AR077242A1 - Formas cristalinas del 2-{4-[n-(5,6-difenilpirazin-2-il)-n-isopropilamino]butiloxi}n-(metilsulfonil)acetamida, composiciones farmaceuticas que las contienen, metodo para prepararlas y uso de las mismas en el tratamiento de isquemias, insuficiencia coronaria y asma, entre otras enfermedades. - Google Patents

Formas cristalinas del 2-{4-[n-(5,6-difenilpirazin-2-il)-n-isopropilamino]butiloxi}n-(metilsulfonil)acetamida, composiciones farmaceuticas que las contienen, metodo para prepararlas y uso de las mismas en el tratamiento de isquemias, insuficiencia coronaria y asma, entre otras enfermedades.

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Publication number
AR077242A1
AR077242A1 ARP100102270A ARP100102270A AR077242A1 AR 077242 A1 AR077242 A1 AR 077242A1 AR P100102270 A ARP100102270 A AR P100102270A AR P100102270 A ARP100102270 A AR P100102270A AR 077242 A1 AR077242 A1 AR 077242A1
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AR
Argentina
Prior art keywords
degrees
acetamide
diffraction
powder
ray
Prior art date
Application number
ARP100102270A
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English (en)
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Actelion Pharmaceuticals Ltd
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Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of AR077242A1 publication Critical patent/AR077242A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
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    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C07D241/22—Benzenesulfonamido pyrazines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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Abstract

Reivindicacion 1: Un cristal Forma-I de 2-{4-[N-(5,6-difenilpirazin-2-il)-N-isopropilamino] butiloxi}-N-(Metilsulfonil) acetamida, que exhibe picos de difraccion en su espectro de difraccion de rayos X en polvo en los siguientes ángulos de difraccion 2theta:9,4 grados, 17,2grados y 19,4 grados, en donde el diagrama de difraccion de rayos X en polvo se obtiene usando radiacion CuKalfa. Reivindicacion 2: Un cristal Forma-II de 2-{4-[N-(5,6-difenilpirazin-2-il)-N-isopropilamino] butiloxi}-N-(Metilsulfonil) acetamida, que exhibe picos de difraccion en su espectro de difraccion de rayos X en polvo en los siguientes ángulos de difraccion 2theta:9,0 grados, 20,7 grados y 22,6 grados, en el espectro de difraccion de rayos X en polvo del compuesto, en donde el diagrama de difraccion de rayos X en polvo se obtiene usando radiacion CuKalfa. Reivindicacion 3: Un cristal Forma-III de 2-{4-[N-(5,6-difenilpirazin-2-il)-N-isopropilamino] butiloxi}-N-(Metilsulfonil) acetamida, que exhibe picos de difraccion en su espectro de difraccion de rayos X en polvo en los siguientes ángulos de difraccion 2theta:9,3 grados, 16,8grados, 20,6 grados y 23,5 grados, en el espectro de difraccion de rayos X en polvo del compuesto, en donde el diagrama de difraccion de rayos X en polvo se obtiene usando radiacion CuKalfa.
ARP100102270A 2009-06-26 2010-06-25 Formas cristalinas del 2-{4-[n-(5,6-difenilpirazin-2-il)-n-isopropilamino]butiloxi}n-(metilsulfonil)acetamida, composiciones farmaceuticas que las contienen, metodo para prepararlas y uso de las mismas en el tratamiento de isquemias, insuficiencia coronaria y asma, entre otras enfermedades. AR077242A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009151727 2009-06-26
JP2009151728 2009-06-26
JP2009151729 2009-06-26

Publications (1)

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AR077242A1 true AR077242A1 (es) 2011-08-10

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ARP100102270A AR077242A1 (es) 2009-06-26 2010-06-25 Formas cristalinas del 2-{4-[n-(5,6-difenilpirazin-2-il)-n-isopropilamino]butiloxi}n-(metilsulfonil)acetamida, composiciones farmaceuticas que las contienen, metodo para prepararlas y uso de las mismas en el tratamiento de isquemias, insuficiencia coronaria y asma, entre otras enfermedades.

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US (4) US8791122B2 (es)
EP (3) EP3689855A1 (es)
JP (1) JPWO2010150865A1 (es)
KR (4) KR102705198B1 (es)
CN (2) CN104326991A (es)
AR (1) AR077242A1 (es)
AU (1) AU2010263569B2 (es)
BR (2) BRPI1015936B1 (es)
CA (1) CA2764475C (es)
CL (1) CL2011003264A1 (es)
CO (1) CO6430432A2 (es)
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DK (2) DK2447254T3 (es)
ES (2) ES2660007T3 (es)
HK (1) HK1244788A1 (es)
HR (2) HRP20180171T1 (es)
HU (3) HUE048467T2 (es)
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LT (3) LT3275871T (es)
MA (1) MA33637B1 (es)
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NO (2) NO2447254T3 (es)
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PT (2) PT2447254T (es)
RU (1) RU2556206C3 (es)
SG (2) SG176915A1 (es)
SI (2) SI3275871T1 (es)
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CN106279047B (zh) 2015-05-13 2019-05-03 普济生物科技（台州）有限公司 一种前列环素受体激动剂的制备方法
WO2016193994A1 (en) 2015-05-29 2016-12-08 Megafine Pharma (P) Ltd. Amorphous selexipag and process for preparation thereof
WO2017029594A1 (en) * 2015-08-17 2017-02-23 Dr. Reddy's Laboratories Limited Processes for preparation of selexipag and its amorphous form
EP3344607B1 (en) 2015-09-03 2019-11-06 Teva Pharmaceuticals International GmbH Solid state forms of selexipag
WO2017042731A1 (en) 2015-09-10 2017-03-16 Lupin Limited Amorphous form of selexipag and solid dispersion thereof
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