ES2124247T3 - Conjugado de calcitonina y de polietilenglicol. - Google Patents

Conjugado de calcitonina y de polietilenglicol.

Info

Publication number
ES2124247T3
ES2124247T3 ES92401164T ES92401164T ES2124247T3 ES 2124247 T3 ES2124247 T3 ES 2124247T3 ES 92401164 T ES92401164 T ES 92401164T ES 92401164 T ES92401164 T ES 92401164T ES 2124247 T3 ES2124247 T3 ES 2124247T3
Authority
ES
Spain
Prior art keywords
calcitonin
conjugate
polyethylene glycol
compound
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92401164T
Other languages
English (en)
Inventor
Henri Wantier
Fabienne Mathieu
Marc Baudrihaye
Clercq Pierre De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Application granted granted Critical
Publication of ES2124247T3 publication Critical patent/ES2124247T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN CONJUGADO DE CALCITONITA O UN POLIPEPTIDO ANALOGO QUE POSEE SUSTANCIALMENTE LA MISMA SECUENCIA DE AMINOACIDOS QUE UNA CALCITONINA NATURAL Y UNA ACTIVIDAD BIOLOGICA DE IGUAL NATURALEZA, CON UNO O VARIOS COMPUESTO(S), COMPRENDIENDO CADA UNO O VARIOS POLIMERO(S) DE POLIETILENO GLICOL POR ENLACE COVALENTE DE DICHO O DICHOS COMPUESTO(S) CON RESPECTIVAMENTE UNO O AL MENOS UN GRUPO CARBOXILO LIBRE DE LA CALCITONINA O SU ANALOGO.
ES92401164T 1991-04-23 1992-04-23 Conjugado de calcitonina y de polietilenglicol. Expired - Lifetime ES2124247T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR919104990A FR2675807B1 (fr) 1991-04-23 1991-04-23 Conjugue de calcitonine et de polyethylene glycol.

Publications (1)

Publication Number Publication Date
ES2124247T3 true ES2124247T3 (es) 1999-02-01

Family

ID=9412158

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92401164T Expired - Lifetime ES2124247T3 (es) 1991-04-23 1992-04-23 Conjugado de calcitonina y de polietilenglicol.

Country Status (5)

Country Link
EP (1) EP0511903B1 (es)
AT (1) ATE172216T1 (es)
DE (1) DE69227276T2 (es)
ES (1) ES2124247T3 (es)
FR (1) FR2675807B1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19514087A1 (de) * 1995-04-13 1996-10-17 Deutsches Krebsforsch Konjugat aus einem Wirkstoff, einem Polyether und ggfs. einem nicht als körperfremd angesehenen, nativen Protein
KR100345214B1 (ko) * 1999-08-17 2002-07-25 이강춘 생체적합성 고분자가 수식된 펩타이드의 비점막 전달
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
WO2003038034A2 (en) * 2001-11-01 2003-05-08 Texas Tech University Calcitonin-like sequence expressed by gonadotropes of the anterior pituitary
US7601688B2 (en) 2002-06-13 2009-10-13 Biocon Limited Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
MX2007000883A (es) 2004-07-19 2007-04-02 Biocon Ltd Conjugados de insulina-oligomero, formulaciones y usos de los mismos.
EP2168602A4 (en) * 2007-06-12 2014-10-29 Inst Pharm & Toxicology Amms LINEAR, PEGYLATED, SITE-SPECIFIC SALMON CALCITONIN DERIVATIVES
BRPI0818004B8 (pt) 2007-10-16 2021-05-25 Biocon Ltd composição farmacêutica sólida administrável por via oral e o processo da mesma.
ITRM20080551A1 (it) * 2008-10-15 2010-04-16 Univ Catania Derivati anfifilici del poliossietilenglicole (peg), procedimento di preparazione e loro usi nella preparazione di sistemi farmaceutici.
CN104774327A (zh) * 2015-04-08 2015-07-15 苏州市兴邦化学建材有限公司 一种大分子量甲基丙烯酸聚乙二醇单甲醚的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
WO1985003934A1 (fr) * 1984-03-06 1985-09-12 Takeda Chemical Industries, Ltd. Proteine modifiee chimiquement et son procede de preparation
JP2997004B2 (ja) * 1989-05-26 2000-01-11 住友製薬株式会社 ポリエチレングリコール誘導体、修飾ペプチドおよびその製造方法
ES2085297T3 (es) * 1989-05-27 1996-06-01 Sumitomo Pharma Procedimiento para preparar derivados de poli(etilenglicol) y proteina modificada.

Also Published As

Publication number Publication date
EP0511903A2 (fr) 1992-11-04
DE69227276D1 (de) 1998-11-19
ATE172216T1 (de) 1998-10-15
FR2675807B1 (fr) 1994-07-01
EP0511903B1 (fr) 1998-10-14
EP0511903A3 (en) 1993-08-11
DE69227276T2 (de) 1999-06-02
FR2675807A1 (fr) 1992-10-30

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