CA2672205A1 - Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides - Google Patents

Info

Publication number

CA2672205A1

CA2672205A1 CA002672205A CA2672205A CA2672205A1 CA 2672205 A1 CA2672205 A1 CA 2672205A1 CA 002672205 A CA002672205 A CA 002672205A CA 2672205 A CA2672205 A CA 2672205A CA 2672205 A1 CA2672205 A1 CA 2672205A1

Authority

CA

Canada

Prior art keywords

substituted

alkylene

alkyl

group

amino acid

Prior art date

2006-12-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 150000001413 amino acids Chemical class 0.000 title claims abstract description 549
• 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 461
• 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 445
• 229920001184 polypeptide Polymers 0.000 title claims abstract description 439
• 238000000034 method Methods 0.000 title claims abstract description 210
• 239000000203 mixture Substances 0.000 title description 44
• SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims abstract description 112
• OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine group Chemical group NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims abstract description 85
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims abstract description 73
• PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims abstract description 56
• RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims abstract description 56
• 230000001225 therapeutic effect Effects 0.000 claims abstract description 26
• 229940024606 amino acid Drugs 0.000 claims description 541
• 125000002947 alkylene group Chemical group 0.000 claims description 121
• 125000000217 alkyl group Chemical group 0.000 claims description 104
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 100
• -1 R4 cannot be H Inorganic materials 0.000 claims description 99
• 150000001875 compounds Chemical class 0.000 claims description 94
• 108090000623 proteins and genes Proteins 0.000 claims description 82
• 235000018102 proteins Nutrition 0.000 claims description 81
• 102000004169 proteins and genes Human genes 0.000 claims description 80
• 125000000547 substituted alkyl group Chemical group 0.000 claims description 62
• 201000010099 disease Diseases 0.000 claims description 55
• 125000005647 linker group Chemical group 0.000 claims description 55
• 229920001223 polyethylene glycol Polymers 0.000 claims description 49
• 229920000642 polymer Polymers 0.000 claims description 48
• 239000002202 Polyethylene glycol Substances 0.000 claims description 47
• 208000035475 disorder Diseases 0.000 claims description 45
• 125000004450 alkenylene group Chemical group 0.000 claims description 44
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 42
• 125000003118 aryl group Chemical group 0.000 claims description 38
• 125000004474 heteroalkylene group Chemical group 0.000 claims description 37
• 238000006243 chemical reaction Methods 0.000 claims description 34
• 229910052736 halogen Inorganic materials 0.000 claims description 33
• 150000002367 halogens Chemical class 0.000 claims description 33
• 229920003169 water-soluble polymer Polymers 0.000 claims description 33
• 125000005549 heteroarylene group Chemical group 0.000 claims description 32
• 125000000732 arylene group Chemical group 0.000 claims description 30
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 28
• 125000001072 heteroaryl group Chemical group 0.000 claims description 28
• 102000040430 polynucleotide Human genes 0.000 claims description 28
• 108091033319 polynucleotide Proteins 0.000 claims description 28
• 239000002157 polynucleotide Substances 0.000 claims description 28
• 150000003839 salts Chemical class 0.000 claims description 28
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 27
• 125000002877 alkyl aryl group Chemical group 0.000 claims description 26
• 239000000651 prodrug Substances 0.000 claims description 26
• 229940002612 prodrug Drugs 0.000 claims description 26
• 229910052739 hydrogen Inorganic materials 0.000 claims description 25
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 24
• 229920000233 poly(alkylene oxides) Polymers 0.000 claims description 22
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 19
• 125000003107 substituted aryl group Chemical group 0.000 claims description 19
• 102000005962 receptors Human genes 0.000 claims description 18
• 108020003175 receptors Proteins 0.000 claims description 18
• 125000003545 alkoxy group Chemical group 0.000 claims description 17
• 239000003795 chemical substances by application Substances 0.000 claims description 17
• 125000002993 cycloalkylene group Chemical group 0.000 claims description 17
• 125000006588 heterocycloalkylene group Chemical group 0.000 claims description 17
• 239000002207 metabolite Substances 0.000 claims description 16
• 125000006239 protecting group Chemical group 0.000 claims description 16
• 125000004419 alkynylene group Chemical group 0.000 claims description 15
• 239000003446 ligand Substances 0.000 claims description 15
• 125000003342 alkenyl group Chemical group 0.000 claims description 14
• 125000005415 substituted alkoxy group Chemical group 0.000 claims description 13
• 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims description 12
• 229960002685 biotin Drugs 0.000 claims description 12
• 235000020958 biotin Nutrition 0.000 claims description 12
• 239000011616 biotin Substances 0.000 claims description 12
• 150000001615 biotins Chemical class 0.000 claims description 12
• 150000002148 esters Chemical group 0.000 claims description 12
• 239000001257 hydrogen Substances 0.000 claims description 12
• 125000005017 substituted alkenyl group Chemical group 0.000 claims description 12
• 125000005055 alkyl alkoxy group Chemical group 0.000 claims description 11
• 239000002773 nucleotide Substances 0.000 claims description 11
• 125000003729 nucleotide group Chemical group 0.000 claims description 11
• 150000002431 hydrogen Chemical class 0.000 claims description 10
• 229910052757 nitrogen Inorganic materials 0.000 claims description 10
• 229920005989 resin Polymers 0.000 claims description 10
• 239000011347 resin Substances 0.000 claims description 10
• 235000000346 sugar Nutrition 0.000 claims description 10
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 9
• 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims description 9
• 102100020880 Kit ligand Human genes 0.000 claims description 9
• 102000013275 Somatomedins Human genes 0.000 claims description 9
• 210000000440 neutrophil Anatomy 0.000 claims description 9
• 230000001698 pyrogenic effect Effects 0.000 claims description 9
• 239000012453 solvate Substances 0.000 claims description 9
• 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims description 8
• 125000000304 alkynyl group Chemical group 0.000 claims description 8
• 229910052799 carbon Inorganic materials 0.000 claims description 8
• 238000004519 manufacturing process Methods 0.000 claims description 8
• 239000003053 toxin Substances 0.000 claims description 8
• 231100000765 toxin Toxicity 0.000 claims description 8
• 108700012359 toxins Proteins 0.000 claims description 8
• 102000003298 tumor necrosis factor receptor Human genes 0.000 claims description 8
• 108010050904 Interferons Proteins 0.000 claims description 7
• 102000014150 Interferons Human genes 0.000 claims description 7
• 102000015696 Interleukins Human genes 0.000 claims description 7
• 108010063738 Interleukins Proteins 0.000 claims description 7
• 230000003213 activating effect Effects 0.000 claims description 7
• 239000007864 aqueous solution Substances 0.000 claims description 7
• 125000002619 bicyclic group Chemical group 0.000 claims description 7
• 230000000295 complement effect Effects 0.000 claims description 7
• 239000003937 drug carrier Substances 0.000 claims description 7
• 230000002401 inhibitory effect Effects 0.000 claims description 7
• 229940079322 interferon Drugs 0.000 claims description 7
• 239000002777 nucleoside Substances 0.000 claims description 7
• 229910052717 sulfur Inorganic materials 0.000 claims description 7
• 102400000068 Angiostatin Human genes 0.000 claims description 6
• 108010079709 Angiostatins Proteins 0.000 claims description 6
• 108010071942 Colony-Stimulating Factors Proteins 0.000 claims description 6
• 102000004127 Cytokines Human genes 0.000 claims description 6
• 108090000695 Cytokines Proteins 0.000 claims description 6
• 108090000394 Erythropoietin Proteins 0.000 claims description 6
• 102000003951 Erythropoietin Human genes 0.000 claims description 6
• 102000018233 Fibroblast Growth Factor Human genes 0.000 claims description 6
• 108050007372 Fibroblast Growth Factor Proteins 0.000 claims description 6
• 108090000385 Fibroblast growth factor 7 Proteins 0.000 claims description 6
• 102000003972 Fibroblast growth factor 7 Human genes 0.000 claims description 6
• 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims description 6
• 102100025390 Integrin beta-2 Human genes 0.000 claims description 6
• 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims description 6
• 108010039445 Stem Cell Factor Proteins 0.000 claims description 6
• 108010009583 Transforming Growth Factors Proteins 0.000 claims description 6
• 102000009618 Transforming Growth Factors Human genes 0.000 claims description 6
• 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims description 6
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 6
• FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 claims description 6
• 108010047295 complement receptors Proteins 0.000 claims description 6
• 102000006834 complement receptors Human genes 0.000 claims description 6
• 229940105423 erythropoietin Drugs 0.000 claims description 6
• 229940126864 fibroblast growth factor Drugs 0.000 claims description 6
• 239000003102 growth factor Substances 0.000 claims description 6
• 210000001616 monocyte Anatomy 0.000 claims description 6
• 150000003833 nucleoside derivatives Chemical class 0.000 claims description 6
• OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims description 6
• 230000002285 radioactive effect Effects 0.000 claims description 6
• 125000004426 substituted alkynyl group Chemical group 0.000 claims description 6
• 102100021943 C-C motif chemokine 2 Human genes 0.000 claims description 5
• 101710155857 C-C motif chemokine 2 Proteins 0.000 claims description 5
• 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims description 5
• 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims description 5
• 238000009830 intercalation Methods 0.000 claims description 5
• 230000005291 magnetic effect Effects 0.000 claims description 5
• 229910052760 oxygen Inorganic materials 0.000 claims description 5
• 108010051696 Growth Hormone Proteins 0.000 claims description 4
• 102000018997 Growth Hormone Human genes 0.000 claims description 4
• 102000001554 Hemoglobins Human genes 0.000 claims description 4
• 108010054147 Hemoglobins Proteins 0.000 claims description 4
• 101000989653 Homo sapiens Membrane frizzled-related protein Proteins 0.000 claims description 4
• 102100029357 Membrane frizzled-related protein Human genes 0.000 claims description 4
• JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims description 4
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 4
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 4
