FR2723962B1 - Hsv1-tk modifiee fonctionnelle - Google Patents

Hsv1-tk modifiee fonctionnelle

Info

Publication number
FR2723962B1
FR2723962B1 FR9410298A FR9410298A FR2723962B1 FR 2723962 B1 FR2723962 B1 FR 2723962B1 FR 9410298 A FR9410298 A FR 9410298A FR 9410298 A FR9410298 A FR 9410298A FR 2723962 B1 FR2723962 B1 FR 2723962B1
Authority
FR
France
Prior art keywords
hsv1
modified functional
functional
modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9410298A
Other languages
English (en)
Other versions
FR2723962A1 (fr
Inventor
David Klatzmann
Benoit Salomon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite Pierre et Marie Curie Paris 6
Original Assignee
Universite Pierre et Marie Curie Paris 6
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite Pierre et Marie Curie Paris 6 filed Critical Universite Pierre et Marie Curie Paris 6
Priority to FR9410298A priority Critical patent/FR2723962B1/fr
Priority to EP95927796A priority patent/EP0777736A1/fr
Priority to US08/793,518 priority patent/US6004803A/en
Priority to PCT/FR1995/001098 priority patent/WO1996006176A1/fr
Priority to JP8507824A priority patent/JPH10506007A/ja
Publication of FR2723962A1 publication Critical patent/FR2723962A1/fr
Application granted granted Critical
Publication of FR2723962B1 publication Critical patent/FR2723962B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
FR9410298A 1994-08-25 1994-08-25 Hsv1-tk modifiee fonctionnelle Expired - Fee Related FR2723962B1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
FR9410298A FR2723962B1 (fr) 1994-08-25 1994-08-25 Hsv1-tk modifiee fonctionnelle
EP95927796A EP0777736A1 (fr) 1994-08-25 1995-08-17 Hsv1-tk modifiee fonctionnelle
US08/793,518 US6004803A (en) 1994-08-25 1995-08-17 Genes encoding HSV1-TK containing a deletion of 5' cryptic promoter sites, vectors and cell lines
PCT/FR1995/001098 WO1996006176A1 (fr) 1994-08-25 1995-08-17 Hsv1-tk modifiee fonctionnelle
JP8507824A JPH10506007A (ja) 1994-08-25 1995-08-17 機能修飾されたｈｓｖ１−ｔｋ

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9410298A FR2723962B1 (fr) 1994-08-25 1994-08-25 Hsv1-tk modifiee fonctionnelle

Publications (2)

Publication Number Publication Date
FR2723962A1 FR2723962A1 (fr) 1996-03-01
FR2723962B1 true FR2723962B1 (fr) 1996-10-31

Family

ID=9466493

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9410298A Expired - Fee Related FR2723962B1 (fr) 1994-08-25 1994-08-25 Hsv1-tk modifiee fonctionnelle

Country Status (5)

Country Link
US (1) US6004803A (fr)
EP (1) EP0777736A1 (fr)
JP (1) JPH10506007A (fr)
FR (1) FR2723962B1 (fr)
WO (1) WO1996006176A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2746016B1 (fr) * 1996-03-15 1998-04-17 Combinaisons d'enzymes pour la destruction de cellules proliferatives
EP1914304A1 (fr) * 1998-10-14 2008-04-23 Darwin Molecular Corporation Mutants de kinase de thymidine et protéines de fusion ayant de la kinase de thymidine et activités de kinase de guanylate
ATE374247T1 (de) 1997-10-14 2007-10-15 Darwin Molecular Corp Thymidinkinase mutanten und fusionproteine mit thymidinkinase und guanylatekinase aktivitäten
AU773542B2 (en) * 1998-06-16 2004-05-27 Board Of Regents Of The University Of Oklahoma, The Glycosulfopeptides and methods of synthesis and use thereof
US9392790B2 (en) 2011-05-06 2016-07-19 The Research Foundation For The State University Of New York Molecular roadblocks for RpoN binding sites
KR102077648B1 (ko) * 2017-12-28 2020-02-14 주식회사 바이오녹스 안전성 및 항암효과가 개선된 종양 용해 바이러스
CN111818932A (zh) * 2018-02-28 2020-10-23 拜耳诺克斯有限公司 包含抗癌病毒和羟基脲作为有效成分的预防或治疗癌症的药物组合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9100612D0 (en) * 1991-01-11 1991-02-27 Univ Edinburgh Method of altering the metabolic state of non-dividing cells,transgenic animals and therapeutic agents
FR2699191B1 (fr) * 1992-12-16 1995-02-10 Univ Paris Curie Nouveaux vecteurs rétroviraux, lignées cellulaires les contenant, et leur utilisation dans le traitement des tumeurs.

Also Published As

Publication number Publication date
EP0777736A1 (fr) 1997-06-11
WO1996006176A1 (fr) 1996-02-29
JPH10506007A (ja) 1998-06-16
FR2723962A1 (fr) 1996-03-01
US6004803A (en) 1999-12-21

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