PL1999259T3 - Specyficzne miejscowo wprowadzanie aminokwasów do cząsteczek - Google Patents

Specyficzne miejscowo wprowadzanie aminokwasów do cząsteczek

Info

Publication number
PL1999259T3
PL1999259T3 PL07752295T PL07752295T PL1999259T3 PL 1999259 T3 PL1999259 T3 PL 1999259T3 PL 07752295 T PL07752295 T PL 07752295T PL 07752295 T PL07752295 T PL 07752295T PL 1999259 T3 PL1999259 T3 PL 1999259T3
Authority
PL
Poland
Prior art keywords
molecules
site
amino acids
specific incorporation
incorporation
Prior art date
Application number
PL07752295T
Other languages
English (en)
Inventor
Pin Wang
Inchan Kwon
Soojin Son
Yi Tang
David A Tirrell
Original Assignee
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn filed Critical California Inst Of Techn
Publication of PL1999259T3 publication Critical patent/PL1999259T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL07752295T 2006-03-03 2007-03-05 Specyficzne miejscowo wprowadzanie aminokwasów do cząsteczek PL1999259T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US77937606P 2006-03-03 2006-03-03
US77937506P 2006-03-03 2006-03-03
EP07752295.1A EP1999259B1 (en) 2006-03-03 2007-03-05 Site-specific incorporation of amino acids into molecules
PCT/US2007/005581 WO2007103307A2 (en) 2006-03-03 2007-03-05 Site-specific incorporation of amino acids into molecules

Publications (1)

Publication Number Publication Date
PL1999259T3 true PL1999259T3 (pl) 2015-01-30

Family

ID=38462077

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07752295T PL1999259T3 (pl) 2006-03-03 2007-03-05 Specyficzne miejscowo wprowadzanie aminokwasów do cząsteczek

Country Status (11)