• 230000001746 atrial effect Effects 0.000 claims description 4
• WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 4
• 230000002757 inflammatory effect Effects 0.000 claims description 4
• 239000001301 oxygen Substances 0.000 claims description 4
• 239000011593 sulfur Substances 0.000 claims description 4
• 238000012546 transfer Methods 0.000 claims description 4
• BNIFSVVAHBLNTN-XKKUQSFHSA-N (2s)-4-amino-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-1-[(2s)-4-amino-2-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-1-[(2s)-6-amino-2-[[(2s)-2-[[(2s)-2-[[(2s,3r)-2-amino-3-hydroxybutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexan Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(O)=O)CCC1 BNIFSVVAHBLNTN-XKKUQSFHSA-N 0.000 claims description 3
• OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical compound C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 claims description 3
• 102000007592 Apolipoproteins Human genes 0.000 claims description 3
• 108010071619 Apolipoproteins Proteins 0.000 claims description 3
• 108010083590 Apoproteins Proteins 0.000 claims description 3
• 102000006410 Apoproteins Human genes 0.000 claims description 3
• 101800001288 Atrial natriuretic factor Proteins 0.000 claims description 3
• 102400001282 Atrial natriuretic peptide Human genes 0.000 claims description 3
• 101800001890 Atrial natriuretic peptide Proteins 0.000 claims description 3
• 102100032367 C-C motif chemokine 5 Human genes 0.000 claims description 3
• 102100032366 C-C motif chemokine 7 Human genes 0.000 claims description 3
• 102100025248 C-X-C motif chemokine 10 Human genes 0.000 claims description 3
• 101710098275 C-X-C motif chemokine 10 Proteins 0.000 claims description 3
• 102100036153 C-X-C motif chemokine 6 Human genes 0.000 claims description 3
• 101710085504 C-X-C motif chemokine 6 Proteins 0.000 claims description 3
• 102100036170 C-X-C motif chemokine 9 Human genes 0.000 claims description 3
• 101710085500 C-X-C motif chemokine 9 Proteins 0.000 claims description 3
• 102000001902 CC Chemokines Human genes 0.000 claims description 3
• 108010040471 CC Chemokines Proteins 0.000 claims description 3
• 108010029697 CD40 Ligand Proteins 0.000 claims description 3
• 101150013553 CD40 gene Proteins 0.000 claims description 3
• 102100032937 CD40 ligand Human genes 0.000 claims description 3
• 108050006947 CXC Chemokine Proteins 0.000 claims description 3
• 102000019388 CXC chemokine Human genes 0.000 claims description 3
• 101100337060 Caenorhabditis elegans glp-1 gene Proteins 0.000 claims description 3
• 102000055006 Calcitonin Human genes 0.000 claims description 3
• 108060001064 Calcitonin Proteins 0.000 claims description 3
• 108010055166 Chemokine CCL5 Proteins 0.000 claims description 3
• 108010055124 Chemokine CCL7 Proteins 0.000 claims description 3
• 102000000012 Chemokine CCL8 Human genes 0.000 claims description 3
• 108010055204 Chemokine CCL8 Proteins 0.000 claims description 3
• 102100022641 Coagulation factor IX Human genes 0.000 claims description 3
• 102100023804 Coagulation factor VII Human genes 0.000 claims description 3
• 108010035532 Collagen Proteins 0.000 claims description 3
• 102000008186 Collagen Human genes 0.000 claims description 3
• 101710104662 Enterotoxin type C-3 Proteins 0.000 claims description 3
• 102100030844 Exocyst complex component 1 Human genes 0.000 claims description 3
• 101710082714 Exotoxin A Proteins 0.000 claims description 3
• 108010076282 Factor IX Proteins 0.000 claims description 3
• 108010023321 Factor VII Proteins 0.000 claims description 3
• 108010054218 Factor VIII Proteins 0.000 claims description 3
• 102000001690 Factor VIII Human genes 0.000 claims description 3
• 108010014173 Factor X Proteins 0.000 claims description 3
• 108010049003 Fibrinogen Proteins 0.000 claims description 3
• 102000008946 Fibrinogen Human genes 0.000 claims description 3
• 108090000368 Fibroblast growth factor 8 Proteins 0.000 claims description 3
• 102100037362 Fibronectin Human genes 0.000 claims description 3
• 108010067306 Fibronectins Proteins 0.000 claims description 3
• 102100040837 Galactoside alpha-(1,2)-fucosyltransferase 2 Human genes 0.000 claims description 3
• 101710115997 Gamma-tubulin complex component 2 Proteins 0.000 claims description 3
• 108010017544 Glucosylceramidase Proteins 0.000 claims description 3
• 102000004547 Glucosylceramidase Human genes 0.000 claims description 3
• 108010086677 Gonadotropins Proteins 0.000 claims description 3
• 102000006771 Gonadotropins Human genes 0.000 claims description 3
• 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims description 3
• 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims description 3
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 3
• 108090000031 Hedgehog Proteins Proteins 0.000 claims description 3
• 102000003693 Hedgehog Proteins Human genes 0.000 claims description 3
• 102000007625 Hirudins Human genes 0.000 claims description 3
• 108010007267 Hirudins Proteins 0.000 claims description 3
• 101000893710 Homo sapiens Galactoside alpha-(1,2)-fucosyltransferase 2 Proteins 0.000 claims description 3
• 101000973997 Homo sapiens Nucleosome assembly protein 1-like 4 Proteins 0.000 claims description 3
• 101000947178 Homo sapiens Platelet basic protein Proteins 0.000 claims description 3
• 101000582950 Homo sapiens Platelet factor 4 Proteins 0.000 claims description 3
• 101000652229 Homo sapiens Suppressor of cytokine signaling 7 Proteins 0.000 claims description 3
• 108010000521 Human Growth Hormone Proteins 0.000 claims description 3
• 102000002265 Human Growth Hormone Human genes 0.000 claims description 3
• 239000000854 Human Growth Hormone Substances 0.000 claims description 3
• 102000008100 Human Serum Albumin Human genes 0.000 claims description 3
• 108091006905 Human Serum Albumin Proteins 0.000 claims description 3
• 101000668058 Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99) RNA-directed RNA polymerase catalytic subunit Proteins 0.000 claims description 3
• 102000003746 Insulin Receptor Human genes 0.000 claims description 3
• 108010001127 Insulin Receptor Proteins 0.000 claims description 3
• 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims description 3
• 108010008212 Integrin alpha4beta1 Proteins 0.000 claims description 3
• 102100026720 Interferon beta Human genes 0.000 claims description 3
• 108010047761 Interferon-alpha Proteins 0.000 claims description 3
• 102000006992 Interferon-alpha Human genes 0.000 claims description 3
• 108090000467 Interferon-beta Proteins 0.000 claims description 3
• 108010002352 Interleukin-1 Proteins 0.000 claims description 3
• 108090000174 Interleukin-10 Proteins 0.000 claims description 3
• 108010065805 Interleukin-12 Proteins 0.000 claims description 3
• 108010002350 Interleukin-2 Proteins 0.000 claims description 3
• 102000000588 Interleukin-2 Human genes 0.000 claims description 3
• 108010002386 Interleukin-3 Proteins 0.000 claims description 3
• 102000000646 Interleukin-3 Human genes 0.000 claims description 3
• 102000004388 Interleukin-4 Human genes 0.000 claims description 3
• 108090000978 Interleukin-4 Proteins 0.000 claims description 3
• 108010002616 Interleukin-5 Proteins 0.000 claims description 3
• 108090001005 Interleukin-6 Proteins 0.000 claims description 3
• 102000004889 Interleukin-6 Human genes 0.000 claims description 3
• 108010002586 Interleukin-7 Proteins 0.000 claims description 3
• 108090001007 Interleukin-8 Proteins 0.000 claims description 3
• 108010002335 Interleukin-9 Proteins 0.000 claims description 3
• 108010001831 LDL receptors Proteins 0.000 claims description 3
• 108010063045 Lactoferrin Proteins 0.000 claims description 3
• 102000010445 Lactoferrin Human genes 0.000 claims description 3
• 102000004058 Leukemia inhibitory factor Human genes 0.000 claims description 3
• 108090000581 Leukemia inhibitory factor Proteins 0.000 claims description 3
• 108060001084 Luciferase Proteins 0.000 claims description 3
• 239000005089 Luciferase Substances 0.000 claims description 3
• 108090000542 Lymphotoxin-alpha Proteins 0.000 claims description 3
• 102000004083 Lymphotoxin-alpha Human genes 0.000 claims description 3
• 108090000375 Mineralocorticoid Receptors Proteins 0.000 claims description 3
• 102000003979 Mineralocorticoid Receptors Human genes 0.000 claims description 3
• 108010015406 Neurturin Proteins 0.000 claims description 3
• 108700020796 Oncogene Proteins 0.000 claims description 3
• 102000043276 Oncogene Human genes 0.000 claims description 3
• 102000004140 Oncostatin M Human genes 0.000 claims description 3
• 108090000630 Oncostatin M Proteins 0.000 claims description 3
• 102000003982 Parathyroid hormone Human genes 0.000 claims description 3
• 108090000445 Parathyroid hormone Proteins 0.000 claims description 3
• 102100036154 Platelet basic protein Human genes 0.000 claims description 3
• 102100030304 Platelet factor 4 Human genes 0.000 claims description 3
• 239000004698 Polyethylene Substances 0.000 claims description 3
• 102000003743 Relaxin Human genes 0.000 claims description 3
• 108090000103 Relaxin Proteins 0.000 claims description 3
• 108090000783 Renin Proteins 0.000 claims description 3
• 102100028255 Renin Human genes 0.000 claims description 3
• 206010040070 Septic Shock Diseases 0.000 claims description 3
• 108010056088 Somatostatin Proteins 0.000 claims description 3
• 102000005157 Somatostatin Human genes 0.000 claims description 3
• 101000882403 Staphylococcus aureus Enterotoxin type C-2 Proteins 0.000 claims description 3
• 101001057112 Staphylococcus aureus Enterotoxin type D Proteins 0.000 claims description 3
• 108010023197 Streptokinase Proteins 0.000 claims description 3
• 102100021669 Stromal cell-derived factor 1 Human genes 0.000 claims description 3
• 101710088580 Stromal cell-derived factor 1 Proteins 0.000 claims description 3
• 102000019197 Superoxide Dismutase Human genes 0.000 claims description 3
• 108010012715 Superoxide dismutase Proteins 0.000 claims description 3
• 102100030529 Suppressor of cytokine signaling 7 Human genes 0.000 claims description 3
• 206010044248 Toxic shock syndrome Diseases 0.000 claims description 3
• 231100000650 Toxic shock syndrome Toxicity 0.000 claims description 3
• 101710120037 Toxin CcdB Proteins 0.000 claims description 3
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 3
• 108090000435 Urokinase-type plasminogen activator Proteins 0.000 claims description 3
• 102000003990 Urokinase-type plasminogen activator Human genes 0.000 claims description 3
• 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 claims description 3
• 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 claims description 3
• 150000001412 amines Chemical class 0.000 claims description 3
• 108010080146 androgen receptors Proteins 0.000 claims description 3
• 102000001307 androgen receptors Human genes 0.000 claims description 3
• 230000002587 anti-hemolytic effect Effects 0.000 claims description 3
• BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims description 3
• 229960004015 calcitonin Drugs 0.000 claims description 3
• NSQLIUXCMFBZME-MPVJKSABSA-N carperitide Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)=O)[C@@H](C)CC)C1=CC=CC=C1 NSQLIUXCMFBZME-MPVJKSABSA-N 0.000 claims description 3
• 229920001436 collagen Polymers 0.000 claims description 3
