BRPI0209249B8 - agonista de receptor de pgi2, inibidor de agregacao de plaqueta, agentes terapeuticos e derivados de composto heterociclico - Google Patents
agonista de receptor de pgi2, inibidor de agregacao de plaqueta, agentes terapeuticos e derivados de composto heterociclicoInfo
- Publication number
- BRPI0209249B8 BRPI0209249B8 BRPI0209249A BR0209249A BRPI0209249B8 BR PI0209249 B8 BRPI0209249 B8 BR PI0209249B8 BR PI0209249 A BRPI0209249 A BR PI0209249A BR 0209249 A BR0209249 A BR 0209249A BR PI0209249 B8 BRPI0209249 B8 BR PI0209249B8
- Authority
- BR
- Brazil
- Prior art keywords
- receptor agonist
- heterocyclic compound
- therapeutic agents
- platelet aggregation
- compound derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/18—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001129765 | 2001-04-26 | ||
PCT/JP2002/004118 WO2002088084A1 (fr) | 2001-04-26 | 2002-04-25 | Derives de composes heterocycliques et medicaments |
Publications (3)
Publication Number | Publication Date |
---|---|
BR0209249A BR0209249A (pt) | 2004-06-08 |
BRPI0209249B1 BRPI0209249B1 (pt) | 2016-04-26 |
BRPI0209249B8 true BRPI0209249B8 (pt) | 2021-05-25 |
Family
ID=18978246
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0209249A BRPI0209249B8 (pt) | 2001-04-26 | 2002-04-25 | agonista de receptor de pgi2, inibidor de agregacao de plaqueta, agentes terapeuticos e derivados de composto heterociclico |
Country Status (19)
Country | Link |
---|---|
US (1) | US7205302B2 (pt) |
EP (1) | EP1400518B1 (pt) |
JP (1) | JP4479152B2 (pt) |
KR (1) | KR100921760B1 (pt) |
CN (1) | CN1301973C (pt) |
BE (1) | BE2016C051I2 (pt) |
BR (1) | BRPI0209249B8 (pt) |
CA (1) | CA2445344C (pt) |
DE (1) | DE60217674T2 (pt) |
DK (1) | DK1400518T3 (pt) |
ES (1) | ES2276931T3 (pt) |
FR (1) | FR16C0042I2 (pt) |
LU (1) | LU93266I2 (pt) |
MX (1) | MXPA03009800A (pt) |
NL (1) | NL300836I2 (pt) |
PT (1) | PT1400518E (pt) |
RU (1) | RU2283835C3 (pt) |
TW (1) | TWI316055B (pt) |
WO (1) | WO2002088084A1 (pt) |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7326706B2 (en) | 2003-08-15 | 2008-02-05 | Bristol-Myers Squibb Company | Pyrazine modulators of cannabinoid receptors |
US7517900B2 (en) | 2003-10-10 | 2009-04-14 | Bristol-Myers Squibb Company | Pyrazole derivatives as cannabinoid receptor modulators |
FR2869224B1 (fr) * | 2004-04-22 | 2006-06-09 | Oreal | Compose 2-oxy-acetamide, ses utilisations et compositions pour stimuler ou induire la pousse des fibres keratiniques et/ou freiner leur chute |
EP1763382A1 (fr) * | 2004-04-22 | 2007-03-21 | L'oreal | Compose 2-oxy-acetamide ses utilisations et compositions pour stimuler ou induire la pousse des fibres keratiniques et/ou freiner leur chute |
AU2006236387A1 (en) * | 2005-04-18 | 2006-10-26 | Neurogen Corporation | Subtituted heteroaryl CB1 antagonists |
