BR9909420A - Composto, kit, composição metalofarmacêutica de diagnóstico ou terapêutica, composição de agente de contraste de ultrassom, composição radiofarmacêutica terapêutica e composição radiofarmacêutica de diagnóstico - Google Patents
Composto, kit, composição metalofarmacêutica de diagnóstico ou terapêutica, composição de agente de contraste de ultrassom, composição radiofarmacêutica terapêutica e composição radiofarmacêutica de diagnósticoInfo
- Publication number
- BR9909420A BR9909420A BR9909420-7A BR9909420A BR9909420A BR 9909420 A BR9909420 A BR 9909420A BR 9909420 A BR9909420 A BR 9909420A BR 9909420 A BR9909420 A BR 9909420A
- Authority
- BR
- Brazil
- Prior art keywords
- composition
- therapeutic
- contrast agent
- diagnostic
- radiopharmaceutical
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 8
- 239000002961 echo contrast media Substances 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 229940127044 therapeutic radiopharmaceutical Drugs 0.000 title abstract 2
- 229940127043 diagnostic radiopharmaceutical Drugs 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 230000033115 angiogenesis Effects 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 239000002872 contrast media Substances 0.000 abstract 2
- 238000003384 imaging method Methods 0.000 abstract 2
- 239000002131 composite material Substances 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000005251 gamma ray Effects 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 229940121896 radiopharmaceutical Drugs 0.000 abstract 1
- 239000012217 radiopharmaceutical Substances 0.000 abstract 1
- 230000002799 radiopharmaceutical effect Effects 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- General Chemical & Material Sciences (AREA)
- Acoustics & Sound (AREA)
- Radiology & Medical Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
COMPOSTO, KIT, COMPOSIçãO METALOFARMACêUTICA DE DIAGNóSTICO OU TERAPêUTICA, COMPOSIçãO DE AGENTE DE CONTRASTE DE ULTRASSOM, COMPOSIçãO RADIOFARMACêUTICA TERAPêUTICA E COMPOSIçãO RADIOFARMACêUTICA DE DIAGNóSTICO" A presente invenção descreve compostos inovadores da fórmula (Q)~ d~-L~ n~-C~ h~, úteis para o diagnóstico e tratamento de câncer, métodos de formação de imagens de tumores em pacientes e métodos de tratamento de câncer em pacientes. A presente invenção também proporciona compostos inovadores úteis para o monitoramento do tratamento terapêutico de angiogênese e destruição de nova vasculatura angiogênica. Os produtos farmacêuticos são compostos de uma porção desejada que se une a um receptor que é regulado para cima durante a angiogênese, um grupo opcional de ligação e um radioisótopo terapeuticamente eficaz ou porção representável diagnosticamente eficaz. A porção representável é um radioisótopo emissor de raio gama ou positron, um agente de contraste de formação de imagens por ressonância magnética, um agente de contraste de raio X ou um agente de contraste de ultrassom.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8015098P | 1998-03-31 | 1998-03-31 | |
US11271598P | 1998-12-18 | 1998-12-18 | |
PCT/US1999/006826 WO1999058162A2 (en) | 1998-03-31 | 1999-03-29 | Pharmaceuticals for the imaging of angiogenic disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9909420A true BR9909420A (pt) | 2001-09-25 |
Family
ID=26763137
