IS5087A - Stöðugar interferónlyfjablöndur á vökvaformi - Google Patents
Stöðugar interferónlyfjablöndur á vökvaformiInfo
- Publication number
- IS5087A IS5087A IS5087A IS5087A IS5087A IS 5087 A IS5087 A IS 5087A IS 5087 A IS5087 A IS 5087A IS 5087 A IS5087 A IS 5087A IS 5087 A IS5087 A IS 5087A
- Authority
- IS
- Iceland
- Prior art keywords
- liquid
- interferon
- compositions
- beta
- stable liquid
- Prior art date
Links
- 239000007788 liquid Substances 0.000 title abstract 7
- 102000014150 Interferons Human genes 0.000 title abstract 4
- 108010050904 Interferons Proteins 0.000 title abstract 4
- 229940079322 interferon Drugs 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 102000003996 Interferon-beta Human genes 0.000 abstract 2
- 108090000467 Interferon-beta Proteins 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 229960001388 interferon-beta Drugs 0.000 abstract 2
- 239000004475 Arginine Substances 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/215—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychiatry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3435396P | 1996-12-24 | 1996-12-24 | |
| PCT/US1997/023817 WO1998028007A1 (en) | 1996-12-24 | 1997-12-23 | Stable liquid interferon formulations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IS5087A true IS5087A (is) | 1999-06-21 |
| IS2070B IS2070B (is) | 2005-12-15 |
Family
ID=21875893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS5087A IS2070B (is) | 1996-12-24 | 1999-06-21 | Stöðugar interferónlyfjablöndur á vökvaformi |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP0948358B2 (is) |
| JP (5) | JP4878664B2 (is) |
| KR (2) | KR20000069664A (is) |
| CN (2) | CN1222315C (is) |
| AT (1) | ATE270899T1 (is) |
| AU (1) | AU738362B2 (is) |
| BG (2) | BG65418B1 (is) |
| BR (1) | BR9714434A (is) |
| CA (1) | CA2275890C (is) |
| CZ (1) | CZ300636B6 (is) |
| DE (1) | DE69729880T3 (is) |
| DK (1) | DK0948358T4 (is) |
| EA (1) | EA002754B1 (is) |
| EE (2) | EE04223B1 (is) |
| ES (1) | ES2224290T5 (is) |
| HU (1) | HU224222B1 (is) |
| IL (1) | IL130524A (is) |
| IS (1) | IS2070B (is) |
| MX (1) | MX337876B (is) |
| NO (1) | NO327844B1 (is) |
| NZ (2) | NZ336548A (is) |
| PL (1) | PL193447B1 (is) |
| PT (1) | PT948358E (is) |
| SI (1) | SI0948358T2 (is) |
| SK (1) | SK284989B6 (is) |
| TR (1) | TR199901968T2 (is) |
| WO (1) | WO1998028007A1 (is) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030190307A1 (en) | 1996-12-24 | 2003-10-09 | Biogen, Inc. | Stable liquid interferon formulations |
| CA2275890C (en) * | 1996-12-24 | 2011-11-01 | Biogen, Inc. | Stable liquid interferon formulations |
| IL135186A0 (en) † | 1997-09-23 | 2001-05-20 | Rentschler Biotechnologie Bmgh | LIQUID INTERFERON-β FORMULATIONS |
| WO2000072873A1 (en) * | 1999-05-31 | 2000-12-07 | Mitsubishi Chemical Corporation | Freeze dried hgf preparations |
| US6887462B2 (en) * | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
| AR034749A1 (es) * | 2001-07-09 | 2004-03-17 | Schering Ag | Formulaciones de interferon beta humano |
| PL370652A1 (en) | 2001-12-21 | 2005-05-30 | Novo Nordisk Health Care Ag | Liquid composition of factor vii polypeptides |
| WO2003061687A1 (en) * | 2002-01-18 | 2003-07-31 | Asahi Kasei Pharma Corporation | High-concentration preparation of soluble thrombomodulin |
| DK2283856T3 (da) | 2002-06-21 | 2017-11-20 | Novo Nordisk Healthcare Ag | Stabiliserede, faste sammensætninger af Faktor VIIa-polypeptider |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| US7897734B2 (en) | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
| TWI272948B (en) | 2003-05-01 | 2007-02-11 | Ares Trading Sa | HSA-free stabilized interferon liquid formulations |
