HRP970307B1 - New benzimidazole derivatives with antihistaminic activity - Google Patents
New benzimidazole derivatives with antihistaminic activityInfo
- Publication number
- HRP970307B1 HRP970307B1 HR970307A HRP970307A HRP970307B1 HR P970307 B1 HRP970307 B1 HR P970307B1 HR 970307 A HR970307 A HR 970307A HR P970307 A HRP970307 A HR P970307A HR P970307 B1 HRP970307 B1 HR P970307B1
- Authority
- HR
- Croatia
- Prior art keywords
- benzimidazole derivatives
- antihistaminic activity
- new benzimidazole
- new
- antihistaminic
- Prior art date
Links
- 230000001387 anti-histamine Effects 0.000 title 1
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES09601236A ES2124167B1 (es) | 1996-06-04 | 1996-06-04 | Nuevos derivados del bencimidazol con actividad antihistaminica. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP970307A2 HRP970307A2 (en) | 1998-04-30 |
| HRP970307B1 true HRP970307B1 (en) | 2002-02-28 |
Family
ID=8295035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR970307A HRP970307B1 (en) | 1996-06-04 | 1997-06-03 | New benzimidazole derivatives with antihistaminic activity |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5877187A (OSRAM) |
| EP (1) | EP0818454B1 (OSRAM) |
| JP (1) | JP4218991B2 (OSRAM) |
| CN (1) | CN1105716C (OSRAM) |
| AR (1) | AR008386A1 (OSRAM) |
| AT (1) | ATE264317T1 (OSRAM) |
| AU (1) | AU725700B2 (OSRAM) |
| BR (1) | BR9703276A (OSRAM) |
| CA (1) | CA2206754C (OSRAM) |
| CZ (1) | CZ289278B6 (OSRAM) |
| DE (2) | DE122011000006I1 (OSRAM) |
| DK (1) | DK0818454T3 (OSRAM) |
| ES (1) | ES2124167B1 (OSRAM) |
| FR (1) | FR11C0023I2 (OSRAM) |
| HR (1) | HRP970307B1 (OSRAM) |
| HU (1) | HU227598B1 (OSRAM) |
| IN (1) | IN186319B (OSRAM) |
| LU (1) | LU91798I2 (OSRAM) |
| MX (1) | MXPA97004127A (OSRAM) |
| NO (2) | NO313195B1 (OSRAM) |
| PL (1) | PL188908B1 (OSRAM) |
| PT (1) | PT818454E (OSRAM) |
| RU (1) | RU2182150C2 (OSRAM) |
| SI (1) | SI0818454T1 (OSRAM) |
| TR (1) | TR199700464A2 (OSRAM) |
| TW (1) | TW438794B (OSRAM) |
| ZA (1) | ZA974893B (OSRAM) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9911752A (pt) | 1998-07-01 | 2001-04-03 | Takeda Chemical Industries Ltd | Agente de regulagem da função do receptor relacionado com a retinóide, derivados de oxazol, de imidazol e de tiazol, composto, processo para regular uma função de receptor relacionado com a retinóide, e, uso de um derivado |
| IL143303A0 (en) | 1998-11-27 | 2002-04-21 | Basf Ag | Substituted benzimidazoles and their use as parp inhibitors |
| ES2151442B1 (es) * | 1999-01-11 | 2001-07-01 | Espanola Prod Quimicos | Nuevo derivado del bencenoetanol. |
| US6826561B2 (en) | 2000-05-22 | 2004-11-30 | Broadcom Corporation | Method and apparatus for performing a binary search on an expanded tree |
| RU2288917C2 (ru) * | 2002-04-19 | 2006-12-10 | Фаэс Фарма, С.А. | Полиморф 4-[2-[4-[1-(2-этоксиэтил)-1h-бензимидазол-2-ил]-1-пиперидинил]этил]-альфа, альфа-диметилбензолуксусной кислоты, способ его получения, фармацевтический препарат на его основе и его применение |
| NZ536551A (en) | 2002-04-19 | 2006-08-31 | Faes Farma S | Preparation of polymorphous cyrstalline form, known as bilastine, and its antihistaminic and antiallergenic use |
