BR112013015898A2 - derivado de ácido graxo solúvel em água, e, métodos para preparar um derivado de ácido graxo e uma proteína terapêutica conjugada. - Google Patents
derivado de ácido graxo solúvel em água, e, métodos para preparar um derivado de ácido graxo e uma proteína terapêutica conjugada.Info
- Publication number
- BR112013015898A2 BR112013015898A2 BR112013015898-0A BR112013015898A BR112013015898A2 BR 112013015898 A2 BR112013015898 A2 BR 112013015898A2 BR 112013015898 A BR112013015898 A BR 112013015898A BR 112013015898 A2 BR112013015898 A2 BR 112013015898A2
- Authority
- BR
- Brazil
- Prior art keywords
- fatty acid
- acid derivative
- preparing
- methods
- water soluble
- Prior art date
Links
- 235000014113 dietary fatty acids Nutrition 0.000 title 2
- 229930195729 fatty acid Natural products 0.000 title 2
- 239000000194 fatty acid Substances 0.000 title 2
- 150000004665 fatty acids Chemical class 0.000 title 2
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061426356P | 2010-12-22 | 2010-12-22 | |
| US61/426356 | 2010-12-22 | ||
| PCT/US2011/065591 WO2012087838A1 (en) | 2010-12-22 | 2011-12-16 | Materials and methods for conjugating a water soluble fatty acid derivative to a protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013015898A2 true BR112013015898A2 (pt) | 2018-06-26 |
Family
ID=45464916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013015898-0A BR112013015898A2 (pt) | 2010-12-22 | 2011-12-16 | derivado de ácido graxo solúvel em água, e, métodos para preparar um derivado de ácido graxo e uma proteína terapêutica conjugada. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8945897B2 (https=) |
| EP (2) | EP2654794B8 (https=) |
| JP (1) | JP6138052B2 (https=) |
| KR (1) | KR102025442B1 (https=) |
| CN (1) | CN103269723B (https=) |
| AR (1) | AR084576A1 (https=) |
| AU (2) | AU2011349574B9 (https=) |
| BR (1) | BR112013015898A2 (https=) |
| CA (1) | CA2822591C (https=) |
| DK (1) | DK2654794T3 (https=) |
| EA (1) | EA032056B1 (https=) |
| ES (1) | ES2800983T3 (https=) |
| HU (1) | HUE049352T2 (https=) |
| MX (1) | MX345608B (https=) |
| NZ (1) | NZ612320A (https=) |
| PL (1) | PL2654794T3 (https=) |
| PT (1) | PT2654794T (https=) |
| SG (1) | SG191298A1 (https=) |
| TW (1) | TWI546279B (https=) |
| WO (1) | WO2012087838A1 (https=) |
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| EP2892908A4 (en) * | 2012-09-10 | 2016-05-11 | Univ Johns Hopkins | FESTPHASENGLYCAN AND GLYCOPEPTIDE ANALYSIS AND MICROFLUIDIC CHIP FOR GLYCOME EXTRACTION AND ANALYSIS AND METHOD FOR THEIR USE |
| CN103897031A (zh) * | 2012-12-25 | 2014-07-02 | 深圳先进技术研究院 | 化学修饰的胸腺五肽及其合成方法 |
| US20140243220A1 (en) * | 2013-02-25 | 2014-08-28 | J. Craig Venter Institute | Metaproteomic Method to Identify Secreted Pattern Recognition Molecules and Adhesive Antimicrobial Factors for Detection of Microbial Agents Eliciting Inflammation in the Human Host |
| EP2976365A1 (en) * | 2013-03-20 | 2016-01-27 | Fresenius Kabi Deutschland GmbH | Process for the preparation of thiol functionalized hydroxyalkyl starch derivatives |
| CN103636918B (zh) * | 2013-12-13 | 2015-11-04 | 东北农业大学 | 一种富含亚油酸的改性分离蛋白制备方法 |
| WO2015095553A1 (en) | 2013-12-20 | 2015-06-25 | Nephrogenesis, Llc | Methods and apparatus for kidney dialysis |
| EP2915569A1 (en) | 2014-03-03 | 2015-09-09 | Cytune Pharma | IL-15/IL-15Ralpha based conjugates purification method |
| CN107921103A (zh) * | 2015-08-12 | 2018-04-17 | 细胞机械股份有限公司 | 涉及长半衰期凝血复合物的方法和组合物 |
| CN106554425B (zh) * | 2015-09-18 | 2018-10-30 | 沈阳药科大学 | 一种聚唾液酸的脂质接枝衍生物及其应用 |
| KR20170065016A (ko) * | 2015-12-02 | 2017-06-12 | 한미약품 주식회사 | 지방산 유도체를 이용한 단백질 결합체 및 이의 제조방법 |
| CN108147990B (zh) * | 2016-12-02 | 2023-01-24 | 上海中医药大学 | 一种膜锚定元件及其应用 |
| CN110637027B (zh) | 2017-02-08 | 2024-08-30 | 百时美施贵宝公司 | 包含药代动力学增强子的修饰的松弛素多肽及其用途 |
| CN107141354A (zh) * | 2017-05-05 | 2017-09-08 | 李斯文 | 一种融合蛋白及光敏剂复合物及其制备方法和应用 |
| WO2019023295A1 (en) | 2017-07-27 | 2019-01-31 | Saint Louis University | Fatty acid modified human epidermal growth factor |
| JP6984923B2 (ja) * | 2017-09-19 | 2021-12-22 | イミュンワーク インク.Immunwork Inc. | アルブミンとの強化された結合親和性を有する医薬構築物 |
| US11845989B2 (en) | 2019-01-23 | 2023-12-19 | Regeneron Pharmaceuticals, Inc. | Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors |
| JP2022523301A (ja) | 2019-01-23 | 2022-04-22 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | アンジオポエチン様７（ａｎｇｐｔｌ７）阻害剤による眼疾患の治療 |
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| TW202128961A (zh) | 2019-11-20 | 2021-08-01 | 美商安維塔生物科學股份有限公司 | 細胞激素融合蛋白及其醫藥組合物及治療應用 |
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| CN113967267B (zh) * | 2020-07-21 | 2022-10-25 | 四川大学 | 脂肪酸修饰的白蛋白的内质网靶向作用及其用途 |
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| EP4561630A1 (en) * | 2022-07-29 | 2025-06-04 | The Trustees of The University of Pennsylvania | Lymphatic targeted anti-coagulant for the prevention of lymphatic thrombosis |
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| CN118209737B (zh) * | 2024-05-22 | 2024-08-09 | 国科大杭州高等研究院 | 一种用于鉴定检测脂肪酸与蛋白质相互作用的方法 |
| CN120801727B (zh) * | 2025-09-15 | 2026-01-06 | 江西本草天工科技有限责任公司 | 系统性红斑狼疮的诊断标志物及其应用 |
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| CN103269723A (zh) | 2013-08-28 |
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| HUE049352T2 (hu) | 2020-09-28 |
| EP2654794B1 (en) | 2020-03-04 |
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| PL2654794T3 (pl) | 2020-07-27 |
| PT2654794T (pt) | 2020-06-11 |
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| TW201305090A (zh) | 2013-02-01 |
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| CA2822591A1 (en) | 2012-06-28 |
| US8945897B2 (en) | 2015-02-03 |
| WO2012087838A1 (en) | 2012-06-28 |
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