BR9804896B1 - Vetor, polinucleotídeo quimérico, plasmídeo de expressão, e, processo para aumentar a transcrição de um gene de interesse em uma célula hospedeira. - Google Patents
Vetor, polinucleotídeo quimérico, plasmídeo de expressão, e, processo para aumentar a transcrição de um gene de interesse em uma célula hospedeira.Info
- Publication number
- BR9804896B1 BR9804896B1 BRPI9804896-1B1A BR9804896A BR9804896B1 BR 9804896 B1 BR9804896 B1 BR 9804896B1 BR 9804896 A BR9804896 A BR 9804896A BR 9804896 B1 BR9804896 B1 BR 9804896B1
- Authority
- BR
- Brazil
- Prior art keywords
- gene
- regulatory dna
- polinucleotide
- transcription
- vector
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000013518 transcription Methods 0.000 title abstract 2
- 230000035897 transcription Effects 0.000 title abstract 2
- 230000001105 regulatory effect Effects 0.000 abstract 5
- 108020004414 DNA Proteins 0.000 abstract 4
- 241000699800 Cricetinae Species 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/847,218 US5888809A (en) | 1997-05-01 | 1997-05-01 | Hamster EF-1α transcriptional regulatory DNA |
PCT/US1998/008906 WO1998049289A1 (en) | 1997-05-01 | 1998-05-01 | HAMSTER EF-1α TRANSCRIPTIONAL REGULATORY DNA |
Publications (2)
Publication Number | Publication Date |
---|---|
BR9804896A BR9804896A (pt) | 1999-08-31 |
BR9804896B1 true BR9804896B1 (pt) | 2013-11-26 |
Family
ID=25300098
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9804896-1B1A BR9804896B1 (pt) | 1997-05-01 | 1998-05-01 | Vetor, polinucleotídeo quimérico, plasmídeo de expressão, e, processo para aumentar a transcrição de um gene de interesse em uma célula hospedeira. |
Country Status (20)
Country | Link |
---|---|
US (1) | US5888809A (pt) |
EP (2) | EP0920498B1 (pt) |
JP (1) | JP2000513948A (pt) |
CN (2) | CN100430477C (pt) |
AT (1) | ATE318900T1 (pt) |
AU (1) | AU742561B2 (pt) |
BR (1) | BR9804896B1 (pt) |
CZ (1) | CZ296544B6 (pt) |
DE (1) | DE69833649T2 (pt) |
DK (1) | DK0920498T3 (pt) |
ES (1) | ES2263206T3 (pt) |
HK (1) | HK1022719A1 (pt) |
HU (1) | HU225764B1 (pt) |
IL (1) | IL127897A (pt) |
NO (1) | NO323853B1 (pt) |
PL (1) | PL195604B1 (pt) |
PT (1) | PT920498E (pt) |
RU (2) | RU2249617C2 (pt) |
SK (1) | SK285664B6 (pt) |
WO (1) | WO1998049289A1 (pt) |
Families Citing this family (119)
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US8183344B2 (en) * | 1996-04-24 | 2012-05-22 | University Of Michigan | Inactivation resistant factor VIII |
US6479256B1 (en) | 1998-03-04 | 2002-11-12 | Icos Corporation | Lectomedin materials and methods |
KR20000046969A (ko) * | 1998-12-31 | 2000-07-25 | 이선경 | 이종 유전자 유래의 유전자 발현 조절요소를 포함하는 강력한전사 활성을 가진 진핵세포 발현벡더 |
EP1325341A2 (en) * | 2000-10-12 | 2003-07-09 | Icos Corporation | Modulation of ligand binding/enzymatic activity of alpha beta proteins |
WO2002050264A2 (en) * | 2000-12-18 | 2002-06-27 | Wyeth | Promoters and recombinant expression constructs |
ATE466941T1 (de) * | 2001-07-04 | 2010-05-15 | Chromagenics Bv | Dns-sequenzen mit anti-repressor-aktivität |
ATE500331T1 (de) * | 2002-06-14 | 2011-03-15 | Chromagenics Bv | Verfahren zur gleichzeitigen herstellung von multiplen proteinen; vektoren und zellen, die hierfür verwendung finden |
WO2003106674A2 (en) * | 2002-06-14 | 2003-12-24 | Chromagenics B.V. | Means and methods for regulating gene expression |
DK1573058T3 (da) * | 2002-12-18 | 2012-01-16 | Chromagenics Bv | Fremgangsmåde til forbedring af proteinproduktion |
WO2004056986A2 (en) * | 2002-12-20 | 2004-07-08 | Chromagenics B.V. | Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors |
EP2380985B1 (en) | 2003-09-23 | 2014-01-01 | University of North Carolina at Chapel Hill | Cells expressing vitamin K epoxide reductase and use thereof |
US8999667B2 (en) * | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
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US20060195935A1 (en) | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
MX2007004595A (es) * | 2004-11-08 | 2007-08-15 | Chromagenics Bv | Seleccion de celulas hospederas que expresan proteinas en altas concentraciones. |
US20060172382A1 (en) | 2004-11-08 | 2006-08-03 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
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US11267880B2 (en) | 2019-05-09 | 2022-03-08 | Boehringer Ingelheim International Gmbh | Anti-Sema3A antibodies and their uses for treating eye or ocular diseases |
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TW202126685A (zh) | 2019-09-24 | 2021-07-16 | 德商百靈佳殷格翰國際股份有限公司 | 抗nrp1a抗體及其用於治療眼或眼部疾病之用途 |
IL298431A (en) | 2020-05-26 | 2023-01-01 | Boehringer Ingelheim Int | Anti-pd-1 antibodies |
JP2024505674A (ja) | 2021-02-05 | 2024-02-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗il1rap抗体 |
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JP3051411B2 (ja) * | 1989-03-14 | 2000-06-12 | 持田製薬株式会社 | 新規dnaならびにそれを含有する発現プラスミド |
US5266491A (en) * | 1989-03-14 | 1993-11-30 | Mochida Pharmaceutical Co., Ltd. | DNA fragment and expression plasmid containing the DNA fragment |
DE69031172T2 (de) * | 1989-12-22 | 1998-03-12 | Applied Research Systems | Modifikation der endogenen genexpression mit hilfe eines regulatorischen elements mittels homologe rekombination |
US5650294A (en) * | 1990-06-25 | 1997-07-22 | Basf Aktiengesellschaft | Isolated promoter and terminator of elongation factor 1-α |
AU664847B2 (en) * | 1991-05-15 | 1995-12-07 | Cell Genesys, Inc. | Genomic modifications with homologous DNA targeting |
CA2051085C (en) * | 1991-09-10 | 2001-08-21 | Shigekazu Nagata | Expression plasmids |
TW402639B (en) * | 1992-12-03 | 2000-08-21 | Transkaryotic Therapies Inc | Protein production and protein delivery |
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