PL1999259T3 - Specyficzne miejscowo wprowadzanie aminokwasów do cząsteczek - Google Patents
Specyficzne miejscowo wprowadzanie aminokwasów do cząsteczekInfo
- Publication number
- PL1999259T3 PL1999259T3 PL07752295T PL07752295T PL1999259T3 PL 1999259 T3 PL1999259 T3 PL 1999259T3 PL 07752295 T PL07752295 T PL 07752295T PL 07752295 T PL07752295 T PL 07752295T PL 1999259 T3 PL1999259 T3 PL 1999259T3
- Authority
- PL
- Poland
- Prior art keywords
- molecules
- site
- amino acids
- specific incorporation
- incorporation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77937506P | 2006-03-03 | 2006-03-03 | |
US77937606P | 2006-03-03 | 2006-03-03 | |
PCT/US2007/005581 WO2007103307A2 (en) | 2006-03-03 | 2007-03-05 | Site-specific incorporation of amino acids into molecules |
EP07752295.1A EP1999259B1 (en) | 2006-03-03 | 2007-03-05 | Site-specific incorporation of amino acids into molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
PL1999259T3 true PL1999259T3 (pl) | 2015-01-30 |
Family
ID=38462077
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL07752295T PL1999259T3 (pl) | 2006-03-03 | 2007-03-05 | Specyficzne miejscowo wprowadzanie aminokwasów do cząsteczek |
Country Status (11)
Country | Link |
---|---|
US (2) | US8518666B2 (pl) |
EP (1) | EP1999259B1 (pl) |
JP (2) | JP5808882B2 (pl) |
AU (2) | AU2007224019A1 (pl) |
CA (1) | CA2644474A1 (pl) |
DK (1) | DK1999259T3 (pl) |
ES (1) | ES2504521T3 (pl) |
PL (1) | PL1999259T3 (pl) |
PT (1) | PT1999259E (pl) |
SI (1) | SI1999259T1 (pl) |
WO (1) | WO2007103307A2 (pl) |
Families Citing this family (68)
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US20050287639A1 (en) | 2004-05-17 | 2005-12-29 | California Institute Of Technology | Methods of incorporating amino acid analogs into proteins |
AU2007248680C1 (en) * | 2006-05-02 | 2014-01-23 | Allozyne, Inc. | Non-natural amino acid substituted polypeptides |
US20080096819A1 (en) * | 2006-05-02 | 2008-04-24 | Allozyne, Inc. | Amino acid substituted molecules |
CA2707840A1 (en) | 2007-08-20 | 2009-02-26 | Allozyne, Inc. | Amino acid substituted molecules |
EP2220218A4 (en) * | 2007-11-02 | 2010-12-08 | Scripps Research Inst | BORONIC AMINO ACID GENETICALLY CODED |
US20100184134A1 (en) | 2009-01-12 | 2010-07-22 | Sutro Biopharma, Inc. | Dual charging system for selectively introducing non-native amino acids into proteins using an in vitro synthesis method |
ES2552773T3 (es) | 2009-02-27 | 2015-12-02 | Atyr Pharma, Inc. | Motivos estructurales de polipéptidos asociados con la actividad de señalización celular |
MY189079A (en) * | 2009-12-11 | 2022-01-25 | Univ Case Western Reserve | Insulin analogues with chlorinated amino acids |
CA2797093C (en) | 2010-04-26 | 2019-10-29 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase |
CN103096911B (zh) | 2010-04-27 | 2018-05-29 | Atyr 医药公司 | 与异亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
CN103096910A (zh) | 2010-04-27 | 2013-05-08 | Atyr医药公司 | 与苏氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
JP6008837B2 (ja) | 2010-04-28 | 2016-10-19 | エータイアー ファーマ, インコーポレイテッド | アラニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
US9068177B2 (en) | 2010-04-29 | 2015-06-30 | Atyr Pharma, Inc | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases |
CA2797393C (en) | 2010-04-29 | 2020-03-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases |
AU2011248490B2 (en) | 2010-04-29 | 2016-11-10 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases |
CA2797978C (en) | 2010-05-03 | 2019-12-03 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases |
CA2797799C (en) | 2010-05-03 | 2020-12-08 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-trna synthetases |
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CN103200953B (zh) | 2010-05-14 | 2017-02-15 | Atyr 医药公司 | 与苯丙氨酰‑β‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
US9034598B2 (en) | 2010-05-17 | 2015-05-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases |
WO2011153277A2 (en) | 2010-06-01 | 2011-12-08 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases |
US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
EP2593125B1 (en) | 2010-07-12 | 2017-11-01 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases |
EA030461B1 (ru) | 2010-07-12 | 2018-08-31 | ЭйТИР ФАРМА, ИНК. | ТЕРАПЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ДЛЯ ЛЕЧЕНИЯ ВОСПАЛИТЕЛЬНОГО НАРУШЕНИЯ, ГИПЕРХОЛЕСТЕРИНЕМИИ, ГИПЕРЛИПИДЕМИИ, ДИАБЕТА 1 И 2 ТИПА, ПОЛИПЕПТИД АМИНОАЦИЛ-тРНК-СИНТЕТАЗЫ (AARS) |
AU2011289833C1 (en) | 2010-07-12 | 2017-06-15 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Histidyl-tRNA synthetases |
EP2608801B1 (en) | 2010-08-25 | 2019-08-21 | aTyr Pharma, Inc. | INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF TYROSYL-tRNA SYNTHETASES |
JP6121904B2 (ja) | 2010-09-08 | 2017-04-26 | ハロザイム インコーポレイテッド | 条件的活性治療用タンパク質を評価および同定する、または発展させる方法 |
WO2012048125A2 (en) | 2010-10-06 | 2012-04-12 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of tryptophanyl trna synthetases |
US20140140962A1 (en) * | 2011-04-29 | 2014-05-22 | The Research Foundation Of State University Of New York | Viruses modified with unnatural moieties and methods of use thereof |
WO2013022982A2 (en) | 2011-08-09 | 2013-02-14 | Atyr Pharma, Inc. | Pegylated tyrosyl-trna synthetase polypeptides |
EP3199624B1 (en) * | 2011-11-03 | 2019-09-11 | Yeda Research and Development Co. Ltd. | Transgenic plants resistant to non-protein amino acids |
WO2013086228A1 (en) | 2011-12-06 | 2013-06-13 | Atyr Pharma, Inc. | Pegylated aspartyl-trna synthetase polypeptides |
US9816084B2 (en) | 2011-12-06 | 2017-11-14 | Atyr Pharma, Inc. | Aspartyl-tRNA synthetases |
WO2013100132A1 (ja) | 2011-12-28 | 2013-07-04 | 中外製薬株式会社 | ペプチド化合物の環化方法 |
CN104220461A (zh) | 2011-12-29 | 2014-12-17 | Atyr医药公司 | 天冬氨酰-tRNA合成酶-FC缀合物 |
WO2013188635A2 (en) * | 2012-06-14 | 2013-12-19 | The Trustees Of The University Of Pennsylvania | Novel methods of identifying proteins via n-terminal tagging and selective pull-down |
US9587235B2 (en) | 2013-03-15 | 2017-03-07 | Atyr Pharma, Inc. | Histidyl-tRNA synthetase-Fc conjugates |
US20160055293A1 (en) * | 2013-03-29 | 2016-02-25 | University Of Washington Through Its Center For Commercialization | Systems, Algorithms, and Software for Molecular Inversion Probe (MIP) Design |
EP2876165A1 (en) | 2013-11-22 | 2015-05-27 | ACIB GmbH | Improved method for producing modifed target polypeptides |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
DK3269809T3 (da) | 2015-03-13 | 2022-09-12 | Chugai Pharmaceutical Co Ltd | MODIFICERET AMINOACYL-tRNA-SYNTETASE OG ANVENDELSE DERAF |
GB201600512D0 (en) | 2016-01-12 | 2016-02-24 | Univ York | Recombinant protein production |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