• 239000002934 diuretic Substances 0.000 claims description 3
• 231100000655 enterotoxin Toxicity 0.000 claims description 3
• 102000015694 estrogen receptors Human genes 0.000 claims description 3
• 108010038795 estrogen receptors Proteins 0.000 claims description 3
• 231100000776 exotoxin Toxicity 0.000 claims description 3
• 239000002095 exotoxin Substances 0.000 claims description 3
• 229960004222 factor ix Drugs 0.000 claims description 3
• 229940012413 factor vii Drugs 0.000 claims description 3
• 229960000301 factor viii Drugs 0.000 claims description 3
• 229940012426 factor x Drugs 0.000 claims description 3
• 229940012952 fibrinogen Drugs 0.000 claims description 3
• 239000002622 gonadotropin Substances 0.000 claims description 3
• WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 claims description 3
• 229940006607 hirudin Drugs 0.000 claims description 3
• 102000002467 interleukin receptors Human genes 0.000 claims description 3
• 108010093036 interleukin receptors Proteins 0.000 claims description 3
• CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims description 3
• 229940078795 lactoferrin Drugs 0.000 claims description 3
• 235000021242 lactoferrin Nutrition 0.000 claims description 3
• OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 claims description 3
• 230000001452 natriuretic effect Effects 0.000 claims description 3
• 230000002188 osteogenic effect Effects 0.000 claims description 3
• 239000000199 parathyroid hormone Substances 0.000 claims description 3
• 229960001319 parathyroid hormone Drugs 0.000 claims description 3
• 108010012038 peptide 78 Proteins 0.000 claims description 3
• 229940125863 peptide 78 Drugs 0.000 claims description 3
• 239000000813 peptide hormone Substances 0.000 claims description 3
• 102000005162 pleiotrophin Human genes 0.000 claims description 3
• 229920000573 polyethylene Polymers 0.000 claims description 3
• 102000003998 progesterone receptors Human genes 0.000 claims description 3
• 108090000468 progesterone receptors Proteins 0.000 claims description 3
• NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims description 3
• 229960000553 somatostatin Drugs 0.000 claims description 3
• 102000005969 steroid hormone receptors Human genes 0.000 claims description 3
• 108020003113 steroid hormone receptors Proteins 0.000 claims description 3
• 229960005202 streptokinase Drugs 0.000 claims description 3
• 231100000617 superantigen Toxicity 0.000 claims description 3
• VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims description 3
• 229960005356 urokinase Drugs 0.000 claims description 3
• YQAXFVHNHSPUPO-RNJOBUHISA-N 2-[[(2s)-2-[[2-[[(2s,4r)-1-[(2s)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]-4-hydroxypyrrolidine-2-carbonyl]amino]acetyl]amino]propanoyl]amino]acetic acid Chemical compound OC(=O)CNC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H]1N(C(=O)CN)CCC1 YQAXFVHNHSPUPO-RNJOBUHISA-N 0.000 claims description 2
• 101000716807 Arabidopsis thaliana Protein SCO1 homolog 1, mitochondrial Proteins 0.000 claims description 2
• 102100036150 C-X-C motif chemokine 5 Human genes 0.000 claims description 2
• 229940124073 Complement inhibitor Drugs 0.000 claims description 2
• OMFXVFTZEKFJBZ-UHFFFAOYSA-N Corticosterone Natural products O=C1CCC2(C)C3C(O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 OMFXVFTZEKFJBZ-UHFFFAOYSA-N 0.000 claims description 2
• 101100246972 Danio rerio pyya gene Proteins 0.000 claims description 2
• 101000947186 Homo sapiens C-X-C motif chemokine 5 Proteins 0.000 claims description 2
• 101001076715 Homo sapiens RNA-binding protein 39 Proteins 0.000 claims description 2
• 102000048143 Insulin-Like Growth Factor II Human genes 0.000 claims description 2
• 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims description 2
• 102000005755 Intercellular Signaling Peptides and Proteins Human genes 0.000 claims description 2
• 108010070716 Intercellular Signaling Peptides and Proteins Proteins 0.000 claims description 2
• 102100037850 Interferon gamma Human genes 0.000 claims description 2
• 108010074328 Interferon-gamma Proteins 0.000 claims description 2
• 101710177504 Kit ligand Proteins 0.000 claims description 2
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 2
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims description 2
• 102100023361 SAP domain-containing ribonucleoprotein Human genes 0.000 claims description 2
• 108010078233 Thymalfasin Proteins 0.000 claims description 2
• 102400000800 Thymosin alpha-1 Human genes 0.000 claims description 2
• 108090000373 Tissue Plasminogen Activator Proteins 0.000 claims description 2
• 102000003978 Tissue Plasminogen Activator Human genes 0.000 claims description 2
• 108010082685 antiarrhythmic peptide Proteins 0.000 claims description 2
• 239000004074 complement inhibitor Substances 0.000 claims description 2
• OMFXVFTZEKFJBZ-HJTSIMOOSA-N corticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OMFXVFTZEKFJBZ-HJTSIMOOSA-N 0.000 claims description 2
• 125000002950 monocyclic group Chemical group 0.000 claims description 2
• 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims description 2
• 125000005551 pyridylene group Chemical group 0.000 claims description 2
• 125000005576 pyrimidinylene group Chemical group 0.000 claims description 2
• 101150036871 pyy gene Proteins 0.000 claims description 2
• 125000005730 thiophenylene group Chemical group 0.000 claims description 2
• NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 claims description 2
• 229960004231 thymalfasin Drugs 0.000 claims description 2
• 229960000187 tissue plasminogen activator Drugs 0.000 claims description 2
• 102100021866 Hepatocyte growth factor Human genes 0.000 claims 2
• 102100039037 Vascular endothelial growth factor A Human genes 0.000 claims 2
• 150000002926 oxygen Chemical class 0.000 claims 2
• 150000003463 sulfur Chemical class 0.000 claims 2
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
• 108090000177 Interleukin-11 Proteins 0.000 claims 1
• 102100024640 Low-density lipoprotein receptor Human genes 0.000 claims 1
• 102000001839 Neurturin Human genes 0.000 claims 1
• 241000253387 Rhodobiaceae Species 0.000 claims 1
• 101710194492 SET-binding protein Proteins 0.000 claims 1
• 101000882406 Staphylococcus aureus Enterotoxin type C-1 Proteins 0.000 claims 1
• 102000015395 alpha 1-Antitrypsin Human genes 0.000 claims 1
• 108010050122 alpha 1-Antitrypsin Proteins 0.000 claims 1
• 229940024142 alpha 1-antitrypsin Drugs 0.000 claims 1
• 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
• 238000012986 modification Methods 0.000 abstract description 21
• 230000004048 modification Effects 0.000 abstract description 19
• 235000001014 amino acid Nutrition 0.000 description 515
• 239000002253 acid Substances 0.000 description 85
• 210000004027 cell Anatomy 0.000 description 43
• 239000003814 drug Substances 0.000 description 36
• 239000000126 substance Substances 0.000 description 32
• 230000000694 effects Effects 0.000 description 31
• 239000003153 chemical reaction reagent Substances 0.000 description 28
• 229940079593 drug Drugs 0.000 description 27
• 125000000524 functional group Chemical group 0.000 description 27
• 125000000623 heterocyclic group Chemical group 0.000 description 27
• 230000000670 limiting effect Effects 0.000 description 27
• 150000007523 nucleic acids Chemical class 0.000 description 27
• 238000006467 substitution reaction Methods 0.000 description 27
• 150000007513 acids Chemical class 0.000 description 22
• 102000039446 nucleic acids Human genes 0.000 description 22
• 108020004707 nucleic acids Proteins 0.000 description 22
• 230000004481 post-translational protein modification Effects 0.000 description 21
• 108020004705 Codon Proteins 0.000 description 19
• 150000001299 aldehydes Chemical class 0.000 description 18
• 238000001212 derivatisation Methods 0.000 description 17
• 230000001965 increasing effect Effects 0.000 description 17
• 238000007792 addition Methods 0.000 description 16
• 230000004071 biological effect Effects 0.000 description 16
• 150000002576 ketones Chemical class 0.000 description 16
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
• 239000013543 active substance Substances 0.000 description 14
• 125000004429 atom Chemical group 0.000 description 14
• 230000035071 co-translational protein modification Effects 0.000 description 13
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 13
• 210000002966 serum Anatomy 0.000 description 13
• 230000027455 binding Effects 0.000 description 12
• 230000015572 biosynthetic process Effects 0.000 description 12
• 238000004422 calculation algorithm Methods 0.000 description 12
• 125000001424 substituent group Chemical group 0.000 description 12
• 238000011282 treatment Methods 0.000 description 12
• 150000001720 carbohydrates Chemical group 0.000 description 11
• 238000001727 in vivo Methods 0.000 description 11
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 11
• 239000002904 solvent Substances 0.000 description 11
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
• 108010076504 Protein Sorting Signals Proteins 0.000 description 10
• 125000003275 alpha amino acid group Chemical group 0.000 description 10
• 239000000463 material Substances 0.000 description 10
• 229910052751 metal Inorganic materials 0.000 description 10
• 239000002184 metal Substances 0.000 description 10
• 230000028327 secretion Effects 0.000 description 10
• 230000014616 translation Effects 0.000 description 10
• 238000013519 translation Methods 0.000 description 10
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 9
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 9
• 230000001588 bifunctional effect Effects 0.000 description 9
• 238000012217 deletion Methods 0.000 description 9
• 230000037430 deletion Effects 0.000 description 9
• 150000003254 radicals Chemical class 0.000 description 9
• 229920002477 rna polymer Polymers 0.000 description 9
• 239000000523 sample Substances 0.000 description 9
• 238000003786 synthesis reaction Methods 0.000 description 9
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
• 230000002378 acidificating effect Effects 0.000 description 8
• 238000004458 analytical method Methods 0.000 description 8
• 125000005842 heteroatom Chemical group 0.000 description 8
• 238000010348 incorporation Methods 0.000 description 8
• 150000003384 small molecules Chemical class 0.000 description 8
• 229940124597 therapeutic agent Drugs 0.000 description 8
• 239000002585 base Substances 0.000 description 7
• 239000013078 crystal Substances 0.000 description 7
• 125000004404 heteroalkyl group Chemical group 0.000 description 7
• 230000005847 immunogenicity Effects 0.000 description 7
• 238000000338 in vitro Methods 0.000 description 7
• 150000002500 ions Chemical class 0.000 description 7
• 229910021645 metal ion Inorganic materials 0.000 description 7
• 239000002245 particle Substances 0.000 description 7
• 238000002360 preparation method Methods 0.000 description 7
• 108020004414 DNA Proteins 0.000 description 6
• 102000004190 Enzymes Human genes 0.000 description 6
• 108090000790 Enzymes Proteins 0.000 description 6
• 241000206602 Eukaryota Species 0.000 description 6
• PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 6
• 108091034117 Oligonucleotide Proteins 0.000 description 6
• 239000004473 Threonine Substances 0.000 description 6