| AR044302A1 (es) * | 2003-05-13 | 2005-09-07 | Ares Trading Sa | Formulaciones con proteinas liquidas estabilizadas en recipientes farmaceuticos |
| ATE454900T1 (de) | 2003-05-23 | 2010-01-15 | Novo Nordisk Healthcare Ag | Stabilisierung von proteinen in lösung |
| CN1318087C (zh) * | 2003-06-06 | 2007-05-30 | 北京三诺佳邑生物技术有限责任公司 | 去白蛋白神经生长因子制剂 |
| ES2574581T3 (es) | 2003-08-14 | 2016-06-20 | Novo Nordisk Health Care Ag | Composición farmacéutica líquida acuosa de polipéptidos de tipo Factor VII |
| AU2004292954A1 (en) * | 2003-11-13 | 2005-06-09 | Alza Corporation | Composition and apparatus for transdermal delivery |
| EP1532983A1 (en) * | 2003-11-18 | 2005-05-25 | ZLB Bioplasma AG | Immunoglobulin preparations having increased stability |
| SI2298287T1 (en) | 2003-12-19 | 2018-08-31 | Novo Nordisk Health Care Ag | Stabilized compositions of factor VII polypeptides |
| ATE543506T1 (de) * | 2004-06-01 | 2012-02-15 | Ares Trading Sa | Methode zur stabilisierung von proteinen |
| WO2006022301A1 (ja) * | 2004-08-24 | 2006-03-02 | Daiichi Asubio Pharma Co., Ltd. | 生理活性ペプチド液状製剤 |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| ATE415421T1 (de) * | 2004-11-10 | 2008-12-15 | Novartis Vaccines & Diagnostic | Deamidiertes interferon-beta |
| US8784399B2 (en) * | 2005-01-12 | 2014-07-22 | Biogen Idec Ma Inc. | Method for delivering interferon-β |
| CA2593112A1 (en) * | 2005-01-21 | 2006-07-27 | Alza Corporation | Therapeutic peptide formulations for coating microneedles with improved stability containing at least one counterion |
| EP1899462B1 (en) | 2005-07-02 | 2011-03-09 | Arecor Limited | Stable aqueous systems comprising proteins |
| DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| CN109503584A (zh) | 2006-05-04 | 2019-03-22 | 勃林格殷格翰国际有限公司 | 多晶型 |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| ES2638977T3 (es) * | 2007-12-04 | 2017-10-24 | Biogen Chesapeake Llc | Formulaciones y procedimientos mejorados para liofilización y liofilizados obtenidos por los mismos |
| RS52417B (en) | 2007-12-20 | 2013-02-28 | Merck Serono S.A. | PEG-INTERFERON-BETA FORMULATIONS |
| PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| JP2011519848A (ja) | 2008-05-01 | 2011-07-14 | アレコー リミテッド | タンパク質製剤 |
| EP2328607A1 (en) | 2008-07-16 | 2011-06-08 | Arecor Limited | Stable formulation of a therapeutic protein |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| KR20190016601A (ko) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
| KR20110067096A (ko) | 2008-09-10 | 2011-06-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 당뇨병 및 관련 상태를 치료하기 위한 병용 요법 |
| DE102008051574A1 (de) | 2008-10-14 | 2010-04-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Herstellung von Interferon-beta und deren Varianten |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| EP2382216A1 (en) | 2008-12-23 | 2011-11-02 | Boehringer Ingelheim International GmbH | Salt forms of organic compound |
| TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
| DE102009032179A1 (de) | 2009-07-07 | 2011-01-13 | Biogenerix Ag | Verfahren zur Reinigung von Interferon beta |
| KR20120107080A (ko) | 2009-11-27 | 2012-09-28 | 베링거 인겔하임 인터내셔날 게엠베하 | 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료 |
| KR101912169B1 (ko) | 2010-02-04 | 2018-10-26 | 체에스엘 베링 아게 | 면역글로불린 제제 |
| EP2361636A1 (en) | 2010-02-26 | 2011-08-31 | CSL Behring AG | Immunoglobulin preparation and storage system for an immunoglobulin preparation |
| DE102010011430A1 (de) * | 2010-03-15 | 2011-09-15 | Kurt Koch | Verfahren für den Bau des Nullenergiehauses in Schalenbauweise durch Ausschäumen aller Wände, Decken und Bedachung |