CN104761509A (zh) * | 2008-02-28 | 2015-07-08 | 日本新药株式会社 | 纤维化抑制剂 |
ES2875944T3 (es) * | 2008-03-18 | 2021-11-11 | Arena Pharm Inc | Moduladores del receptor de prostaciclina (PG12) útiles para el tratamiento de trastornos relacionados con el mismo |
WO2009154246A1 (ja) * | 2008-06-19 | 2009-12-23 | 日本新薬株式会社 | 勃起不全治療剤 |
WO2009157397A1 (ja) * | 2008-06-23 | 2009-12-30 | 日本新薬株式会社 | 非ステロイド性抗炎症剤投与に伴う腸管傷害治療剤 |
CN105168218A (zh) * | 2008-06-23 | 2015-12-23 | 日本新药株式会社 | 椎管狭窄症治疗剂 |
SI2289518T1 (sl) | 2008-06-23 | 2017-02-28 | Nippon Shinyaku Co., Ltd. | Terapevtsko sredstvo za vnetno črevesno bolezen |
MY163762A (en) | 2008-07-23 | 2017-10-31 | Toray Industries | Therapeutic agent for chronic renal failure |
PL2315587T3 (pl) * | 2008-08-13 | 2018-03-30 | Actelion Pharmaceuticals Ltd. | Kompozycje terapeutyczne zawierające macitentan |
AR077242A1 (es) | 2009-06-26 | 2011-08-10 | Actelion Pharmaceuticals Ltd | Formas cristalinas del 2-{4-[n-(5,6-difenilpirazin-2-il)-n-isopropilamino]butiloxi}n-(metilsulfonil)acetamida, composiciones farmaceuticas que las contienen, metodo para prepararlas y uso de las mismas en el tratamiento de isquemias, insuficiencia coronaria y asma, entre otras enfermedades. |
WO2011024874A1 (ja) * | 2009-08-26 | 2011-03-03 | 日本新薬株式会社 | 塩基付加塩 |
ES2525748T3 (es) | 2009-11-13 | 2014-12-29 | Toray Industries, Inc. | Agente terapéutico o profiláctico para la diabetes |
MX352415B (es) | 2010-02-05 | 2017-11-22 | Heptares Therapeutics Ltd Star | Derivados de 1, 2, 4-triazin-4-amina. |
SG186989A1 (en) | 2010-07-14 | 2013-02-28 | Novartis Ag | Ip receptor agonist heterocyclic compounds |
CN104053659B (zh) | 2012-01-13 | 2016-11-09 | 诺华股份有限公司 | 用于治疗肺动脉高压(pah)及相关病症的作为ip 受体激动剂的稠合的吡咯类 |
EP2816023A4 (en) | 2012-02-13 | 2015-09-09 | Takeda Pharmaceutical | AROMATIC CORE COMPOUND |
JP6121339B2 (ja) | 2012-02-13 | 2017-04-26 | 武田薬品工業株式会社 | 芳香環化合物 |
JP6400479B2 (ja) | 2012-10-29 | 2018-10-03 | 株式会社カルディオ | 肺疾患特異的治療剤 |
WO2014125413A1 (en) | 2013-02-13 | 2014-08-21 | Novartis Ag | Ip receptor agonist heterocyclic compounds |
US9968716B2 (en) | 2013-10-15 | 2018-05-15 | Ono Pharmaceutical Co., Ltd. | Drug-eluting stent graft |
CN103588598B (zh) * | 2013-11-20 | 2015-06-17 | 苏州大学 | 一种制备2-烯醛衍生物的方法 |
CN104829465B (zh) * | 2015-02-13 | 2018-04-27 | 普济生物科技(台州)有限公司 | 一种4-异丙氨基-1-丁醇的制备方法 |
CN106279047B (zh) * | 2015-05-13 | 2019-05-03 | 普济生物科技(台州)有限公司 | 一种前列环素受体激动剂的制备方法 |
WO2016193994A1 (en) | 2015-05-29 | 2016-12-08 | Megafine Pharma (P) Ltd. | Amorphous selexipag and process for preparation thereof |
CN106467496B (zh) * | 2015-08-14 | 2020-12-08 | 苏州国匡医药科技有限公司 | 4-[(5,6-二苯基哌嗪-2-基)(异丙基)胺基]-1-丁醇的制备方法 |
US10188648B2 (en) | 2015-09-03 | 2019-01-29 | Teva Pharmaceuticals International Gmbh | Solid state forms of selexipag |
WO2017042828A2 (en) * | 2015-09-10 | 2017-03-16 | Megafine Pharma (P) Ltd. | Process for the preparation of selexipag and intermediates thereof |
