69728608D1 (de) 2004-05-19
CA2206754C (en) 2007-01-23
NO2011008I2 (no) 2012-05-14
TW438794B (en) 2001-06-07
CZ289278B6 (cs) 2001-12-12
US5877187A (en) 1999-03-02
DK0818454T3 (da) 2004-07-12
CN1176964A (zh) 1998-03-25
TR199700464A3 (tr) 1997-12-21
FR11C0023I1 (OSRAM) 2011-08-19
ES2124167B1 (es) 1999-09-16
TR199700464A2 (xx) 1997-12-21
PL188908B1 (pl) 2005-05-31
CN1105716C (zh) 2003-04-16
HRP970307A2 (en) 1998-04-30
ZA974893B (en) 1997-12-30
FR11C0023I2 (fr) 2012-03-16
NO2011008I1 (no) 2011-06-06
CA2206754A1 (en) 1997-12-04
JP4218991B2 (ja) 2009-02-04
HRP970307B1 (en) 2002-02-28
ATE264317T1 (de) 2004-04-15
EP0818454A1 (en) 1998-01-14
SI0818454T1 (en) 2004-08-31
RU2182150C2 (ru) 2002-05-10
NO972525D0 (no) 1997-06-03
BR9703276A (pt) 2004-08-17
MXPA97004127A (es) 2005-07-25
PL320358A1 (en) 1997-12-08
AR008386A1 (es) 2000-01-19
PT818454E (pt) 2004-08-31
IN186319B (OSRAM) 2001-08-04
DE122011000006I1 (de) 2011-06-16

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