TR201908836T4 - Oksim bağına yönelik nükleofilik katalizörler. - Google Patents

Oksim bağına yönelik nükleofilik katalizörler. Download PDF

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Publication number
TR201908836T4
TR201908836T4 TR2019/08836T TR201908836T TR201908836T4 TR 201908836 T4 TR201908836 T4 TR 201908836T4 TR 2019/08836 T TR2019/08836 T TR 2019/08836T TR 201908836 T TR201908836 T TR 201908836T TR 201908836 T4 TR201908836 T4 TR 201908836T4
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Turkey
Prior art keywords
soluble polymer
water
oxidized carbohydrate
methods
oxime bond
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TR2019/08836T
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English (en)
Inventor
Siekmann Juergen
Haider Stefan
Rottensteiner Hanspeter
Ivens Andreas
Turecek Peter
Zoechling Oliver
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Baxalta GmbH
Baxalta Inc
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Publication of TR201908836T4 publication Critical patent/TR201908836T4/tr

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

Buluş, konjugasyonu mümkün kılan koşullar altında, oksitlenmiş karbonhidrat kısmının, aktif hale getirilmiş bir suda çözünebilir polimer ile temas ettirilmesini içeren, suda çözünebilir bir polimerin, bir terapötik proteinin bir oksitlenmiş karbonhidrat kısmı ile konjuge edilmesine yönelik malzemeler ve yöntemler ile ilgilidir. Daha spesifik olarak, mevcut buluş yukarıda bahsi geçen malzemeler ve yöntemler ile ilgilidir, burada suda çözünebilir polimer bir aktif aminooksi grubu içermektedir ve burada bir oksim veya hidrazon bağı, oksitlenmiş karbonhidrat kısmı ve suda çözünebilir polimer üzerindeki aktif aminooksi grubu arasında oluşturulmaktadır ve burada konjugasyon, bir nükleofilik katalizörün mevcudiyetinde gerçekleştirilmektedir.
TR2019/08836T 2010-07-30 2011-07-29 Oksim bağına yönelik nükleofilik katalizörler. TR201908836T4 (tr)

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US36918610P 2010-07-30 2010-07-30

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TR201908836T4 true TR201908836T4 (tr) 2019-07-22

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EP (3) EP4023247A1 (tr)
JP (7) JP6325818B2 (tr)
KR (6) KR102325780B1 (tr)
CN (3) CN103370082A (tr)
AR (1) AR082941A1 (tr)
AU (1) AU2011282571C1 (tr)
BR (1) BR112013001611B1 (tr)
CA (1) CA2806684C (tr)
CY (1) CY1121943T1 (tr)
DK (1) DK2598172T3 (tr)
EA (2) EA025738B9 (tr)
ES (1) ES2731626T3 (tr)
HR (1) HRP20190990T1 (tr)
HU (1) HUE043790T2 (tr)
LT (1) LT2598172T (tr)
MX (1) MX346271B (tr)
NZ (1) NZ605972A (tr)
PL (1) PL2598172T3 (tr)
PT (1) PT2598172T (tr)
RS (1) RS58900B1 (tr)
SG (2) SG187171A1 (tr)
SI (1) SI2598172T1 (tr)
TR (1) TR201908836T4 (tr)
TW (1) TWI534152B (tr)
WO (1) WO2012016131A1 (tr)

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CN103370082A (zh) * 2010-07-30 2013-10-23 巴克斯特国际公司 用于肟键联的亲核性催化剂

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