AR079945A1 - Derivados de pirazina como inhibidores de glucogeno sintasa quinasa 3 (gsk3) - Google Patents
Derivados de pirazina como inhibidores de glucogeno sintasa quinasa 3 (gsk3)Info
- Publication number
- AR079945A1 AR079945A1 ARP110100182A ARP110100182A AR079945A1 AR 079945 A1 AR079945 A1 AR 079945A1 AR P110100182 A ARP110100182 A AR P110100182A AR P110100182 A ARP110100182 A AR P110100182A AR 079945 A1 AR079945 A1 AR 079945A1
- Authority
- AR
- Argentina
- Prior art keywords
- glucogeno
- sintasa
- quinasa
- gsk3
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Derivados de pirazina de formula (1) o sales farmacéuticamente aceptables de los mismos en donde n es 2 o 3; m es 2 o 3, Re s -CH3 o -CH2-CH3, y su uso en la fabricacion de un medicamento para su uso en el tratamiento de trastornos o afecciones oseos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29619610P | 2010-01-19 | 2010-01-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR079945A1 true AR079945A1 (es) | 2012-02-29 |
Family
ID=43743548
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110100182A AR079945A1 (es) | 2010-01-19 | 2011-01-19 | Derivados de pirazina como inhibidores de glucogeno sintasa quinasa 3 (gsk3) |
Country Status (14)
Country | Link |
---|---|
US (2) | US8198285B2 (es) |
EP (1) | EP2526097A1 (es) |
JP (1) | JP2013517321A (es) |
KR (1) | KR20120120307A (es) |
CN (1) | CN102812017A (es) |
AR (1) | AR079945A1 (es) |
AU (1) | AU2011208530A1 (es) |
BR (1) | BR112012017884A2 (es) |
CA (1) | CA2786520A1 (es) |
MX (1) | MX2012008328A (es) |
RU (1) | RU2012135093A (es) |
TW (1) | TW201130814A (es) |
UY (1) | UY33191A (es) |
WO (1) | WO2011089416A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2699256T3 (es) | 2011-05-23 | 2019-02-08 | Merck Patent Gmbh | Piridina y derivados de pirazina |
AU2014240603B2 (en) | 2013-03-14 | 2017-11-09 | Massachusetts Institute Of Technology | Compositions and methods for epithelial stem cell expansion and culture |
KR102493376B1 (ko) | 2014-09-03 | 2023-01-27 | 더 브리검 앤드 우먼즈 하스피털, 인크. | 청력 손실의 치료를 위해 내이 털세포를 생성하기 위한 조성물, 시스템, 및 방법 |
AU2017205194A1 (en) | 2016-01-08 | 2018-07-19 | Massachusetts Institute Of Technology | Production of differentiated enteroendocrine cells and insulin producing cells |
US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
US11260130B2 (en) | 2016-03-02 | 2022-03-01 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV |
SG10201910821XA (en) | 2016-12-30 | 2020-01-30 | Frequency Therapeutics Inc | 1h-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells |
CN113195707A (zh) | 2018-08-17 | 2021-07-30 | 频率治疗公司 | 用于通过上调jag-1来生成毛细胞的组合物和方法 |
WO2020037326A1 (en) | 2018-08-17 | 2020-02-20 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating foxo |
EP3920885A1 (en) | 2019-02-08 | 2021-12-15 | Frequency Therapeutics, Inc. | Valproic acid compounds and wnt agonists for treating ear disorders |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
TR199801530T2 (xx) | 1996-02-13 | 1998-11-23 | Zeneca Limited | VEGF �nhibit�rleri olarak kinazolin t�revleri. |
JP4464466B2 (ja) | 1996-03-05 | 2010-05-19 | アストラゼネカ・ユーケイ・リミテッド | 4―アニリノキナゾリン誘導体 |
GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
CZ306810B6 (cs) | 1999-02-10 | 2017-07-19 | Astrazeneca Ab | Použití chinazolinového derivátu jako inhibitoru angiogeneze |
EP1200422A2 (en) | 2000-02-05 | 2002-05-02 | Vertex Pharmaceuticals Incorporated | Pyrazole compositions useful as inhibitors of erk |
WO2001092224A1 (en) | 2000-05-31 | 2001-12-06 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
BR0112225A (pt) | 2000-07-07 | 2003-05-06 | Angiogene Pharm Ltd | Composto, composição farmacêutica, uso de um composto, e, processo papa preparar um composto |