• 230000001413 cellular effect Effects 0.000 description 6
• 231100000433 cytotoxic Toxicity 0.000 description 6
• 230000001472 cytotoxic effect Effects 0.000 description 6
• 239000012039 electrophile Substances 0.000 description 6
• 229940088598 enzyme Drugs 0.000 description 6
• 238000005755 formation reaction Methods 0.000 description 6
• 125000000468 ketone group Chemical group 0.000 description 6
• 239000002609 medium Substances 0.000 description 6
• 239000000047 product Substances 0.000 description 6
• 229960001153 serine Drugs 0.000 description 6
• 238000012360 testing method Methods 0.000 description 6
• 229960002898 threonine Drugs 0.000 description 6
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 5
• 241000588724 Escherichia coli Species 0.000 description 5
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 5
• 241001465754 Metazoa Species 0.000 description 5
• 241000700605 Viruses Species 0.000 description 5
• 239000007801 affinity label Substances 0.000 description 5
• 235000004279 alanine Nutrition 0.000 description 5
• 125000000539 amino acid group Chemical group 0.000 description 5
• 239000005557 antagonist Substances 0.000 description 5
• 230000008901 benefit Effects 0.000 description 5
• 235000014633 carbohydrates Nutrition 0.000 description 5
• 125000004432 carbon atom Chemical group C* 0.000 description 5
• 239000000975 dye Substances 0.000 description 5
• 230000002708 enhancing effect Effects 0.000 description 5
• 230000000269 nucleophilic effect Effects 0.000 description 5
• 229920001542 oligosaccharide Polymers 0.000 description 5
• 150000002482 oligosaccharides Chemical class 0.000 description 5
• 239000007800 oxidant agent Substances 0.000 description 5
• 239000007856 photoaffinity label Substances 0.000 description 5
• 230000008569 process Effects 0.000 description 5
• 230000009257 reactivity Effects 0.000 description 5
• 230000002829 reductive effect Effects 0.000 description 5
• 231100000331 toxic Toxicity 0.000 description 5
• 230000002588 toxic effect Effects 0.000 description 5
• 102000014914 Carrier Proteins Human genes 0.000 description 4
• 229920000858 Cyclodextrin Polymers 0.000 description 4
• 241000196324 Embryophyta Species 0.000 description 4
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
• 102000003745 Hepatocyte Growth Factor Human genes 0.000 description 4
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 4
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 4
• 238000005481 NMR spectroscopy Methods 0.000 description 4
• 241000589157 Rhizobiales Species 0.000 description 4
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
• 108020005038 Terminator Codon Proteins 0.000 description 4
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 4
• 230000009471 action Effects 0.000 description 4
• 239000012190 activator Substances 0.000 description 4
• 239000000556 agonist Substances 0.000 description 4
• 230000000692 anti-sense effect Effects 0.000 description 4
• 238000003491 array Methods 0.000 description 4
• 229960001230 asparagine Drugs 0.000 description 4
• 108091008324 binding proteins Proteins 0.000 description 4
• 150000001735 carboxylic acids Chemical class 0.000 description 4
• 230000008859 change Effects 0.000 description 4
• 239000002738 chelating agent Substances 0.000 description 4
• 239000003638 chemical reducing agent Substances 0.000 description 4
• 125000004122 cyclic group Chemical group 0.000 description 4
• 235000018417 cysteine Nutrition 0.000 description 4
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 4
• 230000003247 decreasing effect Effects 0.000 description 4
• 235000014113 dietary fatty acids Nutrition 0.000 description 4
• 238000006471 dimerization reaction Methods 0.000 description 4
• XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 4
• 210000003527 eukaryotic cell Anatomy 0.000 description 4
• 229930195729 fatty acid Natural products 0.000 description 4
• 239000000194 fatty acid Substances 0.000 description 4
• 150000004665 fatty acids Chemical class 0.000 description 4
• 230000014509 gene expression Effects 0.000 description 4
• 229920002521 macromolecule Polymers 0.000 description 4
• 229930182817 methionine Natural products 0.000 description 4
• 239000000693 micelle Substances 0.000 description 4
• 239000002105 nanoparticle Substances 0.000 description 4
• 150000007530 organic bases Chemical class 0.000 description 4
• 239000008194 pharmaceutical composition Substances 0.000 description 4
• 229920001515 polyalkylene glycol Polymers 0.000 description 4
• 230000005855 radiation Effects 0.000 description 4
• 230000002441 reversible effect Effects 0.000 description 4
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 4
• 238000012216 screening Methods 0.000 description 4
• 208000024891 symptom Diseases 0.000 description 4
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 3
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 3
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
• 108091023037 Aptamer Proteins 0.000 description 3
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 3
• 241000271566 Aves Species 0.000 description 3
• 241000894006 Bacteria Species 0.000 description 3
• 241000938605 Crocodylia Species 0.000 description 3
• FDKWRPBBCBCIGA-UWTATZPHSA-N D-Selenocysteine Natural products [Se]C[C@@H](N)C(O)=O FDKWRPBBCBCIGA-UWTATZPHSA-N 0.000 description 3
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 3
• 241000238631 Hexapoda Species 0.000 description 3
• XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 3
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 3
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 3
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 3
• ZKZBPNGNEQAJSX-REOHCLBHSA-N L-selenocysteine Chemical compound [SeH]C[C@H](N)C(O)=O ZKZBPNGNEQAJSX-REOHCLBHSA-N 0.000 description 3
• AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 3
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 3
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 3
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 3
• 239000004472 Lysine Substances 0.000 description 3
• 108091005461 Nucleic proteins Proteins 0.000 description 3
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 3
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 3
• 108020004566 Transfer RNA Proteins 0.000 description 3
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 3
• 238000002441 X-ray diffraction Methods 0.000 description 3
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 3
• 239000002671 adjuvant Substances 0.000 description 3
• 125000003172 aldehyde group Chemical group 0.000 description 3
• 125000003277 amino group Chemical group 0.000 description 3
• 230000003388 anti-hormonal effect Effects 0.000 description 3
• 230000005875 antibody response Effects 0.000 description 3
• 239000000427 antigen Substances 0.000 description 3
• 108091007433 antigens Proteins 0.000 description 3
• 102000036639 antigens Human genes 0.000 description 3
• 239000003963 antioxidant agent Substances 0.000 description 3
• 230000003078 antioxidant effect Effects 0.000 description 3
• 235000006708 antioxidants Nutrition 0.000 description 3
• 235000009582 asparagine Nutrition 0.000 description 3
• 238000003556 assay Methods 0.000 description 3
• 230000009286 beneficial effect Effects 0.000 description 3
• 210000004369 blood Anatomy 0.000 description 3
• 239000008280 blood Substances 0.000 description 3
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
• 239000007795 chemical reaction product Substances 0.000 description 3
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
• 238000010168 coupling process Methods 0.000 description 3
• 125000004093 cyano group Chemical class *C#N 0.000 description 3
• 239000000412 dendrimer Substances 0.000 description 3
• 229920000736 dendritic polymer Polymers 0.000 description 3
• 238000002149 energy-dispersive X-ray emission spectroscopy Methods 0.000 description 3
• 238000005516 engineering process Methods 0.000 description 3
• 229920001002 functional polymer Polymers 0.000 description 3
• 229960002989 glutamic acid Drugs 0.000 description 3
• 235000013922 glutamic acid Nutrition 0.000 description 3
• 239000004220 glutamic acid Substances 0.000 description 3
• 150000004676 glycans Chemical class 0.000 description 3
• 239000001963 growth medium Substances 0.000 description 3
• 230000002209 hydrophobic effect Effects 0.000 description 3
• 229960004716 idoxuridine Drugs 0.000 description 3
• 229910052759 nickel Inorganic materials 0.000 description 3
• 125000000449 nitro group Chemical class [O-][N+](*)=O 0.000 description 3
• 125000004433 nitrogen atom Chemical group N* 0.000 description 3
• 125000004430 oxygen atom Chemical group O* 0.000 description 3
• 239000004031 partial agonist Substances 0.000 description 3
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
• 229920001451 polypropylene glycol Polymers 0.000 description 3
• 229920001282 polysaccharide Polymers 0.000 description 3
• 239000005017 polysaccharide Substances 0.000 description 3
• 230000000069 prophylactic effect Effects 0.000 description 3
• 239000001397 quillaja saponaria molina bark Substances 0.000 description 3
• 230000004044 response Effects 0.000 description 3
• 229930182490 saponin Natural products 0.000 description 3
• 150000007949 saponins Chemical class 0.000 description 3
• 229940055619 selenocysteine Drugs 0.000 description 3
• ZKZBPNGNEQAJSX-UHFFFAOYSA-N selenocysteine Natural products [SeH]CC(N)C(O)=O ZKZBPNGNEQAJSX-UHFFFAOYSA-N 0.000 description 3
• 235000016491 selenocysteine Nutrition 0.000 description 3
• 239000013605 shuttle vector Substances 0.000 description 3
• 239000007787 solid Substances 0.000 description 3
• 239000000758 substrate Substances 0.000 description 3
• 125000005309 thioalkoxy group Chemical group 0.000 description 3
• 210000001519 tissue Anatomy 0.000 description 3
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 3
• HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
• 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 2
• XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical compound OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 description 2
• 101710081722 Antitrypsin Proteins 0.000 description 2
• 239000004475 Arginine Substances 0.000 description 2
• FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
• RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
• 238000002965 ELISA Methods 0.000 description 2
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 2
• 241000233866 Fungi Species 0.000 description 2
• 239000004471 Glycine Substances 0.000 description 2
• AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
• 108020005004 Guide RNA Proteins 0.000 description 2
• 241000205062 Halobacterium Species 0.000 description 2
• 241000282412 Homo Species 0.000 description 2
• 241000282414 Homo sapiens Species 0.000 description 2
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
• MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 2
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 2
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 2
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 2
• LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 description 2
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 2
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 2