| JP4489586B2 (ja) * | 2002-06-13 | 2010-06-23 | バーテックス ファーマシューティカルズ インコーポレイテッド | 細菌感染を治療するジャイレースおよび／またはトポイソメラーゼｉｖ阻害剤としての２−ウレイド−６−ヘテロアリール−３ｈ−ベンゾイミダゾール−４−カルボン酸誘導体および関連化合物 |
| US20070188330A1 (en) * | 2006-01-24 | 2007-08-16 | Morhard Robert C | System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks |
| US7247623B2 (en) * | 2005-08-19 | 2007-07-24 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with non-drying antihistamines |
| US8367704B2 (en) * | 2008-02-12 | 2013-02-05 | Yuhan Corporation | Process for preparation of 2-methyl-2′ phenylpropionic acid derivatives and novel intermediate compounds |
| JP2010013472A (ja) * | 2009-09-09 | 2010-01-21 | Faes Farma Sa | ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体 |
| CN102675101B (zh) * | 2012-05-16 | 2014-01-29 | 王蕾 | 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法 |
| CZ307500B6 (cs) | 2012-08-15 | 2018-10-24 | Zentiva, K.S. | Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty |
| MX366869B (es) * | 2013-03-15 | 2019-07-29 | Hercules Inc | Composición y método para producir composiciones para el cuidado personal con propiedades de deposición mejoradas. |
| CN103214455B (zh) * | 2013-03-30 | 2018-08-31 | 北京万全德众医药生物技术有限公司 | 一种比拉斯汀的制备方法 |
| CN103214454A (zh) * | 2013-03-30 | 2013-07-24 | 北京万全德众医药生物技术有限公司 | 一种比拉斯汀晶型及制备方法 |
| WO2014188453A2 (en) * | 2013-05-24 | 2014-11-27 | Msn Laboratories Private Limited | Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid |
| CN103351380B (zh) * | 2013-06-30 | 2019-01-22 | 北京万全德众医药生物技术有限公司 | 一种制备比拉斯汀的方法 |
| CN104447683A (zh) * | 2013-09-12 | 2015-03-25 | 天津市汉康医药生物技术有限公司 | 一种稳定的比拉斯汀化合物 |
| CN103896915A (zh) * | 2014-04-01 | 2014-07-02 | 中国药科大学 | 苯并咪唑类衍生物、其制备方法及其在医药上的应用 |
| EP3040334A1 (en) | 2014-12-29 | 2016-07-06 | Faes Farma, S.A. | New benzimidazole derivatives as antihistamine agents |
| CN106349214B (zh) * | 2015-07-13 | 2020-11-03 | 南京长澳医药科技有限公司 | 一种比拉斯汀杂质的制备方法 |
| CN107849007B (zh) * | 2015-07-24 | 2024-08-09 | 乌奎玛公司 | 比拉斯汀的晶型及其制备方法 |
| CN105272977A (zh) * | 2015-09-19 | 2016-01-27 | 万全万特制药江苏有限公司 | 一种制备比拉斯汀中间体的方法 |
| EP3170816A1 (en) | 2015-11-20 | 2017-05-24 | Faes Farma, S.A. | Supersaturated compositions of benzimidazole compounds |
| EP3170817A1 (en) | 2015-11-20 | 2017-05-24 | Faes Farma, S.A. | Co-crystals of benzimidazole compounds |
| WO2017167949A1 (en) | 2016-04-01 | 2017-10-05 | Krka, D.D., Novo Mesto | Crystalline forms of bilastine |
| EP3452462A4 (en) * | 2016-05-05 | 2019-10-23 | MSN Laboratories Private Limited, R&D Center | Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof |
| CN107365298A (zh) * | 2017-03-14 | 2017-11-21 | 罗欣生物科技（上海）有限公司 | 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法 |
| CN109456316A (zh) * | 2017-09-06 | 2019-03-12 | 万全万特制药江苏有限公司 | 一种比拉斯汀杂质的制备方法 |
| EP3453384B1 (en) | 2017-09-07 | 2020-05-27 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical tablet composition comprising bilastine |
| CA3079303A1 (en) | 2017-10-16 | 2019-04-25 | Faes Farma, S.A. | Aqueous compositions comprising bilastine and mometasone |
| ES2864176T3 (es) | 2017-12-18 | 2021-10-13 | Tiefenbacher Alfred E Gmbh & Co Kg | Composición farmacéutica en comprimido que comprende la forma 3 de bilastina y una carga soluble en agua |
