PT2654794T - Materiais e métodos para conjugação de um derivado de ácido gordo solúvel em água a uma proteína - Google Patents

Materiais e métodos para conjugação de um derivado de ácido gordo solúvel em água a uma proteína

Info

Publication number
PT2654794T
PT2654794T PT118061035T PT11806103T PT2654794T PT 2654794 T PT2654794 T PT 2654794T PT 118061035 T PT118061035 T PT 118061035T PT 11806103 T PT11806103 T PT 11806103T PT 2654794 T PT2654794 T PT 2654794T
Authority
PT
Portugal
Prior art keywords
conjugating
protein
materials
methods
fatty acid
Prior art date
Application number
PT118061035T
Other languages
English (en)
Original Assignee
Baxalta Inc
Baxalta GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxalta Inc, Baxalta GmbH filed Critical Baxalta Inc
Publication of PT2654794T publication Critical patent/PT2654794T/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
PT118061035T 2010-12-22 2011-12-16 Materiais e métodos para conjugação de um derivado de ácido gordo solúvel em água a uma proteína PT2654794T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201061426356P 2010-12-22 2010-12-22

Publications (1)

Publication Number Publication Date
PT2654794T true PT2654794T (pt) 2020-06-11

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PT118061035T PT2654794T (pt) 2010-12-22 2011-12-16 Materiais e métodos para conjugação de um derivado de ácido gordo solúvel em água a uma proteína

Country Status (20)

Country Link
US (1) US8945897B2 (pt)
EP (2) EP3673921A1 (pt)
JP (1) JP6138052B2 (pt)
KR (1) KR102025442B1 (pt)
CN (1) CN103269723B (pt)
AR (1) AR084576A1 (pt)
AU (2) AU2011349574B9 (pt)
BR (1) BR112013015898A2 (pt)
CA (1) CA2822591C (pt)
DK (1) DK2654794T3 (pt)
EA (1) EA032056B1 (pt)
ES (1) ES2800983T3 (pt)
HU (1) HUE049352T2 (pt)
MX (1) MX345608B (pt)
NZ (1) NZ612320A (pt)
PL (1) PL2654794T3 (pt)
PT (1) PT2654794T (pt)
SG (1) SG191298A1 (pt)
TW (1) TWI546279B (pt)
WO (1) WO2012087838A1 (pt)

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CN106554425B (zh) * 2015-09-18 2018-10-30 沈阳药科大学 一种聚唾液酸的脂质接枝衍生物及其应用
JP6989503B2 (ja) * 2015-12-02 2022-01-05 ハンミ ファーマシューティカル カンパニー リミテッド 脂肪酸誘導体を用いたタンパク質結合体及びその製造方法
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CN113967267B (zh) * 2020-07-21 2022-10-25 四川大学 脂肪酸修饰的白蛋白的内质网靶向作用及其用途
KR20230148819A (ko) 2021-02-26 2023-10-25 리제너론 파마슈티칼스 인코포레이티드 글루코코르티코이드 및 안지오포이에틴-유사 7 (angptl7) 억제제를 이용한 염증의 치료
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