• 102000000853 LDL receptors Human genes 0.000 description 2
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 2
• 102000003960 Ligases Human genes 0.000 description 2
• 108090000364 Ligases Proteins 0.000 description 2
• OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
• 241000124008 Mammalia Species 0.000 description 2
• AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
• 102100021584 Neurturin Human genes 0.000 description 2
• 108091028043 Nucleic acid sequence Proteins 0.000 description 2
• 102000035195 Peptidases Human genes 0.000 description 2
• 108091005804 Peptidases Proteins 0.000 description 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
• 108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 2
• 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 2
• 239000004721 Polyphenylene oxide Substances 0.000 description 2
• NBBJYMSMWIIQGU-UHFFFAOYSA-N Propionic aldehyde Chemical compound CCC=O NBBJYMSMWIIQGU-UHFFFAOYSA-N 0.000 description 2
• 239000004365 Protease Substances 0.000 description 2
• KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 2
• LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 2
• CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
• QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 2
• 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 description 2
• 230000021736 acetylation Effects 0.000 description 2
• 238000006640 acetylation reaction Methods 0.000 description 2
• 230000010933 acylation Effects 0.000 description 2
• 238000005917 acylation reaction Methods 0.000 description 2
• 239000000654 additive Substances 0.000 description 2
• 230000002776 aggregation Effects 0.000 description 2
• 238000004220 aggregation Methods 0.000 description 2
• 125000003158 alcohol group Chemical group 0.000 description 2
• 229910001413 alkali metal ion Inorganic materials 0.000 description 2
• 230000004075 alteration Effects 0.000 description 2
• 229910052782 aluminium Inorganic materials 0.000 description 2
• 230000001475 anti-trypsic effect Effects 0.000 description 2
• 238000013459 approach Methods 0.000 description 2
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
• 235000009697 arginine Nutrition 0.000 description 2
• 125000004104 aryloxy group Chemical group 0.000 description 2
• 235000003704 aspartic acid Nutrition 0.000 description 2
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
• 239000011324 bead Substances 0.000 description 2
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 2
• 239000012620 biological material Substances 0.000 description 2
• 230000001851 biosynthetic effect Effects 0.000 description 2
• 238000005251 capillar electrophoresis Methods 0.000 description 2
• 150000001732 carboxylic acid derivatives Chemical class 0.000 description 2
• 229920002678 cellulose Polymers 0.000 description 2
• 239000001913 cellulose Substances 0.000 description 2
• 235000010980 cellulose Nutrition 0.000 description 2
• 125000003636 chemical group Chemical group 0.000 description 2
• 239000000460 chlorine Substances 0.000 description 2
• 229910052801 chlorine Inorganic materials 0.000 description 2
• 229920001577 copolymer Polymers 0.000 description 2
• 230000008878 coupling Effects 0.000 description 2
• 238000005859 coupling reaction Methods 0.000 description 2
• 238000002425 crystallisation Methods 0.000 description 2
• 230000008025 crystallization Effects 0.000 description 2
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
• UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 description 2
• 230000002939 deleterious effect Effects 0.000 description 2
• 238000003745 diagnosis Methods 0.000 description 2
• 239000000539 dimer Substances 0.000 description 2
• ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 2
• VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 2
• 239000002552 dosage form Substances 0.000 description 2
• 230000007613 environmental effect Effects 0.000 description 2
• 230000002255 enzymatic effect Effects 0.000 description 2
• 125000004185 ester group Chemical group 0.000 description 2
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
• 230000005281 excited state Effects 0.000 description 2
• 238000001914 filtration Methods 0.000 description 2
• 238000002866 fluorescence resonance energy transfer Methods 0.000 description 2
• 239000011737 fluorine Substances 0.000 description 2
• 229910052731 fluorine Inorganic materials 0.000 description 2
• 230000006870 function Effects 0.000 description 2
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
• 235000004554 glutamine Nutrition 0.000 description 2
• 125000003827 glycol group Chemical group 0.000 description 2
• 230000013595 glycosylation Effects 0.000 description 2
• 238000006206 glycosylation reaction Methods 0.000 description 2
• 125000001188 haloalkyl group Chemical group 0.000 description 2
• 230000003862 health status Effects 0.000 description 2
• IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 2
• VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 2
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 2
• BRWIZMBXBAOCCF-UHFFFAOYSA-N hydrazinecarbothioamide Chemical compound NNC(N)=S BRWIZMBXBAOCCF-UHFFFAOYSA-N 0.000 description 2
• 150000007857 hydrazones Chemical class 0.000 description 2
• 150000002430 hydrocarbons Chemical group 0.000 description 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
• 238000005286 illumination Methods 0.000 description 2
• 150000002466 imines Chemical group 0.000 description 2
• 150000002475 indoles Chemical class 0.000 description 2
• 150000007529 inorganic bases Chemical class 0.000 description 2
• 230000003993 interaction Effects 0.000 description 2
• 239000000138 intercalating agent Substances 0.000 description 2
• 229940125425 inverse agonist Drugs 0.000 description 2
• 238000004255 ion exchange chromatography Methods 0.000 description 2
• 229910052742 iron Inorganic materials 0.000 description 2
• SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 2
• 229960000310 isoleucine Drugs 0.000 description 2
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 2
• FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 2
• 238000002372 labelling Methods 0.000 description 2
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
• 150000002605 large molecules Chemical class 0.000 description 2
• 238000002844 melting Methods 0.000 description 2
• 230000008018 melting Effects 0.000 description 2
• 230000002503 metabolic effect Effects 0.000 description 2
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 2
• 238000000386 microscopy Methods 0.000 description 2
• 150000007522 mineralic acids Chemical class 0.000 description 2
• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 2
• TXXHDPDFNKHHGW-UHFFFAOYSA-N muconic acid Chemical group OC(=O)C=CC=CC(O)=O TXXHDPDFNKHHGW-UHFFFAOYSA-N 0.000 description 2
• FUZZWVXGSFPDMH-UHFFFAOYSA-N n-hexanoic acid Natural products CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 2
• 231100000252 nontoxic Toxicity 0.000 description 2
• 230000003000 nontoxic effect Effects 0.000 description 2
• 150000007524 organic acids Chemical class 0.000 description 2
• 150000002905 orthoesters Chemical class 0.000 description 2
• 230000026792 palmitoylation Effects 0.000 description 2
• 230000036961 partial effect Effects 0.000 description 2
• 239000000546 pharmaceutical excipient Substances 0.000 description 2
• 230000003285 pharmacodynamic effect Effects 0.000 description 2
• 230000000144 pharmacologic effect Effects 0.000 description 2
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 2
• 229960005190 phenylalanine Drugs 0.000 description 2
• 230000026731 phosphorylation Effects 0.000 description 2
• 238000006366 phosphorylation reaction Methods 0.000 description 2
• 230000004962 physiological condition Effects 0.000 description 2
• BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
• 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 2
• 229920000570 polyether Polymers 0.000 description 2
• 229920005862 polyol Polymers 0.000 description 2
• 150000003077 polyols Chemical class 0.000 description 2
• 230000001323 posttranslational effect Effects 0.000 description 2
• 235000019260 propionic acid Nutrition 0.000 description 2
• 238000000746 purification Methods 0.000 description 2
• 239000002096 quantum dot Substances 0.000 description 2
• IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 2
• 239000000376 reactant Substances 0.000 description 2
• 238000010188 recombinant method Methods 0.000 description 2
• YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical group OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
• 229920006395 saturated elastomer Polymers 0.000 description 2
• 229910052710 silicon Inorganic materials 0.000 description 2
• SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 2
• 239000000243 solution Substances 0.000 description 2
• 241000894007 species Species 0.000 description 2
• 125000004434 sulfur atom Chemical group 0.000 description 2
• 230000002194 synthesizing effect Effects 0.000 description 2
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
• 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
• 238000002560 therapeutic procedure Methods 0.000 description 2
• 238000002076 thermal analysis method Methods 0.000 description 2
• 238000002411 thermogravimetry Methods 0.000 description 2
• 239000002753 trypsin inhibitor Substances 0.000 description 2
• 125000004417 unsaturated alkyl group Chemical group 0.000 description 2
• 239000004474 valine Substances 0.000 description 2
• 229920002554 vinyl polymer Polymers 0.000 description 2
• 238000011179 visual inspection Methods 0.000 description 2
• DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 2
• QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 description 1
• YPGMOWHXEQDBBV-QWWZWVQMSA-N (4S,5S)-1,2-dithiane-4,5-diol Chemical compound O[C@@H]1CSSC[C@H]1O YPGMOWHXEQDBBV-QWWZWVQMSA-N 0.000 description 1
• BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
• 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 1
• UKAUYVFTDYCKQA-UHFFFAOYSA-N -2-Amino-4-hydroxybutanoic acid Natural products OC(=O)C(N)CCO UKAUYVFTDYCKQA-UHFFFAOYSA-N 0.000 description 1
• WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
• AMMPLVWPWSYRDR-UHFFFAOYSA-N 1-methylbicyclo[2.2.2]oct-2-ene-4-carboxylic acid Chemical compound C1CC2(C(O)=O)CCC1(C)C=C2 AMMPLVWPWSYRDR-UHFFFAOYSA-N 0.000 description 1
• 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 description 1
• SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 description 1
• VGONTNSXDCQUGY-RRKCRQDMSA-N 2'-deoxyinosine Chemical group C1[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CNC2=O)=C2N=C1 VGONTNSXDCQUGY-RRKCRQDMSA-N 0.000 description 1
• 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 description 1
• 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 1
• UPHOPMSGKZNELG-UHFFFAOYSA-N 2-hydroxynaphthalene-1-carboxylic acid Chemical group C1=CC=C2C(C(=O)O)=C(O)C=CC2=C1 UPHOPMSGKZNELG-UHFFFAOYSA-N 0.000 description 1
• GMPMGSCJCDAUMP-UHFFFAOYSA-H 2-hydroxypropane-1,2,3-tricarboxylate;lead(2+);trihydrate Chemical compound O.O.O.[Pb+2].[Pb+2].[Pb+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O GMPMGSCJCDAUMP-UHFFFAOYSA-H 0.000 description 1
• 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 description 1
