BRPI0318680B8 - composição de ácido hialurônico (ha), método para preparar a composição e para estabilizar ácido hialurônico (ha) reticulado - Google Patents

composição de ácido hialurônico (ha), método para preparar a composição e para estabilizar ácido hialurônico (ha) reticulado

Info

Publication number
BRPI0318680B8
BRPI0318680B8 BRPI0318680A BR0318680A BRPI0318680B8 BR PI0318680 B8 BRPI0318680 B8 BR PI0318680B8 BR PI0318680 A BRPI0318680 A BR PI0318680A BR 0318680 A BR0318680 A BR 0318680A BR PI0318680 B8 BRPI0318680 B8 BR PI0318680B8
Authority
BR
Brazil
Prior art keywords
composition
cross
linked
patient
hyaluronic acid
Prior art date
Application number
BRPI0318680A
Other languages
English (en)
Other versions
BRPI0318680B1 (pt
BR0318680A (pt
Inventor
h sherwood Charles
K Sadozai Khalid
Bui Kyle
B Gooding Tamara
Original Assignee
Anika Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anika Therapeutics Inc filed Critical Anika Therapeutics Inc
Publication of BR0318680A publication Critical patent/BR0318680A/pt
Publication of BRPI0318680B1 publication Critical patent/BRPI0318680B1/pt
Publication of BRPI0318680B8 publication Critical patent/BRPI0318680B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Abstract

"composição de ácido hialurônico (ha), método para aumentar tecido em um paciente, para preparar a composição e para estabilizar ácido hialurônico (ha) reticulado". uma composição de ácido hialurônico (ha) inclui partículas de gel de ha hidratadas, insolúveis na água, reticuladas. o ha inclui reticulações representadas pela seguinte fórmula estrutural: ha<39>-u-r~ 2~-uha<39>. as variáveis são definidas neste contexto. um método para aumentar tecido em um paciente inclui inserir uma agulha em um paciente em um local no paciente que está com necessidade de aumento de tecido, em que a agulha está acoplada a uma seringa carregada com composição de ha, e aplicar força à seringa, para distribuir a composição de ha ao paciente. um método para preparar a composição de ha inclui formar partículas de ha reticuladas desidratadas, insolúveis na água, separar as partículas desidratadas, insolúveis na água, por diâmetro médio, selecionar um subconjunto de partículas por diâmetro médio, e hidratar o subconjunto de partículas desidratadas com uma solução aquosa fisiologicamente compatível. um outro método para se preparar a composição de ha reticulada inclui a reticulação de um precursor do ha reticulado com um biscarbodimida na presença de um amortecedor de ph e desidratar o ha reticulado. inclui-se igualmente um método para aumentar tecido em um paciente que tem necessidade de aumento de tecido. um método para estabilizar ha reticulado inclui hidratar ha reticulado desidratado, insolúvel na água, com uma solução aquosa fisiologicamente compatível que inclui um anestésico local, em que o valor de módulo de armazenamento g<39> para a composição estabilizada é pelo menos cerca de 110% do valor de g<39> para uma composição não estabilizada. inclui-se igualmente uma composição de ha estabilizada.
BRPI0318680A 2003-12-22 2003-12-23 composição de ácido hialurônico (ha), método para preparar a composição e para estabilizar ácido hialurônico (ha) reticulado BRPI0318680B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/743,557 US8124120B2 (en) 2003-12-22 2003-12-22 Crosslinked hyaluronic acid compositions for tissue augmentation
PCT/US2003/041354 WO2005067994A1 (en) 2003-12-22 2003-12-23 Crosslinked hyaluronic acid compositions for tissue augmentation

Publications (3)

Publication Number Publication Date
BR0318680A BR0318680A (pt) 2006-12-12
BRPI0318680B1 BRPI0318680B1 (pt) 2017-06-06
BRPI0318680B8 true BRPI0318680B8 (pt) 2021-05-25

Family

ID=34678675

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0318680A BRPI0318680B8 (pt) 2003-12-22 2003-12-23 composição de ácido hialurônico (ha), método para preparar a composição e para estabilizar ácido hialurônico (ha) reticulado

Country Status (13)

Country Link
US (1) US8124120B2 (pt)
EP (2) EP2656833B1 (pt)
JP (1) JP4594866B2 (pt)
KR (1) KR20060127897A (pt)
CN (1) CN100441241C (pt)
AU (2) AU2003300392C1 (pt)
BR (1) BRPI0318680B8 (pt)
CA (1) CA2551121C (pt)
DK (2) DK2656833T3 (pt)
MX (1) MXPA06007250A (pt)
RU (1) RU2351367C9 (pt)
WO (1) WO2005067994A1 (pt)
ZA (1) ZA200605025B (pt)

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US20050136122A1 (en) 2005-06-23
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RU2006126693A (ru) 2008-01-27
DK2656833T3 (en) 2018-05-07
JP4594866B2 (ja) 2010-12-08
CN100441241C (zh) 2008-12-10
US8124120B2 (en) 2012-02-28
EP2656833A1 (en) 2013-10-30
BRPI0318680B1 (pt) 2017-06-06
AU2003300392B2 (en) 2009-03-26
CA2551121A1 (en) 2005-07-28
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EP1699500A1 (en) 2006-09-13
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AU2003300392A1 (en) 2005-08-03
BR0318680A (pt) 2006-12-12
RU2351367C2 (ru) 2009-04-10
CN1893989A (zh) 2007-01-10
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