DE69838483D1 - Thymidinkinase mutanten und fusionproteine mit thymidinkinase und guanylatekinase aktivitäten - Google Patents
Thymidinkinase mutanten und fusionproteine mit thymidinkinase und guanylatekinase aktivitätenInfo
- Publication number
- DE69838483D1 DE69838483D1 DE69838483T DE69838483T DE69838483D1 DE 69838483 D1 DE69838483 D1 DE 69838483D1 DE 69838483 T DE69838483 T DE 69838483T DE 69838483 T DE69838483 T DE 69838483T DE 69838483 D1 DE69838483 D1 DE 69838483D1
- Authority
- DE
- Germany
- Prior art keywords
- thymidine kinase
- fusion proteins
- mutations
- guanylatekinase
- mutanes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
- C12N9/1211—Thymidine kinase (2.7.1.21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1229—Phosphotransferases with a phosphate group as acceptor (2.7.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/028—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a herpesvirus
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6181297P | 1997-10-14 | 1997-10-14 | |
US61812P | 1997-10-14 | ||
PCT/US1998/021672 WO1999019466A2 (en) | 1997-10-14 | 1998-10-14 | Thymidine kinase mutants and fusion proteins having thymidine kinase and guanylate kinase activities |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69838483D1 true DE69838483D1 (de) | 2007-11-08 |
DE69838483T2 DE69838483T2 (de) | 2008-07-03 |
Family
ID=22038301
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69838483T Expired - Lifetime DE69838483T2 (de) | 1997-10-14 | 1998-10-14 | Thymidinkinase mutanten und fusionproteine mit thymidinkinase und guanylatekinase aktivitäten |
Country Status (7)
Country | Link |
---|---|
US (7) | US7888091B2 (de) |
EP (3) | EP2386629A1 (de) |
JP (3) | JP2002516061A (de) |
AT (1) | ATE374247T1 (de) |
CA (1) | CA2306443A1 (de) |
DE (1) | DE69838483T2 (de) |
WO (1) | WO1999019466A2 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE374247T1 (de) * | 1997-10-14 | 2007-10-15 | Darwin Molecular Corp | Thymidinkinase mutanten und fusionproteine mit thymidinkinase und guanylatekinase aktivitäten |
GB0008966D0 (en) | 2000-04-13 | 2000-05-31 | Imp College Innovations Ltd | Vectors for gene therapy |
GB0010105D0 (en) * | 2000-04-26 | 2000-06-14 | Ml Lab Plc | Cell ablation |
AU783845B2 (en) * | 2000-05-12 | 2005-12-15 | Wolfgang Knecht | Novel deoxynucleoside kinase enzyme variants |
AU2001296864A1 (en) | 2000-08-31 | 2002-03-13 | Mayo Foundation For Medical Education And Research | Detection of varicella-zoster virus |
WO2002061390A2 (en) * | 2001-01-31 | 2002-08-08 | Mayo Foundation For Medical Education And Research | Detection of herpes simplex virus |
US7691571B2 (en) | 2001-01-31 | 2010-04-06 | Mayo Foundation For Medical Education And Research | Detection of bordetella |
US7439271B2 (en) * | 2001-06-27 | 2008-10-21 | The Gillette Company | Reduction of hair growth |
DK1509600T3 (da) | 2002-05-23 | 2009-04-27 | Wolfgang Knecht | Plante thymidin kinaser og deres anvendelse |
WO2003100045A1 (en) * | 2002-05-23 | 2003-12-04 | Wolfgang Knecht | Plant thymidine kinases and their use |
US7074598B2 (en) | 2002-09-25 | 2006-07-11 | Mayo Foundation For Medical Education And Research | Detection of vancomycin-resistant enterococcus spp. |
US7365176B2 (en) | 2002-09-26 | 2008-04-29 | Mayo Foundation For Medical Education And Research | Detection of Epstein-Barr virus |
US7074599B2 (en) | 2002-09-27 | 2006-07-11 | Mayo Foundation For Medical Education And Research | Detection of mecA-containing Staphylococcus spp. |
US7427475B2 (en) | 2003-11-18 | 2008-09-23 | Mayo Foundation For Medical Education And Research | Detection of group B streptococcus |
GB0413702D0 (en) | 2004-06-18 | 2004-07-21 | Molmed Spa | Thymidine kinase |
WO2013036526A1 (en) | 2011-09-06 | 2013-03-14 | Novozymes A/S | Glucoamylase variants and polynucleotides encoding same |
EP3988671A1 (de) * | 2013-02-20 | 2022-04-27 | Emory University | Zusammensetzungen zur sequenzierung von nukleinsäuren in mischungen |
AU2014236086B2 (en) | 2013-03-14 | 2020-03-05 | Genvivo, Inc. | Improved thymidine kinase gene |
US9951114B2 (en) | 2013-06-04 | 2018-04-24 | Virginia Commonwealth University | Recombinant cancer therapeutic cytokine |
WO2014197586A1 (en) | 2013-06-04 | 2014-12-11 | Virginia Commonwealth University | Mda-9/syntenin promoter to image and treat metastatic cancer cells |
US9750823B2 (en) | 2013-06-04 | 2017-09-05 | Virginia Commonwealth University | Use of a truncated CCN1 promoter for cancer diagnostics, therapeutics and theranostics |