• XCIDNCPEXLYEOP-UHFFFAOYSA-N 2-oxo-1h-pyrazine-3-carbaldehyde Chemical compound OC1=NC=CN=C1C=O XCIDNCPEXLYEOP-UHFFFAOYSA-N 0.000 description 1
• 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
• 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 1
• 125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 description 1
• 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 description 1
• XLZYKTYMLBOINK-UHFFFAOYSA-N 3-(4-hydroxybenzoyl)benzoic acid Chemical compound OC(=O)C1=CC=CC(C(=O)C=2C=CC(O)=CC=2)=C1 XLZYKTYMLBOINK-UHFFFAOYSA-N 0.000 description 1
• WGLQHUKCXBXUDV-UHFFFAOYSA-L 3-aminophthalate Chemical compound NC1=CC=CC(C([O-])=O)=C1C([O-])=O WGLQHUKCXBXUDV-UHFFFAOYSA-L 0.000 description 1
• 125000000474 3-butynyl group Chemical group [H]C#CC([H])([H])C([H])([H])* 0.000 description 1
• ZRPLANDPDWYOMZ-UHFFFAOYSA-N 3-cyclopentylpropionic acid Chemical compound OC(=O)CCC1CCCC1 ZRPLANDPDWYOMZ-UHFFFAOYSA-N 0.000 description 1
• 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 description 1
• 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 1
• 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 description 1
• 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 description 1
• KDDQRKBRJSGMQE-UHFFFAOYSA-N 4-thiazolyl Chemical group [C]1=CSC=N1 KDDQRKBRJSGMQE-UHFFFAOYSA-N 0.000 description 1
• CWDWFSXUQODZGW-UHFFFAOYSA-N 5-thiazolyl Chemical group [C]1=CN=CS1 CWDWFSXUQODZGW-UHFFFAOYSA-N 0.000 description 1
• 108700028369 Alleles Proteins 0.000 description 1
• 241000203069 Archaea Species 0.000 description 1
• 241000205042 Archaeoglobus fulgidus Species 0.000 description 1
• 108090001008 Avidin Proteins 0.000 description 1
• 239000005711 Benzoic acid Substances 0.000 description 1
• HWSISDHAHRVNMT-UHFFFAOYSA-N Bismuth subnitrate Chemical compound O[NH+]([O-])O[Bi](O[N+]([O-])=O)O[N+]([O-])=O HWSISDHAHRVNMT-UHFFFAOYSA-N 0.000 description 1
• 101100282617 Bovine herpesvirus 1.1 (strain Cooper) gC gene Proteins 0.000 description 1
• NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
• WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
• BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
• 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
• 241000223782 Ciliophora Species 0.000 description 1
• WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
• 241000195493 Cryptophyta Species 0.000 description 1
• RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Chemical group OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
• YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 1
• 229920002307 Dextran Polymers 0.000 description 1
• FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical class CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
• 238000004435 EPR spectroscopy Methods 0.000 description 1
• 238000006783 Fischer indole synthesis reaction Methods 0.000 description 1
• BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
• 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 1
• 241000193385 Geobacillus stearothermophilus Species 0.000 description 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
• 108010024636 Glutathione Proteins 0.000 description 1
• 108010053070 Glutathione Disulfide Proteins 0.000 description 1
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
• 229940121672 Glycosylation inhibitor Drugs 0.000 description 1
• 102000009465 Growth Factor Receptors Human genes 0.000 description 1
• 108010009202 Growth Factor Receptors Proteins 0.000 description 1
• 241000204933 Haloferax volcanii Species 0.000 description 1
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• 235000020853 Inedia Nutrition 0.000 description 1
• ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
• LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
• UKAUYVFTDYCKQA-VKHMYHEASA-N L-homoserine Chemical compound OC(=O)[C@@H](N)CCO UKAUYVFTDYCKQA-VKHMYHEASA-N 0.000 description 1
• QEFRNWWLZKMPFJ-ZXPFJRLXSA-N L-methionine (R)-S-oxide Chemical compound C[S@@](=O)CC[C@H]([NH3+])C([O-])=O QEFRNWWLZKMPFJ-ZXPFJRLXSA-N 0.000 description 1
• QEFRNWWLZKMPFJ-UHFFFAOYSA-N L-methionine sulphoxide Natural products CS(=O)CCC(N)C(O)=O QEFRNWWLZKMPFJ-UHFFFAOYSA-N 0.000 description 1
• ZFOMKMMPBOQKMC-KXUCPTDWSA-N L-pyrrolysine Chemical compound C[C@@H]1CC=N[C@H]1C(=O)NCCCC[C@H]([NH3+])C([O-])=O ZFOMKMMPBOQKMC-KXUCPTDWSA-N 0.000 description 1
• 241000209510 Liliopsida Species 0.000 description 1
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
• 241000203407 Methanocaldococcus jannaschii Species 0.000 description 1
• 241001302042 Methanothermobacter thermautotrophicus Species 0.000 description 1
• 241000243190 Microsporidia Species 0.000 description 1
• 229920000881 Modified starch Polymers 0.000 description 1
• TXXHDPDFNKHHGW-CCAGOZQPSA-N Muconic acid Chemical group OC(=O)\C=C/C=C\C(O)=O TXXHDPDFNKHHGW-CCAGOZQPSA-N 0.000 description 1
• 150000001204 N-oxides Chemical class 0.000 description 1
• 206010028851 Necrosis Diseases 0.000 description 1
• GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
• 229910003849 O-Si Inorganic materials 0.000 description 1
• 108010038807 Oligopeptides Proteins 0.000 description 1
• 102000015636 Oligopeptides Human genes 0.000 description 1
• 108700026244 Open Reading Frames Proteins 0.000 description 1
• 101000989950 Otolemur crassicaudatus Hemoglobin subunit alpha-A Proteins 0.000 description 1
• 229910003872 O—Si Inorganic materials 0.000 description 1
• 229910019142 PO4 Inorganic materials 0.000 description 1
• 208000037062 Polyps Diseases 0.000 description 1
• 239000004372 Polyvinyl alcohol Substances 0.000 description 1
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
• 102000029797 Prion Human genes 0.000 description 1
• 108091000054 Prion Proteins 0.000 description 1
• 241001415846 Procellariidae Species 0.000 description 1
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
• 241000589516 Pseudomonas Species 0.000 description 1
• 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
• 241000589540 Pseudomonas fluorescens Species 0.000 description 1
• 241000589776 Pseudomonas putida Species 0.000 description 1
• 241000205156 Pyrococcus furiosus Species 0.000 description 1
• 241000522615 Pyrococcus horikoshii Species 0.000 description 1
• IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 1
• 238000001530 Raman microscopy Methods 0.000 description 1
• 238000001069 Raman spectroscopy Methods 0.000 description 1
• 108020004511 Recombinant DNA Proteins 0.000 description 1
• 108091028664 Ribonucleotide Proteins 0.000 description 1
• 102000007562 Serum Albumin Human genes 0.000 description 1
• 108010071390 Serum Albumin Proteins 0.000 description 1
• 229910007161 Si(CH3)3 Inorganic materials 0.000 description 1
• XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
• 108010082714 Silver Proteins Proteins 0.000 description 1
• 229920002472 Starch Polymers 0.000 description 1
• 235000021355 Stearic acid Nutrition 0.000 description 1
• 108010090804 Streptavidin Proteins 0.000 description 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
• FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
• RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical class OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 description 1
• 101800001530 Thymosin alpha Proteins 0.000 description 1
• GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
• 206010054094 Tumour necrosis Diseases 0.000 description 1
• 229910052770 Uranium Inorganic materials 0.000 description 1
• COQLPRJCUIATTQ-UHFFFAOYSA-N Uranyl acetate Chemical compound O.O.O=[U]=O.CC(O)=O.CC(O)=O COQLPRJCUIATTQ-UHFFFAOYSA-N 0.000 description 1
• 102000026557 Urotensins Human genes 0.000 description 1
• 108010011107 Urotensins Proteins 0.000 description 1
• HGMCCUMQECCTMA-UHFFFAOYSA-N [Ag].C1(=CC=CC=C1)C1=C2C=CC(C(=C3C=CC(=C(C=4C=CC(=C(C5=CC=C1N5)C5=CC=CC=C5)N4)C4=CC=CC=C4)N3)C3=CC=CC=C3)=N2 Chemical compound [Ag].C1(=CC=CC=C1)C1=C2C=CC(C(=C3C=CC(=C(C=4C=CC(=C(C5=CC=C1N5)C5=CC=CC=C5)N4)C4=CC=CC=C4)N3)C3=CC=CC=C3)=N2 HGMCCUMQECCTMA-UHFFFAOYSA-N 0.000 description 1
• 238000002835 absorbance Methods 0.000 description 1
• 238000010521 absorption reaction Methods 0.000 description 1
• DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
• KQNKJJBFUFKYFX-UHFFFAOYSA-N acetic acid;trihydrate Chemical compound O.O.O.CC(O)=O KQNKJJBFUFKYFX-UHFFFAOYSA-N 0.000 description 1
• 125000002252 acyl group Chemical group 0.000 description 1
• 238000012867 alanine scanning Methods 0.000 description 1
• HAXFWIACAGNFHA-UHFFFAOYSA-N aldrithiol Chemical compound C=1C=CC=NC=1SSC1=CC=CC=N1 HAXFWIACAGNFHA-UHFFFAOYSA-N 0.000 description 1
• 150000001335 aliphatic alkanes Chemical class 0.000 description 1
• 125000004171 alkoxy aryl group Chemical group 0.000 description 1
• 125000003282 alkyl amino group Chemical group 0.000 description 1
• 125000004644 alkyl sulfinyl group Chemical group 0.000 description 1
• 125000004390 alkyl sulfonyl group Chemical group 0.000 description 1
• 125000004414 alkyl thio group Chemical group 0.000 description 1
• 125000005237 alkyleneamino group Chemical group 0.000 description 1
• 125000005238 alkylenediamino group Chemical group 0.000 description 1
• 125000005530 alkylenedioxy group Chemical group 0.000 description 1
• 125000005529 alkyleneoxy group Chemical group 0.000 description 1
• HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 1
• BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
• WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
• 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
• 150000001450 anions Chemical class 0.000 description 1
• 125000002178 anthracenyl group Chemical group C1(=CC=CC2=CC3=CC=CC=C3C=C12)* 0.000 description 1
• 239000003242 anti bacterial agent Substances 0.000 description 1
• 229940088710 antibiotic agent Drugs 0.000 description 1
• 239000002246 antineoplastic agent Substances 0.000 description 1
• 239000003443 antiviral agent Substances 0.000 description 1
• 239000002249 anxiolytic agent Substances 0.000 description 1
• 239000012736 aqueous medium Substances 0.000 description 1
• 239000003125 aqueous solvent Substances 0.000 description 1
• 125000006615 aromatic heterocyclic group Chemical group 0.000 description 1
• 125000005160 aryl oxy alkyl group Chemical group 0.000 description 1
• 150000005840 aryl radicals Chemical class 0.000 description 1
• 125000005165 aryl thioxy group Chemical group 0.000 description 1
• 239000012298 atmosphere Substances 0.000 description 1
• 238000001479 atomic absorption spectroscopy Methods 0.000 description 1
• 238000001593 atomic mass spectrometry Methods 0.000 description 1
• GOOXRYWLNNXLFL-UHFFFAOYSA-H azane oxygen(2-) ruthenium(3+) ruthenium(4+) hexachloride Chemical compound N.N.N.N.N.N.N.N.N.N.N.N.N.N.[O--].[O--].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru+3].[Ru+3].[Ru+4] GOOXRYWLNNXLFL-UHFFFAOYSA-H 0.000 description 1
• 230000001580 bacterial effect Effects 0.000 description 1
• SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 1
• 229940092714 benzenesulfonic acid Drugs 0.000 description 1
• 229940049706 benzodiazepine Drugs 0.000 description 1
• 235000010233 benzoic acid Nutrition 0.000 description 1
• GONOPSZTUGRENK-UHFFFAOYSA-N benzyl(trichloro)silane Chemical compound Cl[Si](Cl)(Cl)CC1=CC=CC=C1 GONOPSZTUGRENK-UHFFFAOYSA-N 0.000 description 1
• 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 description 1
• 239000011230 binding agent Substances 0.000 description 1
