BR9907040A - Composto, composição farmacêutica, e, processos para tratar ou prevenir condições causadas pela adesão de células mediada por alfa4 em um paciente e para preparar o composto - Google Patents
Composto, composição farmacêutica, e, processos para tratar ou prevenir condições causadas pela adesão de células mediada por alfa4 em um paciente e para preparar o compostoInfo
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- BR9907040A BR9907040A BR9907040-5A BR9907040A BR9907040A BR 9907040 A BR9907040 A BR 9907040A BR 9907040 A BR9907040 A BR 9907040A BR 9907040 A BR9907040 A BR 9907040A
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
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- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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- C07C239/08—Hydroxylamino compounds or their ethers or esters
- C07C239/14—Hydroxylamino compounds or their ethers or esters having nitrogen atoms of hydroxylamino groups further bound to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
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- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
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- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/40—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
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- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
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- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
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- C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
- C07C275/48—Y being a hydrogen or a carbon atom
- C07C275/54—Y being a carbon atom of a six-membered aromatic ring, e.g. benzoylureas
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- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
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- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Abstract
"COMPOSTO, COMPOSIçãO FARMACêUTICA, E, PROCESSOS PARA TRATAR OU PREVENIR CONDIçõES CAUSADAS PELA ADESãO DE CéLULAS MEDIADA POR ALFA4 EM UM PACIENTE E PARA PREPARAR O COMPOSTO". A presente invenção refere-se a uma composição farmacêutica compreendendo como um ingrediente ativo um composto de fórmula (I): em que o anel A é um anel aromático ou um anel heterocíclico; Q é uma ligação, carbonila, alquileno inferior, alquenileno inferior, -O-(alquileno inferior), etc; n é 0, 1 ou 2; Z é oxigênio ou enxofre; W é oxigênio, enxofre, -CH=CH-, -NH- ou -N=CH-; R¹, R² e R³ são iguais ou diferentes e são hidrogênio, halogênio, hidroxila, um grupo alquila inferior substituído ou não substituído, um grupo alcóxi inferior substituído ou não substituído, um grupo amino substituído ou não substituído, etc.; R^ 4^ é tetrazolila, grupo carboxila, amida ou éster; R^ 5^ é hidrogênio, nitro, amino, hidroxila, alcanoíla inferior, alquila inferior, etc.; R^ 6^ é selecionado dentre (a) um grupo fenila substituído ou não substituído, (b) um grupo piridila substituído ou não substituído, (c) um grupo tienila substituído ou não substituído, (d) um grupo benzofuranila substituído ou não substituído, etc.; ou um seu sal farmaceuticamente aceitável.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US7184098P | 1998-01-20 | 1998-01-20 | |
US60/071840 | 1998-01-20 | ||
PCT/US1999/000993 WO1999036393A1 (en) | 1998-01-20 | 1999-01-19 | INHIBITORS OF α4 MEDIATED CELL ADHESION |
Publications (2)
Publication Number | Publication Date |
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BR9907040A true BR9907040A (pt) | 2000-10-17 |
BR9907040B1 BR9907040B1 (pt) | 2010-11-30 |
Family
ID=22103927
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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BRPI9907040-5A BR9907040B1 (pt) | 1998-01-20 | 1999-01-19 | composto derivado de l-fenilalanina como inibidor de adesão celular mediada por integrina alfa4, composição farmacêutica, uso do composto, e, processo para prepará-lo. |
