AU2001260661A1 - Compounds exhibiting thrombopoietin-like activities - Google Patents

Compounds exhibiting thrombopoietin-like activities

Info

Publication number
AU2001260661A1
AU2001260661A1 AU2001260661A AU6066101A AU2001260661A1 AU 2001260661 A1 AU2001260661 A1 AU 2001260661A1 AU 2001260661 A AU2001260661 A AU 2001260661A AU 6066101 A AU6066101 A AU 6066101A AU 2001260661 A1 AU2001260661 A1 AU 2001260661A1
Authority
AU
Australia
Prior art keywords
activities
compounds exhibiting
exhibiting thrombopoietin
thrombopoietin
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001260661A
Inventor
Toru Esaki
Shinya Fujiwara
Kunihiro Hattori
Toshiro Kozono
Tomokazu Ozaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of AU2001260661A1 publication Critical patent/AU2001260661A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2001260661A 2000-05-30 2001-05-30 Compounds exhibiting thrombopoietin-like activities Abandoned AU2001260661A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000161036 2000-05-30
JP2000-161036 2000-05-30
PCT/JP2001/004561 WO2001092211A1 (en) 2000-05-30 2001-05-30 Compounds exhibiting thrombopoietin-like activities

Publications (1)

Publication Number Publication Date
AU2001260661A1 true AU2001260661A1 (en) 2001-12-11

Family

ID=18665138

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001260661A Abandoned AU2001260661A1 (en) 2000-05-30 2001-05-30 Compounds exhibiting thrombopoietin-like activities

Country Status (6)

Country Link
US (1) US6887890B2 (en)
EP (1) EP1291341A4 (en)
JP (1) JP3966816B2 (en)
AU (1) AU2001260661A1 (en)
TW (1) TWI282785B (en)
WO (1) WO2001092211A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070105824A1 (en) 2003-04-29 2007-05-10 Erickson-Miller Connie L Methods for treating degenerative diseases/injuries
EP1942906A2 (en) * 2005-10-13 2008-07-16 SmithKline Beecham Corporation Methods for the preservation of platelet efficacy during storage
CA2630234A1 (en) * 2005-11-23 2007-05-31 Ligand Pharmaceuticals Inc. Thrombopoietin activity modulating compounds and methods
US7879318B2 (en) * 2006-01-23 2011-02-01 Mcw Research Foundation, Inc. Method of reducing the effects of ischemia by administration of a thrombopoietin receptor ligand
CN101578264A (en) * 2006-12-18 2009-11-11 Ambrx公司 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
US20110160130A1 (en) * 2007-02-16 2011-06-30 Connie Erickson-Miller Cancer treatment method
US20110129550A1 (en) 2007-02-16 2011-06-02 Connie Erickson-Miller Cancer treatment method
UY30915A1 (en) 2007-02-16 2008-09-02 Smithkline Beecham Corp CANCER TREATMENT METHOD
CA2709224C (en) * 2007-10-09 2015-06-23 The Trustees Of The University Of Pennsylvania Thrombopoietin receptor agonist (tpora) kills acute human myeloid leukemia cells
US8476249B2 (en) 2009-05-07 2013-07-02 Glaxosmithkline Llc Method of treating thrombocytopenia
JP5819305B2 (en) * 2009-10-13 2015-11-24 リガンド・ファーマシューティカルズ・インコーポレイテッド Hematopoietic growth factor mimicking small molecule compounds and their use
AU2016324158B2 (en) * 2015-09-17 2020-08-27 City Of Hope PCNA inhibitors

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3415103A1 (en) * 1984-04-21 1985-10-31 Bayer Ag, 5090 Leverkusen METHOD FOR FLUORESCENT EXTINGUISHING AND NEW CATIONIC AROMATIC NITRO COMPOUNDS
JPH01261650A (en) * 1988-04-13 1989-10-18 Canon Inc Electrophotographic sensitive body
PL188795B1 (en) * 1995-06-07 2005-04-29 Glaxo Group Ltd Peptides and compounds capable to bond to a receptor of thrombopoetin
JPH10212289A (en) 1997-01-31 1998-08-11 Kyowa Hakko Kogyo Co Ltd Pyrrolophenanthridine derivative
JPH111477A (en) 1997-06-12 1999-01-06 Hokuriku Seiyaku Co Ltd 1,4-benzodiazepine and use thereof
JPH11152276A (en) 1997-11-20 1999-06-08 Hokuriku Seiyaku Co Ltd Benzodiazepine derivative
JP2002529502A (en) 1998-11-17 2002-09-10 スミスクライン・ビーチャム・コーポレイション Treatment of thrombocytopenia
GC0000177A (en) * 1998-12-17 2006-03-29 Smithkline Beecham Thrombopoietin mimetics
JP2002543126A (en) 1999-05-03 2002-12-17 スミスクライン・ビーチャム・コーポレイション CXCR-4 receptor antagonist-thrombopoietin mimic
CN1376150A (en) 1999-07-26 2002-10-23 盐野义制药株式会社 Drug compositions exhibiting thrombo poietin agonism
DE60025632T2 (en) 1999-09-10 2006-08-10 Smithkline Beecham Corp. Thrombopoietin mimetics
AU771460B2 (en) 1999-09-24 2004-03-25 Smithkline Beecham Corporation Thrombopoietin mimetics
JP2003513965A (en) 1999-11-05 2003-04-15 スミスクライン・ビーチャム・コーポレイション Semicarbazone derivatives and their use as thrombopoietin mimetics

Also Published As

Publication number Publication date
EP1291341A4 (en) 2005-04-27
JP3966816B2 (en) 2007-08-29
US20030162724A1 (en) 2003-08-28
WO2001092211A1 (en) 2001-12-06
EP1291341A1 (en) 2003-03-12
TWI282785B (en) 2007-06-21
US6887890B2 (en) 2005-05-03

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