ATE135701T1 - Imidazolderivate, starke und selektive angiotensin-ii-rezeptor-antagonisten - Google Patents

Imidazolderivate, starke und selektive angiotensin-ii-rezeptor-antagonisten

Info

Publication number
ATE135701T1
ATE135701T1 AT91115644T AT91115644T ATE135701T1 AT E135701 T1 ATE135701 T1 AT E135701T1 AT 91115644 T AT91115644 T AT 91115644T AT 91115644 T AT91115644 T AT 91115644T AT E135701 T1 ATE135701 T1 AT E135701T1
Authority
AT
Austria
Prior art keywords
alkyl
hydrogen
powerful
receptor antagonists
imidazole derivatives
Prior art date
Application number
AT91115644T
Other languages
English (en)
Inventor
Teruo Oku
Hiroyuki Setoi
Hiroshi Kayakiri
Shigeki Satoh
Takayuki Inoue
Yuki Saitoh
Akio Kuroda
Hirokazu Tanaka
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909020838A external-priority patent/GB9020838D0/en
Priority claimed from GB909023467A external-priority patent/GB9023467D0/en
Priority claimed from GB909028216A external-priority patent/GB9028216D0/en
Priority claimed from GB919103874A external-priority patent/GB9103874D0/en
Priority claimed from GB919106956A external-priority patent/GB9106956D0/en
Priority claimed from GB919107231A external-priority patent/GB9107231D0/en
Priority claimed from GB919112803A external-priority patent/GB9112803D0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Application granted granted Critical
Publication of ATE135701T1 publication Critical patent/ATE135701T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT91115644T 1990-09-25 1991-09-14 Imidazolderivate, starke und selektive angiotensin-ii-rezeptor-antagonisten ATE135701T1 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB909020838A GB9020838D0 (en) 1990-09-25 1990-09-25 Condensed imidazole derivatives and process for preparation thereof
GB909023467A GB9023467D0 (en) 1990-10-29 1990-10-29 Condensed imidazole derivatives and process for preparation thereof
GB909028216A GB9028216D0 (en) 1990-12-31 1990-12-31 Condensed imidazole derivatives and process for preparation thereof
GB919103874A GB9103874D0 (en) 1991-02-25 1991-02-25 Heterocyclic derivatives
GB919106956A GB9106956D0 (en) 1991-04-03 1991-04-03 Heterocyclic derivatives
GB919107231A GB9107231D0 (en) 1991-04-05 1991-04-05 Heterocyclic derivatives
GB919112803A GB9112803D0 (en) 1991-06-14 1991-06-14 Heterocyclic derivatives

Publications (1)

Publication Number Publication Date
ATE135701T1 true ATE135701T1 (de) 1996-04-15

Family

ID=27562836

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91115644T ATE135701T1 (de) 1990-09-25 1991-09-14 Imidazolderivate, starke und selektive angiotensin-ii-rezeptor-antagonisten

Country Status (15)

Country Link
US (1) US5210092A (de)
EP (1) EP0480204B1 (de)
JP (1) JPH04288075A (de)
KR (1) KR920006347A (de)
CN (1) CN1059723A (de)
AT (1) ATE135701T1 (de)
AU (1) AU650473B2 (de)
CA (1) CA2052125A1 (de)
DE (1) DE69118082T2 (de)
FI (1) FI914163L (de)
HU (1) HUT59404A (de)
IE (1) IE913164A1 (de)
IL (1) IL99443A0 (de)
NO (1) NO913750L (de)
PT (1) PT99038A (de)

Families Citing this family (46)