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9909420-7A BR9909420A (pt) | 1998-03-31 | 1999-03-29 | Composto, kit, composição metalofarmacêutica de diagnóstico ou terapêutica, composição de agente de contraste de ultrassom, composição radiofarmacêutica terapêutica e composição radiofarmacêutica de diagnóstico |
Country Status (20)
Country | Link |
---|---|
US (2) | US20020001566A1 (pt) |
EP (1) | EP1068224B1 (pt) |
JP (1) | JP4487019B2 (pt) |
KR (1) | KR20010042288A (pt) |
CN (1) | CN1295578A (pt) |
AR (1) | AR020586A1 (pt) |
AT (1) | ATE295369T1 (pt) |
AU (1) | AU5541799A (pt) |
BR (1) | BR9909420A (pt) |
CA (1) | CA2324555A1 (pt) |
DE (1) | DE69925262T2 (pt) |
EA (1) | EA200001007A1 (pt) |
EE (1) | EE200000574A (pt) |
ES (1) | ES2241313T3 (pt) |
HU (1) | HUP0101468A2 (pt) |
IL (1) | IL138093A0 (pt) |
NO (1) | NO20004917L (pt) |
PL (1) | PL343804A1 (pt) |
SK (1) | SK13952000A3 (pt) |
WO (1) | WO1999058162A2 (pt) |
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1999
- 1999-03-29 ES ES99941944T patent/ES2241313T3/es not_active Expired - Lifetime
- 1999-03-29 JP JP2000548013A patent/JP4487019B2/ja not_active Expired - Fee Related
- 1999-03-29 PL PL99343804A patent/PL343804A1/xx unknown
- 1999-03-29 HU HU0101468A patent/HUP0101468A2/hu unknown
- 1999-03-29 IL IL13809399A patent/IL138093A0/xx unknown
- 1999-03-29 AT AT99941944T patent/ATE295369T1/de not_active IP Right Cessation
- 1999-03-29 WO PCT/US1999/006826 patent/WO1999058162A2/en active IP Right Grant
- 1999-03-29 EE EEP200000574A patent/EE200000574A/xx unknown
- 1999-03-29 DE DE69925262T patent/DE69925262T2/de not_active Expired - Lifetime
- 1999-03-29 KR KR1020007010831A patent/KR20010042288A/ko not_active Application Discontinuation
- 1999-03-29 AU AU55417/99A patent/AU5541799A/en not_active Abandoned
- 1999-03-29 CA CA002324555A patent/CA2324555A1/en not_active Abandoned
- 1999-03-29 EA EA200001007A patent/EA200001007A1/ru unknown
- 1999-03-29 CN CN99804710A patent/CN1295578A/zh active Pending
- 1999-03-29 EP EP99941944A patent/EP1068224B1/en not_active Expired - Lifetime
- 1999-03-29 SK SK1395-2000A patent/SK13952000A3/sk unknown
- 1999-03-29 BR BR9909420-7A patent/BR9909420A/pt not_active IP Right Cessation
- 1999-03-30 AR ARP990101448A patent/AR020586A1/es not_active Application Discontinuation
- 1999-03-30 US US09/281,474 patent/US20020001566A1/en not_active Abandoned
- 1999-03-30 US US09/281,207 patent/US6322770B1/en not_active Expired - Fee Related
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2000
- 2000-09-29 NO NO20004917A patent/NO20004917L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO20004917L (no) | 2000-11-02 |
CN1295578A (zh) | 2001-05-16 |
US6322770B1 (en) | 2001-11-27 |
EE200000574A (et) | 2002-10-15 |
AU5541799A (en) | 1999-11-29 |
AR020586A1 (es) | 2002-05-22 |
DE69925262D1 (de) | 2005-06-16 |
ES2241313T3 (es) | 2005-10-16 |
SK13952000A3 (sk) | 2001-12-03 |
EP1068224A2 (en) | 2001-01-17 |
PL343804A1 (en) | 2001-09-10 |
JP4487019B2 (ja) | 2010-06-23 |
WO1999058162A3 (en) | 2000-04-06 |
EA200001007A1 (ru) | 2001-04-23 |
NO20004917D0 (no) | 2000-09-29 |
US20020001566A1 (en) | 2002-01-03 |
IL138093A0 (en) | 2001-10-31 |
WO1999058162A2 (en) | 1999-11-18 |
EP1068224B1 (en) | 2005-05-11 |
ATE295369T1 (de) | 2005-05-15 |
JP2002514611A (ja) | 2002-05-21 |
KR20010042288A (ko) | 2001-05-25 |
HUP0101468A2 (hu) | 2001-08-28 |
CA2324555A1 (en) | 1999-11-18 |
DE69925262T2 (de) | 2006-02-23 |
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