WO2018143145A1 (ja) | 2017-01-31 | 2018-08-09 | 中外製薬株式会社 | 無細胞翻訳系におけるペプチドの合成方法 |
MX2019008449A (es) | 2017-02-08 | 2019-09-09 | Bristol Myers Squibb Co | Polipetidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos. |
JP6917050B2 (ja) * | 2017-03-06 | 2021-08-11 | 学校法人早稲田大学 | 最適特性を有する非天然型タンパク質の製造方法 |
AU2018256435A1 (en) | 2017-04-20 | 2019-11-07 | Atyr Pharma, Inc. | Compositions and methods for treating lung inflammation |
US11542299B2 (en) | 2017-06-09 | 2023-01-03 | Chugai Seiyaku Kabushiki Kaisha | Method for synthesizing peptide containing N-substituted amino acid |
JP7295841B2 (ja) * | 2017-07-25 | 2023-06-21 | バイオコン・リミテッド | インスリン&インスリン類似体の配列の同定のためのペプチドマッピング方法 |
WO2019117274A1 (ja) | 2017-12-15 | 2019-06-20 | 中外製薬株式会社 | ペプチドの製造方法、及び塩基の処理方法 |
CN108588040B (zh) * | 2018-06-08 | 2021-06-15 | 中国医学科学院病原生物学研究所 | 重组MtMetRS、其晶体及它们在制备抗结核药物中的应用 |
DK3849614T3 (da) * | 2018-09-11 | 2024-02-26 | Ambrx Inc | Interleukin-2-polypeptidkonjugater og anvendelser deraf |
JP7568510B2 (ja) | 2018-11-30 | 2024-10-16 | 中外製薬株式会社 | ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法 |
WO2020138336A1 (ja) | 2018-12-26 | 2020-07-02 | 中外製薬株式会社 | コドン拡張のための変異tRNA |
CA3133185A1 (en) * | 2019-03-13 | 2020-09-17 | St. Jude Children's Research Hospital | Vaccine compositions and methods for reducing transmission of streptococcus pneumoniae |
EP3939962A4 (en) | 2019-03-15 | 2022-12-28 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR PREPARING AN AROMATIC AMINO ACID DERIVATIVE |
EP4026906A4 (en) | 2019-12-26 | 2023-12-27 | Chugai Seiyaku Kabushiki Kaisha | COMPOSITION FOR TRANSLATION AND METHOD FOR PRODUCING PEPTIDES |
PE20230457A1 (es) | 2020-03-31 | 2023-03-10 | Protomer Tech Inc | Conjugados para reactividad selectiva a dioles vecinales |
CN115551875A (zh) | 2020-05-05 | 2022-12-30 | 基因泰克公司 | 用于酪氨酸酶介导的位点特异性蛋白质缀合的系统和方法 |
EP4166675A1 (en) | 2020-06-25 | 2023-04-19 | Chugai Seiyaku Kabushiki Kaisha | Translation system provided with modified genetic code table |
PE20231948A1 (es) | 2020-11-19 | 2023-12-05 | Protomer Tech Inc | Compuestos aromaticos que contienen boro y analogos de insulina |
WO2023069816A2 (en) | 2021-09-20 | 2023-04-27 | The Broad Institute, Inc. | Compositions and methods for multiplex decoding of quadruplet codons |
WO2023225534A1 (en) | 2022-05-18 | 2023-11-23 | Protomer Technologies Inc. | Aromatic boron-containing compounds and related insulin analogs |
WO2023250446A2 (en) * | 2022-06-22 | 2023-12-28 | The University Of Chicago | ENGINEERED tRNA AND METHODS OF USE |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE193551T1 (de) | 1991-03-18 | 2000-06-15 | Scripps Research Inst | Oligosaccharide als enzymsubstrate und - inhibitoren: verfahren und zusammensetzungen |
AU751331B2 (en) | 1997-04-11 | 2002-08-15 | California Institute Of Technology | Apparatus and method for automated protein design |
US7449443B2 (en) | 2000-03-23 | 2008-11-11 | California Institute Of Technology | Method for stabilization of proteins using non-natural amino acids |
CA2444098C (en) * | 2001-04-19 | 2016-06-21 | The Scripps Research Institute | Methods and composition for the production of orthogonal trna-aminoacyltrna synthetase pairs |
AU2003248370A1 (en) * | 2002-02-27 | 2003-09-09 | California Institute Of Technology | Computational method for designing enzymes for incorporation of amino acid analogs into proteins |