| EA033415B1 (ru) | 2010-05-05 | 2019-10-31 | Boehringer Ingelheim Int | Способы лечения ожирения, применение ингибитора dpp-4 в этих способах и способ лечения пациентов, страдающих диабетом типа 2 |
| KR20130093012A (ko) | 2010-06-24 | 2013-08-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 당뇨병 요법 |
| US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
| EP2649993B1 (en) | 2010-12-09 | 2017-04-05 | Maruishi Pharmaceutical Co., Ltd. | Stabilizer of acetaminophen |
| CN103702680A (zh) | 2011-03-15 | 2014-04-02 | 比金戴克股份有限公司 | 采用快速滴定递增剂量方案用于降低与肌肉内施用干扰素有关的流感样症状的方法 |
| PL3517539T3 (pl) | 2011-07-15 | 2023-04-24 | Boehringer Ingelheim International Gmbh | Podstawiona dimeryczna pochodna chinazoliny, sposób jej wytwarzania i jej zastosowanie w kompozycjach farmaceutycznych do leczenia cukrzycy typu I i II |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| CN104254345B (zh) * | 2012-04-19 | 2018-01-16 | C·R·巴德股份有限公司 | 在环氧乙烷灭菌下具有增强的pH稳定性的输注液 |
| EP2849754B1 (en) | 2012-05-14 | 2022-09-14 | Boehringer Ingelheim International GmbH | Linagliptin, a xanthine derivative as dpp-4 inhibitor, for use in the treatment of sirs and/or sepsis |
| US20130303462A1 (en) | 2012-05-14 | 2013-11-14 | Boehringer Ingelheim International Gmbh | Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| ITMI20120913A1 (it) | 2012-05-28 | 2013-11-29 | Nicoletta Maxia | Uso della n-acetil-5-metossitriptamina o suoi analoghi per favorire il meccanismo di impianto dell' embrione, e relative composizioni e mezzi di coltura |
| CN103143000B (zh) * | 2013-03-07 | 2014-11-05 | 安徽安科生物工程（集团）股份有限公司 | 一种重组人干扰素α2b制剂 |
| ES2950384T3 (es) | 2014-02-28 | 2023-10-09 | Boehringer Ingelheim Int | Uso médico de un inhibidor de DPP-4 |
| JP2014208669A (ja) * | 2014-06-17 | 2014-11-06 | 株式会社スリー・ディー・マトリックス | タンパク質の凝集抑制剤 |
| HUE069126T2 (hu) | 2014-12-03 | 2025-02-28 | Csl Behring Ag | Immunoglobulinokat tartalmazó megnövelt stabilitású gyógyszerészeti termék |
| AU2017276758A1 (en) | 2016-06-10 | 2018-11-08 | Boehringer Ingelheim International Gmbh | Combinations of Linagliptin and metformin |
| KR101943160B1 (ko) * | 2016-10-06 | 2019-01-30 | 에이비온 주식회사 | 인터페론 베타 변이체의 안정화 제제 |
| CN111201037B (zh) | 2017-08-22 | 2024-04-02 | 比奥根Ma公司 | 含有抗β淀粉样蛋白抗体的药物组合物 |
| KR102731889B1 (ko) * | 2019-07-18 | 2024-11-19 | 에이비온 주식회사 | 2당화된 인터페론-베타 단백질의 정제 방법 |
| CN110714051B (zh) * | 2019-11-20 | 2023-04-07 | 迈克生物股份有限公司 | 蛋白c活性测定试剂盒 |
| KR102593710B1 (ko) * | 2020-04-29 | 2023-10-25 | 에이비온 주식회사 | 이중 돌연변이를 가지는 인간 인터페론-베타 변이체 및 인간 인터페론-베타 변이체의 안정성을 향상시키는 방법 |
| CN114177273B (zh) * | 2021-11-29 | 2024-05-28 | 苏州人本药业有限公司 | 一种含有神经毒素的液体制剂及其制备方法 |
| EP4456900A1 (en) * | 2021-12-27 | 2024-11-06 | Enalare Therapeutics Inc. | Respiratory stimulant parenteral formulations |
Family Cites Families (16)
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|---|---|---|---|---|
| JPS57175125A (en) * | 1981-04-20 | 1982-10-28 | Wakunaga Yakuhin Kk | Preparation of beta-interferon |
| DE3262575D1 (en) * | 1981-12-23 | 1985-04-18 | Schering Corp | Stabilised interferon formulations and their preparation |
| JPS60243028A (ja) * | 1984-04-28 | 1985-12-03 | Kyowa Hakko Kogyo Co Ltd | インタ−フエロンの可溶化方法 |
| JPS63196268A (ja) * | 1987-02-10 | 1988-08-15 | Kanegafuchi Chem Ind Co Ltd | 無血清培地で継代増殖可能な形質転換細胞、その育種方法およびその細胞による蛋白質の生産方法 |
| EP0284249A1 (en) * | 1987-03-13 | 1988-09-28 | Interferon Sciences, Inc. | Lyophilized lymphokine composition |
| DE3729863A1 (de) * | 1987-09-05 | 1989-03-16 | Boehringer Mannheim Gmbh | Stabilisierte erythropoietin-lyophilisate |
| US4895716A (en) * | 1987-06-09 | 1990-01-23 | Biogen, Inc. | Stabilized formulations of gamma interferons |