• 239000013060 biological fluid Substances 0.000 description 1
• 229960000074 biopharmaceutical Drugs 0.000 description 1
• 239000004305 biphenyl Substances 0.000 description 1
• 235000010290 biphenyl Nutrition 0.000 description 1
• 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 description 1
• 229960001482 bismuth subnitrate Drugs 0.000 description 1
• 239000000872 buffer Substances 0.000 description 1
• KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
• ZTQSAGDEMFDKMZ-UHFFFAOYSA-N butyric aldehyde Natural products CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 description 1
• OKIIEJOIXGHUKX-UHFFFAOYSA-L cadmium iodide Chemical compound [Cd+2].[I-].[I-] OKIIEJOIXGHUKX-UHFFFAOYSA-L 0.000 description 1
• AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
• 239000000920 calcium hydroxide Substances 0.000 description 1
• 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
• 238000004364 calculation method Methods 0.000 description 1
• 125000002837 carbocyclic group Chemical group 0.000 description 1
• 150000001721 carbon Chemical group 0.000 description 1
• 150000004649 carbonic acid derivatives Chemical group 0.000 description 1
• XEVRDFDBXJMZFG-UHFFFAOYSA-N carbonyl dihydrazine Chemical compound NNC(=O)NN XEVRDFDBXJMZFG-UHFFFAOYSA-N 0.000 description 1
• 239000001768 carboxy methyl cellulose Substances 0.000 description 1
• 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
• 125000002843 carboxylic acid group Chemical group 0.000 description 1
• 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
• 239000002327 cardiovascular agent Substances 0.000 description 1
• 229940125692 cardiovascular agent Drugs 0.000 description 1
• 230000015556 catabolic process Effects 0.000 description 1
• 239000003054 catalyst Substances 0.000 description 1
• 150000001768 cations Chemical class 0.000 description 1
• 238000004113 cell culture Methods 0.000 description 1
• 239000006143 cell culture medium Substances 0.000 description 1
• 239000013592 cell lysate Substances 0.000 description 1
• 210000000170 cell membrane Anatomy 0.000 description 1
• 238000012512 characterization method Methods 0.000 description 1
• 238000009614 chemical analysis method Methods 0.000 description 1
• 238000002144 chemical decomposition reaction Methods 0.000 description 1
• 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
• 229930002875 chlorophyll Natural products 0.000 description 1
• 235000019804 chlorophyll Nutrition 0.000 description 1
• ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
• 238000004587 chromatography analysis Methods 0.000 description 1
• 235000013985 cinnamic acid Nutrition 0.000 description 1
• 229930016911 cinnamic acid Natural products 0.000 description 1
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
• 229960004316 cisplatin Drugs 0.000 description 1
• 235000015165 citric acid Nutrition 0.000 description 1
• 239000005515 coenzyme Substances 0.000 description 1
• 238000004040 coloring Methods 0.000 description 1
• 238000009833 condensation Methods 0.000 description 1
• 230000005494 condensation Effects 0.000 description 1
• 238000006482 condensation reaction Methods 0.000 description 1
• 230000021615 conjugation Effects 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 150000004696 coordination complex Chemical class 0.000 description 1
• 108010082242 corticosterone receptor Proteins 0.000 description 1
• 239000002537 cosmetic Substances 0.000 description 1
• 238000012258 culturing Methods 0.000 description 1
• 125000000392 cycloalkenyl group Chemical group 0.000 description 1
• 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 description 1
• 229960003067 cystine Drugs 0.000 description 1
• 230000006378 damage Effects 0.000 description 1
• 230000034994 death Effects 0.000 description 1
• 230000007423 decrease Effects 0.000 description 1
• 239000005549 deoxyribonucleoside Substances 0.000 description 1
• 239000005547 deoxyribonucleotide Substances 0.000 description 1
• 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
• 238000001514 detection method Methods 0.000 description 1
• 230000001627 detrimental effect Effects 0.000 description 1
• 229910052805 deuterium Inorganic materials 0.000 description 1
• 238000011161 development Methods 0.000 description 1
• 230000018109 developmental process Effects 0.000 description 1
• 229960002086 dextran Drugs 0.000 description 1
• 229960000633 dextran sulfate Drugs 0.000 description 1
• ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
• 238000000113 differential scanning calorimetry Methods 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• 230000006806 disease prevention Effects 0.000 description 1
• 238000009826 distribution Methods 0.000 description 1
• VHJLVAABSRFDPM-ZXZARUISSA-N dithioerythritol Chemical compound SC[C@H](O)[C@H](O)CS VHJLVAABSRFDPM-ZXZARUISSA-N 0.000 description 1
• MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical group CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
• 239000003118 drug derivative Substances 0.000 description 1
• 238000009510 drug design Methods 0.000 description 1
• 238000010894 electron beam technology Methods 0.000 description 1
• 238000000804 electron spin resonance spectroscopy Methods 0.000 description 1
• 238000002389 environmental scanning electron microscopy Methods 0.000 description 1
• 238000006911 enzymatic reaction Methods 0.000 description 1
• AFAXGSQYZLGZPG-UHFFFAOYSA-N ethanedisulfonic acid Chemical compound OS(=O)(=O)CCS(O)(=O)=O AFAXGSQYZLGZPG-UHFFFAOYSA-N 0.000 description 1
• CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 1
• DQJJMWZRDSGUJP-UHFFFAOYSA-N ethenoxyethene;furan-2,5-dione Chemical compound C=COC=C.O=C1OC(=O)C=C1 DQJJMWZRDSGUJP-UHFFFAOYSA-N 0.000 description 1
• 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
• 241001233957 eudicotyledons Species 0.000 description 1
• 238000001704 evaporation Methods 0.000 description 1
• 230000008020 evaporation Effects 0.000 description 1
• 230000005284 excitation Effects 0.000 description 1
• 230000001747 exhibiting effect Effects 0.000 description 1
• 238000002474 experimental method Methods 0.000 description 1
• 229940044631 ferric chloride hexahydrate Drugs 0.000 description 1
• KTWOOEGAPBSYNW-UHFFFAOYSA-N ferrocene Chemical compound [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 description 1
• 125000001153 fluoro group Chemical group F* 0.000 description 1
• 125000003709 fluoroalkyl group Chemical group 0.000 description 1
• 238000009472 formulation Methods 0.000 description 1
• 238000001640 fractional crystallisation Methods 0.000 description 1
• 239000012458 free base Substances 0.000 description 1
• 238000004108 freeze drying Methods 0.000 description 1
• 239000000417 fungicide Substances 0.000 description 1
• 230000004927 fusion Effects 0.000 description 1
• 239000007789 gas Substances 0.000 description 1
• 238000007429 general method Methods 0.000 description 1
• 230000002068 genetic effect Effects 0.000 description 1
• 230000009477 glass transition Effects 0.000 description 1
• 239000000174 gluconic acid Chemical group 0.000 description 1
• 235000012208 gluconic acid Nutrition 0.000 description 1
• 239000008103 glucose Substances 0.000 description 1
• RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 1
• YPZRWBKMTBYPTK-BJDJZHNGSA-N glutathione disulfide Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@H](C(=O)NCC(O)=O)CSSC[C@@H](C(=O)NCC(O)=O)NC(=O)CC[C@H](N)C(O)=O YPZRWBKMTBYPTK-BJDJZHNGSA-N 0.000 description 1
• 150000002334 glycols Chemical class 0.000 description 1
• PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
• 229910052737 gold Inorganic materials 0.000 description 1
• 239000010931 gold Substances 0.000 description 1
• 230000012010 growth Effects 0.000 description 1
• 239000000122 growth hormone Substances 0.000 description 1
• 229940093915 gynecological organic acid Drugs 0.000 description 1
• 150000003278 haem Chemical class 0.000 description 1
• 125000005252 haloacyl group Chemical group 0.000 description 1
• 125000005843 halogen group Chemical group 0.000 description 1
• 238000003306 harvesting Methods 0.000 description 1
• 230000036541 health Effects 0.000 description 1
• 239000001307 helium Substances 0.000 description 1
• 229910052734 helium Inorganic materials 0.000 description 1
• SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
• 229920000669 heparin Polymers 0.000 description 1
• 229960002897 heparin Drugs 0.000 description 1
• 239000002634 heparin fragment Substances 0.000 description 1
• 210000003494 hepatocyte Anatomy 0.000 description 1
• 125000004366 heterocycloalkenyl group Chemical group 0.000 description 1
• 239000004312 hexamethylene tetramine Substances 0.000 description 1
• 235000010299 hexamethylene tetramine Nutrition 0.000 description 1
• 238000004128 high performance liquid chromatography Methods 0.000 description 1
• 239000000710 homodimer Substances 0.000 description 1
• 229940088597 hormone Drugs 0.000 description 1
• 239000005556 hormone Substances 0.000 description 1
• 150000004677 hydrates Chemical class 0.000 description 1
• 238000006460 hydrolysis reaction Methods 0.000 description 1
• 230000003301 hydrolyzing effect Effects 0.000 description 1
• 239000012216 imaging agent Substances 0.000 description 1
• 125000001841 imino group Chemical group [H]N=* 0.000 description 1
• 238000003018 immunoassay Methods 0.000 description 1
• 230000001976 improved effect Effects 0.000 description 1
• 238000011534 incubation Methods 0.000 description 1
• 125000001041 indolyl group Chemical group 0.000 description 1
• 238000009616 inductively coupled plasma Methods 0.000 description 1
• 238000002329 infrared spectrum Methods 0.000 description 1
• 239000003112 inhibitor Substances 0.000 description 1
• 239000003999 initiator Substances 0.000 description 1
• 229910001410 inorganic ion Inorganic materials 0.000 description 1
• 230000002452 interceptive effect Effects 0.000 description 1
• 239000000543 intermediate Substances 0.000 description 1
• PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
• NQXWGWZJXJUMQB-UHFFFAOYSA-K iron trichloride hexahydrate Chemical compound O.O.O.O.O.O.[Cl-].Cl[Fe+]Cl NQXWGWZJXJUMQB-UHFFFAOYSA-K 0.000 description 1
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
• 238000002955 isolation Methods 0.000 description 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
• 239000004310 lactic acid Substances 0.000 description 1
• 235000014655 lactic acid Nutrition 0.000 description 1
• FYDKNKUEBJQCCN-UHFFFAOYSA-N lanthanum(3+);trinitrate Chemical compound [La+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O FYDKNKUEBJQCCN-UHFFFAOYSA-N 0.000 description 1
• 239000011133 lead Substances 0.000 description 1
• 229940046892 lead acetate Drugs 0.000 description 1
• RLJMLMKIBZAXJO-UHFFFAOYSA-N lead nitrate Chemical compound [O-][N+](=O)O[Pb]O[N+]([O-])=O RLJMLMKIBZAXJO-UHFFFAOYSA-N 0.000 description 1
• 108700041430 link Proteins 0.000 description 1
• 150000002632 lipids Chemical class 0.000 description 1
• 239000002502 liposome Substances 0.000 description 1
• 239000007788 liquid Substances 0.000 description 1
• 230000004807 localization Effects 0.000 description 1
• HWYHZTIRURJOHG-UHFFFAOYSA-N luminol Chemical compound O=C1NNC(=O)C2=C1C(N)=CC=C2 HWYHZTIRURJOHG-UHFFFAOYSA-N 0.000 description 1
• 239000006166 lysate Substances 0.000 description 1