WO2004035605A2 (en) | 2002-10-16 | 2004-04-29 | The Scripps Research Institute | Glycoprotein synthesis |
JP4896745B2 (ja) | 2004-02-02 | 2012-03-14 | アンブレツクス・インコーポレイテツド | 修飾されたヒトインターフェロンポリペプチドおよびこれらの使用 |
US20050260711A1 (en) | 2004-03-30 | 2005-11-24 | Deepshikha Datta | Modulating pH-sensitive binding using non-natural amino acids |
US20050287639A1 (en) | 2004-05-17 | 2005-12-29 | California Institute Of Technology | Methods of incorporating amino acid analogs into proteins |
CA2569381A1 (en) | 2004-07-21 | 2006-08-31 | Ambrx, Inc. | Biosynthetic polypeptides utilizing non-naturally encoded amino acids |
US20090181858A1 (en) | 2004-09-21 | 2009-07-16 | The Scripps Research Institute | Adding photoregulated amino acids to the genetic code |
JP2008516637A (ja) | 2004-10-20 | 2008-05-22 | ザ スクリップス リサーチ インスティテュート | 真正細菌へのn−アセチルガラクトサミンアミノ酸のインビボ部位特異的組込み |
CA2590429C (en) | 2004-12-22 | 2014-10-07 | Ambrx, Inc. | Compositions of aminoacyl-trna synthetase and uses thereof |
US7385028B2 (en) | 2004-12-22 | 2008-06-10 | Ambrx, Inc | Derivatization of non-natural amino acids and polypeptides |
AU2006255280A1 (en) | 2005-06-03 | 2006-12-14 | Ambrx, Inc. | Incorporation of non-naturally encoded amino acids into proteins |
EP1937824B1 (en) | 2005-08-18 | 2013-03-13 | Ambrx, Inc. | COMPOSITIONS OF tRNA AND USES THEREOF |
SG170116A1 (en) | 2005-12-14 | 2011-04-29 | Ambrx Inc | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
WO2007094916A2 (en) | 2006-01-19 | 2007-08-23 | Ambrx, Inc. | Non-natural amino acid polypeptides having modulated immunogenicity |
-
2007
- 2007-03-05 PT PT77522951T patent/PT1999259E/pt unknown
- 2007-03-05 DK DK07752295.1T patent/DK1999259T3/da active
- 2007-03-05 EP EP07752295.1A patent/EP1999259B1/en not_active Not-in-force
- 2007-03-05 ES ES07752295.1T patent/ES2504521T3/es active Active
- 2007-03-05 CA CA002644474A patent/CA2644474A1/en not_active Abandoned
- 2007-03-05 AU AU2007224019A patent/AU2007224019A1/en not_active Abandoned
- 2007-03-05 PL PL07752295T patent/PL1999259T3/pl unknown
- 2007-03-05 SI SI200731519T patent/SI1999259T1/sl unknown
- 2007-03-05 JP JP2008557434A patent/JP5808882B2/ja active Active
- 2007-03-05 WO PCT/US2007/005581 patent/WO2007103307A2/en active Application Filing
- 2007-03-05 US US11/682,272 patent/US8518666B2/en not_active Expired - Fee Related
-
2013
- 2013-04-30 JP JP2013095341A patent/JP2013146274A/ja active Pending
- 2013-08-16 US US13/969,368 patent/US8980581B2/en active Active
-
2014
- 2014-05-20 AU AU2014202733A patent/AU2014202733A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US8518666B2 (en) | 2013-08-27 |
PT1999259E (pt) | 2014-09-24 |
WO2007103307A2 (en) | 2007-09-13 |
CA2644474A1 (en) | 2007-09-13 |
WO2007103307B1 (en) | 2008-05-02 |
WO2007103307A3 (en) | 2008-03-13 |
EP1999259A2 (en) | 2008-12-10 |
US20080044854A1 (en) | 2008-02-21 |
ES2504521T3 (es) | 2014-10-08 |
JP2009528824A (ja) | 2009-08-13 |
AU2014202733A1 (en) | 2014-06-12 |
US20140045261A1 (en) | 2014-02-13 |
EP1999259B1 (en) | 2014-06-25 |
SI1999259T1 (sl) | 2014-11-28 |
US8980581B2 (en) | 2015-03-17 |
JP2013146274A (ja) | 2013-08-01 |
AU2007224019A1 (en) | 2007-09-13 |
JP5808882B2 (ja) | 2015-11-10 |
DK1999259T3 (da) | 2014-10-06 |
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