ES2070329T3 - Derivados de polipeptidos. - Google Patents

Derivados de polipeptidos.

Info

Publication number
ES2070329T3
ES2070329T3 ES90911595T ES90911595T ES2070329T3 ES 2070329 T3 ES2070329 T3 ES 2070329T3 ES 90911595 T ES90911595 T ES 90911595T ES 90911595 T ES90911595 T ES 90911595T ES 2070329 T3 ES2070329 T3 ES 2070329T3
Authority
ES
Spain
Prior art keywords
derivatives
peptide
amino group
detectable element
polypeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90911595T
Other languages
English (en)
Inventor
Rainer Albert
Wilfried Bauer
Janos Pless
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898916597A external-priority patent/GB8916597D0/en
Priority claimed from GB909004258A external-priority patent/GB9004258D0/en
Priority claimed from GB909005295A external-priority patent/GB9005295D0/en
Application filed by Sandoz AG filed Critical Sandoz AG
Application granted granted Critical
Publication of ES2070329T3 publication Critical patent/ES2070329T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

UN PEPTIDO BIOLOGICAMENTE ACTIVO SELECCIONADO ENTRE FACTORES DE CRECIMIENTO HORMONAS PEPTIDAS INTERFERONS Y CYTOLAINES Y SUS ANALOGOS Y DERIVADOS, Y QUE SOPORTA POR LO MENOS UN GRUPO QUELANTE UNIDO A UN GRUPO AMINO DE DICHO PEPTIDO, EL GRUPO QUELANTE DEBE SER SUSCEPTIBLE DE MEZCLARSE CON UN ELEMENTO PERCEPTIBLE Y DICHO GRUPO AMINO CON DEBIL AFINIDAD PARA LA UNION CON LOS RECEPTORES DEL OBJETIVO, ESTAN MEZCLADOS CON UN ELEMENTO PERCEPTIBLE Y SON UTILES EN PRODUCTOS FARMACEUTICOS, P.EJ . UN RADIOFARMACEUTICO PARA OBTENER IMAGENES EN VIVO DE LOS TEJIDOS OBJETO DE ANALISIS O PARA TERAPIA.
ES90911595T 1989-07-20 1990-07-12 Derivados de polipeptidos. Expired - Lifetime ES2070329T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898916597A GB8916597D0 (en) 1989-07-20 1989-07-20 Improvements in or relating to organic compounds
GB909004258A GB9004258D0 (en) 1990-02-26 1990-02-26 Improvements in or relating to organic compounds
GB909005295A GB9005295D0 (en) 1990-03-09 1990-03-09 Improvements in or relating to organic compounds

Publications (1)

Publication Number Publication Date
ES2070329T3 true ES2070329T3 (es) 1995-06-01

Family

ID=27264588

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90911595T Expired - Lifetime ES2070329T3 (es) 1989-07-20 1990-07-12 Derivados de polipeptidos.

Country Status (13)

Country Link
EP (1) EP0436005B1 (es)
JP (1) JPH04500823A (es)
AT (1) ATE120374T1 (es)
AU (1) AU638043B2 (es)
CA (1) CA2032499C (es)
DE (1) DE69018226T2 (es)
DK (1) DK0436005T3 (es)
ES (1) ES2070329T3 (es)
FI (1) FI101938B1 (es)
HU (1) HU219336B (es)
IE (1) IE67637B1 (es)
IL (1) IL95118A (es)
WO (1) WO1991001144A1 (es)

