BRPI0516385A - composições contendo aminoácidos não naturais e polipeptìdeos, métodos envolvendo os mesmos e usos dos mesmos - Google Patents

composições contendo aminoácidos não naturais e polipeptìdeos, métodos envolvendo os mesmos e usos dos mesmos

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Publication number
BRPI0516385A
BRPI0516385A BRPI0516385-4A BRPI0516385A BRPI0516385A BR PI0516385 A BRPI0516385 A BR PI0516385A BR PI0516385 A BRPI0516385 A BR PI0516385A BR PI0516385 A BRPI0516385 A BR PI0516385A
Authority
BR
Brazil
Prior art keywords
unnatural amino
polypeptides
amino acids
methods
amino acid
Prior art date
Application number
BRPI0516385-4A
Other languages
English (en)
Inventor
Zhenwei Miao
Junjie Liu
Thea Norman
Russel Driver
Original Assignee
Ambrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambrx Inc filed Critical Ambrx Inc
Publication of BRPI0516385A publication Critical patent/BRPI0516385A/pt
Publication of BRPI0516385B1 publication Critical patent/BRPI0516385B1/pt

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/04—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
    • C07C225/08—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
    • C07C225/10—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings with doubly-bound oxygen atoms bound to carbon atoms not being part of rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by oxygen atoms
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    • C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
    • C07C251/54—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by singly-bound oxygen atoms
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    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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Abstract

COMPOSIçõES CONTENDO AMINOáCIDOS NãO NATURAIS E POLIPEPTìDEOS, MéTODOS ENVOLVENDO OS MESMOS E USOS DOS MESMOS. Revela-se no presente aminoácidos não naturais e polipeptídeos que incluem pelo menos um aminoácido não natural, e métodos de produção de tais aminoácidos não naturais e polipeptídeos. Os aminoácidos não naturais, por eles mesmos, ou como partem de um polipeptídeo, podem incluir uma ampla faixa de possíveis funcionalidades, mas tipicamente, têm pelo menos um grupo oxima, carbonila, dicarbonila, e/ou hidroxilamina. Também estão aqui revelados polipeptídeos de aminoácido não natural que são adicionalmente modificados no modo pós-traducional, métodos para realizar essas modificações, e métodos de purificar tais polipeptídeos. Tipicamente, os polipeptídeos de aminoácido não natural modificados incluem pelo menos um grupo oxima, carbonila, dicarbonila e/ou hidroxilamina. Também se apresentam métodos para uso de tais polipeptídeos de aminoácido não natural e polipeptídeos de aminoácido não natural modificados, incluindo uso terapêutico, de diagnóstico, e outros usos biotecnológicos.
BRPI0516385-4A 2004-12-22 2005-12-21 Composto ou sal do mesmo contendo aminoácidos não naturais e polipeptídeos, métodos para produção e derivatização de um polipeptídeo BRPI0516385B1 (pt)

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US69630205P 2005-07-01 2005-07-01
US69606805P 2005-07-01 2005-07-01
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US60/696,068 2005-07-01
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US20080213840A1 (en) 2008-09-04
EP2399893A2 (en) 2011-12-28
US20100120686A1 (en) 2010-05-13
EP1828224A4 (en) 2009-02-25
US7332571B2 (en) 2008-02-19
SG158149A1 (en) 2010-01-29
US8263740B2 (en) 2012-09-11
WO2006069246A3 (en) 2008-09-25
US8809511B2 (en) 2014-08-19
IL220740A (en) 2017-10-31
CA2590590A1 (en) 2006-06-29
US20110288279A1 (en) 2011-11-24
US20110118451A1 (en) 2011-05-19
US20080268519A1 (en) 2008-10-30
US20110124880A1 (en) 2011-05-26
DK1828224T3 (en) 2016-07-18
US20090123968A1 (en) 2009-05-14
CA3005835A1 (en) 2006-06-29
GB2438982A (en) 2007-12-12
EP1828224B1 (en) 2016-04-06
EP2399893B1 (en) 2018-08-15
BRPI0516385B1 (pt) 2021-07-20
IL183346A (en) 2014-06-30
US8367612B2 (en) 2013-02-05
SG158148A1 (en) 2010-01-29
IL183346A0 (en) 2007-09-20
US8008456B2 (en) 2011-08-30
US20080153979A1 (en) 2008-06-26
JP5425398B2 (ja) 2014-02-26
HK1111702A1 (zh) 2008-08-15
US7696312B2 (en) 2010-04-13
IL227753A (en) 2017-10-31
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US7385028B2 (en) 2008-06-10
US20090111147A1 (en) 2009-04-30
US20130030160A1 (en) 2013-01-31
US8791231B2 (en) 2014-07-29
NZ555308A (en) 2010-10-29
US20080177038A1 (en) 2008-07-24
US8859802B2 (en) 2014-10-14
AU2010226982B2 (en) 2012-02-23
SG158186A1 (en) 2010-01-29
US8048988B2 (en) 2011-11-01
US8846876B2 (en) 2014-09-30
US9637441B2 (en) 2017-05-02
EP1828224A2 (en) 2007-09-05
GB0713066D0 (en) 2007-08-15
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US20080182969A1 (en) 2008-07-31
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