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US (2) | US6521666B1 (pt) |
EP (1) | EP1049662B1 (pt) |
JP (2) | JP3634749B2 (pt) |
KR (1) | KR100411331B1 (pt) |
CN (1) | CN1301964C (pt) |
AR (1) | AR014448A1 (pt) |
AT (1) | ATE330935T1 (pt) |
AU (1) | AU749568B2 (pt) |
BR (1) | BR9907040B1 (pt) |
CA (1) | CA2318527C (pt) |
CY (1) | CY1105433T1 (pt) |
DE (1) | DE69932032T2 (pt) |
DK (1) | DK1049662T3 (pt) |
ES (1) | ES2264252T3 (pt) |
HK (1) | HK1029979A1 (pt) |
IL (2) | IL137385A0 (pt) |
MY (1) | MY153569A (pt) |
NZ (1) | NZ506081A (pt) |
PT (1) | PT1049662E (pt) |
SG (1) | SG118147A1 (pt) |
TW (1) | TW591007B (pt) |
WO (1) | WO1999036393A1 (pt) |
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- 1999-01-18 MY MYPI99000210A patent/MY153569A/en unknown
- 1999-01-19 BR BRPI9907040-5A patent/BR9907040B1/pt not_active IP Right Cessation
- 1999-01-19 KR KR10-2000-7006563A patent/KR100411331B1/ko not_active IP Right Cessation
- 1999-01-19 EP EP99904115A patent/EP1049662B1/en not_active Expired - Lifetime
- 1999-01-19 ES ES99904115T patent/ES2264252T3/es not_active Expired - Lifetime
- 1999-01-19 AU AU24584/99A patent/AU749568B2/en not_active Ceased
- 1999-01-19 DK DK99904115T patent/DK1049662T3/da active
- 1999-01-19 DE DE69932032T patent/DE69932032T2/de not_active Expired - Lifetime
- 1999-01-19 SG SG200204434A patent/SG118147A1/en unknown
- 1999-01-19 PT PT99904115T patent/PT1049662E/pt unknown
- 1999-01-19 IL IL13738599A patent/IL137385A0/xx active IP Right Grant
- 1999-01-19 CN CNB998022381A patent/CN1301964C/zh not_active Expired - Fee Related
- 1999-01-19 JP JP2000540111A patent/JP3634749B2/ja not_active Expired - Fee Related
- 1999-01-19 TW TW088100776A patent/TW591007B/zh not_active IP Right Cessation
- 1999-01-19 CA CA002318527A patent/CA2318527C/en not_active Expired - Fee Related
- 1999-01-19 WO PCT/US1999/000993 patent/WO1999036393A1/en active IP Right Grant
- 1999-01-19 AT AT99904115T patent/ATE330935T1/de active
- 1999-01-19 NZ NZ506081A patent/NZ506081A/xx not_active IP Right Cessation
- 1999-01-21 AR ARP990100226A patent/AR014448A1/es active IP Right Grant
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2000
- 2000-07-19 US US09/619,712 patent/US6521666B1/en not_active Expired - Lifetime
- 2000-07-19 IL IL137385A patent/IL137385A/en not_active IP Right Cessation
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2001
- 2001-01-10 HK HK01100247A patent/HK1029979A1/xx not_active IP Right Cessation
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2002
- 2002-11-04 US US10/286,777 patent/US6855843B2/en not_active Expired - Fee Related
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2004
- 2004-07-08 JP JP2004202046A patent/JP2005002116A/ja active Pending
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---|---|
EP1049662B1 (en) | 2006-06-21 |
JP3634749B2 (ja) | 2005-03-30 |
HK1029979A1 (en) | 2001-04-20 |
CA2318527C (en) | 2006-10-17 |
DE69932032D1 (de) | 2006-08-03 |
SG118147A1 (en) | 2006-01-27 |
US6855843B2 (en) | 2005-02-15 |
ATE330935T1 (de) | 2006-07-15 |
CN1288457A (zh) | 2001-03-21 |
PT1049662E (pt) | 2006-09-29 |
CN1301964C (zh) | 2007-02-28 |
US20030191118A1 (en) | 2003-10-09 |
IL137385A0 (en) | 2001-07-24 |
JP2005002116A (ja) | 2005-01-06 |
DK1049662T3 (da) | 2006-10-23 |
ES2264252T3 (es) | 2006-12-16 |
BR9907040B1 (pt) | 2010-11-30 |
WO1999036393A1 (en) | 1999-07-22 |
NZ506081A (en) | 2003-02-28 |
IL137385A (en) | 2006-08-20 |
KR100411331B1 (ko) | 2003-12-18 |
DE69932032T2 (de) | 2006-12-28 |
MY153569A (en) | 2015-02-27 |
AR014448A1 (es) | 2001-02-28 |
US6521666B1 (en) | 2003-02-18 |
CA2318527A1 (en) | 1999-07-22 |
AU749568B2 (en) | 2002-06-27 |
JP2002509131A (ja) | 2002-03-26 |
CY1105433T1 (el) | 2010-04-28 |
TW591007B (en) | 2004-06-11 |
AU2458499A (en) | 1999-08-02 |
KR20010033180A (ko) | 2001-04-25 |
EP1049662A1 (en) | 2000-11-08 |
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