DE69925262D1 - Pharmazeutika zur bildgebung der angiogenischen krankheiten - Google Patents
Pharmazeutika zur bildgebung der angiogenischen krankheitenInfo
- Publication number
- DE69925262D1 DE69925262D1 DE69925262T DE69925262T DE69925262D1 DE 69925262 D1 DE69925262 D1 DE 69925262D1 DE 69925262 T DE69925262 T DE 69925262T DE 69925262 T DE69925262 T DE 69925262T DE 69925262 D1 DE69925262 D1 DE 69925262D1
- Authority
- DE
- Germany
- Prior art keywords
- pharmaceuticals
- imaging
- angiogenic diseases
- angiogenic
- diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000002491 angiogenic effect Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000003384 imaging method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8015098P | 1998-03-31 | 1998-03-31 | |
US80150P | 1998-03-31 | ||
US11271598P | 1998-12-18 | 1998-12-18 | |
US112715P | 1998-12-18 | ||
PCT/US1999/006826 WO1999058162A2 (en) | 1998-03-31 | 1999-03-29 | Pharmaceuticals for the imaging of angiogenic disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69925262D1 true DE69925262D1 (de) | 2005-06-16 |
DE69925262T2 DE69925262T2 (de) | 2006-02-23 |
Family
ID=26763137
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69925262T Expired - Lifetime DE69925262T2 (de) | 1998-03-31 | 1999-03-29 | Pharmazeutika zur bildgebung der angiogenischen krankheiten |
Country Status (20)
Country | Link |
---|---|
US (2) | US6322770B1 (de) |
EP (1) | EP1068224B1 (de) |
JP (1) | JP4487019B2 (de) |
KR (1) | KR20010042288A (de) |
CN (1) | CN1295578A (de) |
AR (1) | AR020586A1 (de) |
AT (1) | ATE295369T1 (de) |
AU (1) | AU5541799A (de) |
BR (1) | BR9909420A (de) |
CA (1) | CA2324555A1 (de) |
DE (1) | DE69925262T2 (de) |
EA (1) | EA200001007A1 (de) |
EE (1) | EE200000574A (de) |
ES (1) | ES2241313T3 (de) |
HU (1) | HUP0101468A2 (de) |
IL (1) | IL138093A0 (de) |
NO (1) | NO20004917L (de) |
PL (1) | PL343804A1 (de) |
SK (1) | SK13952000A3 (de) |
WO (1) | WO1999058162A2 (de) |
Families Citing this family (60)
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---|---|---|---|---|
US6749853B1 (en) * | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
US6537520B1 (en) | 1998-03-31 | 2003-03-25 | Bristol-Myers Squibb Pharma Company | Pharmaceuticals for the imaging of angiogenic disorders |
US6794518B1 (en) | 1998-12-18 | 2004-09-21 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
US6989139B2 (en) | 2000-02-15 | 2006-01-24 | Bristol-Myers Squibb Pharma Company | Matrix metalloproteinase inhibitors |
EP1281067B1 (de) * | 2000-05-08 | 2007-01-17 | Vivactis NV | Verfahren zur hochdurchsatzprofilierung neuer werkstoffe |
US7109167B2 (en) | 2000-06-02 | 2006-09-19 | Bracco International B.V. | Compounds for targeting endothelial cells, compositions containing the same and methods for their use |
US8263739B2 (en) | 2000-06-02 | 2012-09-11 | Bracco Suisse Sa | Compounds for targeting endothelial cells, compositions containing the same and methods for their use |
EP1296678A2 (de) * | 2000-06-21 | 2003-04-02 | Bristol-Myers Squibb Pharma Company | Arzneimittel mit vitronektin-rezeptor-antagonistischer wirkung zur anwendung in der kombinationstherapie |
EP1311302A2 (de) * | 2000-06-21 | 2003-05-21 | Bristol-Myers Squibb Pharma Company | Pharmaka zur bilderzeugung von angiogenenische erkrankungen |
CA2413538A1 (en) * | 2000-07-06 | 2002-01-17 | Bristol-Myers Squibb Pharma Company | Stable radiopharmaceutical compositions and methods for preparation thereof |
WO2002055111A2 (en) * | 2000-11-27 | 2002-07-18 | Bristol Myers Squibb Medical I | Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent |
TW593278B (en) | 2001-01-23 | 2004-06-21 | Wyeth Corp | 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands |
US7271180B2 (en) * | 2001-01-23 | 2007-09-18 | Wyeth | 1-Aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands |
CZ20032872A3 (cs) | 2001-04-23 | 2005-01-12 | Mallinckrodt Inc. | Peptický ligand, který váže receptor somatostatinu |