Country Link
US (2) US8518666B2 (pl)
EP (1) EP1999259B1 (pl)
JP (2) JP5808882B2 (pl)
AU (2) AU2007224019A1 (pl)
CA (1) CA2644474A1 (pl)
DK (1) DK1999259T3 (pl)
ES (1) ES2504521T3 (pl)
PL (1) PL1999259T3 (pl)
PT (1) PT1999259E (pl)
SI (1) SI1999259T1 (pl)
WO (1) WO2007103307A2 (pl)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050287639A1 (en) 2004-05-17 2005-12-29 California Institute Of Technology Methods of incorporating amino acid analogs into proteins
US20080096819A1 (en) * 2006-05-02 2008-04-24 Allozyne, Inc. Amino acid substituted molecules
AU2007248680C1 (en) * 2006-05-02 2014-01-23 Allozyne, Inc. Non-natural amino acid substituted polypeptides
CA2707840A1 (en) 2007-08-20 2009-02-26 Allozyne, Inc. Amino acid substituted molecules
WO2009059056A2 (en) * 2007-11-02 2009-05-07 The Scripps Research Institute A genetically encoded boronate amino acid
US20100184134A1 (en) 2009-01-12 2010-07-22 Sutro Biopharma, Inc. Dual charging system for selectively introducing non-native amino acids into proteins using an in vitro synthesis method
US20120004185A1 (en) 2009-02-27 2012-01-05 Atyr Pharma, Inc. Polypeptide structural motifs associated with cell signaling activity
NZ600477A (en) * 2009-12-11 2014-07-25 Univ Case Western Reserve Insulin analogues with chlorinated amino acids
WO2011139714A2 (en) 2010-04-26 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase
ES2638311T3 (es) 2010-04-27 2017-10-19 Atyr Pharma, Inc. Descubrimiento innovador de composiciones terapéuticas, diagnósticas y de anticuerpos relacionadas con fragmentos de proteína de treonil ARNt sintetasas
AU2011248614B2 (en) 2010-04-27 2017-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases
US8993723B2 (en) 2010-04-28 2015-03-31 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl-tRNA synthetases
CA2797393C (en) 2010-04-29 2020-03-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases
US9068177B2 (en) 2010-04-29 2015-06-30 Atyr Pharma, Inc Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases
JP6008838B2 (ja) 2010-04-29 2016-10-19 エータイアー ファーマ， インコーポレイテッド アスパラギニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
EP2566516B1 (en) 2010-05-03 2019-07-03 aTyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-trna synthetases
WO2011140132A2 (en) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases
JP5976638B2 (ja) 2010-05-03 2016-08-23 エータイアー ファーマ， インコーポレイテッド アルギニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
EP2566496B1 (en) 2010-05-03 2018-02-28 aTyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases
CN103096909A (zh) 2010-05-04 2013-05-08 Atyr医药公司 与谷氨酰-脯氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
AU2011248101B2 (en) 2010-05-04 2016-10-20 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-tRNA synthetase complex
US8945541B2 (en) 2010-05-14 2015-02-03 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases
WO2011146410A2 (en) 2010-05-17 2011-11-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-trna synthetases
US8962560B2 (en) 2010-06-01 2015-02-24 Atyr Pharma Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Lysyl-tRNA synthetases
WO2012009289A2 (en) 2010-07-12 2012-01-19 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of aspartyl-trna synthetases
US20130202576A1 (en) 2010-07-12 2013-08-08 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases
US8999321B2 (en) 2010-07-12 2015-04-07 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
AU2011289831C1 (en) 2010-07-12 2017-06-15 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
WO2012027611A2 (en) 2010-08-25 2012-03-01 Atyr Pharma, Inc. INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF TYROSYL-tRNA SYNTHETASES
KR20130096731A (ko) 2010-09-08 2013-08-30 할로자임, 아이엔씨 조건부 활성 치료적 단백질을 평가，확인 또는 진화시키는 방법