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US5177074A (en) * 1991-03-26 1993-01-05 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan
TW274551B (de) * 1991-04-16 1996-04-21 Takeda Pharm Industry Co Ltd
US5252574A (en) * 1991-04-26 1993-10-12 Merck & Co., Inc. Angiotensin II antagonists incorporating a substituted thiophene or furan
US5198438A (en) * 1991-05-07 1993-03-30 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan
US5354759A (en) * 1991-09-12 1994-10-11 Fujisawa Pharmaceutical Co., Ltd. Angiotenin II antagonizing heterocyclic compounds
WO1993019067A1 (en) * 1991-09-12 1993-09-30 Fujisawa Pharmaceutical Co., Ltd. Imidazopyridine derivatives as angiotensin ii antagonists
GB9201789D0 (en) * 1992-01-28 1992-03-11 Fujisawa Pharmaceutical Co Heterocyclic derivatives
US5283242A (en) * 1991-10-24 1994-02-01 American Home Products Corporation Substituted benzimidazoles and quinazolines as antihypertensives
WO1993018030A1 (en) * 1992-03-03 1993-09-16 Fujisawa Pharmaceutical Co., Ltd. Benzimidazole derivatives as angiotensin ii antagonists
US5364869A (en) * 1992-03-09 1994-11-15 Abbott Laboratories Heterocycle-substituted benzyaminopyridine angiotensin II receptor antagonists
EP0577023A3 (en) * 1992-07-01 1996-12-18 Hoechst Ag Angiotensin-ii receptor-antagonists for the treatment of arrhythmices
EP0577025A3 (de) * 1992-07-01 1998-02-04 Hoechst Aktiengesellschaft Angiotensin-II-Rezeptorantagonisten zur Behandlung und Prophylaxe von koronaren Herzerkrankungen
GB9218449D0 (en) 1992-08-29 1992-10-14 Boots Co Plc Therapeutic agents
WO1994005633A1 (en) * 1992-09-01 1994-03-17 Ciba-Geigy Ag 3-cyano-4-halogeno-2-(subst.phenyl)-pyrroles as pesticides and fungicides
DK0664802T3 (da) * 1992-10-13 2000-06-05 Searle & Co N-Arylheteroarylalkyl-1-phenyl-imidazol-2-on-forbindelser til behandling af kredsløbssygdomme
DE4236026A1 (de) * 1992-10-24 1994-04-28 Merck Patent Gmbh Imidazopyridine
US5376666A (en) * 1992-11-30 1994-12-27 The Du Pont Merck Pharmaceutical Company Angiotension-II receptor blocking, azacycloalkyl or azacycloalkenyl
EP0627433B1 (de) * 1992-12-07 2003-03-05 Eisai Co., Ltd. Verfahren zur herstellung von imidazopyridinderivaten und zwischenprodukte
US5455260A (en) * 1993-05-21 1995-10-03 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aliphatic amino bis-aryl squalene synthase inhibitors
US5338740A (en) * 1993-07-13 1994-08-16 Pfizer Inc. Angiotensin II receptor antagonists
BR9608502A (pt) * 1995-06-07 1999-07-06 Nippon Shinyaku Co Ltd Derivado da pirrola e composição medicinal
CN1268137A (zh) * 1997-07-03 2000-09-27 杜邦药品公司 治疗神经失调的咪唑并嘧啶和咪唑并吡啶
US6124463A (en) * 1998-07-02 2000-09-26 Dupont Pharmaceuticals Benzimidazoles as corticotropin release factor antagonists
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
US7772271B2 (en) 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
JP2008506702A (ja) 2004-07-14 2008-03-06 ピーティーシー セラピューティクス，インコーポレーテッド Ｃ型肝炎を治療するための方法
NZ553329A (en) 2004-07-22 2010-09-30 Ptc Therapeutics Inc Thienopyridines for treating hepatitis C
US7531560B2 (en) * 2004-11-10 2009-05-12 Boehringer Ingelheim Pharmaceuticals, Inc. Anti-cytokine heterocyclic compounds
PE20070341A1 (es) * 2005-07-29 2007-04-13 Wyeth Corp Derivados de pirrol como moduladores del receptor de progesterona
PE20070182A1 (es) * 2005-07-29 2007-03-06 Wyeth Corp Derivados cianopirrol-fenil amida como moduladores del receptor de progesterona
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
AR072297A1 (es) 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
EP2321341B1 (de) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Zur behandlung von erkrankungen des magen-darm-trakts, entzündlichen erkrankungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US8703776B2 (en) 2011-06-15 2014-04-22 Cymabay Therapeutics, Inc. Agonists of GPR131 and uses thereof
WO2013032939A1 (en) * 2011-08-26 2013-03-07 Metabolex, Inc. Bicyclic agonists of gpr131 and uses thereof
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
CA2905242C (en) 2013-03-15 2016-11-29 Pfizer Inc. Indole compounds that activate ampk
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CN105764916B (zh) 2013-06-05 2021-05-18 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法

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Publication number Priority date Publication date Assignee Title
DE3130251A1 (de) * 1981-07-31 1983-02-17 A. Nattermann & Cie GmbH, 5000 Köln 6-(4-((omega)-(1-imidazolyl)-alkyl)-phenyl)-3-oxo -2,3,4,5-tetrahydro-pyridazine und deren saeureadditionssalze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
US4916129A (en) * 1989-01-19 1990-04-10 E. I. Du Pont De Nemours And Company Combination β-blocking/angiotensin II blocking antihypertensives
IE64514B1 (en) * 1989-05-23 1995-08-09 Zeneca Ltd Azaindenes
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
IL96019A0 (en) * 1989-10-31 1991-07-18 Fujisawa Pharmaceutical Co Imidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
TW300219B (de) * 1991-09-14 1997-03-11 Hoechst Ag

Also Published As

Publication number Publication date
US5210092A (en) 1993-05-11
EP0480204A1 (de) 1992-04-15
EP0480204B1 (de) 1996-03-20
PT99038A (pt) 1992-08-31
FI914163A0 (fi) 1991-09-04
NO913750D0 (no) 1991-09-24
AU650473B2 (en) 1994-06-23
KR920006347A (ko) 1992-04-27
DE69118082T2 (de) 1996-10-17
CA2052125A1 (en) 1992-03-26
HU913052D0 (en) 1992-01-28
DE69118082D1 (de) 1996-04-25
NO913750L (no) 1992-03-26
AU8345491A (en) 1992-04-02
JPH04288075A (ja) 1992-10-13
FI914163A7 (fi) 1992-03-26
FI914163L (fi) 1992-03-26
HUT59404A (en) 1992-05-28
IE913164A1 (en) 1992-02-25
CN1059723A (zh) 1992-03-25
IL99443A0 (en) 1992-08-18

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties