MX2009006617A - Composiciones que contienen, metodos que involucran y usos de aminoacidos y polipeptidos no naturales. - Google Patents

Composiciones que contienen, metodos que involucran y usos de aminoacidos y polipeptidos no naturales.

Info

Publication number
MX2009006617A
MX2009006617A MX2009006617A MX2009006617A MX2009006617A MX 2009006617 A MX2009006617 A MX 2009006617A MX 2009006617 A MX2009006617 A MX 2009006617A MX 2009006617 A MX2009006617 A MX 2009006617A MX 2009006617 A MX2009006617 A MX 2009006617A
Authority
MX
Mexico
Prior art keywords
natural amino
polypeptides
amino acids
amino acid
methods
Prior art date
Application number
MX2009006617A
Other languages
English (en)
Inventor
Zhenwei Miao
Junjie Liu
Original Assignee
Ambrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambrx Inc filed Critical Ambrx Inc
Publication of MX2009006617A publication Critical patent/MX2009006617A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered

Abstract

Se revelan en la presente aminoácidos no naturales y polipéptidos que incluyen por lo menos un aminoácido no natural y métodos para la fabricación de tales aminoácidos no naturales y polipéptidos. Los aminoácidos no naturales, por sí mismos o como parte de un polipéptido, pueden incluir un amplio intervalo de funcionalidades, pero tienen por lo menos comúnmente por lo menos un grupo indol, carbonilo y/o hidracina. También se revelan en la presente polipéptidos de aminoácidos no naturales que son modificados además post-traduccionalmente, métodos para efectuar tales modificaciones y métodos para purificar tales polipéptidos. Comúnmente, los polipéptidos de aminoácidos no naturales modificados incluyen por lo menos un grupo indol, carbonilo y/o hidracina. Se revelan además métodos para usar tales polipéptidos de aminoácidos no naturales y polipéptidos de aminoácidos no naturales modificados, en los que se incluyen usos terapéuticos, de diagnósticos y otros usos de biotecnología.
MX2009006617A 2006-12-18 2007-12-18 Composiciones que contienen, metodos que involucran y usos de aminoacidos y polipeptidos no naturales. MX2009006617A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87059406P 2006-12-18 2006-12-18
PCT/US2007/088011 WO2008077079A1 (en) 2006-12-18 2007-12-18 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides

Publications (1)

Publication Number Publication Date
MX2009006617A true MX2009006617A (es) 2009-07-24

Family

ID=39536734

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006617A MX2009006617A (es) 2006-12-18 2007-12-18 Composiciones que contienen, metodos que involucran y usos de aminoacidos y polipeptidos no naturales.

Country Status (8)

Country Link
EP (1) EP2079687A1 (es)
JP (1) JP2010512800A (es)
KR (1) KR20090100407A (es)
CN (1) CN101578264A (es)
AU (1) AU2007333737A1 (es)
CA (1) CA2672205A1 (es)
MX (1) MX2009006617A (es)
WO (2) WO2008077079A1 (es)