WO2017042731A1 (en) * | 2015-09-10 | 2017-03-16 | Lupin Limited | Amorphous form of selexipag and solid dispersion thereof |
WO2017060827A1 (en) * | 2015-10-07 | 2017-04-13 | Lupin Limited | An imrpoved process for the preparation of selexipag or its pharmaceutically acceptable salts |
KR20180081141A (ko) * | 2015-12-02 | 2018-07-13 | 니뽄 신야쿠 가부시키가이샤 | 2-{4-[n-(5,6-디페닐피라진-2-일)-n-이소프로필아미노]부틸옥시}-n-(메틸술포닐)아세트아미드를 함유하는 의약 조성물 |
WO2017109772A1 (en) * | 2015-12-20 | 2017-06-29 | Mapi Pharma Ltd. | Amorphous form of selexipag |
US11512042B2 (en) | 2015-12-23 | 2022-11-29 | Commonwealth Scientific And Industrial Research Organisation | Enamine compounds for absorbance of electromagnetic energy |
EP3192502A1 (en) | 2016-01-15 | 2017-07-19 | Sandoz Ag | Pharmaceutical composition of selexipag |
EP3436439B1 (en) * | 2016-04-01 | 2022-02-16 | Honour (R&D) | Process for the preparation of diphenylpyrazine derivatives |
CN107286104A (zh) * | 2016-04-12 | 2017-10-24 | 常州方楠医药技术有限公司 | 一种赛乐西帕与药用辅料的固体分散体及其制备方法 |
CN105949135A (zh) * | 2016-05-10 | 2016-09-21 | 湖南欧亚生物有限公司 | 一种赛乐西帕的合成方法 |
CA3029960A1 (en) * | 2016-07-05 | 2018-01-11 | Maithri Drugs Private Limited | Novel process for the preparation of 2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-n-(methylsulfonyl)acetamide and novel polymorphs thereof |
WO2018015974A1 (en) | 2016-07-20 | 2018-01-25 | Mylan Laboratories Limited | Polymorphic forms and amorphous solid dispersion of selexipag |
WO2018015975A1 (en) * | 2016-07-22 | 2018-01-25 | Sun Pharmaceutical Industries Limited | Amorphous solid dispersion of selexipag |
WO2018022704A1 (en) | 2016-07-26 | 2018-02-01 | Teva Pharmaceuticals International Gmbh | Crystalline form vi of selexipag |
CN109563055B (zh) * | 2016-07-29 | 2021-12-24 | 成都苑东生物制药股份有限公司 | 氨基吡嗪类化合物或盐、异构体、其制备方法及用途 |
EP3495348A4 (en) | 2016-07-29 | 2020-01-22 | Toray Industries, Inc. | GUANIDINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES |
CN106316967B (zh) * | 2016-08-19 | 2019-02-05 | 上海艾康睿医药科技有限公司 | 西里帕格中间体及西里帕格的制备方法 |
WO2018078383A1 (en) | 2016-10-27 | 2018-05-03 | Cipla Limited | Pharmaceutical composition comprising amorphous selexipag |
RU2019121646A (ru) | 2016-12-14 | 2021-01-15 | Респира Терапьютикс, Инк. | Способы и композиции для лечения легочной гипертензии и других заболеваний легких |
CN110582271B (zh) | 2017-03-01 | 2022-06-14 | 阿瑞那制药公司 | 包含pgi2受体激动剂的组合物及其制备方法 |
JOP20190204A1 (ar) | 2017-03-08 | 2019-09-05 | Actelion Pharmaceuticals Ltd | تركيبة صيدلانية تشتمل على سيليكسيباغ |
CN107365275B (zh) * | 2017-06-14 | 2020-07-03 | 杭州华东医药集团新药研究院有限公司 | 高纯度的赛乐西帕 |
BR112020001748A2 (pt) | 2017-07-27 | 2020-07-21 | Allergan, Inc. | agonistas de receptor de prostaciclina para redução de gordura corporal |
CN117510418A (zh) | 2017-09-28 | 2024-02-06 | 日本新药株式会社 | 结晶 |
US10407396B2 (en) * | 2017-11-16 | 2019-09-10 | Apotex Inc. | Crystalline form of selexipag |
AR113882A1 (es) * | 2017-11-16 | 2020-06-24 | Nippon Shinyaku Co Ltd | Preparación de liberación controlada |
US11299475B2 (en) | 2018-02-07 | 2022-04-12 | Medshine Discovery Inc. | Prostacyclin receptor agonist |
MX2020008695A (es) | 2018-02-21 | 2020-09-25 | Nippon Shinyaku Co Ltd | Composicion granular, metodo de produccion para composicion granular y metodo para mejorar la propiedad de disolucion para composicion granular. |
CN108558653A (zh) * | 2018-05-14 | 2018-09-21 | 湖南华腾制药有限公司 | 赛乐西帕中间体及赛乐西帕的制备方法 |
CN108774183A (zh) * | 2018-08-03 | 2018-11-09 | 成都苑东生物制药股份有限公司 | 一种乙二醇类化合物的制备方法 |
CN108863955B (zh) * | 2018-08-03 | 2021-08-13 | 成都苑东生物制药股份有限公司 | 二苯基吡嗪类化合物或其药学上可接受的盐、异构体及其制备方法和用途 |
CN109125325B (zh) * | 2018-09-25 | 2021-05-25 | 中国人民解放军总医院 | 前列环素受体激动剂的医药用途 |
US20220331313A1 (en) | 2019-05-06 | 2022-10-20 | Actelion Pharmaceuticals Ltd | Methods for treating sarcoidosis-associated pulmonary hypertension |
JP2022533394A (ja) | 2019-05-21 | 2022-07-22 | アクテリオン ファーマシューティカルズ リミテッド | 肺動脈性肺高血圧症の治療を受けている患者のセレキシパグへの移行方法 |
WO2020249602A1 (en) | 2019-06-11 | 2020-12-17 | Actelion Pharmaceuticals Ltd | Methods for treating pulmonary arterial hypertension |
JP2022545195A (ja) * | 2019-08-19 | 2022-10-26 | 日本新薬株式会社 | 塩 |
PE20221455A1 (es) | 2019-10-23 | 2022-09-21 | Actelion Pharmaceuticals Ltd | Composicion farmaceutica que comprende selexipag |
CA3158292A1 (en) | 2019-11-29 | 2021-06-03 | Alessandro MARESTA | Methods of treating pulmonary arterial hypertension |
CA3161960A1 (en) | 2019-12-16 | 2021-06-24 | Tenax Therapeutics, Inc. | Levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction (ph-hfpef) |
EP4096643A1 (en) | 2020-01-31 | 2022-12-07 | Actelion Pharmaceuticals Ltd | Controlled release selexipag composition |
US20230073428A1 (en) | 2020-02-03 | 2023-03-09 | Actelion Pharmaceuticals Ltd | Methods of treating and assessing pulmonary arterial hypertension with selexipag |
WO2022106621A1 (en) | 2020-11-20 | 2022-05-27 | Actelion Pharmaceuticals Ltd | Selexipag for use via intracolonic administration |
TW202241425A (zh) | 2021-01-29 | 2022-11-01 | 瑞士商艾克泰聯製藥有限公司 | 用於製造二苯基吡𠯤衍生物之程序 |
TW202239408A (zh) | 2021-01-29 | 2022-10-16 | 瑞士商艾克泰聯製藥有限公司 | 包含二苯基吡𠯤衍生物的醫藥組成物 |
BR112023019899A2 (pt) | 2021-03-31 | 2023-11-07 | Nippon Shinyaku Co Ltd | Agente terapêutico para transtorno da marcha |
JP7010404B1 (ja) | 2021-03-31 | 2022-02-10 | 日本新薬株式会社 | 歩行障害治療剤 |
WO2022238375A1 (en) | 2021-05-11 | 2022-11-17 | Actelion Pharmaceuticals Ltd | Methods of treating pulmonary hypertension |
CN118206499A (zh) * | 2021-11-29 | 2024-06-18 | 郑州大学 | 一种2,3,5-三取代吡嗪类化合物及其制备方法和应用 |
WO2023131608A1 (en) | 2022-01-04 | 2023-07-13 | Actelion Pharmaceuticals Ltd | Controlled release compositions |
WO2023214059A1 (en) | 2022-05-06 | 2023-11-09 | Actelion Pharmaceuticals Ltd | Diphenylpyrazine compounds as prodrugs |
WO2024017964A1 (en) | 2022-07-20 | 2024-01-25 | Actelion Pharmaceuticals Ltd | Injectable pharmaceutical composition comprising a diphenylpyrazine derivative |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1604084A (en) * | 1977-05-17 | 1981-12-02 | Diamond Shamrock Corp | Pharmaceutical preparations containing 1,2,4-triazine derivatives |
US4513135A (en) * | 1982-03-05 | 1985-04-23 | Eli Lilly And Company | Diaryl-pyrazine derivatives affecting GABA binding |
FR2665159B1 (fr) | 1990-07-24 | 1992-11-13 | Rhone Poulenc Sante | Nouveaux derives de la pyridine et de la quinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent. |
JPH06501926A (ja) * | 1990-08-06 | 1994-03-03 | 藤沢薬品工業株式会社 | 複素環式化合物 |
US5219510A (en) * | 1990-09-26 | 1993-06-15 | Eastman Kodak Company | Method of manufacture of cellulose ester film |
JP3169413B2 (ja) | 1992-01-31 | 2001-05-28 | エーザイ株式会社 | イミダゾール誘導体 |
JPH0733752A (ja) | 1993-07-16 | 1995-02-03 | Sankyo Co Ltd | ジフェニルピラジン誘導体及び除草剤 |
AUPP003297A0 (en) * | 1997-10-27 | 1997-11-20 | Fujisawa Pharmaceutical Co., Ltd. | 4,5-diaryloxazole compounds |
AUPQ253199A0 (en) * | 1999-08-30 | 1999-09-23 | Fujisawa Pharmaceutical Co., Ltd. | Non-prostanoid prostaglandin I2-agonist |
-
2002
- 2002-04-24 TW TW091108440A patent/TWI316055B/zh active
- 2002-04-25 KR KR1020037014044A patent/KR100921760B1/ko active Protection Beyond IP Right Term
- 2002-04-25 CA CA2445344A patent/CA2445344C/en not_active Expired - Lifetime
- 2002-04-25 WO PCT/JP2002/004118 patent/WO2002088084A1/ja active IP Right Grant
- 2002-04-25 ES ES02722772T patent/ES2276931T3/es not_active Expired - Lifetime
- 2002-04-25 US US10/476,196 patent/US7205302B2/en active Active
- 2002-04-25 BR BRPI0209249A patent/BRPI0209249B8/pt active IP Right Grant
- 2002-04-25 RU RU2003134190A patent/RU2283835C3/ru active Protection Beyond IP Right Term
- 2002-04-25 DK DK02722772T patent/DK1400518T3/da active
- 2002-04-25 JP JP2002585386A patent/JP4479152B2/ja not_active Expired - Lifetime
- 2002-04-25 MX MXPA03009800A patent/MXPA03009800A/es active IP Right Grant
- 2002-04-25 EP EP02722772A patent/EP1400518B1/en not_active Expired - Lifetime
- 2002-04-25 PT PT02722772T patent/PT1400518E/pt unknown
- 2002-04-25 CN CNB028089774A patent/CN1301973C/zh not_active Expired - Lifetime
- 2002-04-25 DE DE60217674T patent/DE60217674T2/de not_active Expired - Lifetime
-
2016
- 2016-10-18 NL NL300836C patent/NL300836I2/nl unknown
- 2016-10-19 LU LU93266C patent/LU93266I2/fr unknown
- 2016-10-24 FR FR16C0042C patent/FR16C0042I2/fr active Active
- 2016-11-03 BE BE2016C051C patent/BE2016C051I2/fr unknown
Also Published As
Publication number | Publication date |
---|---|
KR100921760B1 (ko) | 2009-10-15 |
FR16C0042I1 (fr) | 2016-12-09 |
RU2003134190A (ru) | 2005-06-10 |
BRPI0209249B1 (pt) | 2016-04-26 |
BE2016C051I2 (pt) | 2021-07-19 |
US20040102436A1 (en) | 2004-05-27 |
JP4479152B2 (ja) | 2010-06-09 |
LU93266I2 (fr) | 2016-12-19 |
DE60217674T2 (de) | 2007-10-11 |
WO2002088084A1 (fr) | 2002-11-07 |
EP1400518A1 (en) | 2004-03-24 |
MXPA03009800A (es) | 2004-01-29 |
DE60217674D1 (de) | 2007-03-08 |
RU2283835C3 (ru) | 2021-02-15 |
NL300836I2 (pt) | 2016-11-16 |
CA2445344A1 (en) | 2002-11-07 |
FR16C0042I2 (fr) | 2017-03-17 |
BR0209249A (pt) | 2004-06-08 |
CN1301973C (zh) | 2007-02-28 |
KR20040015174A (ko) | 2004-02-18 |
RU2283835C2 (ru) | 2006-09-20 |
EP1400518A4 (en) | 2005-04-20 |
CN1516690A (zh) | 2004-07-28 |
ES2276931T3 (es) | 2007-07-01 |
EP1400518B1 (en) | 2007-01-17 |
DK1400518T3 (da) | 2007-03-26 |
CA2445344C (en) | 2011-07-26 |
JPWO2002088084A1 (ja) | 2004-09-09 |
PT1400518E (pt) | 2007-03-30 |
US7205302B2 (en) | 2007-04-17 |
TWI316055B (pt) | 2009-10-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0209249B8 (pt) | agonista de receptor de pgi2, inibidor de agregacao de plaqueta, agentes terapeuticos e derivados de composto heterociclico | |
EE200300403A (et) | N-asendatud mittearomaatne heterotsükliline ühend, seda sisaldav ravimkompositsioon ning ühendi kasutamine ravimina | |
CY1106522T1 (el) | Ετepοκυκλικη ενωση και αντικαρκινικο μεσο που πepιεχει την ιδια ως δραστικο συστατικο | |
BR9907040A (pt) | Composto, composição farmacêutica, e, processos para tratar ou prevenir condições causadas pela adesão de células mediada por alfa4 em um paciente e para preparar o composto | |
DE60043349D1 (de) | Chinazolin-derivate und ihre verwendung als arzneimittel | |
EA200301306A1 (ru) | Производные 1-фенилсульфонил-1,3-дигидро-2h-индол-2-она, их получение и их терапевтическое применение | |
AR056215A1 (es) | Derivados de indol como inhibidores de la proteina activadora de 5-lipoxigenasa (flap), composiciones farmaceuticas que los comprenden y su uso en el tratamiento de trastornos respiratorios e inflamatorios | |
PT784054E (pt) | Derivados de tetraidroquinoxalinadiona 1,2,3,4 e sua utilizacao como antagonistas do receptor glutamato | |
DK0976748T3 (da) | Pyrrolidinderivater med phospholispase A2-hæmmende aktivitet | |
ATE135701T1 (de) | Imidazolderivate, starke und selektive angiotensin-ii-rezeptor-antagonisten | |
PT719253E (pt) | Piperidinas 3-amino-5-carboxi-substituidas e pirrolidinas 3-amino-4-carboxi-substituidas como antagonistas de taquicinina | |
HK1126216A1 (en) | 2,4,5-triphenyl imidazoline derivatives as inhibitors of the interaction between p53 and mdm2 proteins for use as anticancer agents | |
EP1302458A4 (en) | ESTERDERIVATE | |
KR900009660A (ko) | 신규 화합물들 | |
TW200732309A (en) | Fused heterocyclic derivative, medicinal composition containing the same, and medicinal use thereof | |
NO20072515L (no) | 2-amido-4-fenyltnazolderivater, fremstilling og terapeutsik anvendelse derav | |