HUP0401904A3 (en) * | 2001-08-08 | 2009-01-28 | Bristol Myers Squibb Pharma Co | Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent |
CN100560131C (zh) | 2001-10-22 | 2009-11-18 | 斯克里普斯研究学院 | 抗体靶向化合物 |
US7279150B2 (en) | 2002-01-24 | 2007-10-09 | Barnes-Jewish Hospital | Chelating agents with lipophilic carriers |
WO2003062198A1 (en) | 2002-01-24 | 2003-07-31 | Barnes Jewish Hospital | Integrin targeted imaging agents |
US20050250700A1 (en) * | 2002-03-01 | 2005-11-10 | Sato Aaron K | KDR and VEGF/KDR binding peptides |
US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
US7666979B2 (en) * | 2002-03-01 | 2010-02-23 | Bracco International B.V. | Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same |
ES2398393T3 (es) | 2002-03-01 | 2013-03-15 | Dyax Corp. | Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico y terapia |
US20050100963A1 (en) | 2002-03-01 | 2005-05-12 | Dyax Corporation | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
US7211240B2 (en) * | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
US7985402B2 (en) | 2002-03-01 | 2011-07-26 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
WO2003096387A2 (en) * | 2002-05-08 | 2003-11-20 | Phoseon Technology, Inc. | High efficiency solid-state light source and methods of use and manufacture |
US6961607B2 (en) * | 2002-07-31 | 2005-11-01 | Uzgiris Egidijus E | Method for assessing myocardial angiogenesis |
US20040224986A1 (en) | 2002-08-16 | 2004-11-11 | Bart De Corte | Piperidinyl targeting compounds that selectively bind integrins |
AU2003265898A1 (en) * | 2002-09-05 | 2004-03-29 | Genentech, Inc. | Infusion catheter having an integrated doppler transducer |
US20040047917A1 (en) * | 2002-09-06 | 2004-03-11 | Stephen Wilson | Drug delivery and targeting with vitamin B12 conjugates |
DE60310958T2 (de) * | 2002-09-19 | 2007-10-11 | Centre National De La Recherche Scientifique (Cnrs) | Synthese und charakterisierung neuer systeme zum hinführen und zur vektorisierung von molekülen von therapeutischem interesse zu targetzellen |
WO2004069281A1 (en) * | 2003-01-30 | 2004-08-19 | The General Hospital Corporation | Bifunctional molecules comprising at least one integrin-binding and their use in imaging and therapy of angiogenesis and related disorders |
WO2004078778A2 (en) | 2003-03-03 | 2004-09-16 | Dyax Corp. | PEPTIDES THAT SPECIFICALLY BIND HGF RECEPTOR (cMet) AND USES THEREOF |
ATE449614T1 (de) * | 2003-05-12 | 2009-12-15 | Lantheus Medical Imaging Inc | Vitronectin rezeptorantagonisten und ihre verwendung als radiopharmazeutika |
US20050079131A1 (en) * | 2003-08-08 | 2005-04-14 | Lanza Gregory M. | Emulsion particles for imaging and therapy and methods of use thereof |
US20050112064A1 (en) * | 2003-08-12 | 2005-05-26 | Sonya Franklin | DNA-dependent MRI contrast agents |
US7803374B2 (en) * | 2004-01-16 | 2010-09-28 | Barnes-Jewish Hospital | Targeted atherosclerosis treatment |
ATE391130T1 (de) * | 2004-02-23 | 2008-04-15 | Dow Global Technologies Inc | Klebstoff auf wasserbasis zum kleben von substraten mit niedriger oberflächenenergie |
JP2008502726A (ja) | 2004-06-09 | 2008-01-31 | ケレオス インコーポレーティッド | キレートモノアミドの親油性誘導体 |
DE602005000853D1 (de) * | 2004-07-02 | 2007-05-24 | Vivactis Nv | Messung der Wärme erzeugt durch einen chemischen oder biologischen Prozess. |
WO2006094725A1 (en) * | 2005-03-10 | 2006-09-14 | Bayer Schering Pharma Aktiengesellschaft | Chelators for radioactively labeled conjugates comprising a stabilizing sidechain |
US20090131327A1 (en) * | 2005-04-29 | 2009-05-21 | Patrick Doherty | Nogo receptor functional motifs and peptide mimetics related thereto and methods of using the same |
CA2630415A1 (en) * | 2005-10-20 | 2007-04-26 | The Scripps Research Institute | Fc labeling for immunostaining and immunotargeting |
WO2007070827A2 (en) * | 2005-12-15 | 2007-06-21 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardium perfusion imaging |
AU2007244705A1 (en) * | 2006-04-27 | 2007-11-08 | Barnes-Jewish Hospital | Detection and imaging of target tissue |