US9399770B2 (en) 2010-10-06 2016-07-26 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tryptophanyl-tRNA synthetases
WO2012149160A2 (en) * 2011-04-29 2012-11-01 The Research Foundation Of State University Of New York Viruses modified with unnatural moieties and methods of use thereof
WO2013022982A2 (en) 2011-08-09 2013-02-14 Atyr Pharma, Inc. Pegylated tyrosyl-trna synthetase polypeptides
EP3199624B1 (en) * 2011-11-03 2019-09-11 Yeda Research and Development Co. Ltd. Transgenic plants resistant to non-protein amino acids
WO2013086216A1 (en) 2011-12-06 2013-06-13 Atyr Pharma, Inc. Improved aspartyl-trna synthetases
WO2013086228A1 (en) 2011-12-06 2013-06-13 Atyr Pharma, Inc. Pegylated aspartyl-trna synthetase polypeptides
US9409952B2 (en) 2011-12-28 2016-08-09 Chugai Seiyaku Kabushiki Kaisha Peptide-compound cyclization method
JP6169608B2 (ja) 2011-12-29 2017-07-26 エータイアー ファーマ， インコーポレイテッド アスパルチルｔＲＮＡシンテターゼ−Ｆｃコンジュゲート
WO2013188635A2 (en) * 2012-06-14 2013-12-19 The Trustees Of The University Of Pennsylvania Novel methods of identifying proteins via n-terminal tagging and selective pull-down
AU2014233436B2 (en) 2013-03-15 2019-12-05 Atyr Pharma, Inc. Histidyl-tRNA synthetase-Fc conjugates
US20160055293A1 (en) * 2013-03-29 2016-02-25 University Of Washington Through Its Center For Commercialization Systems, Algorithms, and Software for Molecular Inversion Probe (MIP) Design
EP2876165A1 (en) 2013-11-22 2015-05-27 ACIB GmbH Improved method for producing modifed target polypeptides
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
EP4166664A1 (en) 2015-03-13 2023-04-19 Chugai Seiyaku Kabushiki Kaisha Modified aminoacyl-trna synthetase and use thereof
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
GB201600512D0 (en) * 2016-01-12 2016-02-24 Univ York Recombinant protein production
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
EP3591048A4 (en) 2017-01-31 2020-12-23 Chugai Seiyaku Kabushiki Kaisha PEPTIDES SYNTHESIS PROCESS IN A CELLLESS TRANSLATION SYSTEM
WO2018148419A1 (en) 2017-02-08 2018-08-16 Bristol-Myers Squibb Company Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
JP6917050B2 (ja) * 2017-03-06 2021-08-11 学校法人早稲田大学 最適特性を有する非天然型タンパク質の製造方法
JP7679175B2 (ja) 2017-04-20 2025-05-19 エータイアー ファーマ， インコーポレイテッド 肺の炎症を治療するための組成物および方法
US11542299B2 (en) 2017-06-09 2023-01-03 Chugai Seiyaku Kabushiki Kaisha Method for synthesizing peptide containing N-substituted amino acid
AU2018306539B2 (en) * 2017-07-25 2022-06-16 Biocon Limited Peptide mapping method for sequence identification of insulin and insulin analogues
US11492369B2 (en) 2017-12-15 2022-11-08 Chugai Seiyaku Kabushiki Kaisha Method for producing peptide, and method for processing bases
CN108588040B (zh) * 2018-06-08 2021-06-15 中国医学科学院病原生物学研究所 重组MtMetRS、其晶体及它们在制备抗结核药物中的应用
LT3849614T (lt) * 2018-09-11 2024-03-25 Ambrx, Inc. Interleukino-2 polipeptido konjugatai ir jų panaudojimas
US12312297B2 (en) 2018-11-07 2025-05-27 Chugai Seiyaku Kabushiki Kaisha O-substituted serine derivative production method
EP3889164A4 (en) 2018-11-30 2022-11-02 Chugai Seiyaku Kabushiki Kaisha METHOD FOR DEPROTECTION AND METHOD FOR RESIN REMOVAL IN A SOLID PHASE REACTION OF A PEPTIDE COMPOUND OR AN AMIDE COMPOUND, AND METHOD FOR PRODUCTION OF A PEPTIDE COMPOUND
US20220205009A1 (en) 2018-12-26 2022-06-30 Chugai Seiyaku Kabushiki Kaisha MUTATED tRNA FOR CODON EXPANSION
JP2022525333A (ja) * 2019-03-13 2022-05-12 セント・ジュード・チルドレンズ・リサーチ・ホスピタル 肺炎連鎖球菌の伝染を低減させるためのワクチン組成物および方法
US12071396B2 (en) 2019-03-15 2024-08-27 Chugai Seiyaku Kabushiki Kaisha Method for preparing aromatic amino acid derivative
PE20221323A1 (es) 2019-11-07 2022-09-09 Chugai Pharmaceutical Co Ltd Compuesto de peptidos ciclicos que tiene accion inhibidora de kras
US20230108274A1 (en) 2019-12-26 2023-04-06 Chugai Seiyaku Kabushiki Kaisha Composition for translation, and method for producing peptide