IL153484A0 (en) | 2000-07-07 | 2003-07-06 | Angiogene Pharm Ltd | Colchinol derivatives as angiogenesis inhibitors |
SE0102438D0 (sv) | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
SE0102439D0 (sv) | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
EP1465610B1 (en) | 2002-01-10 | 2008-12-31 | F. Hoffmann-La Roche Ag | Use of a gsk-3beta inhibitor in the manufacture of a medicament for increasing bone formation |
AU2003215325B8 (en) | 2002-03-05 | 2008-10-09 | Eli Lilly And Company | Purine derivatives as kinase inhibitors |
CA2484209C (en) | 2002-05-03 | 2013-06-11 | Exelixis, Inc. | Protein kinase modulators and methods of use |
SE0203752D0 (sv) | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
SE0203753D0 (sv) | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
SE0203754D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
EP1606267B1 (en) | 2003-03-11 | 2008-07-30 | Pfizer Products Inc. | Pyrazine compounds as transforming growth factor (tgf) inhibitors |
AU2004274861A1 (en) | 2003-06-06 | 2005-03-31 | Wyeth | Methods and materials for identifying agents which modulate bone remodeling and agents identified thereby |
JP2007502300A (ja) | 2003-08-13 | 2007-02-08 | カイロン コーポレイション | Gsk−3インヒビターおよびその使用 |
WO2005020921A2 (en) | 2003-08-29 | 2005-03-10 | Exelixis, Inc. | C-kit modulators and methods of use |
US20050064044A1 (en) | 2003-09-19 | 2005-03-24 | Georges Rawadi | GSK-3beta inhibitors in the treatment of bone-related diseases |
JP2007524682A (ja) | 2004-02-12 | 2007-08-30 | メルク エンド カムパニー インコーポレーテッド | 代謝調節型グルタミン酸受容体−5の調節物質としてのビピリジルアミド |
TW200800203A (en) | 2006-03-08 | 2008-01-01 | Astrazeneca Ab | New use |
BRPI0808523A2 (pt) * | 2007-03-01 | 2014-08-19 | Novartis Vaccines & Diagnostic | Inibidores de pim cinase e métodos de seu uso |
JP5702293B2 (ja) | 2008-11-10 | 2015-04-15 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Atrキナーゼの阻害剤として有用な化合物 |
-
2011
- 2011-01-18 CN CN2011800145753A patent/CN102812017A/zh active Pending
- 2011-01-18 CA CA2786520A patent/CA2786520A1/en not_active Abandoned
- 2011-01-18 KR KR1020127021445A patent/KR20120120307A/ko not_active Application Discontinuation
- 2011-01-18 AU AU2011208530A patent/AU2011208530A1/en not_active Abandoned
- 2011-01-18 JP JP2012549417A patent/JP2013517321A/ja active Pending
- 2011-01-18 US US13/008,154 patent/US8198285B2/en not_active Expired - Fee Related
- 2011-01-18 RU RU2012135093/04A patent/RU2012135093A/ru not_active Application Discontinuation
- 2011-01-18 EP EP11701554A patent/EP2526097A1/en not_active Withdrawn
- 2011-01-18 BR BR112012017884A patent/BR112012017884A2/pt not_active IP Right Cessation
- 2011-01-18 MX MX2012008328A patent/MX2012008328A/es not_active Application Discontinuation
- 2011-01-18 WO PCT/GB2011/050065 patent/WO2011089416A1/en active Application Filing
- 2011-01-19 UY UY0001033191A patent/UY33191A/es not_active Application Discontinuation
- 2011-01-19 TW TW100102003A patent/TW201130814A/zh unknown
- 2011-01-19 AR ARP110100182A patent/AR079945A1/es unknown
-
2012
- 2012-05-07 US US13/465,458 patent/US20130123275A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2526097A1 (en) | 2012-11-28 |
JP2013517321A (ja) | 2013-05-16 |
UY33191A (es) | 2011-08-31 |
BR112012017884A2 (pt) | 2019-09-24 |
US20130123275A1 (en) | 2013-05-16 |
US8198285B2 (en) | 2012-06-12 |
CN102812017A (zh) | 2012-12-05 |
RU2012135093A (ru) | 2014-03-10 |
WO2011089416A1 (en) | 2011-07-28 |
AU2011208530A1 (en) | 2012-08-09 |
US20120022082A1 (en) | 2012-01-26 |
MX2012008328A (es) | 2012-08-08 |
KR20120120307A (ko) | 2012-11-01 |
TW201130814A (en) | 2011-09-16 |
CA2786520A1 (en) | 2011-07-28 |
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Legal Events
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---|---|---|---|
FB | Suspension of granting procedure |