DE69024381T2 (de) | Benzo-annellierte-N-enthaltende heterocyclische Derivate | |
BR0213464A (pt) | Derivados de 3-azabiciclo[3.1.0]hexano como antagonistas receptores de opióide | |
ATE377602T1 (de) | Morphinanderivate und ihre medizinische anwendung | |
TR200002481T2 (tr) | Muskarinik Reseptör antegonistleri olarak 2-ariletil-(piperidin-4-ilmetil) amin türevleri | |
AR040126A1 (es) | Compuesto de fenilsulfonilo, composicion farmaceutica que lo comprende y su uso para la elaboracion de un medicamento | |
NO20070157L (no) | Substituerte diketopiperaziner som oksytocinantagonister | |
BR0309558A (pt) | Derivados de quinazolina e medicamentos | |
PE20091552A1 (es) | Farmacoforos duales - antagonistas muscarinicos de pde4 | |
DE69931378D1 (de) | Chinazolin derivate und therapeutische verwendungen davon |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: PAGAR RESTAURACAO. |
|
B08H | Application fees: decision cancelled [chapter 8.8 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/04/2016, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/04/2002 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
B22O | Other matters related to patents and certificates of addition of invention: legal action concerning patent |
Free format text: INPI NO 52402.001484/2022-07 ORIGEM: 2A VARA FEDERAL CIVEL DA SJDF (TRF1) PROCESSO NO: 52400.129576/2014-52 SUBJUDICE COM PEDIDO DE ANTECIPACAO DE TUTELA AUTOR: NIPPON SHINYAKU CO., LTD. REU(S): INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL ? INPI |
|
B19A | Notification of judicial decision: notification of judicial decision |
Free format text: PROCESSO INPI NO 52402.001484/2022-07 PROCESSO JUDICIAL: 1004522-04.2022.4.01.3400 NUP: 00424.030538/2022-81 (REF. 1004522-04.2022.4.01.3400) POLO ATIVO: NIPPON SHINYAKU CO., LTD. POLO PASSIVO:INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI E OUTROS. DECISAO: "PELO EXPOSTO, AD CAUTELAM, DEFIRO O PEDIDO DE TUTELA DE URGENCIA PARA DETERMINAR QUE A REQUERIDA SUSPENDA OS EFEITOS DO DESPACHO 16.3 DO INPI, PUBLICADO NA RPI DE 25.05.2021, QUE NOTICIOU O TERMINO DO PRAZO DA PATENTE PI0209249-2 PARA O DIA 25.04.2022. |
|
B16B | Notification of grant cancelled [chapter 16.2 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 16.3 NA RPI NO 2629 DE 25/05/2021 POR MOTIVO DO PROCESSO INPI NO 52402.001484/2022-07 PROCESSO JUDICIAL: 1004522-04.2022.4.01.3400 NUP: 00424.030538/2022-81 (REF. 1004522-04.2022.4.01.3400) POLO ATIVO: NIPPON SHINYAKU CO., LTD. POLO PASSIVO:INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI E OUTROS. DECISAO: PELO EXPOSTO, AD CAUTELAM, DEFIRO O PEDIDO DE TUTELA DE URGENCIA PARA DETERMINAR QUE A REQUERIDA SUSPENDA OS EFEITOS DO DESPACHO 16.3 DO INPI, PUBLICADO NA RPI DE 25.05.2021, QUE NOTICIOU O TERMINO DO PRAZO DA PATENTE PI0209249-2 PARA O DIA 25.04.2022. |