| ES2835287T3 (es) | 2017-12-18 | 2021-06-22 | Tiefenbacher Alfred E Gmbh & Co Kg | Composición farmacéutica de comprimido que comprende la forma polimórfica 3 de bilastina y aluminometasilicato de magnesio |
| PL3740191T3 (pl) | 2018-01-18 | 2021-11-29 | Faes Farma, S.A. | Kompozycje oftalmiczne zawierające bilastynę, beta-cyklodektrynę i co najmniej jeden środek żelatujący |
| CN109081827A (zh) * | 2018-11-06 | 2018-12-25 | 北京天弘天达医药科技股份有限公司 | 一种比拉斯汀的制备方法及应用 |
| EP3725298A1 (en) | 2019-04-16 | 2020-10-21 | Faes Farma, S.A. | Stable and preserved pharmaceutical compositions of bilastine |
| WO2022023463A1 (en) | 2020-07-30 | 2022-02-03 | Faes Farma, S.A. | Decongestant drug delivery system |
| CN112110893A (zh) * | 2020-10-28 | 2020-12-22 | 山东齐环医药科技有限公司 | 一种比拉斯汀的制备方法 |
| EP4247331B1 (en) | 2020-11-18 | 2025-10-08 | BioPharma Synergies, S. L. | Orodispersible powder composition comprising an antihistamine compound |
| CA3200779A1 (en) | 2020-12-23 | 2022-06-30 | Strusi ORAZIO LUCA | A non-micronized bilastine composition |
| MX2024009978A (es) | 2022-02-17 | 2024-08-26 | Faes Farma Sa | Composicion de bilastina para administracion parenteral una vez al dia. |
| WO2024224308A1 (en) * | 2023-04-27 | 2024-10-31 | Leiutis Pharmaceuticals Llp | Liquid parenteral formulations of bilastine free of cyclodextrins |
| WO2024224326A1 (en) * | 2023-04-27 | 2024-10-31 | Leiutis Pharmaceuticals Llp | Liquid parenteral formulations of bilastine |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8904174D0 (en) * | 1989-02-23 | 1989-04-05 | British Bio Technology | Compounds |
| AU7759591A (en) * | 1990-04-13 | 1991-11-11 | Smithkline Beecham Corporation | Substituted benzimidazoles |
| ES2048109B1 (es) * | 1992-07-20 | 1994-12-16 | Espanola Prod Quimicos | Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol. |
| ES2086270T5 (es) * | 1992-08-03 | 2001-02-01 | Sepracor Inc | Metabolitos de terfenadina y sus isomeros opticamente puros para tratar trastornos alergicos. |
| HU226037B1 (en) * | 1993-06-25 | 2008-03-28 | Aventis Inc | Process for producing antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives and novel intermediates |
-
1996
- 1996-06-04 ES ES09601236A patent/ES2124167B1/es not_active Expired - Fee Related
-
1997
- 1997-06-03 NO NO19972525A patent/NO313195B1/no not_active IP Right Cessation
- 1997-06-03 HR HR970307A patent/HRP970307B1/xx not_active IP Right Cessation
- 1997-06-03 EP EP97500099A patent/EP0818454B1/en not_active Expired - Lifetime
- 1997-06-03 DK DK97500099T patent/DK0818454T3/da active
- 1997-06-03 DE DE122011000006C patent/DE122011000006I1/de active Pending
- 1997-06-03 ZA ZA9704893A patent/ZA974893B/xx unknown
- 1997-06-03 PT PT97500099T patent/PT818454E/pt unknown
- 1997-06-03 RU RU97108980/04A patent/RU2182150C2/ru active
- 1997-06-03 AT AT97500099T patent/ATE264317T1/de active
- 1997-06-03 DE DE69728608T patent/DE69728608T2/de not_active Expired - Lifetime
- 1997-06-03 CA CA002206754A patent/CA2206754C/en not_active Expired - Lifetime
- 1997-06-03 AU AU24672/97A patent/AU725700B2/en not_active Expired