• 239000011777 magnesium Substances 0.000 description 1
• 229910052749 magnesium Inorganic materials 0.000 description 1
• 239000001630 malic acid Substances 0.000 description 1
• 235000011090 malic acid Nutrition 0.000 description 1
• 229960002510 mandelic acid Drugs 0.000 description 1
• 238000004949 mass spectrometry Methods 0.000 description 1
• 239000011159 matrix material Substances 0.000 description 1
• 230000007246 mechanism Effects 0.000 description 1
• 230000010534 mechanism of action Effects 0.000 description 1
• 230000003340 mental effect Effects 0.000 description 1
• 229960003151 mercaptamine Drugs 0.000 description 1
• 230000037353 metabolic pathway Effects 0.000 description 1
• 230000004060 metabolic process Effects 0.000 description 1
• 239000002082 metal nanoparticle Substances 0.000 description 1
• 229940098779 methanesulfonic acid Drugs 0.000 description 1
• 229960004011 methenamine Drugs 0.000 description 1
• HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 description 1
• 229920000609 methyl cellulose Polymers 0.000 description 1
• WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
• 239000001923 methylcellulose Substances 0.000 description 1
• 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
• LSDPWZHWYPCBBB-UHFFFAOYSA-O methylsulfide anion Chemical compound [SH2+]C LSDPWZHWYPCBBB-UHFFFAOYSA-O 0.000 description 1
• 239000011859 microparticle Substances 0.000 description 1
• 230000003278 mimic effect Effects 0.000 description 1
• 230000000116 mitigating effect Effects 0.000 description 1
• 238000006011 modification reaction Methods 0.000 description 1
• 235000019426 modified starch Nutrition 0.000 description 1
• 239000003607 modifier Substances 0.000 description 1
• 238000001565 modulated differential scanning calorimetry Methods 0.000 description 1
• MEFBJEMVZONFCJ-UHFFFAOYSA-N molybdate Chemical compound [O-][Mo]([O-])(=O)=O MEFBJEMVZONFCJ-UHFFFAOYSA-N 0.000 description 1
• 150000002772 monosaccharides Chemical class 0.000 description 1
• 125000004572 morpholin-3-yl group Chemical group N1C(COCC1)* 0.000 description 1
• 238000002703 mutagenesis Methods 0.000 description 1
• 231100000350 mutagenesis Toxicity 0.000 description 1
• 230000035772 mutation Effects 0.000 description 1
• OKPYIWASQZGASP-UHFFFAOYSA-N n-(2-hydroxypropyl)-2-methylprop-2-enamide Chemical compound CC(O)CNC(=O)C(C)=C OKPYIWASQZGASP-UHFFFAOYSA-N 0.000 description 1
• 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• 125000003136 n-heptyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
• 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• KVBGVZZKJNLNJU-UHFFFAOYSA-N naphthalene-2-sulfonic acid Chemical compound C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-N 0.000 description 1
• 230000017074 necrotic cell death Effects 0.000 description 1
• 229910017604 nitric acid Inorganic materials 0.000 description 1
• 125000004971 nitroalkyl group Chemical class 0.000 description 1
• FYWSTUCDSVYLPV-UHFFFAOYSA-N nitrooxythallium Chemical compound [Tl+].[O-][N+]([O-])=O FYWSTUCDSVYLPV-UHFFFAOYSA-N 0.000 description 1
• 231100000957 no side effect Toxicity 0.000 description 1
• 125000003835 nucleoside group Chemical group 0.000 description 1
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical group CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
• OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Chemical group CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
• 230000003287 optical effect Effects 0.000 description 1
• 210000000056 organ Anatomy 0.000 description 1
• 235000005985 organic acids Nutrition 0.000 description 1
• YPZRWBKMTBYPTK-UHFFFAOYSA-N oxidized gamma-L-glutamyl-L-cysteinylglycine Natural products OC(=O)C(N)CCC(=O)NC(C(=O)NCC(O)=O)CSSCC(C(=O)NCC(O)=O)NC(=O)CCC(N)C(O)=O YPZRWBKMTBYPTK-UHFFFAOYSA-N 0.000 description 1
• 238000012856 packing Methods 0.000 description 1
• FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Chemical group OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
• 230000005298 paramagnetic effect Effects 0.000 description 1
• 230000037361 pathway Effects 0.000 description 1
• 108010087558 pectate lyase Proteins 0.000 description 1
• 238000010647 peptide synthesis reaction Methods 0.000 description 1
• KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 1
• 239000010452 phosphate Substances 0.000 description 1
• 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
• PTMHPRAIXMAOOB-UHFFFAOYSA-N phosphoramidic acid Chemical class NP(O)(O)=O PTMHPRAIXMAOOB-UHFFFAOYSA-N 0.000 description 1
• SXADIBFZNXBEGI-UHFFFAOYSA-N phosphoramidous acid Chemical group NP(O)O SXADIBFZNXBEGI-UHFFFAOYSA-N 0.000 description 1
• DHRLEVQXOMLTIM-UHFFFAOYSA-N phosphoric acid;trioxomolybdenum Chemical compound O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.OP(O)(O)=O DHRLEVQXOMLTIM-UHFFFAOYSA-N 0.000 description 1
• IYDGMDWEHDFVQI-UHFFFAOYSA-N phosphoric acid;trioxotungsten Chemical compound O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.OP(O)(O)=O IYDGMDWEHDFVQI-UHFFFAOYSA-N 0.000 description 1
• 230000000704 physical effect Effects 0.000 description 1
• 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
• 125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 description 1
• IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 description 1
• 239000013612 plasmid Substances 0.000 description 1
• 229910052697 platinum Inorganic materials 0.000 description 1
• 238000001907 polarising light microscopy Methods 0.000 description 1
• 229920001308 poly(aminoacid) Polymers 0.000 description 1
• 229920001583 poly(oxyethylated polyols) Polymers 0.000 description 1
• 229920001748 polybutylene Polymers 0.000 description 1
• 125000003367 polycyclic group Chemical group 0.000 description 1
• 229920002704 polyhistidine Polymers 0.000 description 1
• 229920002451 polyvinyl alcohol Polymers 0.000 description 1
• 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
• 239000011591 potassium Substances 0.000 description 1
• 229910052700 potassium Inorganic materials 0.000 description 1
• 239000000276 potassium ferrocyanide Substances 0.000 description 1
• WSHYKIAQCMIPTB-UHFFFAOYSA-M potassium;2-oxo-3-(3-oxo-1-phenylbutyl)chromen-4-olate Chemical compound [K+].[O-]C=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 WSHYKIAQCMIPTB-UHFFFAOYSA-M 0.000 description 1
• 230000036515 potency Effects 0.000 description 1
• 239000000843 powder Substances 0.000 description 1
• 238000001556 precipitation Methods 0.000 description 1
• 239000002243 precursor Substances 0.000 description 1
• 230000002265 prevention Effects 0.000 description 1
• 230000035755 proliferation Effects 0.000 description 1
• 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 description 1
• 125000003373 pyrazinyl group Chemical group 0.000 description 1
• 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 description 1
• 229940107700 pyruvic acid Drugs 0.000 description 1
• 238000012205 qualitative assay Methods 0.000 description 1
• 150000004053 quinones Chemical class 0.000 description 1
• 239000011541 reaction mixture Substances 0.000 description 1
• 238000001953 recrystallisation Methods 0.000 description 1
• 230000009467 reduction Effects 0.000 description 1
• 238000011160 research Methods 0.000 description 1
• 238000004007 reversed phase HPLC Methods 0.000 description 1
• 239000002342 ribonucleoside Substances 0.000 description 1
• 239000002336 ribonucleotide Substances 0.000 description 1
• 125000002652 ribonucleotide group Chemical group 0.000 description 1
• 238000007363 ring formation reaction Methods 0.000 description 1
• 229960004889 salicylic acid Drugs 0.000 description 1
• 229930195734 saturated hydrocarbon Natural products 0.000 description 1
• 238000004626 scanning electron microscopy Methods 0.000 description 1
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
• 230000035945 sensitivity Effects 0.000 description 1
• 239000010703 silicon Substances 0.000 description 1
• 229910001961 silver nitrate Inorganic materials 0.000 description 1
• 229940126586 small molecule drug Drugs 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 229910000029 sodium carbonate Inorganic materials 0.000 description 1
• XMVONEAAOPAGAO-UHFFFAOYSA-N sodium tungstate Chemical compound [Na+].[Na+].[O-][W]([O-])(=O)=O XMVONEAAOPAGAO-UHFFFAOYSA-N 0.000 description 1
• 239000007790 solid phase Substances 0.000 description 1
• 238000012306 spectroscopic technique Methods 0.000 description 1
• 238000004611 spectroscopical analysis Methods 0.000 description 1
• 235000019698 starch Nutrition 0.000 description 1
• 239000008107 starch Substances 0.000 description 1
• 239000007858 starting material Substances 0.000 description 1
• 238000007619 statistical method Methods 0.000 description 1
• 239000008117 stearic acid Chemical group 0.000 description 1
• 230000003637 steroidlike Effects 0.000 description 1
• 238000003860 storage Methods 0.000 description 1
• 150000008163 sugars Chemical class 0.000 description 1
• 230000002483 superagonistic effect Effects 0.000 description 1
• 239000013589 supplement Substances 0.000 description 1
• 230000008685 targeting Effects 0.000 description 1
• 239000011975 tartaric acid Substances 0.000 description 1
• 235000002906 tartaric acid Nutrition 0.000 description 1
• IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 description 1
• XOGGUFAVLNCTRS-UHFFFAOYSA-N tetrapotassium;iron(2+);hexacyanide Chemical compound [K+].[K+].[K+].[K+].[Fe+2].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] XOGGUFAVLNCTRS-UHFFFAOYSA-N 0.000 description 1
• 229940126585 therapeutic drug Drugs 0.000 description 1
• 150000007970 thio esters Chemical class 0.000 description 1
• 125000003396 thiol group Chemical group [H]S* 0.000 description 1
• 150000003573 thiols Chemical class 0.000 description 1
• 238000003354 tissue distribution assay Methods 0.000 description 1
• 238000013518 transcription Methods 0.000 description 1
• 230000035897 transcription Effects 0.000 description 1
• 238000010361 transduction Methods 0.000 description 1
• 230000026683 transduction Effects 0.000 description 1
• 230000007704 transition Effects 0.000 description 1
• 230000032258 transport Effects 0.000 description 1
• 239000013638 trimer Substances 0.000 description 1
• WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
• 229910052721 tungsten Inorganic materials 0.000 description 1
• 239000010937 tungsten Substances 0.000 description 1
• 241001515965 unidentified phage Species 0.000 description 1
• DNYWZCXLKNTFFI-UHFFFAOYSA-N uranium Chemical compound [U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U] DNYWZCXLKNTFFI-UHFFFAOYSA-N 0.000 description 1
• 229910002007 uranyl nitrate Inorganic materials 0.000 description 1
• 239000000780 urotensin Substances 0.000 description 1
• UUUGYDOQQLOJQA-UHFFFAOYSA-L vanadyl sulfate Chemical compound [V+2]=O.[O-]S([O-])(=O)=O UUUGYDOQQLOJQA-UHFFFAOYSA-L 0.000 description 1
• 229940041260 vanadyl sulfate Drugs 0.000 description 1
• 229910000352 vanadyl sulfate Inorganic materials 0.000 description 1
• 239000013598 vector Substances 0.000 description 1
• 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
• 230000004580 weight loss Effects 0.000 description 1
• 230000036642 wellbeing Effects 0.000 description 1
• 125000002256 xylenyl group Chemical group C1(C(C=CC=C1)C)(C)* 0.000 description 1