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US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5948384A (en) * 1990-09-14 1999-09-07 Syngenix Limited Particulate agents
GB9020075D0 (en) 1990-09-14 1990-10-24 Filler Aaron G Contrast agents for magnetic resonance imaging of axonal transport
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
GB9115375D0 (en) * 1991-07-17 1991-09-04 Salutar Inc Compounds
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US6919067B2 (en) 1991-09-13 2005-07-19 Syngenix Limited Compositions comprising a tissue glue and therapeutic agents
WO1993009816A1 (en) * 1991-11-14 1993-05-27 Battelle Memorial Institute Method for diagnosing and treating cancer
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
DE69231586T2 (de) * 1992-01-03 2001-07-19 Rhomed Inc Pharmazeutische anwendungen auf der basis von peptid-metall-ionen
US5371184A (en) * 1992-02-05 1994-12-06 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5643549A (en) * 1992-02-20 1997-07-01 Rhomed Incorporated Leukostimulatory agent for in vivo leukocyte tagging
CA2131315A1 (en) * 1992-03-25 1993-09-30 Geert J. Ensing Method of intraoperatively detecting and locating tumoral tissues
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
CA2094785A1 (en) * 1992-05-08 1993-11-09 Jean Gariepy Metal chelating peptide
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5620675A (en) 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5871711A (en) * 1992-06-23 1999-02-16 Diatide, Inc. Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US5346686A (en) * 1992-10-05 1994-09-13 Mallinckrodt Medical, Inc. Labelled interleukin-8 and medical uses thereof
US5449761A (en) * 1993-09-28 1995-09-12 Cytogen Corporation Metal-binding targeted polypeptide constructs
JPH07149668A (ja) * 1993-11-30 1995-06-13 Kanegafuchi Chem Ind Co Ltd アミロイド沈着検出用物質
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
CA2195648A1 (en) 1994-07-25 1996-02-08 Christoph Seidel Metal chelate-labelled peptides
DE19505960A1 (de) * 1995-02-21 1996-08-22 Deutsches Krebsforsch Konjugat zur individuellen Dosierung von Arzneimitteln
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
US5753206A (en) * 1995-06-07 1998-05-19 Immunomedics, Inc. Radiometal-binding analogues of luteinizing hormone releasing hormone
WO1998002192A1 (en) * 1996-07-12 1998-01-22 Immunomedics, Inc. Radiometal-binding peptide analogues
GB9708265D0 (en) * 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
AU5113198A (en) * 1996-12-02 1998-06-29 Raymond M. Reilly A radiolabelled ligand for selectively introducing an auger electron emitting radionuclide into the nucleus of a cancer cell
US6200546B1 (en) 1997-04-22 2001-03-13 The Curators Of The University Of Missouri Gastrin receptor-avid peptide conjugates
US7060247B2 (en) 1997-04-22 2006-06-13 The Curators Of The University Of Missouri Gastrin receptor-avid peptide conjugates
EP0961591B1 (en) * 1997-11-24 2008-05-14 Board of Supervisors of Louisiana State University and Agricultural and Mechanical College Method to enhance tissue accumulation of radiolabeled compounds
US6180082B1 (en) 1997-11-24 2001-01-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method to enhance tissue accumulation of radiolabeled compounds
US6548663B1 (en) 1998-03-31 2003-04-15 Bristol-Myers Squibb Pharma Company Benzodiazepine vitronectin receptor antagonist pharmaceuticals
BR9909420A (pt) 1998-03-31 2001-09-25 Du Pont Pharm Co Composto, kit, composição metalofarmacêutica de diagnóstico ou terapêutica, composição de agente de contraste de ultrassom, composição radiofarmacêutica terapêutica e composição radiofarmacêutica de diagnóstico
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
US6524553B2 (en) 1998-03-31 2003-02-25 Bristol-Myers Squibb Pharma Company Quinolone vitronectin receptor antagonist pharmaceuticals
CA2299389A1 (en) * 1998-06-05 1999-12-09 Mallinckrodt, Inc. Radiolabeled peptides for the diagnosis and treatment of breast and prostate tumors and metastases of such tumors
US6866837B2 (en) 1998-06-05 2005-03-15 Mallinckrodt Inc. Radiolabeled peptides for the diagnosis and treatment of breast and prostate tumors and metastases of such tumors
US6465613B1 (en) 1998-11-19 2002-10-15 Tulane University Hydrophilic somatostatin analogs
US6794518B1 (en) 1998-12-18 2004-09-21 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
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AU2012202855B2 (en) * 2004-09-03 2015-02-26 Philipps-Universitat Marburg GLP-1 and exendin related invention
DE102004043153B4 (de) * 2004-09-03 2013-11-21 Philipps-Universität Marburg Erfindung betreffend GLP-1 und Exendin
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GB8610551D0 (en) * 1986-04-30 1986-06-04 Hoffmann La Roche Polypeptide & protein derivatives
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CA1335725C (en) * 1987-09-25 1995-05-30 Stephen W. Hadley Method of diagnosing blood clots using fibrin-binding proteins
JPH04500805A (ja) * 1988-10-04 1992-02-13 カンサー・リサーチ・キャンペーン・テクノロジー・リミテッド 標的剤

Also Published As

Publication number Publication date
CA2032499C (en) 2002-05-14
EP0436005A1 (en) 1991-07-10
CA2032499A1 (en) 1991-01-21
FI911319A0 (fi) 1991-03-18
HU219336B (en) 2001-03-28
IL95118A (en) 1995-01-24
AU638043B2 (en) 1993-06-17
JPH04500823A (ja) 1992-02-13
FI101938B (fi) 1998-09-30
HU906177D0 (en) 1991-08-28
DE69018226T2 (de) 1995-09-21
DE69018226D1 (de) 1995-05-04
WO1991001144A1 (en) 1991-02-07
IL95118A0 (en) 1991-06-10
HUT56583A (en) 1991-09-30
EP0436005B1 (en) 1995-03-29
AU6070990A (en) 1991-02-22
IE67637B1 (en) 1996-04-17
ATE120374T1 (de) 1995-04-15
FI101938B1 (fi) 1998-09-30
DK0436005T3 (da) 1995-07-03
IE902619A1 (en) 1991-02-27

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