IL133642A0 - Dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4 - Google Patents
Dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4Info
- Publication number
- IL133642A0 IL133642A0 IL13364298A IL13364298A IL133642A0 IL 133642 A0 IL133642 A0 IL 133642A0 IL 13364298 A IL13364298 A IL 13364298A IL 13364298 A IL13364298 A IL 13364298A IL 133642 A0 IL133642 A0 IL 133642A0
- Authority
- IL
- Israel
- Prior art keywords
- vla
- leukocyte adhesion
- adhesion mediated
- inhibit leukocyte
- dipeptide compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90441597A | 1997-07-31 | 1997-07-31 | |
| PCT/US1998/015314 WO1999006435A1 (en) | 1997-07-31 | 1998-07-30 | Dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL133642A0 true IL133642A0 (en) | 2001-04-30 |
Family
ID=25419114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13364298A IL133642A0 (en) | 1997-07-31 | 1998-07-30 | Dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0994895A1 (en) |
| JP (1) | JP2001512137A (en) |
| KR (1) | KR20010022412A (en) |
| CN (1) | CN1265673A (en) |
| AR (1) | AR016387A1 (en) |
| AU (1) | AU8661298A (en) |
| BR (1) | BR9811599A (en) |
| CA (1) | CA2291475A1 (en) |
| HU (1) | HUP0002682A3 (en) |
| IL (1) | IL133642A0 (en) |
| NO (1) | NO20000412L (en) |
| PL (1) | PL338554A1 (en) |
| WO (1) | WO1999006435A1 (en) |
| ZA (1) | ZA986834B (en) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6221888B1 (en) | 1997-05-29 | 2001-04-24 | Merck & Co., Inc. | Sulfonamides as cell adhesion inhibitors |
| US6903075B1 (en) | 1997-05-29 | 2005-06-07 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
| WO1998053818A1 (en) * | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Sulfonamides as cell adhesion inhibitors |
| US6093696A (en) * | 1997-05-30 | 2000-07-25 | Celltech Therapeutics, Limited | Tyrosine derivatives |
| US6482849B1 (en) | 1997-06-23 | 2002-11-19 | Tanabe Seiyaku Co., Ltd. | Inhibitors of α4β1 mediated cell adhesion |
| US6455550B1 (en) * | 1997-08-22 | 2002-09-24 | Hoffmann-La Roche Inc. | N-alkanoylphenylalanine derivatives |
| MY153569A (en) | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
| US6329372B1 (en) | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
| ES2226413T3 (en) | 1998-02-26 | 2005-03-16 | Celltech Therapeutics Limited | PHENYLALANINE DERIVATIVES AS INTEGRIN ALFA-4 INHIBITORS. |
| US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
| GB9811159D0 (en) | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9811969D0 (en) | 1998-06-03 | 1998-07-29 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9812088D0 (en) * | 1998-06-05 | 1998-08-05 | Celltech Therapeutics Ltd | Chemical compounds |
| US6685617B1 (en) | 1998-06-23 | 2004-02-03 | Pharmacia & Upjohn Company | Inhibitors of α4β1 mediated cell adhesion |
| GB9814414D0 (en) | 1998-07-03 | 1998-09-02 | Celltech Therapeutics Ltd | Chemical compounds |
| US6339101B1 (en) * | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
| US6333340B1 (en) * | 1998-08-14 | 2001-12-25 | Gpi Nil Holdings, Inc. | Small molecule sulfonamides for vision and memory disorders |
| GB9821061D0 (en) | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9821222D0 (en) | 1998-09-30 | 1998-11-25 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9825652D0 (en) | 1998-11-23 | 1999-01-13 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9826174D0 (en) | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
| SI1154993T1 (en) * | 1999-02-18 | 2004-12-31 | F. Hoffmann-La Roche Ag | Thioamide derivatives |
| US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
| ATE343383T1 (en) * | 1999-08-13 | 2006-11-15 | Biogen Idec Inc | CELL ADHESION INHIBITORS |
| JP2003509488A (en) * | 1999-09-24 | 2003-03-11 | ジェネンテック・インコーポレーテッド | Tyrosine derivative |
| US6534513B1 (en) | 1999-09-29 | 2003-03-18 | Celltech R&D Limited | Phenylalkanoic acid derivatives |
| US6455539B2 (en) | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