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CN102307905B (zh) * 2008-12-10 2015-11-25 斯克利普斯研究院 利用化学反应性非天然氨基酸产生载体-肽偶联物
US9238878B2 (en) 2009-02-17 2016-01-19 Redwood Bioscience, Inc. Aldehyde-tagged protein-based drug carriers and methods of use
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
BR112013003522B1 (pt) * 2010-08-17 2021-05-25 Ambrx, Inc. polipeptídeos relaxina modificados compreendendo um aminoácido não codificado naturalmente, seu método de preparação e seu uso, bem como ácido nucleico e célula hospedeira
WO2012097333A2 (en) 2011-01-14 2012-07-19 Redwood Bioscience, Inc. Aldehyde-tagged immunoglobulin polypeptides and method of use thereof
US20150018530A1 (en) * 2012-02-29 2015-01-15 Ambrx, Inc. Novel Prodrug Containing Molecule Compositions and Their Uses
EP2820030A4 (en) * 2012-02-29 2015-04-15 Ambrx Inc INTERLEUKIN-3-POLYPEPTIDE CONJUGATES AND ITS USES
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
NZ703298A (en) * 2012-06-07 2016-04-29 Ambrx Inc Prostate-specific membrane antigen antibody drug conjugates
EP3488870B1 (en) * 2012-06-19 2024-03-20 Ambrx, Inc. Anti-cd70 antibody drug conjugates
EP3721902A1 (en) 2013-03-14 2020-10-14 The Scripps Research Institute Targeting agent antibody conjugates and uses thereof
US9394285B2 (en) 2013-03-15 2016-07-19 Pfizer Inc. Indole and indazole compounds that activate AMPK
AU2014337367B2 (en) 2013-10-15 2020-04-30 The Scripps Research Institute Peptidic chimeric antigen receptor T cell switches and uses thereof
WO2016154621A1 (en) 2015-03-26 2016-09-29 The California Institute For Biomedical Research SWITCHABLE NON-scFv CHIMERIC RECEPTORS, SWITCHES, AND USES THEREOF
US11091546B2 (en) 2015-04-15 2021-08-17 The Scripps Research Institute Optimized PNE-based chimeric receptor T cell switches and uses thereof
CN109071634A (zh) 2016-04-26 2018-12-21 R.P.谢勒技术有限责任公司 抗体偶联物及其制备和使用方法
KR20230172612A (ko) 2016-10-19 2023-12-22 더 스크립스 리서치 인스티튜트 인간화된 표적화 모이어티 및/또는 최적화된 키메라 항원 수용체-상호작용 도메인을 갖는 키메라 항원 수용체 효과기 세포 스위치 및 이의 용도
BR112019016139A2 (pt) 2017-02-08 2020-04-07 Bristol-Myers Squibb Company polipeptídio de relaxina modificada compreendendo um melhorador farmacocinético e usos do mesmo
CA3137333A1 (en) * 2019-05-13 2020-11-19 Wenbin Wang A tag for labeling biomolecules
CN114524934B (zh) * 2020-11-23 2024-01-30 华东理工大学 多肽聚合物或多肽模拟物在骨修复中的应用
CN117642511A (zh) * 2021-07-07 2024-03-01 味之素株式会社 含非天然氨基酸的蛋白质的分泌生产方法
WO2024077277A1 (en) 2022-10-07 2024-04-11 Ambrx, Inc. Drug linkers and antibody conjugates thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0832065T3 (da) * 1995-06-06 2001-11-19 Pfizer Substituerede N-(indol-2-carbonyl)glycinamider og derivater som glycogenphosphorylaseinhibitorer
EP1067950B1 (en) * 1998-04-10 2008-05-14 Mayo Foundation For Medical Education And Research Neo-tryptophan
US6858577B1 (en) * 1999-06-29 2005-02-22 Ortho-Mcneil Pharmaceutical, Inc. Indole peptidomimetics as thrombin receptor antagonists
AU2001260661A1 (en) * 2000-05-30 2001-12-11 Chugai Seiyaku Kabushiki Kaisha Compounds exhibiting thrombopoietin-like activities
CA2464214C (en) * 2001-10-22 2011-02-08 The Research Foundation Of State University Of New York Protein kinase and phosphatase inhibitors, methods for designing them, and methods of using them

Also Published As

Publication number Publication date
WO2008077079A1 (en) 2008-06-26
EP2079687A1 (en) 2009-07-22
KR20090100407A (ko) 2009-09-23
AU2007333737A1 (en) 2008-06-26
WO2011028195A2 (en) 2011-03-10
JP2010512800A (ja) 2010-04-30
CN101578264A (zh) 2009-11-11
WO2011028195A3 (en) 2011-06-16
CA2672205A1 (en) 2008-06-26

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