BR112022019687A2 (pt) 2020-03-31 2022-12-20 Protomer Tech Inc Conjugados para responsividade seletiva a dióis vicinais
JP2023524288A (ja) 2020-05-05 2023-06-09 ジェネンテック， インコーポレイテッド チロシナーゼ媒介部位特異的タンパク質コンジュゲーションのためのシステム及び方法
JPWO2021261577A1 (pl) 2020-06-25 2021-12-30
MX2023002906A (es) * 2020-10-17 2023-04-05 Sun Pharmaceutical Ind Ltd Agonistas duales glp-1/gip.
MX2023005935A (es) 2020-11-19 2023-05-29 Protomer Tech Inc Compuestos aromaticos que contienen boro y analogos de insulina.
US20240384267A1 (en) 2021-09-20 2024-11-21 The Broad Institute, Inc. Compositions and methods for multiplex decoding of quadruplet codons
IL317049A (en) 2022-05-18 2025-01-01 Protomer Tech Inc Aromatic boron-containing compounds and related insulin analogs
JP2025525377A (ja) * 2022-06-22 2025-08-05 ザ・ユニバーシティ・オブ・シカゴ 操作されたｔＲＮＡおよび使用方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3476455B2 (ja) 1991-03-18 2003-12-10 ザ スクリップス リサーチ インスティテュート ＮｅｕＡｃα２、６Ｇａｌβ１、４ＧｌｃＮＡｃ及びシアリルＬｅｘの合成法
EP0974111B1 (en) 1997-04-11 2003-01-08 California Institute Of Technology Apparatus and method for automated protein design
US7449443B2 (en) 2000-03-23 2008-11-11 California Institute Of Technology Method for stabilization of proteins using non-natural amino acids
EP1456360B1 (en) * 2001-04-19 2015-06-03 The Scripps Research Institute Methods and composition for the production of orthoganal trna-aminoacyltrna synthetase pairs
AU2003248370A1 (en) * 2002-02-27 2003-09-09 California Institute Of Technology Computational method for designing enzymes for incorporation of amino acid analogs into proteins
SG160203A1 (en) 2002-10-16 2010-04-29 Scripps Research Inst Glycoprotein synthesis
BRPI0507169A (pt) 2004-02-02 2007-06-26 Ambrx Inc polipeptìdeos do hormÈnio de crescimento humano modificados e seu usos
US20050260711A1 (en) 2004-03-30 2005-11-24 Deepshikha Datta Modulating pH-sensitive binding using non-natural amino acids
US20050287639A1 (en) 2004-05-17 2005-12-29 California Institute Of Technology Methods of incorporating amino acid analogs into proteins
WO2006091231A2 (en) 2004-07-21 2006-08-31 Ambrx, Inc. Biosynthetic polypeptides utilizing non-naturally encoded amino acids
US20090181858A1 (en) 2004-09-21 2009-07-16 The Scripps Research Institute Adding photoregulated amino acids to the genetic code
US20080064059A1 (en) 2004-10-20 2008-03-13 Scripps Research Institute In Vivo Site-Specific Incorporation of N-Acetyl-Galactosamine Amino Acids in Eubacteria
US7385028B2 (en) 2004-12-22 2008-06-10 Ambrx, Inc Derivatization of non-natural amino acids and polypeptides
US7736872B2 (en) 2004-12-22 2010-06-15 Ambrx, Inc. Compositions of aminoacyl-TRNA synthetase and uses thereof
JP2008541766A (ja) 2005-06-03 2008-11-27 アンブレツクス・インコーポレイテツド タンパク質中への天然にコードされないアミノ酸の取り込み
NZ565294A (en) 2005-08-18 2010-06-25 Ambrx Inc Compositions of tRNA and uses thereof
CN105384807A (zh) 2005-12-14 2016-03-09 Ambrx公司 含有非天然氨基酸和多肽的组合物、涉及非天然氨基酸和多肽的方法以及非天然氨基酸和多肽的用途
CA2636797A1 (en) 2006-01-19 2007-08-23 Ambrx, Inc. Non-natural amino acid polypeptides having modulated immunogenicity

Also Published As

Publication number Publication date
WO2007103307A2 (en) 2007-09-13
US20140045261A1 (en) 2014-02-13
US20080044854A1 (en) 2008-02-21
DK1999259T3 (da) 2014-10-06
JP2009528824A (ja) 2009-08-13
US8518666B2 (en) 2013-08-27
SI1999259T1 (sl) 2014-11-28
AU2014202733A1 (en) 2014-06-12
WO2007103307A3 (en) 2008-03-13
JP5808882B2 (ja) 2015-11-10
WO2007103307B1 (en) 2008-05-02
PT1999259E (pt) 2014-09-24
JP2013146274A (ja) 2013-08-01
EP1999259A2 (en) 2008-12-10
AU2007224019A1 (en) 2007-09-13
CA2644474A1 (en) 2007-09-13
ES2504521T3 (es) 2014-10-08
EP1999259B1 (en) 2014-06-25
US8980581B2 (en) 2015-03-17

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