EP2076120A1 (de) * | 2006-09-29 | 2009-07-08 | Washington University | Kombination für die behandlung von revaskularisierung |
US20100016706A1 (en) * | 2006-12-08 | 2010-01-21 | Molecular Image, Inc. | Methods for diagnosis and monitoring of neurologic diseases using magnetic resonance methods |
US8194963B2 (en) * | 2008-03-10 | 2012-06-05 | Siemens Medical Solutions Usa, Inc. | Efficient estimator of pharmacokinetic parameters in breast MRI |
KR101430627B1 (ko) | 2008-05-13 | 2014-08-14 | 유니버시티 오브 캔사스 | 금속 추출 펩타이드(map) 태그 및 관련된 방법 |
US20100178245A1 (en) * | 2009-01-13 | 2010-07-15 | Arnsdorf Morton F | Biocompatible Microbubbles to Deliver Radioactive Compounds to Tumors, Atherosclerotic Plaques, Joints and Other Targeted Sites |
WO2010093706A2 (en) | 2009-02-10 | 2010-08-19 | The Scripps Research Institute | Chemically programmed vaccination |
CN101659694B (zh) * | 2009-05-06 | 2012-12-12 | 河北科技大学 | 抗肿瘤环五肽化合物及其制备方法 |
WO2013181461A2 (en) | 2012-06-01 | 2013-12-05 | University Of Kansas | Metal abstraction peptide with superoxide dismutase activity |
WO2014160903A2 (en) * | 2013-03-27 | 2014-10-02 | Theranos, Inc. | Biological sample processing |
ES2662326T5 (es) * | 2013-04-12 | 2021-08-04 | Evox Therapeutics Ltd | Vesículas de suministro terapéutico |
DE102013113156A1 (de) * | 2013-11-28 | 2015-05-28 | Freie Universität Berlin | Verbindung und Verfahren zur selektiven Radiomarkierung von Polypeptiden mittels Festphasensynthese |
KR102548998B1 (ko) * | 2020-03-31 | 2023-06-29 | 재단법인 아산사회복지재단 | 혈전영상을 위한 방사성의약품 및 조성물 |
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-
1999
- 1999-03-29 EA EA200001007A patent/EA200001007A1/ru unknown
- 1999-03-29 IL IL13809399A patent/IL138093A0/xx unknown
- 1999-03-29 ES ES99941944T patent/ES2241313T3/es not_active Expired - Lifetime
- 1999-03-29 JP JP2000548013A patent/JP4487019B2/ja not_active Expired - Fee Related
- 1999-03-29 DE DE69925262T patent/DE69925262T2/de not_active Expired - Lifetime
- 1999-03-29 EP EP99941944A patent/EP1068224B1/de not_active Expired - Lifetime
- 1999-03-29 CA CA002324555A patent/CA2324555A1/en not_active Abandoned
- 1999-03-29 CN CN99804710A patent/CN1295578A/zh active Pending
- 1999-03-29 HU HU0101468A patent/HUP0101468A2/hu unknown
- 1999-03-29 PL PL99343804A patent/PL343804A1/xx unknown
- 1999-03-29 AT AT99941944T patent/ATE295369T1/de not_active IP Right Cessation
- 1999-03-29 AU AU55417/99A patent/AU5541799A/en not_active Abandoned
- 1999-03-29 EE EEP200000574A patent/EE200000574A/xx unknown
- 1999-03-29 KR KR1020007010831A patent/KR20010042288A/ko not_active Application Discontinuation
- 1999-03-29 BR BR9909420-7A patent/BR9909420A/pt not_active IP Right Cessation
- 1999-03-29 SK SK1395-2000A patent/SK13952000A3/sk unknown
- 1999-03-29 WO PCT/US1999/006826 patent/WO1999058162A2/en active IP Right Grant
- 1999-03-30 US US09/281,207 patent/US6322770B1/en not_active Expired - Fee Related
- 1999-03-30 AR ARP990101448A patent/AR020586A1/es not_active Application Discontinuation
- 1999-03-30 US US09/281,474 patent/US20020001566A1/en not_active Abandoned
-
2000
- 2000-09-29 NO NO20004917A patent/NO20004917L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU5541799A (en) | 1999-11-29 |
HUP0101468A2 (hu) | 2001-08-28 |
SK13952000A3 (sk) | 2001-12-03 |
PL343804A1 (en) | 2001-09-10 |
BR9909420A (pt) | 2001-09-25 |
US20020001566A1 (en) | 2002-01-03 |
CA2324555A1 (en) | 1999-11-18 |
AR020586A1 (es) | 2002-05-22 |
KR20010042288A (ko) | 2001-05-25 |
WO1999058162A2 (en) | 1999-11-18 |
JP4487019B2 (ja) | 2010-06-23 |
US6322770B1 (en) | 2001-11-27 |
IL138093A0 (en) | 2001-10-31 |
EA200001007A1 (ru) | 2001-04-23 |
CN1295578A (zh) | 2001-05-16 |
JP2002514611A (ja) | 2002-05-21 |
ATE295369T1 (de) | 2005-05-15 |
EP1068224B1 (de) | 2005-05-11 |
EP1068224A2 (de) | 2001-01-17 |
NO20004917L (no) | 2000-11-02 |
NO20004917D0 (no) | 2000-09-29 |
DE69925262T2 (de) | 2006-02-23 |
EE200000574A (et) | 2002-10-15 |
ES2241313T3 (es) | 2005-10-16 |
WO1999058162A3 (en) | 2000-04-06 |
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