| JPH02124832A (ja) * | 1988-07-08 | 1990-05-14 | Toray Ind Inc | インターヘェロンβ組成物 |
| DE3939346A1 (de) * | 1989-11-29 | 1991-06-06 | Behringwerke Ag | Arzneimitel zur subkutanen oder intramuskulaeren applikation enthaltend polypeptide |
| IL109350A (en) * | 1993-05-12 | 2001-01-28 | Genentech Inc | Stable liquid compositions of gamma interferon |
| TW249202B (is) * | 1993-08-13 | 1995-06-11 | Ciba Gerigy Corp | |
| US5545723A (en) * | 1994-03-15 | 1996-08-13 | Biogen Inc. | Muteins of IFN-β |
| CA2185353A1 (en) * | 1994-04-08 | 1995-10-19 | David A. Hafler | Treatment of autoimmune disease using oral tolerization and/or type i interferon |
| IT1272252B (it) * | 1994-05-16 | 1997-06-16 | Applied Research Systems | Formulazioni liquide di interferone beta |
| TW426523B (en) * | 1995-04-06 | 2001-03-21 | Hoffmann La Roche | Interferon solution |
| CA2275890C (en) * | 1996-12-24 | 2011-11-01 | Biogen, Inc. | Stable liquid interferon formulations |
-
1997
- 1997-12-23 CA CA2275890A patent/CA2275890C/en not_active Expired - Lifetime
- 1997-12-23 EE EEP199900313A patent/EE04223B1/xx unknown
- 1997-12-23 NZ NZ336548A patent/NZ336548A/en not_active IP Right Cessation
- 1997-12-23 AT AT97952621T patent/ATE270899T1/de active
- 1997-12-23 AU AU56191/98A patent/AU738362B2/en not_active Expired
- 1997-12-23 SI SI9730670T patent/SI0948358T2/sl unknown
- 1997-12-23 CN CNB971814996A patent/CN1222315C/zh not_active Expired - Lifetime
- 1997-12-23 HU HU0000829A patent/HU224222B1/hu active IP Right Grant
- 1997-12-23 BR BR9714434-7A patent/BR9714434A/pt active Search and Examination
- 1997-12-23 KR KR1019997005701A patent/KR20000069664A/ko not_active Ceased
- 1997-12-23 EP EP97952621A patent/EP0948358B2/en not_active Expired - Lifetime
- 1997-12-23 TR TR1999/01968T patent/TR199901968T2/xx unknown
- 1997-12-23 SK SK858-99A patent/SK284989B6/sk not_active IP Right Cessation
- 1997-12-23 DK DK97952621.7T patent/DK0948358T4/da active
- 1997-12-23 ES ES97952621T patent/ES2224290T5/es not_active Expired - Lifetime
- 1997-12-23 IL IL13052497A patent/IL130524A/xx not_active IP Right Cessation
- 1997-12-23 JP JP52905698A patent/JP4878664B2/ja not_active Expired - Fee Related
- 1997-12-23 EA EA199900597A patent/EA002754B1/ru not_active IP Right Cessation
- 1997-12-23 CZ CZ0228299A patent/CZ300636B6/cs not_active IP Right Cessation
- 1997-12-23 CN CN2005100915177A patent/CN1733296B/zh not_active Expired - Lifetime
- 1997-12-23 WO PCT/US1997/023817 patent/WO1998028007A1/en not_active Application Discontinuation
- 1997-12-23 KR KR1020077010020A patent/KR101042660B1/ko not_active Expired - Lifetime
- 1997-12-23 DE DE69729880T patent/DE69729880T3/de not_active Expired - Lifetime
- 1997-12-23 EE EEP200300127A patent/EE04266B1/xx unknown
- 1997-12-23 PL PL97334365A patent/PL193447B1/pl unknown
- 1997-12-23 PT PT97952621T patent/PT948358E/pt unknown
-
1999
- 1999-06-21 IS IS5087A patent/IS2070B/is unknown
- 1999-06-23 NO NO993121A patent/NO327844B1/no not_active IP Right Cessation
- 1999-06-23 MX MX2012000515A patent/MX337876B/es unknown
- 1999-07-19 BG BG109523A patent/BG65418B1/bg unknown
- 1999-07-19 BG BG103594A patent/BG65171B1/bg unknown
-
2001
- 2001-07-05 NZ NZ512792A patent/NZ512792A/xx not_active IP Right Cessation
-
2007
- 2007-05-18 JP JP2007133540A patent/JP2007204501A/ja not_active Withdrawn
-
2011
- 2011-01-07 JP JP2011002557A patent/JP5851695B2/ja not_active Expired - Lifetime
- 2011-10-04 JP JP2011220534A patent/JP2012006979A/ja not_active Withdrawn
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2014
- 2014-02-25 JP JP2014033581A patent/JP2014098029A/ja not_active Withdrawn
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