| KR20020067050A (en) | 1999-12-28 | 2002-08-21 | 화이자 프로덕츠 인코포레이티드 | Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases |
| WO2001079173A2 (en) | 2000-04-17 | 2001-10-25 | Celltech R & D Limited | Enamine derivatives as cell adhesion molecules |
| US6545013B2 (en) | 2000-05-30 | 2003-04-08 | Celltech R&D Limited | 2,7-naphthyridine derivatives |
| US6403608B1 (en) | 2000-05-30 | 2002-06-11 | Celltech R&D, Ltd. | 3-Substituted isoquinolin-1-yl derivatives |
| US6960597B2 (en) | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
| EP1301488A1 (en) | 2000-07-07 | 2003-04-16 | Celltech R&D Limited | Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists |
| WO2002008206A1 (en) | 2000-07-21 | 2002-01-31 | Elan Pharmaceuticals, Inc. | 3-amino-2-(4-aminocarbonyloxy)phenyl-propionic acid derivatives as alpha-4- integrin inhibitors |
| AU2001275724A1 (en) | 2000-08-02 | 2002-02-13 | Celltech R&D Limited | 3-substituted isoquinolin-1-yl derivatives |
| MY129000A (en) | 2000-08-31 | 2007-03-30 | Tanabe Seiyaku Co | INHIBITORS OF a4 MEDIATED CELL ADHESION |
| JP2004526733A (en) * | 2001-03-20 | 2004-09-02 | メルク エンド カムパニー インコーポレーテッド | Substituted N-arylsulfonyl-proline derivatives as potent cell adhesion inhibitors |
| MY140707A (en) | 2002-02-28 | 2010-01-15 | Mitsubishi Tanabe Pharma Corp | Process for preparing a phenylalanine derivative and intermediates thereof |
| AU2005231467A1 (en) * | 2004-04-01 | 2005-10-20 | Elan Pharmaceuticals, Inc. | Steroid sparing agents and methods of using same |
| US20100150915A1 (en) | 2007-02-20 | 2010-06-17 | Stewart Edward J | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
| ES2525065T3 (en) | 2008-04-11 | 2014-12-17 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and their conjugates |
| EP2774919A1 (en) * | 2013-03-06 | 2014-09-10 | Pharmeste S.R.L. In Liquidazione | Novel sulfonamide TRPA1 receptor antagonists |
| WO2014142255A1 (en) | 2013-03-14 | 2014-09-18 | 武田薬品工業株式会社 | Heterocyclic compound |
| WO2015002230A1 (en) | 2013-07-03 | 2015-01-08 | 武田薬品工業株式会社 | Amide compound |
| US10053468B2 (en) | 2013-07-03 | 2018-08-21 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995015973A1 (en) * | 1993-12-06 | 1995-06-15 | Cytel Corporation | Cs-1 peptidomimetics, compositions and methods of using the same |
| US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
-
1998
- 1998-07-30 EP EP98937991A patent/EP0994895A1/en not_active Withdrawn
- 1998-07-30 KR KR1020007000992A patent/KR20010022412A/en not_active Application Discontinuation
- 1998-07-30 ZA ZA9806834A patent/ZA986834B/en unknown
- 1998-07-30 WO PCT/US1998/015314 patent/WO1999006435A1/en not_active Application Discontinuation
- 1998-07-30 JP JP2000505190A patent/JP2001512137A/en not_active Withdrawn
- 1998-07-30 BR BR9811599-5A patent/BR9811599A/en not_active Application Discontinuation
- 1998-07-30 PL PL98338554A patent/PL338554A1/en unknown
- 1998-07-30 AU AU86612/98A patent/AU8661298A/en not_active Abandoned
- 1998-07-30 HU HU0002682A patent/HUP0002682A3/en unknown
- 1998-07-30 AR ARP980103776A patent/AR016387A1/en unknown
- 1998-07-30 IL IL13364298A patent/IL133642A0/en unknown
- 1998-07-30 CA CA002291475A patent/CA2291475A1/en not_active Abandoned
- 1998-07-30 CN CN98807762A patent/CN1265673A/en active Pending
-
2000
- 2000-01-27 NO NO20000412A patent/NO20000412L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20000412D0 (en) | 2000-01-27 |
| WO1999006435A1 (en) | 1999-02-11 |
| CN1265673A (en) | 2000-09-06 |
| KR20010022412A (en) | 2001-03-15 |
| AR016387A1 (en) | 2001-07-04 |
| HUP0002682A3 (en) | 2001-12-28 |
| EP0994895A1 (en) | 2000-04-26 |
| BR9811599A (en) | 2000-09-19 |
| PL338554A1 (en) | 2000-11-06 |
| AU8661298A (en) | 1999-02-22 |
| HUP0002682A1 (en) | 2001-07-30 |
| ZA986834B (en) | 2000-05-02 |
| JP2001512137A (en) | 2001-08-21 |
| NO20000412L (en) | 2000-03-24 |
| CA2291475A1 (en) | 1999-02-11 |
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