- 1997-06-03 SI SI9730652T patent/SI0818454T1/xx unknown
- 1997-06-04 IN IN1498DE1997 patent/IN186319B/en unknown
- 1997-06-04 HU HU9700997A patent/HU227598B1/hu active Protection Beyond IP Right Term
- 1997-06-04 CN CN97114905A patent/CN1105716C/zh not_active Expired - Lifetime
- 1997-06-04 BR BR9703276-0A patent/BR9703276A/pt not_active IP Right Cessation
- 1997-06-04 US US08/868,743 patent/US5877187A/en not_active Expired - Lifetime
- 1997-06-04 JP JP16201097A patent/JP4218991B2/ja not_active Expired - Lifetime
- 1997-06-04 TR TR97/00464A patent/TR199700464A2/xx unknown
- 1997-06-04 PL PL97320358A patent/PL188908B1/pl unknown
- 1997-06-04 MX MXPA97004127A patent/MXPA97004127A/es active IP Right Grant
- 1997-06-04 CZ CZ19971723A patent/CZ289278B6/cs not_active IP Right Cessation
- 1997-06-05 AR ARP970102441A patent/AR008386A1/es active IP Right Grant
- 1997-07-22 TW TW086110371A patent/TW438794B/zh not_active IP Right Cessation
-
2011
- 2011-03-22 LU LU91798C patent/LU91798I2/fr unknown
- 2011-05-24 NO NO2011008C patent/NO2011008I2/no unknown
- 2011-07-08 FR FR11C0023C patent/FR11C0023I2/fr active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP970307A2 (en) | New benzimidazole derivatives with antihistaminic activity | |
| IL133285A0 (en) | Benzimidazole derivatives | |
| PT900210E (pt) | Derivados azahexano heterociclicos com actividade antviral | |
| DE69720493D1 (de) | Naphthyridin-derivate | |
| IL141506A0 (en) | 4,4-biarylpiperidine derivatives with opioid receptor activity | |
| ID26743A (id) | Turunan 1,2,4,5-tetrahidro-benzo [d] azepin | |
| IL133674A0 (en) | Benzimidazole derivatives | |
| IL126095A0 (en) | Azolobenzazepine derivatives as neurogically active agents | |
| IL127432A0 (en) | Substituted benzimidazole derivatives | |
| IL146629A0 (en) | Indolylpiperidine derivatives as antihistaminic and antiallergic agents | |
| ZA9810039B (en) | Azoline derivatives | |
| EP0910356A4 (en) | BIPHENYLAMIDO DERIVATIVES AS MELATONERGIC AGENTS | |
| GB9623283D0 (en) | Heterocyclic derivatives | |
| GB9714552D0 (en) | Benzimidazole derivatives | |
| GB9703047D0 (en) | Benzimidazole derivatives | |
| ZA985598B (en) | Benzimidazole derivatives | |
| GB9711982D0 (en) | Benzimidazole derivatives | |
| SI0994890T1 (en) | Benzimidazole derivatives | |
| GB9416143D0 (en) | Benzimidazole derivatives | |
| NO970498D0 (no) | Benzimidazolderivater med dopaminergisk aktivitet | |
| ZA956538B (en) | Benzimidazole derivatives. | |
| ZA981224B (en) | Benzimidazole derivatives. | |
| GB9609665D0 (en) | Triterpine derivatives with immunosuppressant activity | |
| GB9722377D0 (en) | Heterocyclic derivatives | |
| GB9626857D0 (en) | Heterocyclic derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| AIPI | Request for the grant of a patent on the basis of a substantive examination of a patent application | ||
| B1PR | Patent granted | ||
| PNAN | Change of the applicant name, address/residence |
Owner name: FAES FARMA, S.A., ES |
|
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20160523 Year of fee payment: 20 |
|
| PB20 | Patent expired after termination of 20 years |
Effective date: 20170603 |