US9454494B2 (en) * | 2014-08-01 | 2016-09-27 | Honeywell International Inc. | Encrypting a communication from a device |
WO2016100233A1 (en) | 2014-12-15 | 2016-06-23 | The Regents Of The University Of California | Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing |
JP7099967B2 (ja) | 2016-07-01 | 2022-07-12 | リサーチ ディベロップメント ファウンデーション | 幹細胞由来移植片からの増殖性細胞の排除 |
US11701384B2 (en) | 2016-09-02 | 2023-07-18 | The Regents Of The University Of California | Methods and compositions involving interleukin-6 receptor alpha-binding single chain variable fragments |
US11542524B2 (en) * | 2017-11-29 | 2023-01-03 | Research Development Foundation | Elimination of proliferating cells from stem cell-derived grafts |
CA3129883A1 (en) * | 2019-02-14 | 2020-08-20 | Ignite Immunotherapy, Inc. | Recombinant vaccinia virus and methods of use thereof |
CN109735571A (zh) * | 2019-03-11 | 2019-05-10 | 四川药智联恒科技有限公司 | 双自杀基因慢病毒表达载体及其应用 |
US20230265457A1 (en) * | 2021-10-25 | 2023-08-24 | Genvivo, Inc. | Compositions and methods for therapeutic delivery |
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US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
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US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
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US4769331A (en) | 1981-09-16 | 1988-09-06 | University Patents, Inc. | Recombinant methods and materials |
USRE32011E (en) | 1981-12-14 | 1985-10-22 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
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EP0758387B1 (de) | 1994-05-02 | 2001-12-19 | University of Washington | Thymidin-kinase-mutanten |
FR2723962B1 (fr) * | 1994-08-25 | 1996-10-31 | Univ Paris Curie | Hsv1-tk modifiee fonctionnelle |
JP2000505288A (ja) * | 1996-02-09 | 2000-05-09 | ローヌ―プーラン・ロレ・エス・アー | チミジンキナーゼ変異体、対応する核酸配列および遺伝子治療におけるそれらの用途 |
FR2746016B1 (fr) * | 1996-03-15 | 1998-04-17 | Combinaisons d'enzymes pour la destruction de cellules proliferatives | |
ATE374247T1 (de) * | 1997-10-14 | 2007-10-15 | Darwin Molecular Corp | Thymidinkinase mutanten und fusionproteine mit thymidinkinase und guanylatekinase aktivitäten |
-
1998
- 1998-10-14 AT AT98953487T patent/ATE374247T1/de not_active IP Right Cessation
- 1998-10-14 JP JP2000516019A patent/JP2002516061A/ja not_active Withdrawn
- 1998-10-14 WO PCT/US1998/021672 patent/WO1999019466A2/en active IP Right Grant
- 1998-10-14 DE DE69838483T patent/DE69838483T2/de not_active Expired - Lifetime
- 1998-10-14 EP EP10182771A patent/EP2386629A1/de not_active Withdrawn
- 1998-10-14 EP EP10182819A patent/EP2386630A1/de not_active Withdrawn
- 1998-10-14 EP EP98953487A patent/EP1025212B1/de not_active Expired - Lifetime
- 1998-10-14 CA CA002306443A patent/CA2306443A1/en not_active Abandoned
-
2008
- 2008-07-04 JP JP2008176378A patent/JP5070145B2/ja not_active Expired - Fee Related
-
2009
- 2009-05-08 US US12/463,261 patent/US7888091B2/en not_active Expired - Fee Related
- 2009-05-08 US US12/463,283 patent/US7888114B2/en not_active Expired - Fee Related
-
2010
- 2010-12-29 US US12/981,428 patent/US8236541B2/en not_active Expired - Fee Related
- 2010-12-29 US US12/981,418 patent/US8163528B2/en not_active Expired - Fee Related
-
2011
- 2011-11-30 US US13/308,188 patent/US20120142071A1/en not_active Abandoned
- 2011-11-30 US US13/308,164 patent/US20120149890A1/en not_active Abandoned
-
2012
- 2012-01-05 JP JP2012000673A patent/JP2012115270A/ja not_active Withdrawn
- 2012-06-29 US US13/538,503 patent/US20130011903A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE69838483T2 (de) | 2008-07-03 |
WO1999019466A2 (en) | 1999-04-22 |
EP1025212B1 (de) | 2007-09-26 |
JP2008301828A (ja) | 2008-12-18 |
US20130011903A1 (en) | 2013-01-10 |
US8163528B2 (en) | 2012-04-24 |
EP2386630A1 (de) | 2011-11-16 |
US20090298156A1 (en) | 2009-12-03 |
US20120149890A1 (en) | 2012-06-14 |
US20100112685A1 (en) | 2010-05-06 |
US8236541B2 (en) | 2012-08-07 |
JP5070145B2 (ja) | 2012-11-07 |
US20110165653A1 (en) | 2011-07-07 |
CA2306443A1 (en) | 1999-04-22 |
US7888114B2 (en) | 2011-02-15 |
EP1025212A2 (de) | 2000-08-09 |
JP2002516061A (ja) | 2002-06-04 |
US7888091B2 (en) | 2011-02-15 |
WO1999019466A3 (en) | 1999-07-08 |
JP2012115270A (ja) | 2012-06-21 |
US20110136221A1 (en) | 2011-06-09 |
ATE374247T1 (de) | 2007-10-15 |
US20120142071A1 (en) | 2012-06-07 |
EP2386629A1 (de) | 2011-11-16 |
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