CA1323303C - Advanced anticancer therapy and cytotoxic medicaments for its implementation - Google Patents
Advanced anticancer therapy and cytotoxic medicaments for its implementationInfo
- Publication number
- CA1323303C CA1323303C CA000543912A CA543912A CA1323303C CA 1323303 C CA1323303 C CA 1323303C CA 000543912 A CA000543912 A CA 000543912A CA 543912 A CA543912 A CA 543912A CA 1323303 C CA1323303 C CA 1323303C
- Authority
- CA
- Canada
- Prior art keywords
- egf
- cytotoxic
- cells
- formula
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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- A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Landscapes
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- Bioinformatics & Cheminformatics (AREA)
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- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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EP86810347 | 1986-08-07 | ||
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IN165717B (forum.php) * | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
US5529932A (en) * | 1988-01-28 | 1996-06-25 | Pharmacia, S.P.A. | Isolated DNA encoding a plant ribosome inactivating protein from the leaves of saponaria officinalis |
IL89220A (en) * | 1988-02-11 | 1994-02-27 | Bristol Myers Squibb Co | Anthracycline immunoconjugates, their production and pharmaceutical compositions containing them |
DE4004573A1 (de) * | 1989-02-17 | 1990-08-23 | Tanabe Seiyaku Co | Neues versuchstier und seine herstellung |
US5354844A (en) * | 1989-03-16 | 1994-10-11 | Boehringer Ingelheim International Gmbh | Protein-polycation conjugates |
US5576288A (en) * | 1989-04-27 | 1996-11-19 | The Salk Institute For Biological Studies | Fibroblast growth factor conjugates |
US5191067A (en) * | 1989-04-27 | 1993-03-02 | The Salk Institute For Biological Studies | Fibroblast growth factor conjugates |
IL95031A (en) | 1989-07-18 | 2007-03-08 | Amgen Inc | Method for the production of a human recombinant tumor necrosis factor inhibitor |
DE69018226T2 (de) * | 1989-07-20 | 1995-09-21 | Sandoz-Patent-Gmbh, 79539 Loerrach | Markierte polypeptidderivate. |
US5208323A (en) * | 1989-08-10 | 1993-05-04 | Universite Laval | Coupling of an anti-tumor to an antibody using glutaraldehyde preactivated anti-tumor agent |
US5182107A (en) * | 1989-09-07 | 1993-01-26 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates |
US5672683A (en) * | 1989-09-07 | 1997-09-30 | Alkermes, Inc. | Transferrin neuropharmaceutical agent fusion protein |
US6329508B1 (en) | 1989-09-07 | 2001-12-11 | Alkermes, Inc. | Transferrin receptor reactive chimeric antibodies |
US5977307A (en) * | 1989-09-07 | 1999-11-02 | Alkermes, Inc. | Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins |
US5527527A (en) * | 1989-09-07 | 1996-06-18 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical agent conjugates |
CA2070416A1 (en) * | 1989-10-23 | 1991-04-24 | Richard Ingram | Polypeptide inhibitors of gamma interferon |
FI923915A7 (fi) * | 1990-03-02 | 1992-09-01 | Boston Medical Ct Corp | Paranettuja kimeerisiä toksiineja |
US6552170B1 (en) | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
US5137877B1 (en) * | 1990-05-14 | 1996-01-30 | Bristol Myers Squibb Co | Bifunctional linking compounds conjugates and methods for their production |
EP0485563B1 (de) * | 1990-05-30 | 1994-12-21 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Polyethersubstituierte tumormittel |
IL98528A0 (en) * | 1990-06-21 | 1992-07-15 | Merck & Co Inc | Pharmaceutical compositions containing hybrid for killing bladder cancer cells |
IE912167A1 (en) * | 1990-07-05 | 1992-01-15 | Akzo Nv | Receptor directed-toxin conjugates |
US5478804A (en) * | 1990-09-19 | 1995-12-26 | The Salk Institute For Biological Studies | Treatment of tumorigenic pathophysiological conditions with FGF-cytoxic conjugates |
EP0510132B1 (en) * | 1990-09-28 | 1997-05-14 | Neorx Corporation | Polymeric carriers for release of covalently linked agents |
US5431899A (en) * | 1991-02-04 | 1995-07-11 | University Of Saskatchewan | Rotavirus VP6 as a diagnostic and targeting agent |
US5464753A (en) * | 1991-03-08 | 1995-11-07 | Univ Illinois | Purification and manipulation of bone marrow and blood cells on the basis of P-glycoprotein expression |
JP3693671B2 (ja) * | 1991-03-15 | 2005-09-07 | アムゲン インコーポレーテッド | ポリペプチドのpeg化 |
AU662155B2 (en) * | 1991-05-10 | 1995-08-24 | Celtrix Pharmaceuticals, Inc. | Targeted delivery of bone growth factors |
EP0529175B1 (en) * | 1991-07-22 | 1995-08-09 | BRACCO International B.V. | Conjugates chelated with paramagnetic metals for targetting |
NZ244306A (en) * | 1991-09-30 | 1995-07-26 | Boehringer Ingelheim Int | Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation |
US5521291A (en) * | 1991-09-30 | 1996-05-28 | Boehringer Ingelheim International, Gmbh | Conjugates for introducing nucleic acid into higher eucaryotic cells |
US5981273A (en) * | 1991-09-30 | 1999-11-09 | Boehringer Ingelheim Int'l. Gmbh | Composition comprising an endosomolytic agent for introducing nucleic acid complexes into higher eucaryotic cells |
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- 1987-07-29 IN IN543/MAS/87A patent/IN165717B/en unknown
- 1987-08-05 AU AU77887/87A patent/AU608531B2/en not_active Expired - Fee Related
- 1987-08-05 DE DE8787201490T patent/DE3770730D1/de not_active Expired - Fee Related
- 1987-08-05 JP JP62504770A patent/JPH01500435A/ja active Pending
- 1987-08-05 WO PCT/EP1987/000435 patent/WO1988000837A2/en active Application Filing
- 1987-08-05 FI FI881579A patent/FI881579A0/fi not_active IP Right Cessation
- 1987-08-05 EP EP87201490A patent/EP0259904B1/en not_active Expired - Lifetime
- 1987-08-06 CA CA000543912A patent/CA1323303C/en not_active Expired - Fee Related
- 1987-08-06 US US07/082,244 patent/US5087616A/en not_active Expired - Fee Related
-
1988
- 1988-04-06 DK DK184788A patent/DK184788A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JPH01500435A (ja) | 1989-02-16 |
US5087616A (en) | 1992-02-11 |
DK184788D0 (da) | 1988-04-06 |
AU7788787A (en) | 1988-02-24 |
DK184788A (da) | 1988-06-06 |
AU608531B2 (en) | 1991-04-11 |
EP0259904A1 (en) | 1988-03-16 |
FI881579L (fi) | 1988-04-06 |
WO1988000837A3 (en) | 1988-03-10 |
IN165717B (forum.php) | 1989-12-23 |
EP0259904B1 (en) | 1991-06-12 |
WO1988000837A2 (en) | 1988-02-11 |
DE3770730D1 (de) | 1991-07-18 |
FI881579A7 (fi) | 1988-04-06 |
FI881579A0 (fi) | 1988-04-06 |
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